| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shin-ichi Iwata, Masahiro Nomoto, Hirofumi Morioka, Atsuro Miyat. Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse (New York, N.Y.). vol 51. issue 4. 2004-03-24. PMID:14696015. |
in this model, mice are intrastriatally injected with 6-hydroxydopamine (6-ohda) and dopaminergic neurons in the substantia nigra (sn) gradually die by retrograde degeneration. |
2004-03-24 |
2023-08-12 |
mouse |
| Claire E Heise, John Mitrofani. Evidence for a glutamatergic projection from the zona incerta to the basal ganglia of rats. The Journal of comparative neurology. vol 468. issue 4. 2004-03-18. PMID:14689481. |
sprague-dawley rats were anaesthetised with ketamine (100 mg/kg) and rompun (10 mg/kg), and injections of cholera toxin subunit b were made into each of the following nuclei: the zi, the substantia nigra (sn), the pedunculopontine tegmental nucleus (ppt), and the entopeduncular nucleus (ep). |
2004-03-18 |
2023-08-12 |
rat |
| Gilbert J Kirouac, Sa Li, Gehan Mabrou. GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus. The Journal of comparative neurology. vol 469. issue 2. 2004-03-18. PMID:14694532. |
previous studies have shown that neurons in the ventral tegmental area (vta) and substantia nigra (sn) project to the ventrolateral periaqueductal gray (pagvl) and dorsal raphe nucleus (dr). |
2004-03-18 |
2023-08-12 |
rat |
| Michael F Salvatore, Subbu Apparsundaram, Greg A Gerhard. Decreased plasma membrane expression of striatal dopamine transporter in aging. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643386. |
using western blot techniques, we investigated whether the source of these age-related changes in dat was correlated with decreases in dat protein levels in the striatum, substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) of 6, 18, and 24-month-old male fischer 344 rats. |
2004-03-11 |
2023-08-12 |
rat |
| Justin Boyes, J Paul Bola. The subcellular localization of GABA(B) receptor subunits in the rat substantia nigra. The European journal of neuroscience. vol 18. issue 12. 2004-03-10. PMID:14686901. |
the inhibitory effects of gaba within the substantia nigra (sn) are mediated in part by metabotropic gaba(b) receptors. |
2004-03-10 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Jacek Wójcikowski, Marta Kot, Anna Haduch, Jan Boksa, Władysława Anna Danie. Disposition of 1,2,3,4,-tetrahydroisoquinoline in the brain of male Wistar and Dark Agouti rats. Brain research. vol 996. issue 2. 2004-03-10. PMID:14697494. |
this study aimed to examine tiq disposition in the whole rat brain and in the striatum and substantia nigra (sn). |
2004-03-10 |
2023-08-12 |
rat |
| David K Simon, Michael T Lin, Leiya Zheng, Guang-Jun Liu, Colette H Ahn, Lauren M Kim, William M Mauck, Florence Twu, M Flint Beal, Donald R John. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiology of aging. vol 25. issue 1. 2004-03-09. PMID:14675733. |
in the substantia nigra (sn), the aggregate levels of point mutations in young controls are similar to the levels in the sn or fctx of elderly subjects. |
2004-03-09 |
2023-08-12 |
human |
| Dagmar Galter, Silvia Buervenich, Andrea Carmine, Maria Anvret, Lars Olso. ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678778. |
aldh1 was found to be expressed highly and specifically in da cells of both substantia nigra (sn) and the ventral tegmental area (vta) of controls. |
2004-03-05 |
2023-08-12 |
human |
| Fiona M Hurley, Daniel J Costello, Aideen M Sulliva. Neuroprotective effects of delayed administration of growth/differentiation factor-5 in the partial lesion model of Parkinson's disease. Experimental neurology. vol 185. issue 2. 2004-03-02. PMID:14736509. |
gdf-5 (25 microg) was injected into either the striatum or substantia nigra (sn) of adult rats at 1 or 2 weeks after 6-hydroxydopamine administration. |
2004-03-02 |
2023-08-12 |
rat |
| William J Burke, Shu Wen Li, Evelyn A Williams, Randal Nonneman, Daniel S Zah. 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. Brain research. vol 989. issue 2. 2004-01-28. PMID:14556942. |
in parkinson's disease (pd), there is a highly selective loss of dopamine (da) neurons in the substantia nigra (sn) greater than in the ventral tegmental area (vta). |
2004-01-28 |
2023-08-12 |
rat |
| Okezie I Aruoma, Theeshan Bahorun, Ling-Sun Je. Neuroprotection by bioactive components in medicinal and food plant extracts. Mutation research. vol 544. issue 2-3. 2004-01-21. PMID:14644322. |
the vulnerable brain regions in hiv/aids individuals include the dentate nucleus in the cerebellum, the red nucleus, substantia nigra (sn) in the mid-brain, the subthalamic nucleus, thalamic fasciculus in the diencephalons, the globus pallidus and striatum (or neostriatum, which consists of caudate and putamen) in the forebrain. |
