| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Imamura, Nozomi Hishikawa, Makoto Sawada, Toshiharu Nagatsu, Mari Yoshida, Yoshio Hashizum. Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. Acta neuropathologica. vol 106. issue 6. 2004-01-16. PMID:14513261. |
the number of mhc class ii-positive microglia in the substantia nigra (sn) and putamen increased as the neuronal degeneration of the sn proceeded. |
2004-01-16 |
2023-08-12 |
Not clear |
| Burkhard Emanuel Jabs, Andreas Joachim Bartsch, Bruno Pfuhlman. Susceptibility to neuroleptic-induced parkinsonism--age and increased substantia nigra echogenicity as putative risk factors. European psychiatry : the journal of the Association of European Psychiatrists. vol 18. issue 4. 2004-01-15. PMID:12814851. |
previous transcranial sonography (tcs) findings of the substantia nigra (sn) in patients with idiopathic parkinson's disease suggest a correlation of echogenicity with nigrostriatal dysfunction. |
2004-01-15 |
2023-08-12 |
Not clear |
| Judith M Horowitz, Danielle M Pastor, Alpna Goyal, Subrata Kar, Navindra Ramdeen, Brian H Hallas, German Torre. BAX protein-immunoreactivity in midbrain neurons of Parkinson's disease patients. Brain research bulletin. vol 62. issue 1. 2004-01-09. PMID:14596892. |
components of signaling pathways that initiate cell death are highly concentrated in vulnerable substantia nigra (sn) neurons and may therefore contribute to the relentless demise of dopamine cells. |
2004-01-09 |
2023-08-12 |
Not clear |
| Sang-H Choi, Da Y Lee, Jae K Ryu, Jean Kim, Eun H Joe, Byung K Ji. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572441. |
one week after intranigral injection of thrombin resulted in a dose-dependent loss of dopaminergic neurons (20-78%) in the rat substantia nigra (sn), as evidenced by tyrosine hydroxylase (th) immunohistochemistry. |
2004-01-06 |
2023-08-12 |
rat |
| F di Michele, P Longone, E Romeo, S Lucchetti, L Brusa, M Pierantozzi, A Bassi, G Bernardi, P Stanzion. Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24. issue 3. 2004-01-06. PMID:14598072. |
moreover, in view of the importance of gaba-ergic transmission to substantia nigra (sn) neurons and gaba-ergic modulation exerted by the two neuroactive steroids, our data indicate a global dysregulation of the sn gaba-ergic system in pd patients. |
2004-01-06 |
2023-08-12 |
Not clear |
| Dhanasekharan Muralikrishnan, Supriti Samantaray, Kochupurackal P Mohanakuma. D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse (New York, N.Y.). vol 50. issue 1. 2003-12-12. PMID:12872288. |
d-deprenyl inhibited ferrous citrate-induced.oh in vitro (0.45 microm) and mptp-induced.oh in vivo in substantia nigra (sn) and in the striatum (1.0 mg/kg, i.p.). |
2003-12-12 |
2023-08-12 |
mouse |
| Hernan Cardenas, Laurel M Boli. Compromised reactive microgliosis in MPTP-lesioned IL-6 KO mice. Brain research. vol 985. issue 1. 2003-11-28. PMID:12957371. |
the persistent gliosis observed in the parkinson's disease substantia nigra (sn) and in humans and animals exposed to the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) may represent a chronic inflammatory response that contributes to pathology. |
2003-11-28 |
2023-08-12 |
mouse |
| Inmaculada Rite, José L Venero, Mayka Tomás-Camardiel, Alberto Machado, Josefina Can. Expression of BDNF mRNA in substantia nigra is dependent on target integrity and independent of neuronal activation. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535953. |
loss of nigral target cells in the striatum was accompanied by significant induction of bdnf mrna levels in the ipsilateral substantia nigra (sn) at 12 and 24 h post lesion. |
2003-11-24 |
2023-08-12 |
Not clear |
| Manfred Gerlach, Kay L Double, Dorit Ben-Shachar, Luigi Zecca, Moussa B H Youdim, Peter Riedere. Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotoxicity research. vol 5. issue 1-2. 2003-11-21. PMID:12832223. |
neuromelanin (nm) is a granular, dark brown pigment produced in some but not all of the dopaminergic neurons of the human substantia nigra (sn). |
2003-11-21 |
2023-08-12 |
human |
| Gerda Andringa, Fu Du, Thomas N Chase, M Catherine Bennet. Mapping of rat brain using the Synuclein-1 monoclonal antibody reveals somatodendritic expression of alpha-synuclein in populations of neurons homologous to those vulnerable to Lewy body formation in human synucleopathies. Journal of neuropathology and experimental neurology. vol 62. issue 10. 2003-11-21. PMID:14575241. |
we explored this issue by extensively characterizing the monoclonal antibody synuclein-1 (syn-1) and using this highly selective antibody to map the distribution of alpha-synuclein throughout rat brain and in human substantia nigra (sn). |
2003-11-21 |
2023-08-12 |
human |
