| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiromi Hayashita-Kinoh, Masanori Yamada, Takanori Yokota, Yoshikuni Mizuno, Hideki Mochizuk. Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model. Biochemical and biophysical research communications. vol 341. issue 4. 2006-04-25. PMID:16460685. |
then, raav-synrz was injected into the substantia nigra (sn) of mpp(+)-treated rats. |
2006-04-25 |
2023-08-12 |
human |
| Daniela Berg, Helmine Hochstrasser, Katherine J Schweitzer, Olaf Ries. Disturbance of iron metabolism in Parkinson's disease -- ultrasonography as a biomarker. Neurotoxicity research. vol 9. issue 1. 2006-04-25. PMID:16464747. |
so far, however, a biomarker indicating increased iron levels in the substantia nigra (sn) in pd patients has been missing. |
2006-04-25 |
2023-08-12 |
human |
| Marcelo E Ezquer, Susana R Valdez, Alicia M Seltze. Inflammatory responses of the substantia nigra after acute hypoxia in neonatal rats. Experimental neurology. vol 197. issue 2. 2006-04-03. PMID:16293246. |
in this work, we assess the possibility of cellular damage to the substantia nigra (sn) after hypoxia-reoxygenation in the new born rat. |
2006-04-03 |
2023-08-12 |
human |
| J Miklossy, D D Doudet, C Schwab, S Yu, E G McGeer, P L McGee. Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Experimental neurology. vol 197. issue 2. 2006-04-03. PMID:16336966. |
it has been established that neuroinflammation is present in the substantia nigra (sn) of parkinson disease (pd) cases but the factors responsible are as yet unknown. |
2006-04-03 |
2023-08-12 |
monkey |
| S Qu, W G Ondo, X Zhang, W J Xie, T H Pan, W D L. Projections of diencephalic dopamine neurons into the spinal cord in mice. Experimental brain research. vol 168. issue 1-2. 2006-03-30. PMID:16044299. |
after being injected into the spinal cord, fg reached the da neurons within the a10 and a11 groups, but didn't target to any other da neuron groups including the a8 and a9 groups in substantia nigra (sn). |
2006-03-30 |
2023-08-12 |
mouse |
| Kelly J Conn, Wenwu Gao, Ann McKee, Michael S Lan, M David Ullman, Patricia B Eisenhauer, Richard E Fine, John M Well. Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353226. |
pathological hallmarks of the disease include the loss of dopaminergic neurons from the substantia nigra (sn) and the presence of lewy bodies (lbs) (alpha-synuclein and ubiquitin-positive, eosinophilic, cytoplasmic inclusions) in many of the surviving neurons. |
2006-03-23 |
2023-08-12 |
human |
| Matteo Marti, Flora Mela, Martina Fantin, Silvia Zucchini, Jeffrey M Brown, Jassir Witta, Manuela Di Benedetto, Beata Buzas, Rainer K Reinscheid, Severo Salvadori, Remo Guerrini, Patrizia Romualdi, Sanzio Candeletti, Michele Simonato, Brian M Cox, Michele Morar. Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 42. 2006-03-15. PMID:16237164. |
the opioid-like neuropeptide nociceptin/orphanin fq (n/ofq) and its receptor (nop) are expressed in the substantia nigra (sn), a brain area containing dopamine neurons that degenerate in parkinson's disease. |
2006-03-15 |
2023-08-12 |
mouse |
| M L Block, G Li, L Qin, X Wu, Z Pei, T Wang, B Wilson, J Yang, J S Hon. Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 2. 2006-03-15. PMID:16449797. |
using mesencephalic neuron-glia cultures, we address the novel possibility that peptides endogenous to the substantia nigra (sn), substance p and dynorphin (10(-13)-10(-14) m), are opposing mediators of microglial activation and consequent da neurotoxicity. |
2006-03-15 |
2023-08-12 |
mouse |
| Daphne M Hasbani, Francisco A Perez, Richard D Palmiter, Karen L O'Malle. Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221852. |
dopamine (da) has been postulated to play a role in the loss of dopaminergic substantia nigra (sn) neurons in parkinson's disease because of its propensity to oxidize and form quinones and other reactive oxygen species that can alter cellular function. |
2006-03-13 |
2023-08-12 |
mouse |
| Ennio Esposit. Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475959. |
