| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin H Son, Hibiki Kawamata, Myung S Yoo, Dae J Kim, Young K Lee, Sooyoul Kim, Ted M Dawson, Hui Zhang, David Sulzer, Lichuan Yang, M Flint Beal, Lorraine A Degiorgio, Hong S Chun, Harriet Baker, Chu Pen. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. Journal of neurochemistry. vol 94. issue 4. 2005-09-27. PMID:16092945. |
the regulatory function of septin 5 in dopaminergic (daergic) neurons of substantia nigra (sn), maintained at relatively low levels, has not yet been delineated. |
2005-09-27 |
2023-08-12 |
mouse |
| Mahmoud M Iravani, Clement C M Leung, Mona Sadeghian, Claire O Haddon, Sarah Rose, Peter Jenne. The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045485. |
at 24 h, lps administration caused a marked reduction in the number of tyrosine hydroxylase-immunoreactive (th-ir) neurons in the substantia nigra (sn) but striatal th-ir was unaffected. |
2005-09-23 |
2023-08-12 |
human |
| Hao Chen, Steven L Parker, Shannon G Matta, Burt M Shar. Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats. The European journal of neuroscience. vol 22. issue 2. 2005-09-23. PMID:16045491. |
the bmax values (fmol/mg) in prefrontal cortex (pfc), nucleus accumbens (nacc), substantia nigra (sn) and ventral tegmental area (vta) were reduced by 26.6% (p<0.05), 32.6% (p<0.01), 23.0% (p<0.01) and 27.6% (p<0.05), respectively. |
2005-09-23 |
2023-08-12 |
human |
| Xiong Zhang, Wenjie Xie, Shen Qu, Tianhong Pan, Xiaotong Wang, Weidong L. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochemical and biophysical research communications. vol 333. issue 2. 2005-09-07. PMID:15950935. |
our present studies have shown that micro-injection of the proteasome inhibitor lactacystin into the substantia nigra (sn) of c57bl/6 mice causes significant loss of dopaminergic cells and induces intracellular inclusion body formation. |
2005-09-07 |
2023-08-12 |
mouse |
| Jiro Fukae, Masashi Takanashi, Shin-ichiro Kubo, Ken-ichi Nishioka, Yusaku Nakabeppu, Hideo Mori, Yoshikuni Mizuno, Nobutaka Hattor. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Acta neuropathologica. vol 109. issue 3. 2005-09-01. PMID:15841414. |
we found higher expression levels of mitochondrial isoforms of ogg1 enzymes in the substantia nigra (sn) in cases of pd. |
2005-09-01 |
2023-08-12 |
human |
| Stanley Fahn, David Sulze. Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. vol 1. issue 1. 2005-08-25. PMID:15717014. |
many of the motoric features that define parkinson disease (pd) result primarily from the loss of the neuromelanin (nm)-containing dopamine (da) neurons of the substantia nigra (sn), and to a lesser extent, other mostly catecholaminergic neurons, and are associated with cytoplasmic "lewy body" inclusions in some of the surviving neurons. |
2005-08-25 |
2023-08-12 |
Not clear |
| L E Bartlett, I Mende. Dopaminergic reinnervation of the globus pallidus by fetal nigral grafts in the rodent model of Parkinson's disease. Cell transplantation. vol 14. issue 2-3. 2005-08-19. PMID:15881421. |
this limitation may be due to an incomplete restoration of the dopaminergic input to other basal ganglia structures such as the external segment of the globus pallidus (gpe, homologue of the rodent gp), which normally receives dopaminergic input from the substantia nigra (sn). |
2005-08-19 |
2023-08-12 |
rat |
| Kimberly B Bjugstad, D Eugene Redmond, Yang D Teng, J D Elsworth, R H Roth, B C Blanchard, Evan Y Snyder, John R Slade. Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures. Cell transplantation. vol 14. issue 4. 2005-08-17. PMID:15929553. |
after mptp damage and in pd, the primate brain is characterized by decreased numbers of dopamine neurons in the substantia nigra (sn) and an increase in neurons expressing th in the caudate nucleus. |
2005-08-17 |
2023-08-12 |
human |
| H Hochstrasser, P Bauer, U Walter, S Behnke, J Spiegel, I Csoti, B Zeiler, A Bornemann, J Pahnke, G Becker, O Riess, D Ber. Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease. Neurology. vol 63. issue 10. 2005-08-04. PMID:15557511. |
transcranial ultrasound may be used to detect increased iron levels of the substantia nigra (sn) in patients with parkinson disease (pd) and in control subjects. |
2005-08-04 |
2023-08-12 |
human |
| S J López-Pérez, P Vergara, J P Ventura-Valenzuela, M E Ureña-Guerrero, J Segovia, C Beas-Zárat. Modification of dopaminergic markers expression in the striatum by neonatal exposure to glutamate during development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 4. 2005-08-01. PMID:15927757. |