2004-01-21 |
2023-08-12 |
human |
| Amanda D Smith, Marci Antion, Michael J Zigmond, Mark C Austi. Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRalpha1 and RET mRNAs in the adult rat. Brain research. Molecular brain research. vol 117. issue 2. 2004-01-20. PMID:14559146. |
da tissue levels in the striatum and tyrosine hydroxylase immunoreactivity in the substantia nigra (sn) and ventral tegmental area (vta) were used to determine the size of the lesions. |
2004-01-20 |
2023-08-12 |
rat |
| Marta Barrachina, Isabel Domínguez, Santiago Ambrosio, Julio Secades, Rafael Lozano, Isidro Ferre. Neuroprotective effect of citicoline in 6-hydroxydopamine-lesioned rats and in 6-hydroxydopamine-treated SH-SY5Y human neuroblastoma cells. Journal of the neurological sciences. vol 215. issue 1-2. 2004-01-20. PMID:14568136. |
finally, citicoline significantly attenuates substantia nigra (sn) dopaminergic cell dropout and tyrosine hydroxylase immunoreactivity in the ipsilateral striatum in rats injected intrastriatally with 6-hydroxydopamine (6-ohda). |
2004-01-20 |
2023-08-12 |
human |
| Bettina Felletschin, Peter Bauer, Uwe Walter, Stephanie Behnke, Jörg Spiegel, Ilona Csoti, Ulrike Sommer, Björn Zeiler, Georg Becker, Olaf Riess, Daniela Ber. Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neuroscience letters. vol 352. issue 1. 2004-01-20. PMID:14615048. |
we investigated 186 pd patients, in whom an increased amount of iron of the substantia nigra (sn) was priorly identified by transcranial ultrasound, for mutations of the whole coding region of ferritin-l and ferritin-h by denaturing high-pressure liquid chromatography and subsequent sequencing. |
2004-01-20 |
2023-08-12 |
Not clear |
| Kazuhiro Imamura, Nozomi Hishikawa, Makoto Sawada, Toshiharu Nagatsu, Mari Yoshida, Yoshio Hashizum. Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. Acta neuropathologica. vol 106. issue 6. 2004-01-16. PMID:14513261. |
the number of mhc class ii-positive microglia in the substantia nigra (sn) and putamen increased as the neuronal degeneration of the sn proceeded. |
2004-01-16 |
2023-08-12 |
Not clear |
| Burkhard Emanuel Jabs, Andreas Joachim Bartsch, Bruno Pfuhlman. Susceptibility to neuroleptic-induced parkinsonism--age and increased substantia nigra echogenicity as putative risk factors. European psychiatry : the journal of the Association of European Psychiatrists. vol 18. issue 4. 2004-01-15. PMID:12814851. |
previous transcranial sonography (tcs) findings of the substantia nigra (sn) in patients with idiopathic parkinson's disease suggest a correlation of echogenicity with nigrostriatal dysfunction. |
2004-01-15 |
2023-08-12 |
Not clear |
| Judith M Horowitz, Danielle M Pastor, Alpna Goyal, Subrata Kar, Navindra Ramdeen, Brian H Hallas, German Torre. BAX protein-immunoreactivity in midbrain neurons of Parkinson's disease patients. Brain research bulletin. vol 62. issue 1. 2004-01-09. PMID:14596892. |
components of signaling pathways that initiate cell death are highly concentrated in vulnerable substantia nigra (sn) neurons and may therefore contribute to the relentless demise of dopamine cells. |
2004-01-09 |
2023-08-12 |
Not clear |
| Sang-H Choi, Da Y Lee, Jae K Ryu, Jean Kim, Eun H Joe, Byung K Ji. Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiology of disease. vol 14. issue 2. 2004-01-06. PMID:14572441. |
one week after intranigral injection of thrombin resulted in a dose-dependent loss of dopaminergic neurons (20-78%) in the rat substantia nigra (sn), as evidenced by tyrosine hydroxylase (th) immunohistochemistry. |
2004-01-06 |
2023-08-12 |
rat |
| F di Michele, P Longone, E Romeo, S Lucchetti, L Brusa, M Pierantozzi, A Bassi, G Bernardi, P Stanzion. Decreased plasma and cerebrospinal fluid content of neuroactive steroids in Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 24. issue 3. 2004-01-06. PMID:14598072. |
moreover, in view of the importance of gaba-ergic transmission to substantia nigra (sn) neurons and gaba-ergic modulation exerted by the two neuroactive steroids, our data indicate a global dysregulation of the sn gaba-ergic system in pd patients. |
2004-01-06 |
2023-08-12 |
Not clear |
| Dhanasekharan Muralikrishnan, Supriti Samantaray, Kochupurackal P Mohanakuma. D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity. Synapse (New York, N.Y.). vol 50. issue 1. 2003-12-12. PMID:12872288. |
d-deprenyl inhibited ferrous citrate-induced.oh in vitro (0.45 microm) and mptp-induced.oh in vivo in substantia nigra (sn) and in the striatum (1.0 mg/kg, i.p.). |
2003-12-12 |
2023-08-12 |
mouse |