| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A A Lee, W H Dillmann, A D McCulloch, F J Villarrea. Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts. Journal of molecular and cellular cardiology. vol 27. issue 10. 1996-03-13. PMID:8576949. |
angiotensin ii (ang ii) has been implicated in the development of cardiac hypertrophy and myocardial fibrosis. |
1996-03-13 |
2023-08-12 |
rat |
| J Fareh, R M Touyz, E L Schiffrin, G Thibaul. Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation. Circulation research. vol 78. issue 2. 1996-03-12. PMID:8575074. |
this study investigates the cellular localization and regulation of endothelin-1 (et-1) and angiotensin ii (ang ii) receptors and the effects of et-1 and ang ii on [ca2+]i in cardiac hypertrophy due to volume overload in the rat. |
1996-03-12 |
2023-08-12 |
rat |
| J Fareh, R M Touyz, E L Schiffrin, G Thibaul. Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation. Circulation research. vol 78. issue 2. 1996-03-12. PMID:8575074. |
cardiac hypertrophy induced a significant downregulation of at1 receptors on fibroblasts, whereas total binding and [ca2+]i sensitivity to ang ii were significantly enhanced in hypertrophied cardiomyocytes. |
1996-03-12 |
2023-08-12 |
rat |
| J Fareh, R M Touyz, E L Schiffrin, G Thibaul. Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation. Circulation research. vol 78. issue 2. 1996-03-12. PMID:8575074. |
this suggests that cardiac ang ii may be involved in the pathophysiology of the cardiac hypertrophy of volume overload. |
1996-03-12 |
2023-08-12 |
rat |
| X Zhang, D E Dostal, K Reiss, W Cheng, J Kajstura, P Li, H Huang, E H Sonnenblick, L G Meggs, K M Bake. Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes. The American journal of physiology. vol 269. issue 5 Pt 2. 1996-01-17. PMID:7503279. |
moreover, renin, ace, and ang ii receptor mrnas increased in stressed myocytes undergoing cellular hypertrophy. |
1996-01-17 |
2023-08-12 |
rat |
| J Fareh, R M Touyz, G Thibault, E L Schiffri. Basal and angiotensin II-induced cytosolic free calcium in adult rat cardiomyocytes and fibroblasts after volume overload. Hypertension (Dallas, Tex. : 1979). vol 26. issue 6 Pt 2. 1996-01-16. PMID:7498986. |
this study investigates basal and angiotensin ii (ang ii)-induced [ca2+]i concentrations in cells from hearts of rats that have undergone cardiac hypertrophy due to volume overload. |
1996-01-16 |
2023-08-12 |
rat |
| M Ishiye, K Umemura, T Uematsu, M Nakashim. Effects of losartan, an angiotensin II antagonist, on the development of cardiac hypertrophy due to volume overload. Biological & pharmaceutical bulletin. vol 18. issue 5. 1996-01-11. PMID:7492986. |
to investigate the contribution of a cardiac renin-angiotensin system to cardiac hypertrophy due to volume overload, the effects of losartan, a non-peptide angiotensin (ang) ii type 1 (at1) receptor antagonist on left ventricular hypertrophy (lvh) was studied. |
1996-01-11 |
2023-08-12 |
rat |
| J Sadoshima, S Izum. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circulation research. vol 77. issue 6. 1995-12-26. PMID:7586215. |
we have previously shown that hypertrophic stimuli, such as angiotensin ii (ang ii), rapidly activate rsk in cardiac myocytes. |
1995-12-26 |
2023-08-12 |
rat |
| J Sadoshima, S Izum. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy. Circulation research. vol 77. issue 6. 1995-12-26. PMID:7586215. |
using cultured neonatal rat ventricular myocytes, we examined whether ang ii activates p70s6k and investigated the effect of rapamycin, a potent yet indirect inhibitor of p70s6k, on the ang ii-induced hypertrophic response. |
1995-12-26 |
2023-08-12 |
rat |
| Q Wang, X P Fan, Z Chen, Q H Zhao, S Q Chen, Z H Wa. [Role of afferent renal nerves in 2K2C Goldblatt hypertension]. Sheng li xue bao : [Acta physiologica Sinica]. vol 47. issue 4. 1995-12-12. PMID:7481878. |
these results suggest that afferent renal nerves may play a partial role in the development of hypertension in 2k2c rats by activating sympathetic nervous system as a result of affecting metabolic activities of brain catecholaminergic neurons, and that high-plasma ang ii and aldosterone as well as heart hypertrophy and proliferation of vascular smooth muscle cells may also participate in the pathogenesis of hypertension in 2k2c rats. |
1995-12-12 |
2023-08-12 |
rat |
| G Wol. Angiotensin as a renal growth promoting factor. Advances in experimental medicine and biology. vol 377. 1995-12-05. PMID:7484425. |
in contrast, proliferation of cultured proximal tubular cells is inhibited by ang ii and cellular hypertrophy of these cells is induced. |
1995-12-05 |
2023-08-12 |
