| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung Hak Kim, So Young Kim, Bokyung Kim, Sang Rae Lee, Sang Hoon Cha, Dong Seok Lee, Hong Jun Le. Prospects of Therapeutic Target and Directions for Ischemic Stroke. Pharmaceuticals (Basel, Switzerland). vol 14. issue 4. 2021-05-02. PMID:33916253. |
these cytokines lead to severe neurotoxicity via the overactivation of microglia in prolonged and lasting insults such as stroke. |
2021-05-02 |
2023-08-13 |
Not clear |
| Abdulhameed Bakreen, Miia Juntunen, Yannick Dunlop, Irene F Ugidos, Tarja Malm, Susanna Miettinen, Jukka Jolkkone. Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats. International journal of molecular sciences. vol 22. issue 4. 2021-04-20. PMID:33546370. |
additive behavioral improvement after combined cell therapy and rehabilitation despite long-term microglia presence in stroke rats. |
2021-04-20 |
2023-08-13 |
rat |
| Lu Jiang, Hongfeng Mu, Fei Xu, Di Xie, Wei Su, Jing Xu, Zeyu Sun, Silvia Liu, Jianhua Luo, Yejie Shi, Rehana K Leak, Lawrence R Wechsler, Jun Chen, Xiaoming H. Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32065074. |
transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery. |
2021-03-23 |
2023-08-13 |
Not clear |
| Lu Jiang, Hongfeng Mu, Fei Xu, Di Xie, Wei Su, Jing Xu, Zeyu Sun, Silvia Liu, Jianhua Luo, Yejie Shi, Rehana K Leak, Lawrence R Wechsler, Jun Chen, Xiaoming H. Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32065074. |
here, we compared the transcriptional profiles of young versus aged microglia during stroke recovery. |
2021-03-23 |
2023-08-13 |
Not clear |
| Ligen Shi, Marcelo Rocha, Wenting Zhang, Ming Jiang, Sicheng Li, Qing Ye, Sulaiman H Hassan, Liqiang Liu, Maya N Adair, Jing Xu, Jianhua Luo, Xiaoming Hu, Lawrence R Wechsler, Jun Chen, Yejie Sh. Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32438860. |
senescence-associated alterations in microglia may have profound impact on cerebral homeostasis and stroke outcomes. |
2021-03-23 |
2023-08-13 |
mouse |
| Ligen Shi, Marcelo Rocha, Wenting Zhang, Ming Jiang, Sicheng Li, Qing Ye, Sulaiman H Hassan, Liqiang Liu, Maya N Adair, Jing Xu, Jianhua Luo, Xiaoming Hu, Lawrence R Wechsler, Jun Chen, Yejie Sh. Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:32438860. |
gene clusters with functional implications in immune inflammatory responses, immune cell chemotaxis, tissue remodeling, and cell-cell interactions were markedly activated in microglia of young but not aged stroke mice. |
2021-03-23 |
2023-08-13 |
mouse |
| Wenjun Deng, Emiri Mandeville, Yasukazu Terasaki, Wenlu Li, Julie Holder, Aaron Tt Chuang, Mingming Ning, Ken Arai, Eng H Lo, Changhong Xin. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 1_suppl. 2021-03-23. PMID:33208001. |
microglia are key regulators of inflammatory response after stroke and brain injury. |
2021-03-23 |
2023-08-13 |
rat |
| Ladonya Jackson, Selin Dumanli, Maribeth H Johnson, Susan C Fagan, Adviye Ergu. Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. Journal of neuroinflammation. vol 17. issue 1. 2021-03-19. PMID:32345303. |
microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. |
2021-03-19 |
2023-08-13 |
Not clear |
| Masahiro Hatakeyama, Itaru Ninomiya, Yutaka Otsu, Kaoru Omae, Yasuko Kimura, Osamu Onodera, Masanori Fukushima, Takayoshi Shimohata, Masato Kanazaw. Cell Therapies under Clinical Trials and Polarized Cell Therapies in Pre-Clinical Studies to Treat Ischemic Stroke and Neurological Diseases: A Literature Review. International journal of molecular sciences. vol 21. issue 17. 2021-02-22. PMID:32867222. |
polarized microglia or peripheral blood mononuclear cells might provide promising therapeutic strategies after stroke because they have pleiotropic effects. |
2021-02-22 |
2023-08-13 |
Not clear |
| Cheng-Ting Jiang, Wan-Feng Wu, Yi-Hui Deng, Jin-Wen G. Modulators of microglia activation and polarization in ischemic stroke (Review). Molecular medicine reports. vol 21. issue 5. 2021-02-16. PMID:32323760. |
it has been shown that m1 microglia promote secondary brain damage, whilst m2 microglia facilitate recovery following stroke. |
2021-02-16 |
2023-08-13 |
Not clear |
