| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David D Song, Clifford W Shults, Abbyann Sisk, Edward Rockenstein, Eliezer Maslia. Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Experimental neurology. vol 186. issue 2. 2004-04-26. PMID:15026254. |
because the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) is a potent complex i inhibitor that can cause oxidative injury and mimic many aspects of pd in treated animals, we sought to determine whether the overexpression of alpha-s in transgenic (tg) mice (alpha-s-tg) would enhance the substantia nigra (sn) pathology resulting from treatment with mptp. |
2004-04-26 |
2023-08-12 |
mouse |
| Jolanta Galazka-Friedman, Erika R Bauminger, Dariusz Koziorowski, Andrzej Friedma. Mössbauer spectroscopy and ELISA studies reveal differences between Parkinson's disease and control substantia nigra. Biochimica et biophysica acta. vol 1688. issue 2. 2004-04-23. PMID:14990343. |
mössbauer data were obtained at 90 and 4.1 k from 21 samples of control and 9 samples of parkinsonian substantia nigra (sn). |
2004-04-23 |
2023-08-12 |
Not clear |
| JinWhan Cho, Nikolai G Kholodilov, Robert E Burk. Patterns of developmental mRNA expression of neurturin and GFRalpha2 in the rat striatum and substantia nigra do not suggest a role in the regulation of natural cell death in dopamine neurons. Brain research. Developmental brain research. vol 148. issue 1. 2004-04-19. PMID:14757528. |
we examined the mrna expression of neurturin (ntn) and its receptor gfralpha2 in rat substantia nigra (sn) and striatum by northern analysis at ages ranging from postnatal day (pnd) 2 to adult. |
2004-04-19 |
2023-08-12 |
rat |
| Gail Chapman, Blaine L Beaman, David A Loeffler, Dianne M Camp, Edward F Domino, Dennis W Dickson, William G Ellis, Ibsen Chen, Susan E Bachus, Peter A LeWit. In situ hybridization for detection of nocardial 16S rRNA: reactivity within intracellular inclusions in experimentally infected cynomolgus monkeys--and in Lewy body-containing human brain specimens. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769363. |
our previous studies found that experimental infection of balb/c mice with the gram-positive bacterium nocardia asteroides induced a parkinsonian-type syndrome with levodopa-responsive movement abnormalities, loss of nigrostriatal dopaminergic neurons, depletion of striatal dopamine, and intraneuronal inclusions in the substantia nigra (sn) with an appearance similar to lewy bodies. |
2004-04-02 |
2023-08-12 |
mouse |
| Yi He, Patricia S Thong, Timothy Lee, S K Leong, Bo Y Mao, Fang Dong, Frank Wat. Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys. Free radical biology & medicine. vol 35. issue 5. 2004-04-01. PMID:12927603. |
though increasing lines of evidence suggest that iron accumulation and iron-induced oxidative stress might be important pathological factors responsible for substantia nigra (sn) cell death in parkinson's disease (pd), it is still unknown whether iron accumulation is a primary cause or consequence of nigral cell death. |
2004-04-01 |
2023-08-12 |
monkey |
| John-Paul Bouffard, Hernando Mena, Mary Ripple, Juan Troncos. Mesencephalic cryptococcal abscesses presenting with parkinsonism as an initial manifestation of AIDS. Movement disorders : official journal of the Movement Disorder Society. vol 18. issue 11. 2004-03-25. PMID:14639681. |
parkinsonism has been associated with hiv/aids and cerebral cryptococcal disease, but to date there has been no report of histological cryptococcal lesions in the substantia nigra (sn) in a patient with parkinsonism. |
2004-03-25 |
2023-08-12 |
Not clear |
| Shin-ichi Iwata, Masahiro Nomoto, Hirofumi Morioka, Atsuro Miyat. Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse (New York, N.Y.). vol 51. issue 4. 2004-03-24. PMID:14696015. |
in this model, mice are intrastriatally injected with 6-hydroxydopamine (6-ohda) and dopaminergic neurons in the substantia nigra (sn) gradually die by retrograde degeneration. |
2004-03-24 |
2023-08-12 |
mouse |
| Claire E Heise, John Mitrofani. Evidence for a glutamatergic projection from the zona incerta to the basal ganglia of rats. The Journal of comparative neurology. vol 468. issue 4. 2004-03-18. PMID:14689481. |
sprague-dawley rats were anaesthetised with ketamine (100 mg/kg) and rompun (10 mg/kg), and injections of cholera toxin subunit b were made into each of the following nuclei: the zi, the substantia nigra (sn), the pedunculopontine tegmental nucleus (ppt), and the entopeduncular nucleus (ep). |
2004-03-18 |
2023-08-12 |
rat |
| Gilbert J Kirouac, Sa Li, Gehan Mabrou. GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus. The Journal of comparative neurology. vol 469. issue 2. 2004-03-18. PMID:14694532. |
previous studies have shown that neurons in the ventral tegmental area (vta) and substantia nigra (sn) project to the ventrolateral periaqueductal gray (pagvl) and dorsal raphe nucleus (dr). |
2004-03-18 |
2023-08-12 |
rat |
