| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Humberto José Martínez, Fidel Castro-Caraballo, Arelis Arrieta, Ernesto Bonill. [Spontaneous motor activity and brain catecholamines in C57BL/6 and albino mice treated with manganese]. Investigacion clinica. vol 45. issue 1. 2004-12-14. PMID:15058754. |
we also determined the concentrations of several monoamines and their metabolites, in the substantia nigra (sn), corpus striatum (cs) and locus coeruleus (lc), by high pressure liquid chromatography with electrochemical detection. |
2004-12-14 |
2023-08-12 |
mouse |
| Tomás González-Hernández, Pedro Barroso-Chinea, Ignacio De La Cruz Muros, María Del Mar Pérez-Delgado, Manuel Rodrígue. Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons. The Journal of comparative neurology. vol 479. issue 2. 2004-12-13. PMID:15452855. |
our results revealed that the expression patterns for vmat2 mrna and protein and dat mrna are similar, with the highest levels in the rostromedial region of substantia nigra (snrm), followed by the caudoventral region of sn (sncv), the ventral tegmental area and pigmented parabrabraquial nucleus (vta/pbp), and finally the linear and interfascicular nuclei (li/if). |
2004-12-13 |
2023-08-12 |
human |
| Gang Li, Shenggang Sun, Xuebing Cao, Jiangxin Zhong, E'tang Ton. LPS-induced degeneration of dopaminergic neurons of substantia nigra in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 1. 2004-12-10. PMID:15165124. |
in order to investigate the neurotoxicity of lipopolysaccharide (lps) on the dopaminergic neurons of substantia nigra and the pathogenesis of parkinson disease, lps was stereotaxically infused into substantia nigra (sn). |
2004-12-10 |
2023-08-12 |
rat |
| G Webster Ross, Helen Petrovitch, Robert D Abbott, James Nelson, William Markesbery, Daron Davis, John Hardman, Lenore Launer, Kamal Masaki, Caroline M Tanner, Lon R Whit. Parkinsonian signs and substantia nigra neuron density in decendents elders without PD. Annals of neurology. vol 56. issue 4. 2004-12-02. PMID:15389895. |
substantia nigra (sn) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the honolulu-asia aging study, aged 74-97 years at death. |
2004-12-02 |
2023-08-12 |
human |
| Adam Przybyłkowski, Iwona Kurkowska-Jastrzebska, Ilona Joniec, Agnieszka Ciesielska, Anna Członkowska, Andrzej Członkowsk. Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306248. |
mptp causes an acute damage of dopaminergic neurons especially in the nigrostriatal dopaminergic system, thus diminishing dopamine (da) content in striatum and decreasing the number of dopaminergic cells in the pars compacta of the substantia nigra (sn). |
2004-11-04 |
2023-08-12 |
mouse |
| Ranjita Betarbet, J Timothy Greenamyr. Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP. Experimental neurology. vol 189. issue 2. 2004-10-28. PMID:15380489. |
(4) substance p expression was up-regulated in the internal segment of the globus pallidus (gpi), but remained unchanged in substantia nigra (sn). |
2004-10-28 |
2023-08-12 |
monkey |
| Xian-Yu Liu, Hui-Fang Zhou, Yan-Li Pan, Xi-Bin Liang, Dong-Bin Niu, Bing Xue, Feng-Qiao Li, Qi-Hua He, Xin-Hong Wang, Xiao-Min Wan. Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats. Experimental neurology. vol 189. issue 1. 2004-10-27. PMID:15296849. |
ed1 immunohistochemical staining showed that a large number of macrophages appeared in the substantia nigra (sn) 14 days after mfb transection. |
2004-10-27 |
2023-08-12 |
rat |
| Judit Soós, József I Engelhardt, László Siklós, László Havas, Katalin Majtény. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257133. |
immunohistochemical techniques revealed a significant increase of poly(adp-ribose) polymerase (parp)-containing nuclei in the dopaminergic neurons of the substantia nigra (sn) in parkinson disease and in diffuse lewy body disease as compared with a group of patients with other neurodegenerative diseases and normal controls. |
2004-10-21 |
2023-08-12 |
Not clear |
| Lidia I Serova, Shreekrishna Maharjan, An Huang, Dong Sun, Gabor Kaley, Esther L Sabba. Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. Brain research. vol 1015. issue 1-2. 2004-10-15. PMID:15223360. |
short-term administration of estradiol benzoate (eb) by five injections of 15 or 40 microg/kg 12 h apart led to increase in th and gtpch mrna levels in dopaminergic and noradrenergic cell bodies of the ventral tegmental area (vta), substantia nigra (sn), locus coeruleus (lc) and the nucleus of solitary tract (nts) depending on dose of administration. |
2004-10-15 |
2023-08-12 |
rat |
| Brian C Kramer, Catherine Mytilineo. Alterations in the cellular distribution of bcl-2, bcl-x and bax in the adult rat substantia nigra following striatal 6-hydroxydopamine lesions. Journal of neurocytology. vol 33. issue 2. 2004-10-13. PMID:15322379. |
