| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumin Kim, Youngsook So. Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia. International journal of molecular sciences. vol 22. issue 16. 2021-09-13. PMID:34445510. |
in this study, we aimed to elucidate whether astrocytes and microglia could crosstalk to induce microglial polarization and proliferation, which can be further regulated under a microenvironment mimicking that of brain stroke. |
2021-09-13 |
2023-08-13 |
Not clear |
| Kai Zheng, Lingmin Lin, Wei Jiang, Lin Chen, Xiyue Zhang, Qian Zhang, Yi Ren, Junwei Ha. Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021-09-09. PMID:34496660. |
notably, microglia displayed a cell differentiation diversity after stroke among its five distinct subtypes. |
2021-09-09 |
2023-08-13 |
mouse |
| Cuicui Yang, Shili Gong, Xiaoping Chen, Mingyang Wang, Li Zhang, Lan Zhang, Chaoying H. Analgecine regulates microglia polarization in ischemic stroke by inhibiting NF-κB through the TLR4 MyD88 pathway. International immunopharmacology. vol 99. 2021-09-08. PMID:34229178. |
therapeutic strategies used to attenuate inflammation and to increase recovery of neurons after a stroke include microglia anti-inflammatory (m2) polarization and repression of proinflammatory (m1). |
2021-09-08 |
2023-08-13 |
rat |
| Shirley Marino Lee, Jacob Hudobenko, Louise D McCullough, Anjali Chauha. Microglia depletion increase brain injury after acute ischemic stroke in aged mice. Experimental neurology. vol 336. 2021-08-30. PMID:33221396. |
aged microglia acquire a senescent phenotype and produce more inflammatory cytokines after stroke. |
2021-08-30 |
2023-08-13 |
mouse |
| Bhakta Prasad Gair. Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia. Cellular and molecular neurobiology. 2021-08-30. PMID:34460037. |
furthermore, this review also sheds the light on the therapeutic potential of microglia in stroke patients. |
2021-08-30 |
2023-08-13 |
Not clear |
| Junxuan Lyu, Di Xie, Tarun N Bhatia, Rehana K Leak, Xiaoming Hu, Xiaoyan Jian. Microglial/Macrophage polarization and function in brain injury and repair after stroke. CNS neuroscience & therapeutics. vol 27. issue 5. 2021-08-27. PMID:33650313. |
after stroke injury, microglia and cns-resident macrophages are rapidly activated and regulate neuropathological processes to steer the course of functional recovery. |
2021-08-27 |
2023-08-13 |
Not clear |
| Qingkun Liu, Siamak K Sorooshyar. Quantitative and Correlational Analysis of Brain and Spleen Immune Cellular Responses Following Cerebral Ischemia. Frontiers in immunology. vol 12. 2021-08-23. PMID:34194419. |
furthermore, the correlation among neurological deficit and various immune cells suggests that microglia and splenic adaptive immune cells (t and b cells) are protective while infiltrating peripheral myeloid cells (macrophage and neutrophils) worsen stroke outcome. |
2021-08-23 |
2023-08-13 |
mouse |
| Xin Zhou, Ya-Ni Zhang, Fang-Fang Li, Zhao Zhang, Li-Yuan Cui, Hong-Yuan He, Xu Yan, Wen-Bin He, Hong-Shuo Sun, Zhong-Ping Feng, Shi-Feng Chu, Nai-Hong Che. Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke. Acta pharmacologica Sinica. 2021-08-13. PMID:34385606. |
neuronal chemokine-like-factor 1 (cklf1) up-regulation promotes m1 polarization of microglia in rat brain after stroke. |
2021-08-13 |
2023-08-13 |
human |
| Sheng-Jun Wen, Xi-Min Zheng, Li-Fen Liu, Na-Na Li, Hai-An Mao, Liang Huang, Qiong-Lan Yua. Effects of primary microglia and astrocytes on neural stem cells in Neural regeneration research. vol 16. issue 9. 2021-08-10. PMID:33510055. |
effects of primary microglia and astrocytes on neural stem cells in transplantation of neural stem cells (nscs) can protect neurons in animal stroke models; however, their low rates of survival and neuronal differentiation limit their clinical application. |
2021-08-10 |
2023-08-13 |
rat |
