| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katrina McGonigal, Jamshid Tanha, Elitza Palazov, Shenghua Li, Deyzi Gueorguieva-Owens, Siyaram Pande. Isolation and functional characterization of single domain antibody modulators of Caspase-3 and apoptosis. Applied biochemistry and biotechnology. vol 157. issue 2. 2009-07-08. PMID:18553063. |
these v(h)h antagonist and agonist of apoptosis could have potential for the development of therapeutics for neurodegenerative diseases and cancer, respectively. |
2009-07-08 |
2023-08-12 |
human |
| K Yamagata, S Ichinose, A Miyashita, M Tagam. Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Neuroscience. vol 153. issue 2. 2009-06-29. PMID:18384965. |
ebselen may be effective in the prevention and/or treatment of neurodegenerative diseases associated with excessive apoptosis in patients with stroke. |
2009-06-29 |
2023-08-12 |
rat |
| Nazzareno Ballatori, Suzanne M Krance, Sylvia Notenboom, Shujie Shi, Kim Tieu, Christine L Hammon. Glutathione dysregulation and the etiology and progression of human diseases. Biological chemistry. vol 390. issue 3. 2009-06-12. PMID:19166318. |
glutathione (gsh) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result, disturbances in gsh homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and neurodegenerative diseases. |
2009-06-12 |
2023-08-12 |
human |
| Baolu Zha. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:19125328. |
the author reviews the studies on the protecting effects of natural antioxidants on neurons in neurodegenerative diseases, especially summarized the results about protective effect of green tea polyphenols on neurons against apoptosis of cellular and animal pd models, and of genestine and nicotine on neurons against a beta-induced apoptosis of hippocampal neuronal and transgenic mouse ad models. |
2009-06-03 |
2023-08-12 |
mouse |
| Volodymyr Rybalchenko, Sung-Yong Hwang, Nataliya Rybalchenko, Peter Koule. The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity. The international journal of biochemistry & cell biology. vol 40. issue 1. 2009-05-01. PMID:17709274. |
exaggerated chronic ca(2+) release can trigger cellular apoptosis underlying a variety of neurodegenerative diseases. |
2009-05-01 |
2023-08-12 |
mouse |
| Parco M Siu, Stephen E Alwa. Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273076. |
apoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. |
2009-04-07 |
2023-08-12 |
Not clear |
| Adrienne M Gorma. Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. Journal of cellular and molecular medicine. vol 12. issue 6A. 2009-04-02. PMID:18624755. |
this review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, alzheimer's, parkinson's and huntington's diseases. |
2009-04-02 |
2023-08-12 |
Not clear |
| Cheng-Gang Zou, Xiu-Zhen Cao, Yue-Shui Zhao, Shun-Yu Gao, Shu-De Li, Xian-Yong Liu, Yan Zhang, Ke-Qin Zhan. The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I. Endocrinology. vol 150. issue 1. 2009-03-12. PMID:18801901. |
the molecular mechanism of endoplasmic reticulum stress-induced apoptosis in pc-12 neuronal cells: the protective effect of insulin-like growth factor i. endoplasmic reticulum (er) stress has been implicated in several neurodegenerative diseases. |
2009-03-12 |
2023-08-12 |
Not clear |
| Orit Bar-Am, Orly Weinreb, Tamar Amit, Moussa B H Youdi. The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats. Journal of molecular neuroscience : MN. vol 37. issue 2. 2009-03-05. PMID:18751929. |
in addition to its unique combination of che and mao enzyme inhibition, these results indicate that ladostigil displays neuroprotective activity against oxidative stress-induced cell apoptosis, which might be valuable for aging and age-associated neurodegenerative diseases. |
2009-03-05 |
2023-08-12 |
human |
| Erin Carlton, Qingshan Teng, Thais Federici, Jun Yang, Jonathan Riley, Nicholas M Bouli. Fusion of the tetanus toxin C fragment binding domain and Bcl-xL for protection of peripheral nerve neurons. Neurosurgery. vol 63. issue 6. 2009-02-19. PMID:19057331. |
apoptosis has been shown to play an important role in motor neuron (mn) degeneration in both neurodegenerative disease and peripheral neuropathy. |
2009-02-19 |
2023-08-12 |
Not clear |