among the multiple classes of 5-ht receptors described in the central nervous system, much attention has been devoted to the role of 5-ht2 receptor family in the control of central dopaminergic activity, because of the moderate to dense localization of both transcript and protein for 5-ht2a and 5-ht2c receptors in the substantia nigra (sn) and ventral tegmental area (vta), as well as their terminal regions. |
2006-03-10 |
2023-08-12 |
human |
| Oliver von Bohlen und Halbach, Liliana Minichiello, Klaus Unsicke. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 12. 2006-03-07. PMID:16037097. |
degeneration of daergic neurons of the substantia nigra and alpha-synuclein-positive aggregates in the remaining substantia nigra (sn) neurons are hallmarks of parkinson's disease (pd). |
2006-03-07 |
2023-08-12 |
mouse |
| Scott E Hemby, Brian Horman, Wenxue Tan. Differential regulation of ionotropic glutamate receptor subunits following cocaine self-administration. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16277980. |
western blotting was used to compare levels of iglur protein expression (nr1-3b, glur1-7, ka2) in the mesolimbic (ventral tegmental area, vta; nucleus accumbens, nac; and prefrontal cortex, pfc) and nigrostriatal pathways (substantia nigra, sn and dorsal caudate-putamen, cpu). |
2006-03-07 |
2023-08-12 |
Not clear |
| Byung P Cho, Dae Y Song, Shuei Sugama, Dong H Shin, Yoshinori Shimizu, Sung S Kim, Yoon S Kim, Tong H Jo. Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia. vol 53. issue 1. 2006-02-24. PMID:16206155. |
phagocytic microglia, characterized by ed1-immunoreactivity or ed1- and ox6-immunoreactivity, appeared in the mfb and substantia nigra (sn) as early as 1-3 days post-lesion (dpl), when there was no apparent loss of sn dopamine (da) neurons. |
2006-02-24 |
2023-08-12 |
rat |
| David M Dietz, Jenica Tapocik, Meriem Gaval-Cruz, Mohamed Kabba. Dopamine transporter, but not tyrosine hydroxylase, may be implicated in determining individual differences in behavioral sensitization to amphetamine. Physiology & behavior. vol 86. issue 3. 2006-02-21. PMID:16126238. |
furthermore, only hr rats pretreated with amphetamine exhibited an increase in dopamine transporter mrna in the ventral tegmental area (vta) and substantia nigra (sn). |
2006-02-21 |
2023-08-12 |
rat |
| P M Carvey, E-Y Chen, J W Lipton, C W Tong, Q A Chang, Z D Lin. Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 5. 2006-02-16. PMID:15583962. |
we injected tumor necrosis factor alpha (tnfalpha) and interleukin 1 beta (il-1beta) into the median forebrain bundle to determine if these pro-inflammatory cytokines could induce da neuron loss in the substantia nigra (sn) by themselves. |
2006-02-16 |
2023-08-12 |
rat |
| Luigi Zecca, Daniela Berg, Thomas Arzberger, Petra Ruprecht, Wolf D Rausch, Massimo Musicco, Davide Tampellini, Peter Riederer, Manfred Gerlach, Georg Becke. In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 10. 2006-02-16. PMID:15986424. |
an increased echogenicity of the substantia nigra (sn) was found previously in parkinsonian patients and in a low percentage of healthy adults. |
2006-02-16 |
2023-08-12 |
human |
| Akifumi Kamata, Yusuke Takeuchi, Kohji Fukunag. Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16277604. |
here we identified isoforms of camkii in the rat substantia nigra (sn). |
2006-02-14 |
2023-08-12 |
rat |
| Chih C Chao, Cheng H Chiang, Yun L Ma, Eminy H Y Le. Molecular mechanism of the neurotrophic effect of GDNF on DA neurons: role of protein kinase CK2. Neurobiology of aging. vol 27. issue 1. 2006-02-14. PMID:16298246. |
in the present study, we have shown that gdnf increased protein kinase ck2 activity in rat substantia nigra (sn) in a dose-dependent and time-dependent manner. |
2006-02-14 |
2023-08-12 |
rat |
| Carrie E John, Evgeny A Budygin, Yolanda Mateo, Sara R Jone. Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16300629. |
in the present report, fast-scan cyclic voltammetry was used to identify the monoamines that were released by electrical stimulation in mouse brain slices containing ventral tegmental area (vta), substantia nigra (sn) -pars compacta (snc) and -pars reticulata (snr). |
2006-02-14 |
2023-08-12 |
mouse |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |