| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kun Wang, Jian-Jun Wang, Yue Wang, Qi-Hua He, Xuan Wang, Xiao-Min Wan. Infusion of epidermal growth factor and basic fibroblast growth factor into the striatum of parkinsonian rats leads to in vitro proliferation and differentiation of adult neural progenitor cells. Neuroscience letters. vol 364. issue 3. 2004-08-12. PMID:15196666. |
this study investigated the proliferation and differentiation of adult neural progenitor cells (anpcs) derived from the striatum and substantia nigra (sn) of parkinsonian rats. |
2004-08-12 |
2023-08-12 |
rat |
| Luigi Zecca, Antonella Stroppolo, Alberto Gatti, Davide Tampellini, Marco Toscani, Mario Gallorini, Giuseppe Giaveri, Paolo Arosio, Paolo Santambrogio, Ruggero G Fariello, Erdem Karatekin, Mark H Kleinman, Nicholas Turro, Oleh Hornykiewicz, Fabio A Zucc. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 26. 2004-08-12. PMID:15210960. |
in this study, a comparative analysis of metal-related neuronal vulnerability was performed in two brainstem nuclei, the locus coeruleus (lc) and substantia nigra (sn), known targets of the etiological noxae in parkinson's disease and related disorders. |
2004-08-12 |
2023-08-12 |
human |
| J Deplazes, K Schöbel, H Hochstrasser, P Bauer, U Walter, S Behnke, J Spiegel, G Becker, O Riess, D Ber. Screening for mutations of the IRP2 gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 4. 2004-08-09. PMID:15057521. |
we recently identified an increased amount of iron in patients with parkinson's disease (pd) and hyperchogenicity of the substantia nigra (sn). |
2004-08-09 |
2023-08-12 |
Not clear |
| Jesus Landeira-Fernandez, Carlos V Grijalv. Participation of the substantia nigra dopaminergic neurons in the occurrence of gastric mucosal erosions. Physiology & behavior. vol 81. issue 1. 2004-08-09. PMID:15059688. |
in the present study, the participation of intrinsic neurons of the substantia nigra (sn) and ventral tegmental area (vta) on the occurrence of stomach ulceration was investigated. |
2004-08-09 |
2023-08-12 |
Not clear |
| Sophie Sarre, Hong Yuan, Nadine Jonkers, An Van Hemelrijck, Guy Ebinger, Yvette Michott. In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198664. |
we investigated the effect of an injection of 6-hydroxydopamine (6-ohda) into the rat medial forebrain bundle (mfb) on the degeneration and the function of the dopaminergic cell bodies in the substantia nigra (sn) 3 and 5 weeks after lesioning. |
2004-08-06 |
2023-08-12 |
rat |
| Hong Jiang, Zhong-Ming Qian, Jun-Xia Xi. [Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 5. 2004-07-22. PMID:14566406. |
to illustrate the mechanism underlying the increase of iron in substantia nigra (sn) in pd, changes of the expression of divalent metal transporter 1 (dmt1) and iron content were examined in sn in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treated mice using immunohistochemistry and histochemistry respectively. |
2004-07-22 |
2023-08-12 |
mouse |
| Yan Xu, Shenggang Sun, Xuebing Cao, Etang Ton. Protective effect of GSH on PD model induced by 6-OHDA in vitro. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 22. issue 4. 2004-07-20. PMID:12674779. |
to study the effects of 6-hydroxydopamine (6-ohda) and reduced glutathione (gsh) on the nigral dopaminergic neurons in brain slices in vitro, immolunohistochemical technique was used to observe the changes of th-stained neurons, including cell bodies and the dendrites, in the substantia nigra (sn) of midbrain slices of rats after incubation for 1 h in the presence of gsh 15 min before and during the period of incubation with 6-ohda. |
2004-07-20 |
2023-08-12 |
rat |
| Jean-Charles Paterna, Joram Feldon, Hansruedi Büele. Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats. Journal of virology. vol 78. issue 13. 2004-07-15. PMID:15194756. |
the two serotypes (expressing enhanced green fluorescent protein [egfp]) were delivered by stereotaxic surgery into the same animals but different hemispheres of the striatum (str), the substantia nigra (sn), or the medial forebrain bundle (mfb). |
2004-07-15 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Małgorzata Zapała, Joanna Wierońsk. Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120584. |
therefore, the effect of multiple administration of 1,2,3,4-tetrahydroisoquinoline (tiq) under conditions of cyp2d blockade on the expression of key markers of pd was studied in the rat striatum (str) and substantia nigra (sn). |
2004-07-12 |
2023-08-12 |
rat |
| Shupeng Li, Kun Yang Kim, Jong Hun Kim, Jin Hoi Kim, Moon Seok Park, Jong Yoon Bahk, Myeong Ok Ki. Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Neuroscience letters. vol 363. issue 1. 2004-07-06. PMID:15157990. |