| Wendy H Fasulo, Scott E Hemb. Time-dependent changes in gene expression profiles of midbrain dopamine neurons following haloperidol administration. Journal of neurochemistry. vol 87. issue 1. 2003-11-12. PMID:12969267. |
the present study examined changes in gene expression profiles of ventral tegmental area (vta) and substantia nigra (sn) tyrosine hydroxylase immunopositive neurons following 1, 10 or 21 days of haloperidol administration (0.5 mg/kg/day). |
2003-11-12 |
2023-08-12 |
Not clear |
| Manuel Rodríguez, Ernesto Pereda, Julián González, Patricio Abdala, Jose A Obes. How is firing activity of substantia nigra cells regulated? Relevance of pattern-code in the basal ganglia. Synapse (New York, N.Y.). vol 49. issue 4. 2003-11-10. PMID:12827640. |
here, we report nonrenewal firing (neuronal firing is influenced by its own previous activity) in cells of the anesthetized rat's substantia nigra (sn). |
2003-11-10 |
2023-08-12 |
rat |
| Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development. Journal of chemical neuroanatomy. vol 26. issue 1. 2003-11-06. PMID:12954528. |
we have used highly sensitive in situ hybridization to determine opioid receptor and peptide expression in embryonic and postnatal rat striatum, to follow the compartmentalization into patch and matrix structures, and have examined their developmental expression in the dopaminergic cell group of the substantia nigra (sn). |
2003-11-06 |
2023-08-12 |
rat |
| Benoît Melchior, Véronique Nerrière-Daguin, David A Laplaud, Séverine Rémy, Sandrine Wiertlewski, Isabelle Neveu, Philippe Naveilhan, Susan O Meakin, Philippe Brache. Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection. Experimental neurology. vol 183. issue 2. 2003-10-31. PMID:14552878. |
unilateral injection of this raav into the substantia nigra (sn) resulted in a protracted expression of trka (or c-myc) immunoreactivity in numerous cell bodies, including tyrosine-hydroxylase (th)-positive dopaminergic neurons. |
2003-10-31 |
2023-08-12 |
human |
| Z H Sun, Y L Lai, W W Zeng, D Zhao, Z W Ye, H C Zuo, Z P Xi. Mesencephalic progenitors can improve rotational behavior and reconstruct nigrostriatal pathway in PD rats. Acta neurochirurgica. Supplement. vol 87. 2003-10-30. PMID:14518548. |
cells were then collected and implanted into the striatum only--single grafts or simultaneously into the substantia nigra (sn) and the striatum--double grafts. |
2003-10-30 |
2023-08-12 |
rat |
| L Zecca, F A Zucca, P Costi, D Tampellini, A Gatti, M Gerlach, P Riederer, R G Fariello, S Ito, M Gallorini, D Sulze. The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour. Journal of neural transmission. Supplementum. issue 65. 2003-10-20. PMID:12946053. |
the pigmented neurons of the substantia nigra (sn) are typically lost in parkinson's disease: however the possible relationship between neuronal vulnerability and the presence of neuromelanin (nm) has not been elucidated. |
2003-10-20 |
2023-08-12 |
human |
| Kazumasa Wakamatsu, Kenichi Fujikawa, Fabio A Zucca, Luigi Zecca, Shosuke It. The structure of neuromelanin as studied by chemical degradative methods. Journal of neurochemistry. vol 86. issue 4. 2003-10-01. PMID:12887698. |
the biosynthesis, structure and function of neuromelanin (nm), the dark brown melanin-like pigment present in the substantia nigra (sn), are not well characterized, in spite of the possible involvement of nm in the etiology and pathogenesis of parkinson's disease. |
2003-10-01 |
2023-08-12 |
human |
| Z Angyán, L Angyá. Differential blood pressure and heart rate responses to supramedullary brain stimulation in cats. Acta physiologica Hungarica. vol 90. issue 1. 2003-09-30. PMID:12666870. |
arterial blood pressure (bp) and heart rate (hr) effects were elicited by electrical stimulation of the lateral hypothalamus (lh), mamillary bodies (mm), substantia nigra (sn), globus pallidus (gp), and the subthalamic nucleus (sub) in conscious, freely moving cats. |
2003-09-30 |
2023-08-12 |
Not clear |
| Ippolita Cantuti-Castelvetri, Barbara Shukitt-Hale, James A Josep. Dopamine neurotoxicity: age-dependent behavioral and histological effects. Neurobiology of aging. vol 24. issue 5. 2003-09-12. PMID:12885577. |
young (6 months) and middle-aged (15 months) rats were chronically treated with da in the substantia nigra (sn, 1 micromol/2 microl vehicle per side/day/5 days) and were subsequently examined for changes in motor function and histology. |
2003-09-12 |
2023-08-12 |
rat |
| Kay L Double, Manfred Gerlach, Volker Schünemann, Alfred X Trautwein, Luigi Zecca, Mario Gallorini, Moussa B H Youdim, Peter Riederer, Dorit Ben-Shacha. Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochemical pharmacology. vol 66. issue 3. 2003-09-12. PMID:12907248. |
the vulnerability of the dopaminergic neurons of the substantia nigra (sn) in parkinson's disease has been related to the presence of the pigment neuromelanin (nm) in these neurons. |
2003-09-12 |
2023-08-12 |
human |