| Michael F Salvatore, Subbu Apparsundaram, Greg A Gerhard. Decreased plasma membrane expression of striatal dopamine transporter in aging. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643386. |
using western blot techniques, we investigated whether the source of these age-related changes in dat was correlated with decreases in dat protein levels in the striatum, substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) of 6, 18, and 24-month-old male fischer 344 rats. |
2004-03-11 |
2023-08-12 |
rat |
| Justin Boyes, J Paul Bola. The subcellular localization of GABA(B) receptor subunits in the rat substantia nigra. The European journal of neuroscience. vol 18. issue 12. 2004-03-10. PMID:14686901. |
the inhibitory effects of gaba within the substantia nigra (sn) are mediated in part by metabotropic gaba(b) receptors. |
2004-03-10 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Jacek Wójcikowski, Marta Kot, Anna Haduch, Jan Boksa, Władysława Anna Danie. Disposition of 1,2,3,4,-tetrahydroisoquinoline in the brain of male Wistar and Dark Agouti rats. Brain research. vol 996. issue 2. 2004-03-10. PMID:14697494. |
this study aimed to examine tiq disposition in the whole rat brain and in the striatum and substantia nigra (sn). |
2004-03-10 |
2023-08-12 |
rat |
| David K Simon, Michael T Lin, Leiya Zheng, Guang-Jun Liu, Colette H Ahn, Lauren M Kim, William M Mauck, Florence Twu, M Flint Beal, Donald R John. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiology of aging. vol 25. issue 1. 2004-03-09. PMID:14675733. |
in the substantia nigra (sn), the aggregate levels of point mutations in young controls are similar to the levels in the sn or fctx of elderly subjects. |
2004-03-09 |
2023-08-12 |
human |
| Dagmar Galter, Silvia Buervenich, Andrea Carmine, Maria Anvret, Lars Olso. ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678778. |
aldh1 was found to be expressed highly and specifically in da cells of both substantia nigra (sn) and the ventral tegmental area (vta) of controls. |
2004-03-05 |
2023-08-12 |
human |
| Fiona M Hurley, Daniel J Costello, Aideen M Sulliva. Neuroprotective effects of delayed administration of growth/differentiation factor-5 in the partial lesion model of Parkinson's disease. Experimental neurology. vol 185. issue 2. 2004-03-02. PMID:14736509. |
gdf-5 (25 microg) was injected into either the striatum or substantia nigra (sn) of adult rats at 1 or 2 weeks after 6-hydroxydopamine administration. |
2004-03-02 |
2023-08-12 |
rat |
| William J Burke, Shu Wen Li, Evelyn A Williams, Randal Nonneman, Daniel S Zah. 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. Brain research. vol 989. issue 2. 2004-01-28. PMID:14556942. |
in parkinson's disease (pd), there is a highly selective loss of dopamine (da) neurons in the substantia nigra (sn) greater than in the ventral tegmental area (vta). |
2004-01-28 |
2023-08-12 |
rat |
| Okezie I Aruoma, Theeshan Bahorun, Ling-Sun Je. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutation research. vol 544. issue 2-3. 2004-01-21. PMID:14644322. |
the vulnerable brain regions in hiv/aids individuals include the dentate nucleus in the cerebellum, the red nucleus, substantia nigra (sn) in the mid-brain, the subthalamic nucleus, thalamic fasciculus in the diencephalons, the globus pallidus and striatum (or neostriatum, which consists of caudate and putamen) in the forebrain. |
2004-01-21 |
2023-08-12 |
human |
| Amanda D Smith, Marci Antion, Michael J Zigmond, Mark C Austi. Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRalpha1 and RET mRNAs in the adult rat. Brain research. Molecular brain research. vol 117. issue 2. 2004-01-20. PMID:14559146. |
da tissue levels in the striatum and tyrosine hydroxylase immunoreactivity in the substantia nigra (sn) and ventral tegmental area (vta) were used to determine the size of the lesions. |
2004-01-20 |
2023-08-12 |
rat |
| Marta Barrachina, Isabel Domínguez, Santiago Ambrosio, Julio Secades, Rafael Lozano, Isidro Ferre. Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells. Journal of the neurological sciences. vol 215. issue 1-2. 2004-01-20. PMID:14568136. |
finally, citicoline significantly attenuates substantia nigra (sn) dopaminergic cell dropout and tyrosine hydroxylase immunoreactivity in the ipsilateral striatum in rats injected intrastriatally with 6-hydroxydopamine (6-ohda). |
2004-01-20 |
2023-08-12 |
human |
| Bettina Felletschin, Peter Bauer, Uwe Walter, Stephanie Behnke, Jörg Spiegel, Ilona Csoti, Ulrike Sommer, Björn Zeiler, Georg Becker, Olaf Riess, Daniela Ber. Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neuroscience letters. vol 352. issue 1. 2004-01-20. PMID:14615048. |
we investigated 186 pd patients, in whom an increased amount of iron of the substantia nigra (sn) was priorly identified by transcranial ultrasound, for mutations of the whole coding region of ferritin-l and ferritin-h by denaturing high-pressure liquid chromatography and subsequent sequencing. |
2004-01-20 |
2023-08-12 |
Not clear |