| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenxia Zhou, Adam W Mailloux, Jacqueline F McGint. Intracerebral baclofen administration decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 5. 2005-05-12. PMID:15592348. |
infusion of baclofen (75 ng/side) into the ventral tegmental area (vta), substantia nigra (sn), nucleus accumbens (na), caudate-putamen (cpu), or medial prefrontal cortex (mpfc) had no effect on behavioral activity in saline-treated rats habituated to a photocell apparatus. |
2005-05-12 |
2023-08-12 |
rat |
| b' Libor Vel\\xc3\\xadsek, Jana Vel\\xc3\\xadskov\\xc3\\xa1, Teresa Ravizza, Filippo S Giorgi, Solomon L Mosh\\xc3\\xa. Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors. Neurobiology of disease. vol 18. issue 2. 2005-05-12. PMID:15686963.' |
the substantia nigra (sn) is involved in circling. |
2005-05-12 |
2023-08-12 |
rat |
| R M Miller, L L Chen, G L Kiser, T L Giesler, T M Kaysser-Kranich, C Palaniappan, H J Federof. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of aging. vol 26. issue 5. 2005-05-09. PMID:15708451. |
the gradual loss of striatal dopamine and dopaminergic neurons residing in the substantia nigra (sn) causes parkinsonism characterized by slow, halting movements, rigidity, and resting tremor when neuronal loss exceeds a threshold of approximately 80%. |
2005-05-09 |
2023-08-12 |
mouse |
| Michael Hsu, Bharath Srinivas, Jyothi Kumar, Rajagopalan Subramanian, Julie Anderse. Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715660. |
an early biochemical change in the parkinsonian substantia nigra (sn) is reduction in total glutathione (gsh + gssg) levels in affected dopaminergic neurons prior to depletion in mitochondrial complex i activity, dopamine loss, and cell death. |
2005-04-28 |
2023-08-12 |
Not clear |
| J K Marcario, K F Manaye, K S SantaCruz, P R Mouton, N E J Berman, P D Chene. Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus. Journal of neurovirology. vol 10. issue 6. 2005-04-19. PMID:15765810. |
to investigate the relationship between morphological correlates and neurophysiological deficits, unbiased stereology was used to assess total neuron number, volume, and neuronal density for all neurons in the globus pallidus (gp) and for dopamine (da)-containing neurons in the substantia nigra (sn) in eight macaques inoculated with macrophage-tropic, neurovirulent siv (sivmac r71/17e), and five control animals. |
2005-04-19 |
2023-08-12 |
human |
| Cole A Giller, Evelyn E Babcock, Dianne B Mendelsoh. Use of sagittal images for localization of the subthalamic nucleus. Technical note. Journal of neurosurgery. vol 102. issue 3. 2005-04-15. PMID:15796399. |
a review of sagittal slices appearing in standard stereotactic atlases showed that the stn lies within the angle formed by the descending internal capsule (ic) and the substantia nigra (sn). |
2005-04-15 |
2023-08-12 |
Not clear |
| Takashi Kondoh, Makoto Bannai, Hitoo Nishino, Kunio Tori. 6-Hydroxydopamine-induced lesions in a rat model of hemi-Parkinson's disease monitored by magnetic resonance imaging. Experimental neurology. vol 192. issue 1. 2005-04-14. PMID:15698634. |
in the present study, location and extent of lesions 1 day after 6-ohda injections (2, 4, 8, or 16 microg as a free base) in the substantia nigra (sn) were evaluated in rats by t(2)-weighted magnetic resonance imaging (mri). |
2005-04-14 |
2023-08-12 |
rat |
| P T Bywood, S M Johnso. Catecholamine neuron groups in rat brain slices differ in their susceptibility to excitatory amino acid induced dendritic degeneration. Neurotoxicity research. vol 3. issue 6. 2005-04-12. PMID:15111241. |
the sections were immunolabelled for tyrosine hydroxylase to identify different groups of catecholamine neurons (substantia nigra (sn), paranigral (pn), interfascicular (if) and hypothalamic a11, a13 and a14) which exhibited prominent dendritic projections in the horizontal plane. |
2005-04-12 |
2023-08-12 |
rat |
| Jessica J Hawes, Marina R Picciott. Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain. The Journal of comparative neurology. vol 479. issue 4. 2005-04-08. PMID:15514977. |
the distribution of immunoreactivity for the three identified neuropeptide galanin receptors, galr1, galr2, and galr3, was determined in areas of the mouse brain involved in drug addiction, including the ventral tegmental area (vta), substantia nigra (sn), nucleus accumbens (na), and locus coeruleus (lc). |
2005-04-08 |
2023-08-12 |
mouse |
| Uwe Walter, Christine Klein, Ruediger Hilker, Reiner Benecke, Peter P Pramstaller, Dirk Dressle. Brain parenchyma sonography detects preclinical parkinsonism. Movement disorders : official journal of the Movement Disorder Society. vol 19. issue 12. 2005-04-07. PMID:15390070. |
