| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabella Wimmer, Tobias Zrzavy, Hans Lassman. Neuroinflammatory responses in experimental and human stroke lesions. Journal of neuroimmunology. vol 323. 2019-10-03. PMID:30196821. |
finally, human stroke lesions develop on a basis of age-dependent microglia pre-activation, which may have major impact on the further activation and functional differentiation of these cells. |
2019-10-03 |
2023-08-13 |
human |
| Haoran Zhao, Lihua Wan, Yan Chen, He Zhang, Yun Xu, Shuwei Qi. FasL incapacitation alleviates CD4 Journal of neuroimmunology. vol 318. 2019-09-30. PMID:29395324. |
fasl incapacitation alleviates cd4 inflammation responses involving the crosstalk between infiltrated t cells and microglia play crucial roles in ischemia stroke. |
2019-09-30 |
2023-08-13 |
Not clear |
| Jyoti Gautam, Yao Ya. Roles of Pericytes in Stroke Pathogenesis. Cell transplantation. vol 27. issue 12. 2019-09-19. PMID:29845887. |
in addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. |
2019-09-19 |
2023-08-13 |
Not clear |
| Christiane Charriaut-Marlangue, Claire Leconte, Zsolt Csaba, Linda Chafa, Julien Pansiot, Mustapha Talatizi, Kristin Simon, Raffaella Moretti, Catherine Marchand-Leroux, Olivier Baud, Valérie C Besso. Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. Brain, behavior, and immunity. vol 73. 2019-08-06. PMID:29852289. |
the bases for these sex differences are poorly understood but might include the number, morphology and activation of microglia in the developing brain when subjected to stroke. |
2019-08-06 |
2023-08-13 |
mouse |
| Tobias Zrzavy, Joana Machado-Santos, Sheren Christine, Christoph Baumgartner, Howard L Weiner, Oleg Butovsky, Hans Lassman. Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain pathology (Zurich, Switzerland). vol 28. issue 6. 2019-05-28. PMID:29222823. |
inflammatory mechanisms, involving granulocytes, t-cells, b-cells, macrophages and activated microglia, have been suggested to play a pathogenic role in experimental models of stroke and may be targets for therapeutic intervention. |
2019-05-28 |
2023-08-13 |
human |
| Bastian Zinnhardt, Maximilian Wiesmann, Lisa Honold, Cristina Barca, Michael Schäfers, Amanda J Kiliaan, Andreas H Jacob. Theranostics. vol 8. issue 10. 2019-05-13. PMID:29774062. |
here, we highlight the recent developments in preclinical and clinical molecular imaging biomarkers of neuroinflammation (endothelial markers, microglia, mmps, cell labeling, future developments) in stroke and outline how imaging biomarkers can be used in overcoming current translational roadblocks and attrition in order to advance new immunomodulatory compounds within the clinical pipeline. |
2019-05-13 |
2023-08-13 |
Not clear |
| Adi Moshe, Sivan Izraely, Orit Sagi-Assif, Roshini Prakash, Alona Telerman, Tsipi Meshel, Thomas Carmichael, Isaac P Wit. Cystatin C takes part in melanoma-microglia cross-talk: possible implications for brain metastasis. Clinical & experimental metastasis. vol 35. issue 5-6. 2019-04-15. PMID:29722001. |
the similarities between melanoma brain metastasis and stroke with respect to cysc expression by and secretion from microglia cells suggest that cysc may be involved in shared pathways between brain metastasis and post-stroke regeneration. |
2019-04-15 |
2023-08-13 |
mouse |
| Wai Ping Yew, Natalia D Djukic, Jaya S P Jayaseelan, Frederick R Walker, Karl A A Roos, Timothy K Chataway, Hakan Muyderman, Neil R Sim. Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. Journal of neuroinflammation. vol 16. issue 1. 2019-04-15. PMID:30626393. |
early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. |
2019-04-15 |
2023-08-13 |
rat |
| Wai Ping Yew, Natalia D Djukic, Jaya S P Jayaseelan, Frederick R Walker, Karl A A Roos, Timothy K Chataway, Hakan Muyderman, Neil R Sim. Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. Journal of neuroinflammation. vol 16. issue 1. 2019-04-15. PMID:30626393. |
this study tested the ability of minocycline treatment early after stroke to modify reactive responses in microglia and astrocytes and improve recovery. |
2019-04-15 |
2023-08-13 |
rat |
| Somayyeh Hamzei Taj, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Alessandra Quarta, Jelle Praet, Annemie Van der Linden, Peter Ponsaerts, Mathias Hoeh. Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke. Journal of neuroinflammation. vol 15. issue 1. 2019-04-10. PMID:29866203. |
targeted intracerebral delivery of the anti-inflammatory cytokine il13 promotes alternative activation of both microglia and macrophages after stroke. |
2019-04-10 |
2023-08-13 |
mouse |
