| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biljana Georgievska, Deniz Kirik, Anders Björklun. Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 29. 2005-03-21. PMID:15269253. |
the effects of continuous glial cell line-derived neurotrophic factor (gdnf) overexpression in the intact nigrostriatal dopamine (da) system was studied using recombinant lentiviral (rlv) vector delivery of gdnf to the striatum or substantia nigra (sn) in the rat. |
2005-03-21 |
2023-08-12 |
rat |
| Manuel Rodríguez Díaz, Teofilo Jorge Alonso, Juan Perdomo Diaz, Tomás Gonzalez Hernández, Rafael Castro Fuentes, Magdalena Sabate, Jose Garcia Dopic. Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra. Glia. vol 49. issue 1. 2005-03-21. PMID:15390097. |
in the present work, the ens-glu pool was studied with microdialysis in the rat substantia nigra (sn). |
2005-03-21 |
2023-08-12 |
rat |
| Heidi Fedorow, Russell Pickford, James M Hook, Kay L Double, Glenda M Halliday, Manfred Gerlach, Peter Riederer, Brett Garne. Dolichol is the major lipid component of human substantia nigra neuromelanin. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686500. |
neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (sn). |
2005-03-21 |
2023-08-12 |
human |
| Gonzalo Bustos, Jorge Abarca, Jorge Campusano, Victor Bustos, Viviana Noriega, Esteban Aliag. Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain. Brain research. Brain research reviews. vol 47. issue 1-3. 2005-03-15. PMID:15572168. |
dopaminergic nigrostriatal neurons may be considered as bipolar functional entities since they are endowed with the ability to synthesize, store and release the transmitter dopamine (da) at the somatodendritic level in the substantia nigra (sn). |
2005-03-15 |
2023-08-12 |
Not clear |
| Karen Müller Smith, Lorri Bauer, Mariellen Fischer, Russell Barkley, Bradford A Navi. Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635701. |
nr4a2, or nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (vta) and the substantia nigra (sn). |
2005-03-14 |
2023-08-12 |
human |
| Jun Wang, Hong Jiang, Jun-Xia Xi. Time dependent effects of 6-OHDA lesions on iron level and neuronal loss in rat nigrostriatal system. Neurochemical research. vol 29. issue 12. 2005-03-09. PMID:15672545. |
the results showed that: 1, 3, 5, 7, and 14 days of postlesion, there was a progressive reduction in the density of the tyrosine hydroxylase immunoreactive (th-ir) cells in the lesioned substantia nigra (sn). |
2005-03-09 |
2023-08-12 |
rat |
| Y Shimizu, S Sugama, L A Degiorgio, B P Cho, T H Jo. Cell-type specific signal transduction and gene regulation via mitogen-activated protein kinase pathway in catecholaminergic neurons by restraint stress. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541904. |
the stimuli, such as stress or reserpine administration, significantly increased the th gene in noradrenergic neurons in the locus ceruleus (lc), but not in dopaminergic neurons in the substantia nigra (sn). |
2005-03-07 |
2023-08-12 |
Not clear |
| Hong Fang, Weida Tong, Leming Shi, Robert L Jakab, John F Bowye. Classification of cDNA array genes that have a highly significant discriminative power due to their unique distribution in four brain regions. DNA and cell biology. vol 23. issue 10. 2005-03-04. PMID:15585124. |
the gene expression profiles for the substantia nigra (sn), striatum (str), parietal cortex (pc), and posterolateral cortical amygdaloid nucleus (plco) brain regions were determined from each brain region. |
2005-03-04 |
2023-08-12 |
Not clear |
| Hideki Mochizuk. [Future of gene therapy for Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651340. |
parkinson's disease (pd) is a good target for gene therapy because the lesion is localized to the substantia nigra (sn). |
2005-03-04 |
2023-08-12 |
mouse |
| Iwona Kurkowska-Jastrzebska, Tomasz Litwin, Ilona Joniec, Agnieszka Ciesielska, Adam Przybyłkowski, Andrzej Członkowski, Anna Członkowsk. Dexamethasone protects against dopaminergic neurons damage in a mouse model of Parkinson's disease. International immunopharmacology. vol 4. issue 10-11. 2005-02-23. PMID:15313429. |
we observed the same protection in both situations: less dopamine depletion and less decrease in the number of dopaminergic cells in the substantia nigra (sn). |
2005-02-23 |
2023-08-12 |
mouse |
