| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franziska M Collmann, Rory Pijnenburg, Somayyeh Hamzei-Taj, Anuka Minassian, Kat Folz-Donahue, Christian Kukat, Markus Aswendt, Mathias Hoeh. Individual Frontiers in immunology. vol 10. 2020-10-28. PMID:31214190. |
the modulation of microglia polarization is an appealing neurotherapeutic strategy for stroke and other brain lesions, as well as neurodegenerative diseases. |
2020-10-28 |
2023-08-13 |
Not clear |
| Zong-Jian Liu, Yuan-Yuan Ran, Shu-Yan Qie, Wei-Jun Gong, Fu-Hai Gao, Zi-Tong Ding, Jia-Ning X. Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway. CNS neuroscience & therapeutics. vol 25. issue 12. 2020-10-26. PMID:31793209. |
however, the effect of melatonin on microglia polarization after stroke and underlying mechanisms remain unknown. |
2020-10-26 |
2023-08-13 |
Not clear |
| Supriya Ramesha, Sruti Rayaprolu, Srikant Rangaraj. Flow Cytometry Approach to Characterize Phagocytic Properties of Acutely-Isolated Adult Microglia and Brain Macrophages In Vitro. Journal of visualized experiments : JoVE. issue 160. 2020-10-22. PMID:32658196. |
microglia and central nervous system (cns)-infiltrating macrophages, collectively called cns mononuclear phagocytes (cns-mps), play central roles in neurological diseases including neurodegeneration and stroke. |
2020-10-22 |
2023-08-13 |
mouse |
| Hao Zhang, Minyi Lu, Xiaofeng Zhang, Yihe Kuai, Ying Mei, Qiwen Tan, Kailun Zhong, Xiaoou Sun, Wen Ta. Isosteviol Sodium Protects against Ischemic Stroke by Modulating Microglia/Macrophage Polarization via Disruption of GAS5/miR-146a-5p sponge. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:31434993. |
stv-na has a profound regulatory effect on microglia response after stroke. |
2020-10-20 |
2023-08-13 |
Not clear |
| Nassir U Al-Khishman, Qi Qi, Austyn D Roseborough, Alexander Levit, Brian L Allman, Udunna C Anazodo, Matthew S Fox, Shawn N Whitehead, Jonathan D Thiesse. TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat. EJNMMI research. vol 10. issue 1. 2020-10-16. PMID:32990808. |
this study aimed to test the ability of tspo to detect activated wm microglia that are immunohistochemically positive for mhcii in rat models of prodromal alzheimer's disease and acute subcortical stroke. |
2020-10-16 |
2023-08-13 |
rat |
| Wei Cai, Xuejiao Dai, Jie Chen, Jingyan Zhao, Mingyue Xu, Lili Zhang, Boyu Yang, Wenting Zhang, Marcelo Rocha, Toshimasa Nakao, Julia Kofler, Yejie Shi, R Anne Stetler, Xiaoming Hu, Jun Che. STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI insight. vol 4. issue 20. 2020-10-15. PMID:31619589. |
efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration of brain homeostasis after stroke. |
2020-10-15 |
2023-08-13 |
mouse |
| Wujun Geng, Hongli Tang, Shan Luo, Ya Lv, Dongdong Liang, Xianhui Kang, Wandong Hon. Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation. American journal of translational research. vol 11. issue 2. 2020-10-01. PMID:30899379. |
exosomes from mirna-126-modified adscs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation. |
2020-10-01 |
2023-08-13 |
rat |
| Walace Gomes-Lea. Why microglia kill neurons after neural disorders? The friendly fire hypothesis. Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089039. |
according to this notion, microglia may cause bystander neuronal damage with a kind of blind "friendly fire", fighting against a non-existing infection during non-infectious disorders, like stroke and trauma. |
2020-10-01 |
2023-08-13 |
rat |
| Steffanie Heindl, Benno Gesierich, Corinne Benakis, Gemma Llovera, Marco Duering, Arthur Lies. Automated Morphological Analysis of Microglia After Stroke. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:29725290. |
automated morphological analysis of microglia after stroke. |
2020-09-30 |
2023-08-13 |
mouse |
| Roxana Surugiu, Daniela Glavan, Mircea Popescu, Otilia Margaritescu, Radu Eugen, Aurel Popa-Wagne. Vasculature Remodeling in a Rat Model of Cerebral Ischemia. The Fate of the BrdU-Labeled Cells Prior to Stroke. Frontiers in neurology. vol 9. 2020-09-29. PMID:30542320. |