| Lu Lian, Yunsha Zhang, Lu Liu, Liji Yang, Yichen Cai, Junping Zhang, Shixin X. Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Frontiers in molecular neuroscience. vol 13. 2021-01-26. PMID:33488360. |
during the acute phase of stroke onset, m2 microglia are the dominant phenotype and exert protective effects on neuronal cells, whereas permanent m1 microglia contribute to prolonged inflammation and are detrimental to brain tissue. |
2021-01-26 |
2023-08-13 |
Not clear |
| Lu Lian, Yunsha Zhang, Lu Liu, Liji Yang, Yichen Cai, Junping Zhang, Shixin X. Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia. Frontiers in molecular neuroscience. vol 13. 2021-01-26. PMID:33488360. |
thus, we briefly reviewed the dynamic response of microglia after a stroke and assessed how specific mirnas affect the behavior of reactive microglia. |
2021-01-26 |
2023-08-13 |
Not clear |
| Shengxiang Zhan. Microglial activation after ischaemic stroke. Stroke and vascular neurology. vol 4. issue 2. 2021-01-25. PMID:31338213. |
ischaemic stroke can induce rapid activation of microglia. |
2021-01-25 |
2023-08-13 |
Not clear |
| Wan Zhang, Tian Tian, Shao-Xin Gong, Wen-Qian Huang, Qin-Yi Zhou, Ai-Ping Wang, Ying Tia. Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke. Neural regeneration research. vol 16. issue 1. 2021-01-23. PMID:32788440. |
therefore, it is clinically important to study the role and regulation of microglia in stroke. |
2021-01-23 |
2023-08-13 |
Not clear |
| Eileen Gülke, Mathias Gelderblom, Tim Magnu. Danger signals in stroke and their role on microglia activation after ischemia. Therapeutic advances in neurological disorders. vol 11. 2021-01-08. PMID:29854002. |
danger signals in stroke and their role on microglia activation after ischemia. |
2021-01-08 |
2023-08-13 |
Not clear |
| Tongshuai Zhang, Dandan Wang, Xuan Li, Yixiang Jiang, Chao Wang, Yao Zhang, Qingfei Kong, Chao Tian, Yongfeng Dai, Wei Zhao, Mingyue Jiang, Yanzhong Chang, Guangyou Wan. Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32044667. |
the administration of either the ar inhibitor epalrestat or a p38-neutralizing antibody blocked the polarization of microglia and alleviated stroke injury. |
2021-01-07 |
2023-08-13 |
mouse |
| Tongshuai Zhang, Dandan Wang, Xuan Li, Yixiang Jiang, Chao Wang, Yao Zhang, Qingfei Kong, Chao Tian, Yongfeng Dai, Wei Zhao, Mingyue Jiang, Yanzhong Chang, Guangyou Wan. Excess salt intake promotes M1 microglia polarization via a p38/MAPK/AR-dependent pathway after cerebral ischemia in mice. International immunopharmacology. vol 81. 2021-01-07. PMID:32044667. |
in conclusion, hsd promotes polarization in pro-inflammatory m1 microglia by upregulating the expression of the ar protein via p38/mapk, thereby exacerbating the development of ischemia stroke. |
2021-01-07 |
2023-08-13 |
mouse |
| Pranay Srivastava, Chunxia G Cronin, Victoria L Scranton, Kenneth A Jacobson, Bruce T Liang, Rajkumar Verm. Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke. Experimental neurology. vol 329. 2020-12-24. PMID:32289314. |
p2x4r, a receptor for adenosine triphosphate (atp), regulates activation of myeloid immune cells (infiltrating monocytes/macrophages and brain-resident microglia) after stroke injury. |
2020-12-24 |
2023-08-13 |
mouse |
| Tsogzolmaa Ganbold, Qingming Bao, Jargalmaa Zandan, Agula Hasi, Huricha Baigud. Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi. ACS applied materials & interfaces. vol 12. issue 10. 2020-11-30. PMID:32073249. |
inhibition of proinflammatory (m1) polarization and promotion of anti-inflammatory (m2) polarization of microglia are potential therapeutic strategies for inflammation reduction and neuronal recovery after stroke. |
2020-11-30 |
2023-08-13 |
Not clear |
| Ashley McDonough, Jonathan R Weinstei. The role of microglia in ischemic preconditioning. Glia. vol 68. issue 3. 2020-11-19. PMID:31386233. |
although there are technological challenges and gaps in knowledge to overcome, the targeting of specific molecular signaling pathways in microglia is a promising direction for development of novel and effective pharmacotherapies for stroke. |
2020-11-19 |
2023-08-13 |
Not clear |