substantia nigra (sn) hyperechogenicity on brain parenchyma sonography (bps) is highly characteristic for idiopathic pd. |
2005-04-07 |
2023-08-12 |
Not clear |
| Fabio A Zucca, Giuseppe Giaveri, Mario Gallorini, Alberto Albertini, Marco Toscani, Gianni Pezzoli, Ralph Lucius, Henrik Wilms, David Sulzer, Shosuke Ito, Kazumasa Wakamatsu, Luigi Zecc. The neuromelanin of human substantia nigra: physiological and pathogenic aspects. Pigment cell research. vol 17. issue 6. 2005-03-29. PMID:15541018. |
neuromelanin (nm) accumulates as a function of age in normal human substantia nigra (sn) but is relatively depleted in the sn of patients with parkinson disease (pd). |
2005-03-29 |
2023-08-12 |
human |
| Allison D Ebert, Feng Chen, Xiaolong He, Vincent L Cryns, Martha C Boh. A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. Experimental neurology. vol 191 Suppl 1. 2005-03-29. PMID:15629764. |
caspase-9 is a critical downstream effector molecule involved in apoptosis, a cell death process thought to be involved in the demise of dopamine (da) neurons in the substantia nigra (sn) affected by parkinson's disease (pd). |
2005-03-29 |
2023-08-12 |
rat |
| Alexander Iova, Andrew Garmashov, Natalia Androuchtchenko, Martin Kehrer, Daniela Berg, Georg Becker, Yurii Garmasho. Postnatal decrease in substantia nigra echogenicity. Implications for the pathogenesis of Parkinson's disease. Journal of neurology. vol 251. issue 12. 2005-03-29. PMID:15645343. |
increased echogenicity of the substantia nigra (sn) on transcranial ultrasonography (tcs) is a typical sign in parkinson's disease (pd). |
2005-03-29 |
2023-08-12 |
Not clear |
| E Grünblatt, S Mandel, J Jacob-Hirsch, S Zeligson, N Amariglo, G Rechavi, J Li, R Ravid, W Roggendorf, P Riederer, M B H Youdi. Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 12. 2005-03-23. PMID:15455214. |
one major finding in the present study is the particular decreased expression of skp1a, a member of the scf (e3) ligase complex specifically in the substantia nigra (sn) of sporadic parkinsonian patients, which may lead to a wide impairment in the function of an entire repertoire of proteins subjected to regulatory ubiquitination. |
2005-03-23 |
2023-08-12 |
human |
| Biljana Georgievska, Deniz Kirik, Anders Björklun. Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 29. 2005-03-21. PMID:15269253. |
the effects of continuous glial cell line-derived neurotrophic factor (gdnf) overexpression in the intact nigrostriatal dopamine (da) system was studied using recombinant lentiviral (rlv) vector delivery of gdnf to the striatum or substantia nigra (sn) in the rat. |
2005-03-21 |
2023-08-12 |
rat |
| Manuel Rodríguez Díaz, Teofilo Jorge Alonso, Juan Perdomo Diaz, Tomás Gonzalez Hernández, Rafael Castro Fuentes, Magdalena Sabate, Jose Garcia Dopic. Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra. Glia. vol 49. issue 1. 2005-03-21. PMID:15390097. |
in the present work, the ens-glu pool was studied with microdialysis in the rat substantia nigra (sn). |
2005-03-21 |
2023-08-12 |
rat |
| Heidi Fedorow, Russell Pickford, James M Hook, Kay L Double, Glenda M Halliday, Manfred Gerlach, Peter Riederer, Brett Garne. Dolichol is the major lipid component of human substantia nigra neuromelanin. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686500. |
neuromelanin is a dark brown pigment present at high concentrations in dopaminergic neurones of the human substantia nigra (sn). |
2005-03-21 |
2023-08-12 |
human |
| Gonzalo Bustos, Jorge Abarca, Jorge Campusano, Victor Bustos, Viviana Noriega, Esteban Aliag. Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain. Brain research. Brain research reviews. vol 47. issue 1-3. 2005-03-15. PMID:15572168. |
dopaminergic nigrostriatal neurons may be considered as bipolar functional entities since they are endowed with the ability to synthesize, store and release the transmitter dopamine (da) at the somatodendritic level in the substantia nigra (sn). |
2005-03-15 |
2023-08-12 |
Not clear |
| Karen Müller Smith, Lorri Bauer, Mariellen Fischer, Russell Barkley, Bradford A Navi. Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 133B. issue 1. 2005-03-14. PMID:15635701. |
nr4a2, or nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (vta) and the substantia nigra (sn). |
2005-03-14 |
2023-08-12 |
human |
| Jun Wang, Hong Jiang, Jun-Xia Xi. Time dependent effects of 6-OHDA lesions on iron level and neuronal loss in rat nigrostriatal system. Neurochemical research. vol 29. issue 12. 2005-03-09. PMID:15672545. |
the results showed that: 1, 3, 5, 7, and 14 days of postlesion, there was a progressive reduction in the density of the tyrosine hydroxylase immunoreactive (th-ir) cells in the lesioned substantia nigra (sn). |
2005-03-09 |
2023-08-12 |
rat |