| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zelda H Cheung, Ke Gong, Nancy Y I. Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 19. 2008-06-13. PMID:18463240. |
accumulating evidence indicates that deregulation of cyclin-dependent kinase 5 (cdk5) activity is associated with apoptosis in various neurodegenerative disease models. |
2008-06-13 |
2023-08-12 |
Not clear |
| Hongjun Fu, Juan Dou, Wenming Li, Jialie Luo, Kenny C Li, Colin S C Lam, Nelson T K Lee, Mingtao Li, Yifan Ha. Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms. Neuropharmacology. vol 54. issue 4. 2008-06-12. PMID:18222492. |
neuronal loss via apoptosis caused by various stimuli may be the fundamental mechanism underlying chronic and acute neurodegenerative diseases. |
2008-06-12 |
2023-08-12 |
Not clear |
| Yun Feng, Yingwei Lu, Xin Lin, Yanfeng Gao, Qianyu Zhao, Wei Li, Rui Wan. Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse. Life sciences. vol 82. issue 13-14. 2008-06-09. PMID:18272183. |
furthermore, these drugs blocked the enhanced release of cytochrome c (cyt c), and consequently inhibited the cell apoptosis induced by the release of cyt c. our results suggest that em1/2 and mor effectively protect brain mitochondria against oxidative stresses induced by in vitro anoxia-reoxygenation and may play an important role in the prevention of deleterious effects during brain ischemia-reperfusion and neurodegenerative diseases. |
2008-06-09 |
2023-08-12 |
mouse |
| Isabelle Lang-Rollin, Georgia Dermentzaki, Kostas Vekrellis, Maria Xilouri, Hardy J Rideout, Leonidas Stefani. A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18194212. |
the type of death described herein may be relevant to neurodegenerative diseases, where morphological evidence for apoptosis has been scant. |
2008-05-22 |
2023-08-12 |
mouse |
| Sonja Dittmer, Mert Sahin, Anna Pantlen, Ambrish Saxena, Diamandis Toutzaris, Ana-Luisa Pina, Andreas Geerts, Stefan Golz, Axel Methne. The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18180304. |
we conclude that gpr39 is a novel inhibitor of cell death, which might represent a therapeutic target with implications for processes involving apoptosis and endoplasmic reticulum stress like cancer, ischemia/reperfusion injury, and neurodegenerative disease. |
2008-05-20 |
2023-08-12 |
Not clear |
| M Miloso, A Scuteri, D Foudah, G Tredic. MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases. Current medicinal chemistry. vol 15. issue 6. 2008-05-19. PMID:18336268. |
although they are characterized by different features and a different onset, all the neurodegenerative diseases share the final steps that lead to cell death by apoptosis. |
2008-05-19 |
2023-08-12 |
Not clear |
| Monica Bari, Sergio Oddi, Chiara De Simone, Paola Spagnolo, Valeria Gasperi, Natalia Battista, Diego Centonze, Mauro Maccarron. Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17714745. |
these findings may be relevant for the manifold cb1r-dependent activities of endocannabinoids, like the regulation of apoptosis and of neurodegenerative diseases. |
2008-04-18 |
2023-08-12 |
Not clear |
| Domagoj Vuci. Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors. Current cancer drug targets. vol 8. issue 2. 2008-04-17. PMID:18336193. |
dysregulation of apoptosis leading to early cell death or the absence of normal cell death contributes to a number of disease conditions including neurodegenerative diseases and cancer. |
2008-04-17 |
2023-08-12 |
human |
| Johann Schoenberger, Johann Bauer, Jutta Moosbauer, Christoph Eilles, Daniela Grim. Innovative strategies in in vivo apoptosis imaging. Current medicinal chemistry. vol 15. issue 2. 2008-04-03. PMID:18220774. |
apoptosis (programmed cell death) plays a key role in the pathogenesis of many disorders including cerebral and myocardial ischemia, autoimmune and neurodegenerative diseases, infections, organ and bone marrow transplant rejection, and tumor response to chemotherapy and/or radiotherapy. |
2008-04-03 |
2023-08-12 |
Not clear |
| Daniel Zemke, Seema Azhar, Arshad Maji. The mTOR pathway as a potential target for the development of therapies against neurological disease. Drug news & perspectives. vol 20. issue 8. 2008-03-27. PMID:18080036. |
many neurodegenerative diseases are characterized by neuronal death via apoptosis, and it is possible that modulation of mtor activity may offer some protection against their effects. |
2008-03-27 |