Not clear |
| M J Black, J F Bertram, J H Campbell, G R Campbel. Angiotensin II induces cardiovascular hypertrophy in perindopril-treated rats. Journal of hypertension. vol 13. issue 6. 1995-11-30. PMID:7594427. |
to investigate whether angiotensin ii (ang ii) exerts a direct effect on cardiovascular hypertrophy in the spontaneously hypertensive rat or acts indirectly through elevation of blood pressure. |
1995-11-30 |
2023-08-12 |
rat |
| C Lambert, Y Massillon, S Meloch. Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters. Circulation research. vol 77. issue 5. 1995-11-20. PMID:7554134. |
angiotensin ii (ang ii) is a growth factor that stimulates protein synthesis and induces cellular hypertrophy in cardiac myocytes. |
1995-11-20 |
2023-08-12 |
Not clear |
| C Lambert, Y Massillon, S Meloch. Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters. Circulation research. vol 77. issue 5. 1995-11-20. PMID:7554134. |
to gain insight into the role of ang ii in cardiac hypertrophy, we examined the expression and subtype distribution of ang ii receptors in the ventricles of embryonic and of 25- to 350-day-old inbred control and cardiomyopathic (chf 146) hamsters. |
1995-11-20 |
2023-08-12 |
Not clear |
| N Nishimura, H Takase, T Morit. [Effects of chronic losartan treatment on myocardial, vascular structure and reactivity with aging in spontaneously hypertensive rats (SHR): its effects compared with those of captopril]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 105. issue 6. 1995-11-08. PMID:7557736. |
these findings suggest that the local ang ii produced by enzymes other than ace also may play a role in vascular hypertrophy and hyperresponsiveness in shr. |
1995-11-08 |
2023-08-12 |
rat |
| N N Kim, F J Villarreal, M P Printz, A A Lee, W H Dillman. Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts. The American journal of physiology. vol 269. issue 3 Pt 1. 1995-11-06. PMID:7573419. |
we conclude that ang ii receptors are localized predominantly on nf and that ang ii can indirectly stimulate hypertrophy of nm by stimulating nf to produce a transferrable factor(s). |
1995-11-06 |
2023-08-12 |
rat |
| N N Kim, F J Villarreal, M P Printz, A A Lee, W H Dillman. Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts. The American journal of physiology. vol 269. issue 3 Pt 1. 1995-11-06. PMID:7573419. |
these data suggest that cardiac fibroblasts may play a critical role in mediating the hypertrophic response to ang ii in the rat heart. |
1995-11-06 |
2023-08-12 |
rat |
| B H Lorel. Cardiac renin-angiotensin system: role in development of pressure-overload hypertrophy. The Canadian journal of cardiology. vol 11 Suppl F. 1995-10-11. PMID:7664219. |
the results of these studies, which employed the aortic banded rat model of cardiac hypertrophy, indicate that the intracardiac conversion of angiotensin i (ang i) to angiotensin ii (ang ii) is significantly increase in hypertrophied hearts compared with hearts from age-matched, sham-operated controls, and that ang ii may have a direct effect of slowing relaxation and altering diastolic tone in the hypertrophied heart. |
1995-10-11 |
2023-08-12 |
rat |
| L Tao, H X Wang, M R Ra. [Effect of angiotensin and taurine on arrhythmia in cultured neonatal rat hypertrophic heart myocytes]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 30. issue 5. 1995-10-03. PMID:7660801. |
angiotensin (ang) ii (1, 10, 100 and 1000 nmol.l-1) was found to increase spontaneous contractile frequency dose-dependently in neonatal rat cardiac myocytes cultured for 3 d. after exposure to ang ii (100 nmol.l-1) for 7 d, neonatal rat heart cells became hypertrophy with increased frequency, elevated apa, prolonged adp50 and adp90, and shortened scl. |
1995-10-03 |
2023-08-12 |
rat |
| N Hübner, R Kreutz, S Takahashi, D Ganten, K Lindpaintne. Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats. A study on cause and effect. Hypertension (Dallas, Tex. : 1979). vol 26. issue 2. 1995-09-13. PMID:7635535. |
we performed a cosegregation analysis in an f2 intercross cohort bred from shrsp and wky from the university of heidelberg (shrsphd and wkyhd) to address the following questions: (1) whether this or another mutation of the angiotensinogen gene may be casually related to the observed differential ang ii plasma levels, (2) whether ang ii plasma levels may be correlated with blood pressure or organ hypertrophy, and (3) whether genetic linkage to the renin or angiotensin-converting enzyme (ace) gene loci (the two classic regulatory enzymes of the renin-angiotensin system) may provide an explanation for elevated ang ii plasma levels. |
1995-09-13 |
2023-08-12 |
rat |