| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Carvey, E-Y Chen, J W Lipton, C W Tong, Q A Chang, Z D Lin. Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 5. 2006-02-16. PMID:15583962. |
we injected tumor necrosis factor alpha (tnfalpha) and interleukin 1 beta (il-1beta) into the median forebrain bundle to determine if these pro-inflammatory cytokines could induce da neuron loss in the substantia nigra (sn) by themselves. |
2006-02-16 |
2023-08-12 |
rat |
| Luigi Zecca, Daniela Berg, Thomas Arzberger, Petra Ruprecht, Wolf D Rausch, Massimo Musicco, Davide Tampellini, Peter Riederer, Manfred Gerlach, Georg Becke. In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 10. 2006-02-16. PMID:15986424. |
an increased echogenicity of the substantia nigra (sn) was found previously in parkinsonian patients and in a low percentage of healthy adults. |
2006-02-16 |
2023-08-12 |
human |
| Akifumi Kamata, Yusuke Takeuchi, Kohji Fukunag. Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16277604. |
here we identified isoforms of camkii in the rat substantia nigra (sn). |
2006-02-14 |
2023-08-12 |
rat |
| Chih C Chao, Cheng H Chiang, Yun L Ma, Eminy H Y Le. Molecular mechanism of the neurotrophic effect of GDNF on DA neurons: role of protein kinase CK2. Neurobiology of aging. vol 27. issue 1. 2006-02-14. PMID:16298246. |
in the present study, we have shown that gdnf increased protein kinase ck2 activity in rat substantia nigra (sn) in a dose-dependent and time-dependent manner. |
2006-02-14 |
2023-08-12 |
rat |
| Carrie E John, Evgeny A Budygin, Yolanda Mateo, Sara R Jone. Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16300629. |
in the present report, fast-scan cyclic voltammetry was used to identify the monoamines that were released by electrical stimulation in mouse brain slices containing ventral tegmental area (vta), substantia nigra (sn) -pars compacta (snc) and -pars reticulata (snr). |
2006-02-14 |
2023-08-12 |
mouse |
| Yasuhiko Izumi, Hideyuki Sawada, Noriyuki Yamamoto, Toshiaki Kume, Hiroshi Katsuki, Shun Shimohama, Akinori Akaik. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16108071. |
parkinson's disease (pd) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn), and it has been suggested that dopamine is one of the main endogenous toxins in the genesis of pd. |
2006-02-07 |
2023-08-12 |
human |
| Cecilia Ericson, Biljana Georgievska, Cecilia Lundber. Ex vivo gene delivery of GDNF using primary astrocytes transduced with a lentiviral vector provides neuroprotection in a rat model of Parkinson's disease. The European journal of neuroscience. vol 22. issue 11. 2006-02-07. PMID:16324109. |
similarly, grafting to the substantia nigra (sn) resulted in a significant overexpression of gdnf ( approximately 0.20 ng/mg tissue) at 1 week. |
2006-02-07 |
2023-08-12 |
rat |
| Yaping Chu, Weidong Le, Katie Kompoliti, Joseph Jankovic, Elliott J Mufson, Jeffrey H Kordowe. Nurr1 in Parkinson's disease and related disorders. The Journal of comparative neurology. vol 494. issue 3. 2006-02-06. PMID:16320253. |
decline of nurr1-ir neuronal number and od was observed within substantia nigra (sn) neurons in pd but not within hippocampal neurons. |
2006-02-06 |
2023-08-12 |
Not clear |
| Birgit Liss, Olga Haeckel, Johannes Wildmann, Takashi Miki, Susumu Seino, Jochen Roepe. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16299504. |
the selective degeneration of dopaminergic (da) midbrain neurons in the substantia nigra (sn) is a hallmark of parkinson disease. |
2006-01-24 |
2023-08-12 |
mouse |
| Sang H Choi, Da Y Lee, Eun S Chung, Young B Hong, Seung U Kim, Byung K Ji. Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16219027. |
seven days after thrombin injection in the rat substantia nigra (sn), tyrosine hydroxylase immunocytochemistry showed a significant loss of nigral dopaminergic neurons. |
2006-01-20 |
2023-08-12 |
rat |
| Thomas D Corso, German Torres, Christopher Goulah, Indrajit Roy, Angelo S Gambino, John Nayda, Timothy Buckley, Ewa K Stachowiak, Earl J Bergey, Haridas Pudavar, Purnendu Dutta, David C Bloom, William J Bowers, Michal K Stachowia. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16039006. |
the effects of hsv-1 amplicon and polyethyleneimine (pei)-mediated transfection of dominant negative fgf receptor-1 mutant fgfr1(tk-) into the rat brain substantia nigra (sn) were examined in vivo to model the reduced fgf signaling documented to occur in parkinson's disease. |
