| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zhang, Huixin Yu, Yang Sun, Xiufeng Lin, Bo Chen, Chen Tan, Guoxian Cao, Zhengwu Wan. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. European journal of pharmacology. vol 564. issue 1-3. 2007-08-17. PMID:17349619. |
these results suggest that salidroside has protective effects against oxidative stress-induced cell apoptosis, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases implicated with oxidative stress. |
2007-08-17 |
2023-08-12 |
human |
| Yumei Wu, Mikiro Tada, Kyota Takahata, Kazuhito Tomizawa, Hideki Matsu. Inhibitory effect of polyunsaturated fatty acids on apoptosis induced by etoposide, okadaic acid and AraC in Neuro2a cells. Acta medica Okayama. vol 61. issue 3. 2007-07-25. PMID:17593950. |
neuronal apoptosis is involved in neurodegenerative diseases such as alzheimer's disease and parkinson.s disease. |
2007-07-25 |
2023-08-12 |
mouse |
| Ramon Roset, Laura Ortet, Gabriel Gil-Gome. Role of Bcl-2 family members on apoptosis: what we have learned from knock-out mice. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-06-29. PMID:17485408. |
deregulation of their role may subvert the homeostasis of a given tissue and collaborate in the genesis of a myriad of diseases characterised by exacerbated or insufficient apoptosis, including diseases such as neurodegenerative diseases or cancer. |
2007-06-29 |
2023-08-12 |
mouse |
| Zoltán Urbányi, Miklós Sass, Judit Laszy, Viktor Takács, István Gyertyán, Tamás Pázmán. Serum amyloid P component induces TUNEL-positive nuclei in rat brain after intrahippocampal administration. Brain research. vol 1145. 2007-06-26. PMID:17337265. |
apoptosis is an important form of cell death in different neurodegenerative diseases including alzheimer's disease. |
2007-06-26 |
2023-08-12 |
rat |
| David A Elliott, Woojin S Kim, David A Jans, Brett Garne. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neuroscience letters. vol 416. issue 2. 2007-06-22. PMID:17320289. |
neuronal apoptosis is crucial for central nervous system development and also contributes to neurodegenerative disease. |
2007-06-22 |
2023-08-12 |
human |
| Sodhi K Rupinder, Aulakh K Gurpreet, Singh Manjee. Cell suicide and caspases. Vascular pharmacology. vol 46. issue 6. 2007-06-14. PMID:17382599. |
conversely dysregulation of apoptosis, resulting in either too less or excessive cell death is implicated in pathogenesis of stroke, myocardial infarction, neurodegenerative diseases, cancer and autoimmmune disorders. |
2007-06-14 |
2023-08-12 |
Not clear |
| M I Smith, M Deshmuk. Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell death and differentiation. vol 14. issue 5. 2007-05-23. PMID:17218955. |
apoptosis triggered by endoplasmic reticulum (er) stress is associated with various pathophysiological conditions including neurodegenerative diseases and ischemia. |
2007-05-23 |
2023-08-12 |
Not clear |
| M Naoi, W Maruyama, Y Akao, H Yi, Y Yamaok. Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447417. |
in neurodegenerative diseases, including parkinson's and alzheimer's diseases, apoptosis is a common type of cell death, and mitochondria emerge as the major organelle to initiate death cascade. |
2007-05-17 |
2023-08-12 |
human |
| Patrizia Fattoretti, Carlo Bertoni-Freddari, Rina Recchioni, Belinda Giorgetti, Marta Balietti, Yessica Grossi, Moreno Solazzi, Tiziana Casoli, Giuseppina Di Stefano, Fiorella Marchesell. Experimental apoptosis provides clues about the role of mitochondrial changes in neuronal death. Annals of the New York Academy of Sciences. vol 1090. 2007-04-26. PMID:17384249. |
a better understanding of the mitochondrial role in neuronal apoptosis may suggest potential interventions to prevent the extensive nerve cell death typical of neurodegenerative diseases. |
2007-04-26 |
2023-08-12 |
human |
| Chor Hui Vivien Koh, Nam Sang Cheun. Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease. Cellular signalling. vol 18. issue 11. 2007-04-10. PMID:16797161. |
this review provides a consolidation of work done using u18666a in the past half century and focuses on the implications of our research findings on the mechanism of u18666a-mediated neuronal apoptosis in primary cortical neurons, which may provide an insight to elucidate the mechanisms of neurodegenerative diseases, particularly npc and ad, where apoptosis might occur through a similar mechanism. |
2007-04-10 |
2023-08-12 |
Not clear |
