| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shun-Ming Ting, Xiurong Zhao, Guanghua Sun, Lidiya Obertas, Mercedes Ricote, Jaroslaw Aronowsk. Brain Cleanup as a Potential Target for Poststroke Recovery: The Role of RXR (Retinoic X Receptor) in Phagocytes. Stroke. vol 51. issue 3. 2020-06-22. PMID:31914884. |
background and purpose- phagocytic cells, such as microglia and blood-derived macrophages, are a key biological modality responsible for phagocytosis-mediated clearance of damaged, dead, or displaced cells that are compromised during senescence or pathological processes, including after stroke. |
2020-06-22 |
2023-08-13 |
mouse |
| Akriti Srivastava, Pranay Srivastava, Rajkumar Verm. Role of bone marrow-derived macrophages (BMDMs) in neurovascular interactions during stroke. Neurochemistry international. vol 129. 2020-06-01. PMID:31145968. |
after stroke onset, microglia - the brain-resident macrophage immune cells - and peripheral immune cells affect stoke injury/recovery by releasing pro-inflammatory and/or anti-inflammatory cytokines depending on their microenvironment. |
2020-06-01 |
2023-08-13 |
Not clear |
| Chuwen Li, Yaqi Bian, Yu Feng, Fan Tang, Liang Wang, Maggie Pui Man Hoi, Dan Ma, Chao Zhao, Simon Ming Yuen Le. Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30839193. |
neuroprotective effects of bhdpc, a novel neuroprotectant, on experimental stroke by modulating microglia polarization. |
2020-05-29 |
2023-08-13 |
mouse |
| Degang Song, Xiangjian Zhang, Junmin Chen, Xiaoxia Liu, Jing Xue, Lan Zhang, Xifa La. Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke. Journal of neuroinflammation. vol 16. issue 1. 2020-05-27. PMID:31810470. |
here, we explored whether wnt/β-catenin pathway activator tws119 facilitated long-term neurological recovery via modulating microglia polarization after experimental stroke. |
2020-05-27 |
2023-08-13 |
Not clear |
| Jun-Long Huang, Wen-Wu Liu, Anatol Manaenko, Xue-Jun Sun, Qi-Yong Mei, Qin H. Hydrogen inhibits microglial activation and regulates microglial phenotype in a mouse middle cerebral artery occlusion model. Medical gas research. vol 9. issue 3. 2020-05-25. PMID:31552875. |
microglia participate in bi-directional control of brain repair after stroke. |
2020-05-25 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
however, myeloid cells participating in stroke pathology include both brain resident microglia and circulating macrophages. |
2020-05-18 |
2023-08-13 |
mouse |
| Murielle G Kluge, Mahmoud Abdolhoseini, Katarzyna Zalewska, Lin Kooi Ong, Sarah J Johnson, Michael Nilsson, Frederick R Walke. Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 12. 2020-05-05. PMID:30204044. |
in this study, we combine a photothrombotic stroke model in mice, acute slice and fluorescent imaging to analyse the loss of microglia process responsiveness. |
2020-05-05 |
2023-08-13 |
mouse |
| Yves Werner, Elvira Mass, Praveen Ashok Kumar, Thomas Ulas, Kristian Händler, Arik Horne, Kathrin Klee, Amelie Lupp, Dagmar Schütz, Friederike Saaber, Christoph Redecker, Joachim L Schultze, Frederic Geissmann, Ralf Stum. Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. Nature neuroscience. vol 23. issue 3. 2020-04-13. PMID:32042176. |
cxcr4 distinguishes hsc-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. |
2020-04-13 |
2023-08-13 |
Not clear |
| Ke Ning, Wen-Wu Liu, Jun-Long Huang, Hong-Tao Lu, Xue-Jun Su. Effects of hydrogen on polarization of macrophages and microglia in a stroke model. Medical gas research. vol 8. issue 4. 2020-02-25. PMID:30713668. |
effects of hydrogen on polarization of macrophages and microglia in a stroke model. |
2020-02-25 |
2023-08-13 |
human |
| Ke Ning, Wen-Wu Liu, Jun-Long Huang, Hong-Tao Lu, Xue-Jun Su. Effects of hydrogen on polarization of macrophages and microglia in a stroke model. Medical gas research. vol 8. issue 4. 2020-02-25. PMID:30713668. |
the polarization of microglia as an important participant in the inflammation following stroke is also found to be involved in stroke. |
2020-02-25 |
2023-08-13 |
human |
| Reza Rahimian, Pierre Cordeau, Jasna Kri. Brain Response to Injuries: When Microglia Go Sexist. Neuroscience. vol 405. 2020-01-30. PMID:29526689. |
finally we describe how advanced methods such as live imaging techniques may help elucidate the role of microglia in the modulation of immune responses and gender difference after stroke. |
2020-01-30 |
2023-08-13 |