to elucidate the expression changes of dat on chronic nicotine and smoke administration, the effects of nicotine and passive cigarette smoke on dat mrna expression in the ventral tegmental area (vta) and the substantia nigra (sn) area were examined using in situ hybridization and rnase protection assay. |
2004-07-06 |
2023-08-12 |
rat |
| Mimoun Azzouz, Scott Ralph, Liang-Fong Wong, Denise Day, Zoe Askham, Robert D Barber, Kyriacos A Mitrophanous, Susan M Kingsman, Nicholas D Mazaraki. Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector. Neuroreport. vol 15. issue 6. 2004-06-29. PMID:15076720. |
eiav carrying the glial cell line-derived neurotrophic factor (gdnf) gene was unilaterally injected into rat striatum and above the substantia nigra (sn). |
2004-06-29 |
2023-08-12 |
rat |
| Hideto Miwa, Tomomi Kubo, Shuhei Morita, Ichiro Nakanishi, Tomoyoshi Kond. Oxidative stress and microglial activation in substantia nigra following striatal MPP+. Neuroreport. vol 15. issue 6. 2004-06-29. PMID:15076730. |
the present study aims to study sequential alterations occurring in both dopaminergic neurons and microglia in substantia nigra (sn) following intrastriatal injection of 1-methyl-4-phenylpridium ion (mpp+) in rats. |
2004-06-29 |
2023-08-12 |
rat |
| José García Dopico, Juan Perdomo Díaz, Teofilo Jorge Alonso, Tomás González Hernández, Rafael Castro Fuentes, Manuel Rodríguez Día. Extracellular taurine in the substantia nigra: taurine-glutamate interaction. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114625. |
taurine has been proposed as an inhibitory transmitter in the substantia nigra (sn), but the mechanisms involved in its release and uptake remain practically unexplored. |
2004-06-21 |
2023-08-12 |
rat |
| D Makarovsky, Y Kalechman, T Sonino, I Freidkin, S Teitz, M Albeck, M Weil, R Geffen-Aricha, G Yadid, B Sredn. Tellurium compound AS101 induces PC12 differentiation and rescues the neurons from apoptotic death. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033807. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2004-06-15 |
2023-08-12 |
Not clear |
| Nikolai Kholodilov, Olga Yarygina, Tinmarla Frances Oo, Hui Zhang, David Sulzer, William Dauer, Robert E Burk. Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 12. 2004-06-10. PMID:15044553. |
we have shown that gdnf suppresses apoptosis in da neurons of the substantia nigra (sn) postnatally both in vitro and during their first phase of natural cell death in vivo. |
2004-06-10 |
2023-08-12 |
mouse |
| Bhisham Chera, Kurt E Schaecher, Anne Rocchini, Syed Z Imam, Eric A Sribnick, Swapan K Ray, Syed F Ali, Naren L Bani. Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Brain research. vol 1006. issue 2. 2004-06-07. PMID:15051518. |
parkinson's disease (pd) is a movement disorder characterized by rigidity, tremor, and bradykinesia, originating from degeneration of dopaminergic neurons in the substantia nigra (sn), retrorubral area, and locus ceoruleus (lc). |
2004-06-07 |
2023-08-12 |
mouse |
| Wenxue Tang, Michael Wesley, Willard M Freeman, Bill Liang, Scott E Hemb. Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140200. |
western blotting was used to compare levels of iglur protein expression (nr1-3b, glur1-7, ka2) in the ventral tegmental area (vta), substantia nigra (sn), nucleus accumbens (nac), striatum and prefrontal cortex (pfc) of rats. |
2004-06-04 |
2023-08-12 |
rat |
| Glen R Wunderlich, Susan Rotzinger, David E A Bush, Norberto J DeSousa, Franco J Vaccarin. Cholecystokinin modulation of locomotor behavior in rats is sensitized by chronic amphetamine and chronic restraint stress exposure. Brain research. vol 1001. issue 1-2. 2004-05-28. PMID:14972658. |
however, chronic amph and chronic rs did not produce detectable changes in the number of cck-immunostained neurons in the ventral tegmental area (vta) or substantia nigra (sn), or in cck levels in any of the subregions of the nacc. |
2004-05-28 |
2023-08-12 |
rat |
| Chang-Lin Liang, Omar Nelson, Umar Yazdani, Parichehr Pasbakhsh, Dwight C Germa. Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. The Journal of comparative neurology. vol 473. issue 1. 2004-05-24. PMID:15067721. |
the dopaminergic neurons in the ventral substantia nigra (sn) are significantly more vulnerable to degeneration in parkinson's disease (pd) than the dopaminergic neurons in the ventral tegmental area (vta). |
2004-05-24 |
2023-08-12 |
human |
| Yun Min Ding, Juliann D Jaumotte, Armando P Signore, Michael J Zigmon. Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086533. |
in substantia nigra (sn) cultures, da neurons were much more affected by 6-ohda than were gaba neurons. |
2004-05-19 |
2023-08-12 |
rat |