| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D H Wang, R L Prewitt, S J Beeb. Regulation of PDGF-A: a possible mechanism for angiotensin II-induced vascular growth. The American journal of physiology. vol 269. issue 1 Pt 2. 1995-09-01. PMID:7631868. |
both aorta and external spermatic artery (first-order arteriole of the cremaster muscle) developed increased wall-to-lumen ratios in the ang ii rats, but this occurred by hypertrophy of the wall in the aorta and reduction of the lumen in the arteriole. |
1995-09-01 |
2023-08-12 |
rat |
| N Fujii, M Tanaka, J Ohnishi, K Yukawa, E Takimoto, S Shimada, M Naruse, F Sugiyama, K Yagami, K Murakam. Alterations of angiotensin II receptor contents in hypertrophied hearts. Biochemical and biophysical research communications. vol 212. issue 2. 1995-08-31. PMID:7542873. |
these results suggest that at1 in the heart is upregulated in response to ang ii-induced hypertrophic change and that, in particular, the upregulation of at1 in particular contributes to the development and/or maintenance of cardiac hypertrophy in conjunction with the increase in ang ii production, because at1 is responsible for cardiac hypertrophy related to the ras. |
1995-08-31 |
2023-08-12 |
mouse |
| L Wang, M Eberhard, P Ern. Stimulation of DNA and RNA synthesis in cultured rabbit cardiac fibroblasts by angiotensin IV. Clinical science (London, England : 1979). vol 88. issue 5. 1995-08-22. PMID:7542190. |
although angiotensin ii (ang ii) has been identified as a key factor in the development of cardiac hypertrophy and remodelling, the role of its degradation fragment ang ii (3-8), angiotensin iv (ang iv), is unknown. |
1995-08-22 |
2023-08-12 |
rabbit |
| T Yamazaki, I Komuro, S Kudoh, Y Zou, I Shiojima, T Mizuno, H Takano, Y Hiroi, K Ueki, K Tob. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circulation research. vol 77. issue 2. 1995-08-22. PMID:7614712. |
many lines of evidence have suggested that angiotensin ii (ang ii) plays a vital role in cardiac hypertrophy, and it has been reported that secretion of ang ii from cultured cardiac myocytes was induced by mechanical stretch. |
1995-08-22 |
2023-08-12 |
rat |
| T Yamazaki, I Komuro, S Kudoh, Y Zou, I Shiojima, T Mizuno, H Takano, Y Hiroi, K Ueki, K Tob. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circulation research. vol 77. issue 2. 1995-08-22. PMID:7614712. |
to examine the role of ang ii in mechanical stress-induced cardiac hypertrophy, we stretched neonatal rat cardiac myocytes in the absence or presence of the ang ii receptor antagonists saralasin (an antagonist of both type 1 and type 2 receptors), cv-11974 (a type 1 receptor-specific antagonist), and pd123319 (a type 2 receptor-specific antagonist). |
1995-08-22 |
2023-08-12 |
rat |
| T Yamazaki, I Komuro, S Kudoh, Y Zou, I Shiojima, T Mizuno, H Takano, Y Hiroi, K Ueki, K Tob. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circulation research. vol 77. issue 2. 1995-08-22. PMID:7614712. |
these results suggest that ang ii plays an important role in mechanical stress-induced cardiac hypertrophy and that there are also other (possibly nonsecretory) factors to induce hypertrophic responses. |
1995-08-22 |
2023-08-12 |
rat |
| T Yamazaki, I Shiojima, I Komuro, R Nagai, Y Yazak. Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 12. issue 10. 1995-07-06. PMID:7769485. |
to elucidate the regulation of cardiac gene expression by mechanical stress and to analyse molecular mechanisms associated with the involvement of angiotensin ii (ang ii) in the development of cardiac hypertrophy and dysfunction. |
1995-07-06 |
2023-08-12 |
Not clear |
| S Kim, K Ohta, A Hamaguchi, T Yukimura, K Miura, H Iwa. Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension (Dallas, Tex. : 1979). vol 25. issue 6. 1995-06-30. PMID:7768570. |
hydralazine (10 mg/kg per day), which completely normalized blood pressure, did not block cardiac hypertrophy or increased cardiac gene expressions by ang ii. |
1995-06-30 |
2023-08-12 |
rat |
| S A Fisher, M Abshe. Norepinephrine and ANG II stimulate secretion of TGF-beta by neonatal rat cardiac fibroblasts in vitro. The American journal of physiology. vol 268. issue 4 Pt 1. 1995-06-01. PMID:7733239. |
paradoxically, the combination of ne and ang ii at intermediate and high concentrations resulted in less tgf-beta secretion (compared with either agent alone) and in hypertrophic growth of fibroblasts. |
1995-06-01 |
2023-08-12 |
rat |
| b' J L Cook, S Bhandaru, J F Giardina, W C Claycomb, R N R\\xc3\\xa. Identification and antisense inhibition of a renin-angiotensin system in transgenic cardiomyocytes. The American journal of physiology. vol 268. issue 4 Pt 2. 1995-06-01. PMID:7733348.' |
this study reveals two separate and distinct findings: 1) at-1 cells proliferate or hypertrophy in response to angiotensin ii (ang ii), depending on their competence to proceed through the cell cycle; and 2) at-1 cells possess components of a ras, and angiotensinogen antisense experiments suggest that the ras is functional in these cells. |