Not clear |
| Shanshan Wang, Brian P Hea. Caveolin-1 in Stroke Neuropathology and Neuroprotection: A Novel Molecular Therapeutic Target for Ischemic-Related Injury. Current vascular pharmacology. vol 17. issue 1. 2020-01-21. PMID:29412114. |
this review focuses on the 1) pathophysiology of stroke (neuronal cell loss, defective blood brain barrier, microglia activation, and inflammation), 2) the role of the membrane protein caveolin- 1 (cav-1) in normal brain physiology and stroke-induced changes, and, 3) we briefly discussed the potential therapeutic role of cav-1 in recovery following stroke. |
2020-01-21 |
2023-08-13 |
Not clear |
| Reza Rahimian, Starlee Lively, Essam Abdelhamid, Melanie Lalancette-Hebert, Lyanne Schlichter, Sachiko Sato, Jasna Kri. Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective. Molecular neurobiology. vol 56. issue 9. 2020-01-13. PMID:30798442. |
delayed galectin-3-mediated reprogramming of microglia after stroke is protective. |
2020-01-13 |
2023-08-13 |
Not clear |
| Abdullah Al Mamun, Haifu Yu, Mehwish A Mirza, Sharmeen Romana, Louise D McCullough, Fudong Li. Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy. Neurochemistry international. vol 127. 2020-01-02. PMID:30586599. |
previously we have reported that irf4 signaling is closely correlated with anti-inflammatory polarization of microglia in adult mice after stroke. |
2020-01-02 |
2023-08-13 |
mouse |
| Yang-Ye Hu, Yuan Wang, Shuang Liang, Xue-Li Yu, Lei Zhang, Lin-Yin Feng, Yi Fen. Senkyunolide I attenuates oxygen-glucose deprivation/reoxygenation-induced inflammation in microglial cells. Brain research. vol 1649. issue Pt A. 2019-11-20. PMID:27524398. |
over-activated microglia during stroke has been documented to aggravate brain damage. |
2019-11-20 |
2023-08-13 |
rat |
| Daojing Li, Wenjing Lang, Chen Zhou, Chao Wu, Fang Zhang, Qiang Liu, Shuang Yang, Junwei Ha. Upregulation of Microglial ZEB1 Ameliorates Brain Damage after Acute Ischemic Stroke. Cell reports. vol 22. issue 13. 2019-11-05. PMID:29590624. |
understanding these mechanisms may ultimately reduce disease burden and allow the manipulation of microglia responses to shape the outcomes of stroke. |
2019-11-05 |
2023-08-13 |
mouse |
| Ioanna Sandvig, Ingrid Lovise Augestad, Asta Kristine Håberg, Axel Sandvi. Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks. The European journal of neuroscience. vol 47. issue 12. 2019-11-04. PMID:29786167. |
experimental evidence suggests that microglia in response to injury can rapidly modify neuronal activity and modulate synaptic function, as well as be beneficial for the proliferation and integration of neural progenitor cells (npcs) from endogenous neurogenic niches into functional networks thereby supporting stroke recovery. |
2019-11-04 |
2023-08-13 |
Not clear |
| Ioanna Sandvig, Ingrid Lovise Augestad, Asta Kristine Håberg, Axel Sandvi. Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks. The European journal of neuroscience. vol 47. issue 12. 2019-11-04. PMID:29786167. |
in this review, we first introduce some of the key cellular and molecular mechanisms underlying neuroplasticity in stroke and then proceed to discuss the crosstalk between microglia and endogenous neuroplasticity in response to brain ischaemia with special focus on the engagement of synapses and neural networks and their implications for grey matter integrity and function in stroke repair. |
2019-11-04 |
2023-08-13 |
Not clear |
| Abdullah Al Mamun, Anjali Chauhan, Haifu Yu, Yan Xu, Romana Sharmeen, Fudong Li. Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice. The European journal of neuroscience. vol 47. issue 2. 2019-10-16. PMID:29131464. |
our results revealed that the irf5 mrna level in sorted microglia increased at 3 days of stroke; whereas irf4 mrna level exhibited biphasic increases, with a transient rise at 24 h and a peak at 10 days. |
2019-10-16 |
2023-08-13 |
mouse |
| Xin Wang, Wei Xuan, Zi-Yu Zhu, Yan Li, Hao Zhu, Ling Zhu, Dan-Yun Fu, Li-Qun Yang, Pei-Ying Li, Wei-Feng Y. The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke. CNS neuroscience & therapeutics. vol 24. issue 12. 2019-10-14. PMID:30350341. |
alternatively, activated microglia, monocytes, and neutrophils in the innate immune system, traditionally considered as major damaging factors after stroke, have been suggested to be extensively involved in brain repair after stroke. |
2019-10-14 |
2023-08-13 |
Not clear |