| Corinna Burger, Oleg S Gorbatyuk, Margaret J Velardo, Carmen S Peden, Philip Williams, Sergei Zolotukhin, Paul J Reier, Ronald J Mandel, Nicholas Muzyczk. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Molecular therapy : the journal of the American Society of Gene Therapy. vol 10. issue 2. 2005-02-16. PMID:15294177. |
rats were injected with raav2/1, raav2/2, or raav2/5 into selected regions of the cns, including the hippocampus (hpc), substantia nigra (sn), striatum, globus pallidus, and spinal cord. |
2005-02-16 |
2023-08-12 |
rat |
| Matthew G Quinlan, Ruth Sharf, David Y Lee, Roy A Wise, Robert Ranald. Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology. vol 175. issue 1. 2005-02-08. PMID:14767633. |
we have recently found that blockade of dopamine d1-type receptors in the ventral tegmental area reduces the rewarding effects of intravenous cocaine; here, we explored the possibility that blockade of d1 receptors in the adjacent substantia nigra (sn)--not usually considered part of reward circuitry--might have similar effects. |
2005-02-08 |
2023-08-12 |
rat |
| Renee M Miller, Linda M Callahan, Cindy Casaceli, Linlin Chen, Gretchen L Kiser, Buena Chui, Tamma M Kaysser-Kranich, Timothy J Sendera, Chockalingam Palaniappan, Howard J Federof. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 34. 2005-01-26. PMID:15329391. |
parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons of the substantia nigra (sn). |
2005-01-26 |
2023-08-12 |
mouse |
| Alessandra Mussi-Ribeiro, Antonio Miranda, Leonardo Gobbo-Netto, Norberto Peporine Lopes, Wagner Ferreira dos Santo. A anticonvulsive fraction from Scaptocosa raptoria (Araneae: Lycosidae) spider venom. Neuroscience letters. vol 371. issue 2-3. 2005-01-25. PMID:15519751. |
injection of phenytoin (390 pmol/200 nl), muscimol (90 pmol/200 nl), baclofen (500 pmol/200 nl) into the substantia nigra (sn) pars reticulata, protected rats from convulsions evoked by unilateral focal injection of bicuculline into the area tempestas by 50, 80, and 100%, respectively. |
2005-01-25 |
2023-08-12 |
rat |
| G Garcia, P Tagliaferro, A Ferri, A M Evangelista de Duffard, R Duffard, A Brusc. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. vol 25. issue 6. 2005-01-14. PMID:15474613. |
dopaminergic neurons from the midbrain nuclei substantia nigra (sn; a9) and ventral tegmental area (vta; a10) were investigated by tyrosine hydroxylase (th) immunostaining in neonate rat brains exposed to 2,4-dichlorophenoxyacetic acid (2,4-d) through lactation. |
2005-01-14 |
2023-08-12 |
rat |
| Jon M Dickson, Richard A Grünewal. Somatic symptom progression in idiopathic Parkinson's disease. Parkinsonism & related disorders. vol 10. issue 8. 2005-01-11. PMID:15542009. |
the substantia nigra (sn) pars compacta is arranged somatotopically. |
2005-01-11 |
2023-08-12 |
Not clear |
| B-Y Zeng, S J R Heales, L Canevari, S Rose, P Jenne. Alterations in expression of dopamine receptors and neuropeptides in the striatum of GTP cyclohydrolase-deficient mice. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530890. |
striatal tyrosine hydroxylase (th) levels are decreased while the number of da neurones in substantia nigra (sn) appears normal. |
2004-12-29 |
2023-08-12 |
mouse |
| JinWhan Cho, Olga Yarygina, Tinmarla Frances Oo, Nikolai G Kholodilov, Robert E Burk. Glial cell line-derived neurotrophic factor receptor GFRalpha1 is expressed in the rat striatum during postnatal development. Brain research. Molecular brain research. vol 127. issue 1-2. 2004-12-22. PMID:15306125. |
dopamine neurons of the substantia nigra (sn) undergo a natural cell death event which is biphasic, with peaks at postnatal days (pnds) 2 and 14. |
2004-12-22 |
2023-08-12 |
rat |
| Stephanie J Cragg, Jérôme Baufreton, Yi Xue, J Paul Bolam, Mark D Beva. Synaptic release of dopamine in the subthalamic nucleus. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15380000. |
the direct modulation of subthalamic nucleus (stn) neurons by dopamine (da) neurons of the substantia nigra (sn) is controversial owing to the thick caliber and low density of da axons in the stn. |
2004-12-22 |
2023-08-12 |
rat |
| Christopher Bishop, Paul D Walke. Intranigral antagonism of neurokinin 1 and 3 receptors reduces intrastriatal dopamine D1 receptor-stimulated locomotion in the rat. Brain research. vol 1023. issue 1. 2004-12-21. PMID:15364027. |
adult male sprague-dawley rats bearing chronic cannulae in the dorsal striatum and/or substantia nigra (sn) were tested for locomotor responses to various drug infusions. |
2004-12-21 |
2023-08-12 |
rat |