| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xian-Yu Liu, Hui-Fang Zhou, Yan-Li Pan, Xi-Bin Liang, Dong-Bin Niu, Bing Xue, Feng-Qiao Li, Qi-Hua He, Xin-Hong Wang, Xiao-Min Wan. Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats. Experimental neurology. vol 189. issue 1. 2004-10-27. PMID:15296849. |
ed1 immunohistochemical staining showed that a large number of macrophages appeared in the substantia nigra (sn) 14 days after mfb transection. |
2004-10-27 |
2023-08-12 |
rat |
| Judit Soós, József I Engelhardt, László Siklós, László Havas, Katalin Majtény. The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease. Neuroreport. vol 15. issue 11. 2004-10-21. PMID:15257133. |
immunohistochemical techniques revealed a significant increase of poly(adp-ribose) polymerase (parp)-containing nuclei in the dopaminergic neurons of the substantia nigra (sn) in parkinson disease and in diffuse lewy body disease as compared with a group of patients with other neurodegenerative diseases and normal controls. |
2004-10-21 |
2023-08-12 |
Not clear |
| Lidia I Serova, Shreekrishna Maharjan, An Huang, Dong Sun, Gabor Kaley, Esther L Sabba. Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration. Brain research. vol 1015. issue 1-2. 2004-10-15. PMID:15223360. |
short-term administration of estradiol benzoate (eb) by five injections of 15 or 40 microg/kg 12 h apart led to increase in th and gtpch mrna levels in dopaminergic and noradrenergic cell bodies of the ventral tegmental area (vta), substantia nigra (sn), locus coeruleus (lc) and the nucleus of solitary tract (nts) depending on dose of administration. |
2004-10-15 |
2023-08-12 |
rat |
| Brian C Kramer, Catherine Mytilineo. Alterations in the cellular distribution of bcl-2, bcl-x and bax in the adult rat substantia nigra following striatal 6-hydroxydopamine lesions. Journal of neurocytology. vol 33. issue 2. 2004-10-13. PMID:15322379. |
in this study we examined the localization of the pro-apoptotic protein bax, and the anti-apoptotic proteins bcl-2 and bcl-x(l) in the substantia nigra (sn) of the adult rat and their response to oxidative stress caused by striatal injections of 6-hydroxydopamine (6-ohda). |
2004-10-13 |
2023-08-12 |
rat |
| Zhaoliang Hu, Margaret Cooper, David P Crockett, Renping Zho. Differentiation of the midbrain dopaminergic pathways during mouse development. The Journal of comparative neurology. vol 476. issue 3. 2004-10-07. PMID:15269972. |
dopaminergic (da) neurons in the substantia nigra (sn) and ventral tegmental area (vta) of the midbrain project to the dorsolateral caudate/putamen and to the ventromedially located nucleus accumbens, respectively, establishing the mesostriatal and the mesolimbic pathways. |
2004-10-07 |
2023-08-12 |
mouse |
| D A Kozlowski, E A Miljan, E G Bremer, C G Harrod, C Gerin, B Connor, D George, B Larson, M C Boh. Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat. Brain research. vol 1016. issue 2. 2004-09-27. PMID:15246853. |
receptor expression was assessed in striatum (st) and substantia nigra (sn) of normal rats and rats acutely or progressively lesioned by 6-ohda injected into the medial forebrain bundle or st, respectively. |
2004-09-27 |
2023-08-12 |
rat |
| Bobby Thomas, Kochupurackal P Mohanakuma. Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum. Journal of pineal research. vol 36. issue 1. 2004-09-21. PMID:14675127. |
we also measured reduced glutathione (gsh) levels, and superoxide dismutase (sod) activity in the nucleus caudatus putamen (ncp) and substantia nigra (sn), 7 days following mptp and/or melatonin administration. |
2004-09-21 |
2023-08-12 |
mouse |
| Beth-Anne Sieber, Alexander Kuzmin, Josep M Canals, Anne Danielsson, Gustavo Paratcha, Ernest Arenas, Jordi Alberch, Sven Ove Ogren, Carlos F Ibáñe. Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Molecular and cellular neurosciences. vol 26. issue 3. 2004-09-17. PMID:15234346. |
adult transgenic mice showed a 30-40% reduction in the total volume of the substantia nigra (sn) without detectable differences in the number of dopaminergic neurons. |
2004-09-17 |
2023-08-12 |
mouse |
| David A Ballok, Aoife M Earls, Catherine Krasnik, Steven A Hoffman, Boris Saki. Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. Journal of neuroimmunology. vol 152. issue 1-2. 2004-09-16. PMID:15223241. |
while fjb-positive somas were not seen in the striatum, increased staining in the substantia nigra (sn) and ventral tegmental area (vta) were detected in behaviorally impaired mrl-lpr mice, but not in age-matched controls. |
2004-09-16 |
2023-08-12 |
mouse |
| Deepak Sarpal, James I Koenig, John P Adelman, Dana Brady, Lucy Clerkin Prendeville, Paul D Shepar. Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells. Synapse (New York, N.Y.). vol 53. issue 2. 2004-09-10. PMID:15170822. |
sk3 mrna was found exclusively in areas that also contained large numbers of da neurons including the substantia nigra (sn), the ventral tegmental area, and related cell groups (vta-a10). |