2023-08-12 |
Not clear |
| Maik Hüttemann, Icksoo Lee, Lobelia Samavati, Hong Yu, Jeffrey W Doa. Regulation of mitochondrial oxidative phosphorylation through cell signaling. Biochimica et biophysica acta. vol 1773. issue 12. 2008-02-15. PMID:18240421. |
a lack of cellular energy, excessive radical production, and dysregulated apoptosis are found alone or in combination in most human diseases, including neurodegenerative diseases, stroke, cardiovascular disorders, ischemia/reperfusion, and cancer. |
2008-02-15 |
2023-08-12 |
human |
| Xiao-Tian Zhang, Tian-Bao Song, Bao-Ling Du, Dong-Min Li, Xiao-Ming L. Caspase-3 antisense oligodeoxynucleotides inhibit apoptosis in gamma-irradiated human leukemia HL-60 cells. Apoptosis : an international journal on programmed cell death. vol 12. issue 4. 2008-01-14. PMID:17219053. |
the results suggest that antisense approach may be useful for therapeutic treatment of certain neurodegenerative diseases in which apoptosis is involved. |
2008-01-14 |
2023-08-12 |
human |
| B E Morrison, N Majdzadeh, S R D'Mell. Histone deacetylases: focus on the nervous system. Cellular and molecular life sciences : CMLS. vol 64. issue 17. 2007-11-09. PMID:17530170. |
neurodegenerative disease strikes millions worldwide and there is mounting evidence suggesting that underlying the onset and progression of these debilitating diseases is inappropriate neuronal apoptosis. |
2007-11-09 |
2023-08-12 |
Not clear |
| Zhenquan Jia, Hara P Misr. Exposure to mixtures of endosulfan and zineb induces apoptotic and necrotic cell death in SH-SY5Y neuroblastoma cells, in vitro. Journal of applied toxicology : JAT. vol 27. issue 5. 2007-10-25. PMID:17309119. |
these findings suggest that the cytotoxicity of endosulfan and zineb, both individually and in mixtures, is associated with the occurrence of early and late apoptotic/necrotic processes in sh-sy5y human neuroblastoma cells and support the contention that pesticide-induced neuronal cell death leading to neurodegenerative disease may, at least in part, be associated with early and late apoptosis of dopaminergic neurons. |
2007-10-25 |
2023-08-12 |
human |
| Wenya Wang, Yi Yang, Chunyi Ying, Wenming Li, Haolan Ruan, Xiaonan Zhu, Yan You, Yifan Han, Ruzhu Chen, Yizheng Wang, Mingtao L. Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology. vol 52. issue 8. 2007-10-25. PMID:17517424. |
glycogen synthase kinase-3beta (gsk-3beta) is closely involved in neuronal apoptosis and pathogenesis of many neurodegenerative diseases, such as alzheimer's disease. |
2007-10-25 |
2023-08-12 |
Not clear |
| Gonzalo Arboleda, Catherine Waters, Rosemary Gibso. Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. Neuroscience letters. vol 421. issue 3. 2007-10-12. PMID:17573191. |
evidence has implicated apoptosis as a mechanism underlying cell death in diverse neurodegenerative diseases including parkinson's disease (pd). |
2007-10-12 |
2023-08-12 |
Not clear |
| Hiroshi Nishida, Megumi Kushida, Yuki Nakajima, Yoshihiro Ogawa, Naoto Tatewaki, Shinji Sato, Tetsuya Konish. Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction. Journal of pharmacological sciences. vol 104. issue 1. 2007-10-09. PMID:17485916. |
sms prevents the apoptosis through the enhancement of anti-oxidant enzymes and inhibition of the jnk signaling pathway with the promotion of nerve cell maturation, thus suggesting benefits of sms for the treating of neurodegenerative diseases. |
2007-10-09 |
2023-08-12 |
Not clear |
| Masahiro Okouchi, Oleksandr Ekshyyan, Magdalena Maracine, Tak Yee A. Neuronal apoptosis in neurodegeneration. Antioxidants & redox signaling. vol 9. issue 8. 2007-09-14. PMID:17571960. |
current and new experimental models for apoptosis research in neurodegenerative diseases are also discussed. |
2007-09-14 |
2023-08-12 |
Not clear |
| R Miller, W Bradley, M Cudkowicz, J Hubble, V Meininger, H Mitsumoto, D Moore, H Pohlmann, D Sauer, V Silani, M Strong, M Swash, E Vernotic. Phase II/III randomized trial of TCH346 in patients with ALS. Neurology. vol 69. issue 8. 2007-09-14. PMID:17709710. |
apoptosis is considered to be a key pathogenic mechanism in neurodegenerative diseases including als. |
2007-09-14 |
2023-08-12 |
Not clear |
| Susan Elmor. Apoptosis: a review of programmed cell death. Toxicologic pathology. vol 35. issue 4. 2007-09-05. PMID:17562483. |
inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. |
2007-09-05 |
2023-08-12 |
human |