| Sheng-Jun Wen, Xi-Min Zheng, Li-Fen Liu, Na-Na Li, Hai-An Mao, Liang Huang, Qiong-Lan Yua. Effects of primary microglia and astrocytes on neural stem cells in Neural regeneration research. vol 16. issue 9. 2021-08-10. PMID:33510055. |
in the present study, we explored the effects of activated astrocytes and microglia on neural stem cells in vitro stroke models. |
2021-08-10 |
2023-08-13 |
rat |
| Wai Ping Yew, Natalia D Djukic, Jaya S P Jayaseelan, Richard J Woodman, Hakan Muyderman, Neil R Sim. Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats. Journal of neuroinflammation. vol 18. issue 1. 2021-08-06. PMID:34332596. |
differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in rats. |
2021-08-06 |
2023-08-13 |
rat |
| Min Cheng, Yue Geng, Yeting Chen, Yongjie Zhang, Runjie Guo, Hong Xu, Jianfeng Liang, Jiajun Xie, Zean Zhang, Xuesong Tia. δ-Opioid receptor activation ameliorates lipopolysaccharide-induced inflammation and apoptosis by inhibiting the MAPK/caspase-3 pathway in BV2 microglial cells. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33206235. |
however, the role of dor in microglia in ischaemic stroke has not yet been fully investigated. |
2021-07-28 |
2023-08-13 |
mouse |
| Vivien Häußler, Tristan Daehn, Björn Rissiek, Vanessa Roth, Christian Gerloff, Thiruma V Arumugam, Tim Magnus, Mathias Gelderblo. Intravenous Immunoglobulin (IVIg) Induce a Protective Phenotype in Microglia Preventing Neuronal Cell Death in Ischaemic Stroke. Neuromolecular medicine. vol 22. issue 1. 2021-07-23. PMID:31559534. |
intravenous immunoglobulin (ivig) induce a protective phenotype in microglia preventing neuronal cell death in ischaemic stroke. |
2021-07-23 |
2023-08-13 |
Not clear |
| Vivien Häußler, Tristan Daehn, Björn Rissiek, Vanessa Roth, Christian Gerloff, Thiruma V Arumugam, Tim Magnus, Mathias Gelderblo. Intravenous Immunoglobulin (IVIg) Induce a Protective Phenotype in Microglia Preventing Neuronal Cell Death in Ischaemic Stroke. Neuromolecular medicine. vol 22. issue 1. 2021-07-23. PMID:31559534. |
although neuroprotective effects of ivig in vivo and in vitro have been established in previous studies, we were able to show for the first time, that ivig modulates the polarization of microglia during the pathogenesis of stroke. |
2021-07-23 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
microglia, the main immune cell in the cerebrum, possess therapeutic potential for strokes as its specific anti-inflammatory phenotype can reduce inflammation and promote neuron regeneration. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
however, the on-demand anti-inflammatory polarization of microglia at the stroke site is uncontrollable for therapeutic application. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
here, we develop a platelet hybrid microglia platform which can specifically polarize to the anti-inflammatory phenotype by ultrasound irradiation for targeted cerebrum repair after stroke. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
the intravenously injected microglia platform showed anti-inflammatory polarization at the stroke site with insonation, and accelerated the m2-type polarization of endogenous microglia for long-term stroke recovery. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
satisfied prognoses were achieved with reduced apoptosis, promoted neurogenesis, and functional recovery, indicating the implications of the microglia platform for stroke therapy. |
2021-07-20 |
2023-08-13 |
Not clear |
| Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin X. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in neurology. vol 12. 2021-07-20. PMID:34276530. |
microglia, the innate immune cells of the central nervous system (cns), can be activated and polarized to take on different phenotypes in response to stimulations associated with stroke, including pro-inflammatory and anti-inflammatory phenotypes, which affect the prognosis of stroke. |
2021-07-20 |
2023-08-13 |
Not clear |