2004-09-10 |
2023-08-12 |
rat |
| Chuantao Jiang, Xinhua Wan, Joseph Jankovic, Samuel T Christian, Zdenek B Pristupa, Hyman B Niznik, John S Sundsmo, Weidong L. Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Clinical neuropharmacology. vol 27. issue 2. 2004-09-09. PMID:15252266. |
in addition, after eight weeks of twice daily administration of 20 mg/kg ipx-750, mice did not show statistical difference in the total number of th-positive neurons in substantia nigra (sn). |
2004-09-09 |
2023-08-12 |
mouse |
| J R Connor, X S Wang, S M Patton, S L Menzies, J C Troncoso, C J Earley, R P Alle. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology. vol 62. issue 9. 2004-09-03. PMID:15136682. |
its etiology is unknown, but mri analyses and immunohistochemical studies on autopsy tissue suggest the substantia nigra (sn) of patients with rls has subnormal amounts of iron. |
2004-09-03 |
2023-08-12 |
Not clear |
| Christina L Zuch, Daniel David, Livia Ujhelyi, John L Hudson, Greg A Gerhardt, Paul L Kaplan, Paula C Bickfor. Beneficial effects of intraventricularly administered BMP-7 following a striatal 6-hydroxydopamine lesion. Brain research. vol 1010. issue 1-2. 2004-09-01. PMID:15126112. |
no significant effect of bmp-7 treatment on spontaneous locomotor activity was observed, however bmp-7 significantly increased the density of tyrosine hydroxylase (th) immunoreactivity (th-ir) in the substantia nigra (sn) pars compacta, in the lesioned hemisphere [31.7+/-5.2 (optical density (o.d.) |
2004-09-01 |
2023-08-12 |
rat |
| Sun-Yong Baek, Jin-Hun Cho, Eul-Sun Kim, Hyun-Ju Kim, Sik Yoon, Bong-Seon Kim, Jae-Bong Kim, Choong-Ryeol Lee, Cheolin Yoo, Ji-Ho Lee, Hun Lee, Jungsun Park, Jae-Woo Kim, Yangho Ki. CDNA array analysis of gene expression profiles in brain of mice exposed to manganese. Industrial health. vol 42. issue 3. 2004-08-19. PMID:15295902. |
this study is performed to detect changes of gene expression in substantia nigra (sn) and striatum in manganese (mn)-exposed mice brain. |
2004-08-19 |
2023-08-12 |
mouse |
| Kun Wang, Jian-Jun Wang, Yue Wang, Qi-Hua He, Xuan Wang, Xiao-Min Wan. Infusion of epidermal growth factor and basic fibroblast growth factor into the striatum of parkinsonian rats leads to in vitro proliferation and differentiation of adult neural progenitor cells. Neuroscience letters. vol 364. issue 3. 2004-08-12. PMID:15196666. |
this study investigated the proliferation and differentiation of adult neural progenitor cells (anpcs) derived from the striatum and substantia nigra (sn) of parkinsonian rats. |
2004-08-12 |
2023-08-12 |
rat |
| Luigi Zecca, Antonella Stroppolo, Alberto Gatti, Davide Tampellini, Marco Toscani, Mario Gallorini, Giuseppe Giaveri, Paolo Arosio, Paolo Santambrogio, Ruggero G Fariello, Erdem Karatekin, Mark H Kleinman, Nicholas Turro, Oleh Hornykiewicz, Fabio A Zucc. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 26. 2004-08-12. PMID:15210960. |
in this study, a comparative analysis of metal-related neuronal vulnerability was performed in two brainstem nuclei, the locus coeruleus (lc) and substantia nigra (sn), known targets of the etiological noxae in parkinson's disease and related disorders. |
2004-08-12 |
2023-08-12 |
human |
| J Deplazes, K Schöbel, H Hochstrasser, P Bauer, U Walter, S Behnke, J Spiegel, G Becker, O Riess, D Ber. Screening for mutations of the IRP2 gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 4. 2004-08-09. PMID:15057521. |
we recently identified an increased amount of iron in patients with parkinson's disease (pd) and hyperchogenicity of the substantia nigra (sn). |
2004-08-09 |
2023-08-12 |
Not clear |
| Jesus Landeira-Fernandez, Carlos V Grijalv. Participation of the substantia nigra dopaminergic neurons in the occurrence of gastric mucosal erosions. Physiology & behavior. vol 81. issue 1. 2004-08-09. PMID:15059688. |
in the present study, the participation of intrinsic neurons of the substantia nigra (sn) and ventral tegmental area (vta) on the occurrence of stomach ulceration was investigated. |
2004-08-09 |
2023-08-12 |
Not clear |
| Sophie Sarre, Hong Yuan, Nadine Jonkers, An Van Hemelrijck, Guy Ebinger, Yvette Michott. In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198664. |
we investigated the effect of an injection of 6-hydroxydopamine (6-ohda) into the rat medial forebrain bundle (mfb) on the degeneration and the function of the dopaminergic cell bodies in the substantia nigra (sn) 3 and 5 weeks after lesioning. |
2004-08-06 |
2023-08-12 |
rat |
| Hong Jiang, Zhong-Ming Qian, Jun-Xia Xi. [Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 5. 2004-07-22. PMID:14566406. |
to illustrate the mechanism underlying the increase of iron in substantia nigra (sn) in pd, changes of the expression of divalent metal transporter 1 (dmt1) and iron content were examined in sn in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treated mice using immunohistochemistry and histochemistry respectively. |
2004-07-22 |
2023-08-12 |
mouse |