1995-06-01 |
2023-08-12 |
mouse |
| b' J L Cook, S Bhandaru, J F Giardina, W C Claycomb, R N R\\xc3\\xa. Identification and antisense inhibition of a renin-angiotensin system in transgenic cardiomyocytes. The American journal of physiology. vol 268. issue 4 Pt 2. 1995-06-01. PMID:7733348.' |
specifically, at-1 cells proliferate in response to ang ii in low-serum medium but hypertrophy in response to ang ii when first treated with mitomycin c (at a concentration that inhibits dna replication but is not cytotoxic). |
1995-06-01 |
2023-08-12 |
mouse |
| b' J L Cook, S Bhandaru, J F Giardina, W C Claycomb, R N R\\xc3\\xa. Identification and antisense inhibition of a renin-angiotensin system in transgenic cardiomyocytes. The American journal of physiology. vol 268. issue 4 Pt 2. 1995-06-01. PMID:7733348.' |
the ang ii-mediated proliferative and hypertrophic responses are inhibited by dup 753. |
1995-06-01 |
2023-08-12 |
mouse |
| S R Orth, T Weinreich, S Bönisch, M Weih, E Rit. Angiotensin II induces hypertrophy and hyperplasia in adult human mesangial cells. Experimental nephrology. vol 3. issue 1. 1995-05-18. PMID:7712140. |
we conclude that ang ii induces hypertrophy and proliferation in adult human mesangial cells. |
1995-05-18 |
2023-08-12 |
human |
| M de Gasparo, H Rogg, M Brink, L Wang, S Whitebread, G Bullock, P Ern. Angiotensin II receptor subtypes and cardiac function. European heart journal. vol 15 Suppl D. 1995-05-17. PMID:7713122. |
treatment of hypertrophic rats with at1 receptor antagonists inhibits cardiac hypertrophy and reverses the increase receptor density, indicating involvement of this ang ii receptor subtype. |
1995-05-17 |
2023-08-12 |
human |
| Z W Hu, X Y Shi, M Okazaki, B B Hoffma. Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells. The American journal of physiology. vol 268. issue 3 Pt 2. 1995-04-27. PMID:7900855. |
angiotensin ii (ang ii) induces vascular smooth muscle contraction and functions as a growth factor stimulating vascular smooth muscle cell (vsmc) hypertrophy. |
1995-04-27 |
2023-08-12 |
rat |
| T Yamashita, H Nakaya, N Tohse, M Kusaka, H Uemura, I Sakuma, H Yasuda, M Kanno, A Kitabatak. Depressed responsiveness to angiotensin II in ventricular myocytes of hypertrophic cardiomyopathic Syrian hamster. Journal of molecular and cellular cardiology. vol 26. issue 11. 1995-04-25. PMID:7897667. |
electromechanical responsiveness to angiotensin ii (ang ii) receptor stimulation in ventricular myocardium and myocytes of hypertrophic cardiomyopathic syrian hamsters (bio 14.6) was examined and compared with that in preparations of normal hamsters (f1b) using conventional microelectrode and patch clamp techniques. |
1995-04-25 |
2023-08-12 |
Not clear |
| T Yamashita, H Nakaya, N Tohse, M Kusaka, H Uemura, I Sakuma, H Yasuda, M Kanno, A Kitabatak. Depressed responsiveness to angiotensin II in ventricular myocytes of hypertrophic cardiomyopathic Syrian hamster. Journal of molecular and cellular cardiology. vol 26. issue 11. 1995-04-25. PMID:7897667. |
the depressed responsiveness to ang ii receptor stimulation in hypertrophic cardiomyopathic hamster is in a marked contrast with the enhanced responsiveness to alpha 1-adrenergic stimulation, which was demonstrated by previous studies, and may be one of adaptational changes to the activated renin-angiotensin system in the cardiomyopathy. |
1995-04-25 |
2023-08-12 |
Not clear |
| Y Hirata, K Kanno, S Eguchi, H Kan. Effect of an AT1 receptor antagonist (CV-11974) on angiotensin II-induced cardiomyocyte hypertrophy in vitro. Blood pressure. Supplement. vol 5. 1995-04-20. PMID:7889209. |
angiotensin (ang) ii, a potent vasoconstrictor is known to be a hypertrophic factor for cardiomyocytes. |
1995-04-20 |
2023-08-12 |
rat |
| Y Hirata, K Kanno, S Eguchi, H Kan. Effect of an AT1 receptor antagonist (CV-11974) on angiotensin II-induced cardiomyocyte hypertrophy in vitro. Blood pressure. Supplement. vol 5. 1995-04-20. PMID:7889209. |
to determine the cellular mechanism by which ang ii induces cardiac hypertrophy, we studied the effects of ang ii on the gene expression of et-1 and et receptor subtypes (eta, etb), as well as its effects on the expression of immediate early oncogenes (c-fos, c-myc) in cultured rat cardiomyocytes in vitro. |
1995-04-20 |
2023-08-12 |
rat |
| Y Hirata, K Kanno, S Eguchi, H Kan. Effect of an AT1 receptor antagonist (CV-11974) on angiotensin II-induced cardiomyocyte hypertrophy in vitro. Blood pressure. Supplement. vol 5. 1995-04-20. PMID:7889209. |
our findings indicate that ang ii immediately upregulates the cardiac et-1 gene in the same manner as it does the immediate early protooncogenes, while the late induction of the etb receptor, mainly via the cardiac at1 receptor, suggests the involvement of endogenous et-1 in ang ii-induced cardiac hypertrophy. |
1995-04-20 |
2023-08-12 |
rat |