in this study, using brdu-labeling of proliferating cells and immunofluorescence of pre- and post-stroke rats, we found that, (i) brdu administered before stroke was incorporated preferentially into the nuclei of endothelial cells lining the lumen of existing blood vessels and newly born neurons in the dentate gyrus but not in the subventricular zone or proliferating microglia, (ii) brdu injection prior to stroke led to the patchy distribution of the newly incorporated endothelial cells into existing blood vessels of the adult rat brain, (iii) brdu injection prior to stroke specifically labeled neuronal precursors cells in a region of soft tissue beyond the inhibitory scar, which seems to be permissive to regenerative events, (iv) brdu injection after stroke led to labeling of endothelial cells crossing or detaching from the disintegrating blood vessels and their incorporation into new blood vessels in the stroke region, scar tissue and the region beyond, (v) brdu injection after stroke led to specific incorporation of brdu-positive nuclei into the "pinwheel" architecture of the ventricular epithelium, (vi) blood vessels in remote areas relative to the infarct core and in the contralateral non-lesioned cortex, showed co-labeled brdu/reca |
2020-09-29 |
2023-08-13 |
rat |
| Xu Zhao, Jing Li, Haitao Su. CD200-CD200R Interaction: An Important Regulator After Stroke. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31440137. |
because of their vital functions in the regulation of neuroinflammation, microglia constitute an important target for stroke. |
2020-09-29 |
2023-08-13 |
human |
| Pascal Gervois, Ivo Lambricht. The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke. Frontiers in immunology. vol 10. 2020-09-28. PMID:31379859. |
microglia play a key role in the inflammatory stroke microenvironment as they can adapt a disease-promoting pro-inflammatory- or pro-regenerative phenotype thereby contributing to the exacerbation or alleviation of ischemic damage, respectively. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlotte Rawlinson, Stuart Jenkins, Laura Thei, Mark L Dallas, Ruoli Che. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32168831. |
post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlotte Rawlinson, Stuart Jenkins, Laura Thei, Mark L Dallas, Ruoli Che. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32168831. |
microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlotte Rawlinson, Stuart Jenkins, Laura Thei, Mark L Dallas, Ruoli Che. Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32168831. |
a major developmental challenge for clinical translation will be the selective suppression of the deleterious effects of microglial activity after stroke whilst retaining (or enhancing) the neurovascular repair and remodelling responses of microglia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Man Cheng, Liu Yang, Zhiping Dong, Mengying Wang, Yan Sun, Huan Liu, Xuan Wang, Na Sai, Guowei Huang, Xumei Zhan. Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells. Journal of cellular and molecular medicine. vol 23. issue 7. 2020-08-06. PMID:31087489. |
however, whether fd is involved in the activation of microglia and the neuroinflammation after experimental stroke and the underlying mechanism is still unclear. |
2020-08-06 |
2023-08-13 |
rat |
| Benjamin Maïer, Nathalie Kubi. Hypertension and Its Impact on Stroke Recovery: From a Vascular to a Parenchymal Overview. Neural plasticity. vol 2019. 2020-07-27. PMID:31737062. |
here, we sought to review the impact of isolated hypertension or hypertension associated to stroke on brain atrophy, neuron connectivity and neurogenesis, and phenotype modification of microglia and astrocytes. |
2020-07-27 |
2023-08-13 |
Not clear |
| Wael Eldahshan, Susan C Fagan, Adviye Ergu. Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery. Pharmacological research. vol 147. 2020-07-21. PMID:31315064. |
inflammation within the neurovascular unit: focus on microglia for stroke injury and recovery. |
2020-07-21 |
2023-08-13 |
Not clear |
| Mei-Juan Zhang, Qiu-Chen Zhao, Ming-Xu Xia, Jian Chen, Yan-Ting Chen, Xiang Cao, Yi Liu, Zeng-Qiang Yuan, Xiao-Ying Wang, Yun X. The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-07. PMID:31914678. |
here, we investigated the potential contributions of hdac3 to inflammasome activation in primary cultured microglia and experimental stroke models. |
2020-07-07 |
2023-08-13 |
mouse |
| Mei-Juan Zhang, Qiu-Chen Zhao, Ming-Xu Xia, Jian Chen, Yan-Ting Chen, Xiang Cao, Yi Liu, Zeng-Qiang Yuan, Xiao-Ying Wang, Yun X. The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 1. 2020-07-07. PMID:31914678. |
in this study, we documented that hdac3 expression was increased in microglia of mouse experimental stroke model. |
2020-07-07 |
2023-08-13 |
mouse |