| Lars Karlsson, María Nazareth González-Alvarado, Mar Larrosa-Flor, Ahmed Osman, Mats Börjesson, Klas Blomgren, Hans Georg Kuh. Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke. Neuroscience. vol 384. 2019-02-21. PMID:29859976. |
in the stroke model, muscular overexpression of pgc-1α resulted in an increased infarct size without any changes in microglia activation or reactive astrocytosis. |
2019-02-21 |
2023-08-13 |
mouse |
| Alessio Facciolà, Giuseppa Visalli, Sebastiano La Maestra, Manuela Ceccarelli, Francesco D'Aleo, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Angela Di Pietr. Carbon nanotubes and central nervous system: Environmental risks, toxicological aspects and future perspectives. Environmental toxicology and pharmacology. vol 65. 2019-02-13. PMID:30500734. |
after their entrance, cnts reach the cns where they may cause cytotoxicity of selected neurons in several cns regions, impairing molecular pathways and contributing to the onset and progression of chronic brain inflammation, microglia activation and white matter abnormalities with an increased risk for autism spectrum disorders, lower iq in children, neurodegenerative diseases and stroke. |
2019-02-13 |
2023-08-13 |
human |
| Melissa A Lopes Pinheiro, Gijs Kooij, Mark R Mizee, Alwin Kamermans, Gaby Enzmann, Ruth Lyck, Markus Schwaninger, Britta Engelhardt, Helga E de Vrie. Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochimica et biophysica acta. vol 1862. issue 3. 2019-01-24. PMID:26527183. |
in ms and stroke the blood-brain barrier is disrupted allowing bone marrow-derived macrophages to invade the brain in support of the resident microglia. |
2019-01-24 |
2023-08-13 |
Not clear |
| Kecheng Zhou, Jiayu Wu, Jie Chen, Ye Zhou, Xiaolong Chen, Qiaoyun Wu, Yangxinzi Xu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Songhe Jian. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. Journal of pharmacological sciences. vol 139. issue 1. 2019-01-24. PMID:30528467. |
neuroinflammation plays a major role in the development of ischemic stroke, and regulation of the proinflammatory tlr4 signaling pathway in microglia stands to be a promising therapeutic strategy for stroke intervention. |
2019-01-24 |
2023-08-13 |
mouse |
| Hai M Nguyen, Linda V Blomster, Palle Christophersen, Heike Wulf. Potassium channel expression and function in microglia: Plasticity and possible species variations. Channels (Austin, Tex.). vol 11. issue 4. 2018-11-22. PMID:28277939. |
potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like alzheimer, parkinson and stroke. |
2018-11-22 |
2023-08-13 |
mouse |
| Reza Rahimian, Louis-Charles Béland, Jasna Kri. Galectin-3: mediator of microglia responses in injured brain. Drug discovery today. vol 23. issue 2. 2018-11-07. PMID:29133191. |
given its putative role as a dynamic fine-tuner of microglia, activation of galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. |
2018-11-07 |
2023-08-13 |
Not clear |
| Ji Wang, Hongyi Xing, Lin Wan, Xingjun Jiang, Chen Wang, Yan W. Treatment targets for M2 microglia polarization in ischemic stroke. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 105. 2018-11-06. PMID:29883947. |
therefore, methods for promoting the differentiation of microglia into the m2 polarized form to alleviate harmful reactions after stroke have become a topic of interest in recent years. |
2018-11-06 |
2023-08-13 |
Not clear |
| Ji Wang, Hongyi Xing, Lin Wan, Xingjun Jiang, Chen Wang, Yan W. Treatment targets for M2 microglia polarization in ischemic stroke. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 105. 2018-11-06. PMID:29883947. |
in the present review, we discussed the neuroprotective effects of microglia m2 polarization and the potential mechanisms and drugs by which microglia can be transformed into the m2 polarized type after stroke. |
2018-11-06 |
2023-08-13 |
Not clear |
| Liqiang Liu, Xiangrong Liu, Rongliang Wang, Feng Yan, Yumin Luo, Ankush Chandra, Yuchuan Ding, Xunming J. Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice. Neurological research. vol 40. issue 6. 2018-10-15. PMID:29619889. |
this transformation of polarity of microglia has influence on the degree of damage following a stroke. |
2018-10-15 |
2023-08-13 |
mouse |
| Gergely Szalay, Bernadett Martinecz, Nikolett Lénárt, Zsuzsanna Környei, Barbara Orsolits, Linda Judák, Eszter Császár, Rebeka Fekete, Brian L West, Gergely Katona, Balázs Rózsa, Ádám Déne. Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nature communications. vol 7. 2018-09-24. PMID:27139776. |
microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. |
2018-09-24 |
2023-08-13 |
Not clear |