| Salvador Harguindey, Stephan J Reshkin, Gorka Orive, Jose Luis Arranz, Eduardo Anitu. Growth and trophic factors, pH and the Na+/H+ exchanger in Alzheimer's disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and potential dangers. Current Alzheimer research. vol 4. issue 1. 2007-03-27. PMID:17316166. |
recent discoveries in research and treatment have shown that failure to induce selective cell apoptosis in hyperproliferative processes, like neoplastic diseases, and the failure to prevent spontaneous cell death in neurodegenerative diseases (hndds) such as alzheimer's disease (ad), multiple sclerosis (ms), amyothrophic lateral sclerosis (als), huntington's disease (hd), and retinitis pigmentosa (rp), can be interpreted as problems stemming from the same basic mechanisms but moving in diametrically opposed directions. |
2007-03-27 |
2023-08-12 |
human |
| Kyu-Yong Lee, Seong-Ho Koh, Min Young Noh, Kun-Woo Park, Young Joo Lee, Seung Hyun Ki. Glycogen synthase kinase-3beta activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells. Brain research. vol 1129. issue 1. 2007-03-22. PMID:17157278. |
these results suggest that optimized inhibitor levels for modulating gsk-3beta activity may prevent apoptosis induced by oxidative stress associated with neurodegenerative diseases. |
2007-03-22 |
2023-08-12 |
Not clear |
| Gülgün Tezel, Martin B Wa. Glaucoma. Chemical immunology and allergy. vol 92. 2007-03-21. PMID:17264498. |
glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosis of retinal ganglion cells (rgcs) and progressive loss of optic nerve axons result in structural and functional deficits in glaucoma patients. |
2007-03-21 |
2023-08-12 |
Not clear |
| Daniela Sanges, Antonella Comitato, Roberta Tammaro, Valeria Marig. Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 46. 2007-01-05. PMID:17088543. |
molecular mechanisms underlying apoptosis in retinitis pigmentosa, as in other neurodegenerative diseases, are still elusive, and this fact hampers the development of a cure for this blinding disease. |
2007-01-05 |
2023-08-12 |
mouse |
| Peter Waldmeier, Donna Bozyczko-Coyne, Michael Williams, Jeffry L Vaugh. Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. Biochemical pharmacology. vol 72. issue 10. 2006-12-15. PMID:16901468. |
recent clinical failures in parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. |
2006-12-15 |
2023-08-12 |
Not clear |
| Peter Waldmeier, Donna Bozyczko-Coyne, Michael Williams, Jeffry L Vaugh. Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. Biochemical pharmacology. vol 72. issue 10. 2006-12-15. PMID:16901468. |
these recent clinical failures require a reassessment of both the relevance of apoptosis to neurodegenerative disease etiology and the available animal models used to prioritize nces for advancement to the clinic in this area. |
2006-12-15 |
2023-08-12 |
Not clear |
| Cassandra L Schlamp, Yan Li, Joel A Dietz, Katherine T Janssen, Robert W Nickell. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC neuroscience. vol 7. 2006-11-14. PMID:17018142. |
glaucoma is a chronic neurodegenerative disease of the retina, characterized by the degeneration of axons in the optic nerve and retinal ganglion cell apoptosis. |
2006-11-14 |
2023-08-12 |
mouse |
| Pawel Kermer, Jan Liman, Jochen H Weishaupt, Mathias Bäh. Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. Neuro-degenerative diseases. vol 1. issue 1. 2006-09-26. PMID:16908969. |
neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. |
2006-09-26 |
2023-08-12 |
Not clear |
| Pawel Kermer, Jan Liman, Jochen H Weishaupt, Mathias Bäh. Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. Neuro-degenerative diseases. vol 1. issue 1. 2006-09-26. PMID:16908969. |
the present article will provide an overview of basic apoptotic mechanisms, the contribution of neuronal apoptosis to the above-mentioned disorders, potential clinical applications and their limitations and the possible implications for future studies regarding these neurodegenerative diseases. |
2006-09-26 |
2023-08-12 |
Not clear |
| Chor Hui Vivien Koh, Matthew Whiteman, Qiao-Xin Li, Barry Halliwell, Andrew M Jenner, Boon Seng Wong, Katrina M Laughton, Markus Wenk, Colin L Masters, Philip M Beart, Ora Bernard, Nam Sang Cheun. Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons. Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16771828. |
the association of neuronal apoptosis with oxidative stress and abeta accumulation may provide clues to the pathogenesis of alzheimer's disease, as well as the role oxidative stress plays in other neurodegenerative diseases. |
2006-09-21 |
2023-08-12 |
Not clear |