| Agnieszka Dejda, Valérie Jolivel, Steve Bourgault, Tommy Seaborn, Alain Fournier, Hubert Vaudry, David Vaudr. Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. Journal of molecular neuroscience : MN. vol 36. issue 1-3. 2009-02-17. PMID:18506634. |
inhibitory effect of pacap on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. |
2009-02-17 |
2023-08-12 |
Not clear |
| Pin-Chao Liao, Hung-Yu Lin, Chiou-Hwa Yuh, Lin-Kwei Yu, Horng-Dar Wan. The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila. Biochemical and biophysical research communications. vol 376. issue 4. 2008-11-13. PMID:18796296. |
heat shock proteins (hsps) are chaperones thought to increase lifespan, enhance stress resistance, and prevent apoptosis and neurodegenerative diseases. |
2008-11-13 |
2023-08-12 |
drosophila_melanogaster |
| Jae Keun Lee, Jin Hee Shin, JaeHong Suh, In Sun Choi, Keun Sil Ryu, Byoung Joo Gwa. Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis. Neurobiology of disease. vol 30. issue 2. 2008-10-13. PMID:18316197. |
these findings provide evidence that timp-3 is an upstream mediator of neuronal apoptosis and likely contributes to neuronal loss in neurodegenerative diseases such as amyotrophic lateral sclerosis. |
2008-10-13 |
2023-08-12 |
mouse |
| Joel A Dietz, Yan Li, Lisa M Chung, Brian S Yandell, Cassandra L Schlamp, Robert W Nickell. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC neuroscience. vol 9. 2008-09-10. PMID:18671875. |
intrinsic apoptosis of neuronal somas is one aspect of neurodegenerative diseases that can be influenced by genetic background. |
2008-09-10 |
2023-08-12 |
mouse |
| Seong Soo Joo, Yeong Min Yoo, Byung Woo Ahn, Sang Yun Nam, Yun-Bae Kim, Kwang Woo Hwang, Do Ik Le. Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological & pharmaceutical bulletin. vol 31. issue 7. 2008-09-02. PMID:18591781. |
considering the importance of inflammation and apoptosis in neurodegenerative conditions, the potential suppressive effects of the rg3, a by-product obtained during the steaming of red ginseng, may indicate that rg3 could provide a beneficial therapeutic approach to treating or preventing neurodegenerative disease. |
2008-09-02 |
2023-08-12 |
Not clear |
| b' Nazmi G\\xc3\\xbcltekin, Kamil Karao\\xc4\\x9flu, Emine K\\xc3\\xbc\\xc3\\xa7\\xc3\\xbckate\\xc5\\x9. [New discoveries in the mechanisms of apoptosis and cell survival and novel potential therapeutic strategies]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. vol 36. issue 2. 2008-08-14. PMID:18497559.' |
the discovery of mechanisms of apoptosis and cell survival has enabled the development of new therapeutic strategies in heart diseases, cancers, neurodegenerative diseases, aids, and many disorders. |
2008-08-14 |
2023-08-12 |
Not clear |
| Francis G Blankenber. In vivo detection of apoptosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49 Suppl 2. 2008-08-06. PMID:18523067. |
the dysregulation of apoptosis can lead to the destruction of normal tissues in a variety of disorders, including autoimmune and neurodegenerative diseases (too much apoptosis) or the growth of tumors (too little apoptosis). |
2008-08-06 |
2023-08-12 |
Not clear |
| LingLing Hou, Tao Hon. Stem cells and neurodegenerative diseases. Science in China. Series C, Life sciences. vol 51. issue 4. 2008-07-29. PMID:18368305. |
neurodegenerative diseases are characterized by the neurodegenerative changes or apoptosis of neurons involved in networks, which are important to specific physiological functions. |
2008-07-29 |
2023-08-12 |
Not clear |
| S G Kalinichenko, N Yu Matveev. Morphological characteristics of apoptosis and its significance in neurogenesis. Neuroscience and behavioral physiology. vol 38. issue 4. 2008-07-24. PMID:18401722. |
apoptosis affects the ordering of connections in neural networks and is involved in the pathogenesis of neurodegenerative diseases--epilepsy, schizophrenia, and alzheimer's disease. |
2008-07-24 |
2023-08-12 |
Not clear |
| James W Simpkins, James A Dyken. Mitochondrial mechanisms of estrogen neuroprotection. Brain research reviews. vol 57. issue 2. 2008-07-01. PMID:17512984. |
the mitochondrial involvement in neurodegenerative diseases reflects the regulatory role mitochondrial failure plays in both necrotic cell death and apoptosis. |
2008-07-01 |
2023-08-12 |
Not clear |