in this study we examined the localization of the pro-apoptotic protein bax, and the anti-apoptotic proteins bcl-2 and bcl-x(l) in the substantia nigra (sn) of the adult rat and their response to oxidative stress caused by striatal injections of 6-hydroxydopamine (6-ohda). |
2004-10-13 |
2023-08-12 |
rat |
| Zhaoliang Hu, Margaret Cooper, David P Crockett, Renping Zho. Differentiation of the midbrain dopaminergic pathways during mouse development. The Journal of comparative neurology. vol 476. issue 3. 2004-10-07. PMID:15269972. |
dopaminergic (da) neurons in the substantia nigra (sn) and ventral tegmental area (vta) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus accumbens, respectively, establishing the mesostriatal and the mesolimbic pathways. |
2004-10-07 |
2023-08-12 |
mouse |
| D A Kozlowski, E A Miljan, E G Bremer, C G Harrod, C Gerin, B Connor, D George, B Larson, M C Boh. Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat. Brain research. vol 1016. issue 2. 2004-09-27. PMID:15246853. |
receptor expression was assessed in striatum (st) and substantia nigra (sn) of normal rats and rats acutely or progressively lesioned by 6-ohda injected into the medial forebrain bundle or st, respectively. |
2004-09-27 |
2023-08-12 |
rat |
| Bobby Thomas, Kochupurackal P Mohanakuma. Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum. Journal of pineal research. vol 36. issue 1. 2004-09-21. PMID:14675127. |
we also measured reduced glutathione (gsh) levels, and superoxide dismutase (sod) activity in the nucleus caudatus putamen (ncp) and substantia nigra (sn), 7 days following mptp and/or melatonin administration. |
2004-09-21 |
2023-08-12 |
mouse |
| Beth-Anne Sieber, Alexander Kuzmin, Josep M Canals, Anne Danielsson, Gustavo Paratcha, Ernest Arenas, Jordi Alberch, Sven Ove Ogren, Carlos F Ibáñe. Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Molecular and cellular neurosciences. vol 26. issue 3. 2004-09-17. PMID:15234346. |
adult transgenic mice showed a 30-40% reduction in the total volume of the substantia nigra (sn) without detectable differences in the number of dopaminergic neurons. |
2004-09-17 |
2023-08-12 |
mouse |
| David A Ballok, Aoife M Earls, Catherine Krasnik, Steven A Hoffman, Boris Saki. Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. Journal of neuroimmunology. vol 152. issue 1-2. 2004-09-16. PMID:15223241. |
while fjb-positive somas were not seen in the striatum, increased staining in the substantia nigra (sn) and ventral tegmental area (vta) were detected in behaviorally impaired mrl-lpr mice, but not in age-matched controls. |
2004-09-16 |
2023-08-12 |
mouse |
| Deepak Sarpal, James I Koenig, John P Adelman, Dana Brady, Lucy Clerkin Prendeville, Paul D Shepar. Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells. Synapse (New York, N.Y.). vol 53. issue 2. 2004-09-10. PMID:15170822. |
sk3 mrna was found exclusively in areas that also contained large numbers of da neurons including the substantia nigra (sn), the ventral tegmental area, and related cell groups (vta-a10). |
2004-09-10 |
2023-08-12 |
rat |
| Chuantao Jiang, Xinhua Wan, Joseph Jankovic, Samuel T Christian, Zdenek B Pristupa, Hyman B Niznik, John S Sundsmo, Weidong L. Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Clinical neuropharmacology. vol 27. issue 2. 2004-09-09. PMID:15252266. |
in addition, after eight weeks of twice daily administration of 20 mg/kg ipx-750, mice did not show statistical difference in the total number of th-positive neurons in substantia nigra (sn). |
2004-09-09 |
2023-08-12 |
mouse |
| J R Connor, X S Wang, S M Patton, S L Menzies, J C Troncoso, C J Earley, R P Alle. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology. vol 62. issue 9. 2004-09-03. PMID:15136682. |
its etiology is unknown, but mri analyses and immunohistochemical studies on autopsy tissue suggest the substantia nigra (sn) of patients with rls has subnormal amounts of iron. |
2004-09-03 |
2023-08-12 |
Not clear |
| Christina L Zuch, Daniel David, Livia Ujhelyi, John L Hudson, Greg A Gerhardt, Paul L Kaplan, Paula C Bickfor. Beneficial effects of intraventricularly administered BMP-7 following a striatal 6-hydroxydopamine lesion. Brain research. vol 1010. issue 1-2. 2004-09-01. PMID:15126112. |
no significant effect of bmp-7 treatment on spontaneous locomotor activity was observed, however bmp-7 significantly increased the density of tyrosine hydroxylase (th) immunoreactivity (th-ir) in the substantia nigra (sn) pars compacta, in the lesioned hemisphere [31.7+/-5.2 (optical density (o.d.) |
2004-09-01 |
2023-08-12 |
rat |
| Sun-Yong Baek, Jin-Hun Cho, Eul-Sun Kim, Hyun-Ju Kim, Sik Yoon, Bong-Seon Kim, Jae-Bong Kim, Choong-Ryeol Lee, Cheolin Yoo, Ji-Ho Lee, Hun Lee, Jungsun Park, Jae-Woo Kim, Yangho Ki. CDNA array analysis of gene expression profiles in brain of mice exposed to manganese. Industrial health. vol 42. issue 3. 2004-08-19. PMID:15295902. |
this study is performed to detect changes of gene expression in substantia nigra (sn) and striatum in manganese (mn)-exposed mice brain. |
2004-08-19 |
2023-08-12 |
mouse |