2006-01-17 |
2023-08-12 |
rat |
| Eilís Dowd, Christelle Monville, Eduardo M Torres, Liang-Fong Wong, Mimoun Azzouz, Nicholas D Mazarakis, Stephen B Dunnet. Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307601. |
rats that were pre-treated 4 weeks prior to lesion surgery with an equine infectious anaemia virus (eiav) vector carrying gdnf [eiav-gdnf, injected into the striatum and above the substantia nigra (sn)] performed significantly better on all of these parameters than control rats. |
2006-01-17 |
2023-08-12 |
human |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
we report pitx3 expression in almost all dopaminergic substantia nigra (sn) and ventral tegmental area (vta) neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Virginia Zbarsky, Krishna P Datla, Shabnam Parkar, Deepal K Rai, Okezie I Aruoma, David T Dexte. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free radical research. vol 39. issue 10. 2006-01-10. PMID:16298737. |
unilateral infusion of 6-ohda into the medial forebrain bundle produced a significant loss of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) as well as a decreased of dopamine (da) content in the striata in the vehicle-treated animals. |
2006-01-10 |
2023-08-12 |
rat |
| Masatoshi Inden, Do-hoon Kim, Meirigeng Qi, Yoshihisa Kitamura, Daijiro Yanagisawa, Kaneyasu Nishimura, Daiju Tsuchiya, Kazuyuki Takata, Kousuke Hayashi, Takashi Taniguchi, Kanji Yoshimoto, Shun Shimohama, Shoichiro Sumi, Kazutomo Inou. Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats. Neuroscience letters. vol 387. issue 3. 2005-12-20. PMID:16023291. |
the aim of this study was to investigate a transplantation strategy for pd by assessing whether double-transplants in the striatum (st) and substantia nigra (sn), or st and subthalamic nucleus (stn) induce functional recovery in 6-hydroxydopamine-lesioned rats. |
2005-12-20 |
2023-08-12 |
mouse |
| Isaac G Onyango, Jeremy B Tuttle, James P Bennet. Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death. Neurobiology of disease. vol 20. issue 1. 2005-12-19. PMID:16137575. |
oxidative stress and deficiency of various neurotrophic factors (ntfs) could be factors triggering neurodegeneration in the substantia nigra (sn). |
2005-12-19 |
2023-08-12 |
human |
| Thomas D Corso, German Torres, Christopher Goulah, Indrajit Roy, Angelo S Gambino, John Nayda, Timothy Buckley, Ewa K Stachowiak, Earl J Bergey, Haridas Pudavar, Purnendu Dutta, David C Bloom, William J Bowers, Michal K Stachowia. Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods. Folia morphologica. vol 64. issue 3. 2005-11-04. PMID:16228947. |
our data result from vectors stereotaxically introduced to the substantia nigra (sn) of adult rats and evaluated 1 week and/or 1 month post injection using histochemical methods to assess recombinant ss-galactosidase enzyme activity. |
2005-11-04 |
2023-08-12 |
rat |
| Angela De Iuliis, Jessica Grigoletto, Alessandra Recchia, Pietro Giusti, Paola Arsla. A proteomic approach in the study of an animal model of Parkinson's disease. Clinica chimica acta; international journal of clinical chemistry. vol 357. issue 2. 2005-11-01. PMID:15946658. |
the aetiology of parkinson's disease (pd), an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of the substantia nigra (sn) pars compacta, remains unclear. |
2005-11-01 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Kochupurackal P Mohanakuma. Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease. Brain research. vol 1049. issue 2. 2005-10-19. PMID:15936733. |
unilateral stereotaxic infusion of rotenone (2-12 mug in 1 mul) into substantia nigra (sn) pars compacta caused significant inhibition of complex-i activity and increased production of hydroxyl radicals in vivo as measured employing spectrophotometric and hplc-electrochemical procedures, respectively. |
2005-10-19 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Maria Sokołowska, Inga Kwiecień, Lidia Włode. Treatment with 1,2,3,4-tetrahydroisoquinolone affects the levels of nitric oxide, S-nitrosothiols, glutathione and the enzymatic activity of gamma-glutamyl transpeptidase in the dopaminergic structures of rat brain. Brain research. vol 1049. issue 2. 2005-10-19. PMID:15946655. |
significantly increased the tissue concentrations of no and gsh in the substantia nigra (sn), striatum (str) and cortex (ctx) of rats receiving this compound both acutely and chronically. |
2005-10-19 |
2023-08-12 |
human |