in addition, th-immunopositive neurons at substantia nigra (sn) were also examined. |
2005-08-01 |
2023-08-12 |
rat |
| Etienne C Hirsch, Stéphane Hunot, Andreas Hartman. Neuroinflammatory processes in Parkinson's disease. Parkinsonism & related disorders. vol 11 Suppl 1. 2005-07-25. PMID:15885630. |
in parkinson's disease (pd), post-mortem examination reveals a loss of dopaminergic (da) neurons in the substantia nigra (sn) associated with a massive astrogliosis and the presence of activated microglial cells. |
2005-07-25 |
2023-08-12 |
Not clear |
| Yasuhiko Izumi, Hideyuki Sawada, Noriko Sakka, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15712215. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2005-07-15 |
2023-08-12 |
human |
| Andreas Hald, Julie Lothariu. Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869932. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra (sn). |
2005-07-15 |
2023-08-12 |
human |
| A D Smith, D A Kozlowski, M C Bohn, M J Zigmon. Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats. Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869944. |
we have previously observed that the delivery of an adenoviral vector encoding for glial cell line-derived neurotrophic factor (adgdnf) into the substantia nigra (sn) 7 days after intrastriatal administration of 6-hydroxydopamine (6-ohda) protects dopamine (da)-dependent behaviors, tyrosine hydroxylase immunoreactive (th+) cells in sn, and amphetamine-induced c-fos induction in striatum. |
2005-07-15 |
2023-08-12 |
rat |
| Thomas Debeir, Laure Ginestet, Chantal François, Stéphanie Laurens, Jean-Claude Martel, Philippe Chopin, Marc Marien, Francis Colpaert, Rita Raisman-Vozar. Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of the rat cortex and globus pallidus. Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869947. |
twenty-eight days after unilateral injection of 6-ohda into the dorsal part of the striatum, th-positive fiber density was reduced by 41% in the dorsal and central part of the structure, and was accompanied by a retrograde loss of 33% of th-positive neurons in the substantia nigra (sn), while the ventral tegmental area was completely spared. |
2005-07-15 |
2023-08-12 |
rat |
| Ella M Nikulina, Klaus A Miczek, Ronald P Hamme. Prolonged effects of repeated social defeat stress on mRNA expression and function of mu-opioid receptors in the ventral tegmental area of rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 6. 2005-07-11. PMID:15668724. |
regional mu-receptor mrna levels were assessed by in situ hybridization histochemistry, and the amount of mrna labeling was measured in the vta and the substantia nigra (sn). |
2005-07-11 |
2023-08-12 |
rat |
| Jong-Min Kim, Sang-Bae Ko, Seon-Joo Kwon, Hyun-Jung Kim, Moon-Ku Han, Dong Woon Kim, Sa Sun Cho, Beom S Jeo. Ferrous and ferric iron accumulates in the brain of aged Long-Evans Cinnamon rats, an animal model of Wilson's disease. Neuroscience letters. vol 382. issue 1-2. 2005-07-11. PMID:15911138. |
we evaluated and compared the distributions of cu, ferrous (fe2+), and ferric (fe3+) iron in four-brain regions, namely, in the cerebral cortex, cerebellum, substantia nigra (sn), and striatum of lec and long-evans agouti rats at 30 and 55 weeks. |
2005-07-11 |
2023-08-12 |
rat |
| Daniela Berg, Berthold Merz, Karlheinz Reiners, Markus Naumann, Georg Becke. Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 3. 2005-06-30. PMID:15486999. |
using transcranial sonography, an area of hyperechogenicity at the substantia nigra (sn) may be detected as a typical marker in patients with parkinson's disease (pd) as well as in approximately 9% of healthy subjects vulnerable to nigrostriatal impairment. |
2005-06-30 |
2023-08-12 |
human |
| Masanori Yamada, Yoshikuni Mizuno, Hideki Mochizuk. Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease. Human gene therapy. vol 16. issue 2. 2005-06-28. PMID:15761265. |
in the present study, the parkin gene therapy was investigated for its ameliorative effects on alpha-synucleinopathy in substantia nigra (sn) of rats. |
2005-06-28 |
2023-08-12 |
rat |
| Julie K Anderse. Iron dysregulation and Parkinson's disease. Journal of Alzheimer's disease : JAD. vol 6. issue 6 Suppl. 2005-06-14. PMID:15665414. |
these data strongly suggest that iron elevations observed in the parkinsonian substantia nigra (sn), the brain region which undergoes selective neurodegeneration in the disease, are actively involved in subsequent neurodegenerative events. |
2005-06-14 |
2023-08-12 |
Not clear |