| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Praneeti Pathipati, Matthieu Lecuyer, Joel Faustino, Jacqueline Strivelli, Donald G Phinney, Zinaida S Vexle. Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles Protect from Neonatal Stroke by Interacting with Microglial Cells. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-06. PMID:34235636. |
herein, we examined if msc-sev protect neonatal brain from stroke and if this effect is mediated via communication with microglia. |
2021-12-06 |
2023-08-13 |
mouse |
| Mikko T Huuskonen, Yaoming Wang, Angeliki Maria Nikolakopoulou, Axel Montagne, Zhonghua Dai, Divna Lazic, Abhay P Sagare, Zhen Zhao, Jose A Fernandez, John H Griffin, Berislav V Zlokovi. Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C. The Journal of experimental medicine. vol 219. issue 1. 2021-12-04. PMID:34846535. |
we show that par1 and par3 were also required for 3k3a-apc's suppression of post-wm stroke microglia and astrocyte responses and overall improvement in neuropathologic and functional outcomes. |
2021-12-04 |
2023-08-13 |
mouse |
| Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Ji. Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke. Biochemical and biophysical research communications. vol 577. 2021-11-26. PMID:34507068. |
microglia are polarized toward the proinflammatory m1 phenotype and neuroprotective m2 phenotype after stroke and play an important role in the pathological process of ischemic stroke. |
2021-11-26 |
2023-08-13 |
rat |
| Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Ji. Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke. Biochemical and biophysical research communications. vol 577. 2021-11-26. PMID:34507068. |
our results revealed that vns can promote m2 microglia polarization and inhibit m1 microglia polarization to alleviate brain injury via inhibition of the tlr4/myd88/nf-κb pathway in microglia in the acute stage of stroke. |
2021-11-26 |
2023-08-13 |
rat |
| Ruiqing Kang, Marcin Gamdzyk, Cameron Lenahan, Jiping Tang, Sheng Tan, John H Zhan. The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke. Current neuropharmacology. vol 18. issue 12. 2021-11-25. PMID:32469699. |
the dual role of microglia in blood-brain barrier dysfunction after stroke. |
2021-11-25 |
2023-08-13 |
Not clear |
| Ruiqing Kang, Marcin Gamdzyk, Cameron Lenahan, Jiping Tang, Sheng Tan, John H Zhan. The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke. Current neuropharmacology. vol 18. issue 12. 2021-11-25. PMID:32469699. |
in this review, we are going to discuss the mechanisms responsible for the dual role of microglia in bbb dysfunction after stroke. |
2021-11-25 |
2023-08-13 |
Not clear |
| Ting Li, Jin Zhao, Wenguang Xie, Wanru Yuan, Jing Guo, Shengru Pang, Wen-Biao Gan, Diego Gómez-Nicola, Shengxiang Zhan. Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. Journal of neuroinflammation. vol 18. issue 1. 2021-11-17. PMID:33757565. |
specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. |
2021-11-17 |
2023-08-13 |
Not clear |
| Chen He, Renhuai Liu, Zhongming Fan, Yi Li, Manping Yang, Hou Wugang, Zhihong Lu, Zongping Fang, Binxiao S. Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review. Pain and therapy. vol 10. issue 2. 2021-11-17. PMID:34278548. |
microglia in the pathophysiology of hemorrhagic stroke and the relationship between microglia and pain after stroke: a narrative review. |
2021-11-17 |
2023-08-13 |
Not clear |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the tgf-β/smad2/3 pathway. |
2021-11-17 |
2023-08-13 |
mouse |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
systemic transplantation of oxygen-glucose deprivation (ogd)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. |
2021-11-17 |
2023-08-13 |
mouse |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
hence, the present findings suggest a new way of action of evs derived from ogd-preconditioned microglia by regulating the tgf-β/smad2/3 pathway in order to promote tissue regeneration and neurological recovery in stroke mice. |
2021-11-17 |
2023-08-13 |
mouse |
| Yuya Ota, Yasue Kubota, Yuji Hotta, Mami Matsumoto, Nayuka Matsuyama, Taiki Kato, Takashi Hamakawa, Tomoya Kataoka, Kazunori Kimura, Kazunobu Sawamoto, Takahiro Yasu. Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis. PloS one. vol 16. issue 11. 2021-11-12. PMID:34752461. |
immunopathological evaluation showed an accumulation of activated microglia, followed by an increase in reactive astrocytes at the peri-infarct zone after photothrombotic stroke. |
2021-11-12 |
2023-08-13 |
rat |
| Ludmila Belayev, Sung-Ha Hong, Raul S Freitas, Hemant Menghani, Shawn J Marcell, Larissa Khoutorova, Pranab K Mukherjee, Madigan M Reid, Reinaldo B Oria, Nicolas G Baza. DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke. CNS neuroscience & therapeutics. vol 26. issue 11. 2021-10-25. PMID:32757264. |
the microglia cell surface receptor (triggering receptor expressed on myeloid cells-2; trem2) regulates the production of pro- and antiinflammatory mediators after stroke. |
2021-10-25 |
2023-08-13 |
Not clear |
| Brooke J Wanrooy, Shu Wen Wen, Connie Hy Won. Dynamic roles of neutrophils in post-stroke neuroinflammation. Immunology and cell biology. vol 99. issue 9. 2021-10-25. PMID:33894069. |
currently, there is some uncertainty as to whether neutrophil diversity is beneficial or harmful in stroke as their interactions with the resident cells of the brain, such as microglia and neurons, would potentially elicit heterogeneous outcomes. |
2021-10-25 |
2023-08-13 |
Not clear |
| Hui Li, Pengfei Wang, Lin Tang, Jingjing Sun, Yanling Zhang, Wei Luo, Cong Luo, Zhaolan Hu, Lin Yan. Distinct Polarization Dynamics of Microglia and Infiltrating Macrophages: A Novel Mechanism of Spinal Cord Ischemia/Reperfusion Injury. Journal of inflammation research. vol 14. 2021-10-23. PMID:34675600. |
recent studies indicate that microglia and monocyte-derived macrophages (mdms) have different roles in diseases such as stroke and spinal cord injury, yet their respective polarized phenotypes and roles remain unclear in spinal cord ischemia/reperfusion injury (sciri). |
2021-10-23 |
2023-08-13 |
Not clear |
| Min Cai, Sisi Sun, Jin Wang, Beibei Dong, Qianzi Yang, Li Tian, Hailong Dong, Shiquan Wang, Wugang Ho. Sevoflurane preconditioning protects experimental ischemic stroke by enhancing anti-inflammatory microglia/macrophages phenotype polarization through GSK-3β/Nrf2 pathway. CNS neuroscience & therapeutics. vol 27. issue 11. 2021-10-22. PMID:34370899. |
in this study, we aimed to assess the effect of spc on microglia polarization after stroke and which signaling pathway was involved in this transition. |
2021-10-22 |
2023-08-13 |
Not clear |
| Zinaida S Vexler, Xian Nan Tang, Midori A Yenar. Inflammation in adult and neonatal stroke. Clinical neuroscience research. vol 6. issue 5. 2021-10-20. PMID:20300490. |
it will review the role of specific cell types and interactions among blood cells, endothelium, glia, microglia, the extracellular matrix and neurons - cumulatively called "neurovascular unit" - in stroke induction and evolution. |
2021-10-20 |
2023-08-12 |
Not clear |
| Kristy A Zera, Marion S Buckwalte. T cells direct microglial repair of white matter after stroke. Trends in neurosciences. vol 44. issue 10. 2021-10-20. PMID:34332802. |
this study elucidates the mechanisms by which tregs direct microglia to alter their phenotype to support oligodendrogenesis, thereby improving white matter integrity and functional recovery after stroke in mice. |
2021-10-20 |
2023-08-13 |
mouse |
| Daniel Berchtold, Josef Priller, Christian Meisel, Andreas Meise. Interaction of microglia with infiltrating immune cells in the different phases of stroke. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:33058417. |
interaction of microglia with infiltrating immune cells in the different phases of stroke. |
2021-10-06 |
2023-08-13 |
Not clear |
| Zhonglin Lyu, Jon Park, Kwang-Min Kim, Hye-Jin Jin, Haodi Wu, Jayakumar Rajadas, Deok-Ho Kim, Gary K Steinberg, Wonjae Le. A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke. Nature biomedical engineering. vol 5. issue 8. 2021-09-13. PMID:34385693. |
here, we report the development and applicability of a functional neurovascular unit on a microfluidic chip as a microphysiological model of ischaemic stroke that recapitulates the function of the blood-brain barrier as well as interactions between therapeutic stem cells and host cells (human brain microvascular endothelial cells, pericytes, astrocytes, microglia and neurons). |
2021-09-13 |
2023-08-13 |
human |