| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuki Imamura, Hideki Hida, Noritaka Aihara, Kazuto Ishida, Yoshie Kanda, Hitoo Nishino, Kazuo Yamad. Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage. Neuroscience research. vol 46. issue 3. 2003-08-14. PMID:12804790. |
intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (sn) followed by the appearance of ed1(+) cells (macrophage/microglia). |
2003-08-14 |
2023-08-12 |
rat |
| Viviana Davila, Zhen Yan, Liviu C Craciun, Diomedes Logothetis, David Sulze. D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843272. |
substantia nigra (sn) dopamine neurons express d2 and d3 dopamine autoreceptors. |
2003-08-14 |
2023-08-12 |
mouse |
| Sang-H Choi, Eun H Joe, Seung U Kim, Byung K Ji. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843292. |
the present study examined whether thrombin-induced microglial activation could contribute to death of dopaminergic neurons in the rat substantia nigra (sn) in vivo. |
2003-08-14 |
2023-08-12 |
rat |
| J Peter H Burbach, Simone Smits, Marten P Smid. Transcription factors in the development of midbrain dopamine neurons. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846974. |
disruption of the function of ptx3 affects the formation of the substantia nigra (sn) and alters the anatomical organization of the midbrain da systems. |
2003-08-04 |
2023-08-12 |
Not clear |
| Robert E Burk. Postnatal developmental programmed cell death in dopamine neurons. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846975. |
the prenatal development of dopamine (da) neurons of the substantia nigra (sn) is characterized by their birth, specification, and migration to their final positions. |
2003-08-04 |
2023-08-12 |
Not clear |
| Susan R Sesack, David B Car. Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia. Physiology & behavior. vol 77. issue 4-5. 2003-07-11. PMID:12526992. |
dopamine (da) neurons in the substantia nigra (sn) and ventral tegmental area (vta) form several projection systems with diverse functions, such as motor planning through the striatum, reward seeking via the nucleus accumbens (nac), and cognitive control through the prefrontal cortex (pfc). |
2003-07-11 |
2023-08-12 |
Not clear |
| Pepijn van den Munckhof, Kelvin C Luk, Line Ste-Marie, Jane Montgomery, Pierre J Blanchet, Abbas F Sadikot, Jacques Droui. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (Cambridge, England). vol 130. issue 11. 2003-07-11. PMID:12702666. |
we now show that only a subset of mesda neurons express pitx3 and that in pitx3-deficient aphakia mice, this subset is progressively lost by apoptosis during fetal (substantia nigra, sn) and postnatal (ventral tegmental area) development, resulting in very low striatal da and akinesia. |
2003-07-11 |
2023-08-12 |
mouse |
| Jos L Venero, Mati Revuelta, Leila Atiki, Marti Santiago, Mayka C Toms-Camardiel, Josefina Cano, Alberto Machad. Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy. Free radical biology & medicine. vol 34. issue 1. 2003-07-07. PMID:12498986. |
unilateral transection of the medial forebrain bundle transiently increased the formation of (*)oh in substantia nigra (sn) but not in striatum during the first 48 h postlesion, when most relevant changes in terms of oxidatively modified proteins take place. |
2003-07-07 |
2023-08-12 |
Not clear |
| Grazyna Kunikowska, Peter Jenne. Alterations in m-RNA expression for Cu,Zn-superoxide dismutase and glutathione peroxidase in the basal ganglia of MPTP-treated marmosets and patients with Parkinson's disease. Brain research. vol 968. issue 2. 2003-07-07. PMID:12663090. |
cu,zn-sod and gpx m-rna was present throughout basal ganglia (nucleus accumbens, caudate-putamen, globus pallidus, substantia nigra) in the common marmoset, with the highest levels being in substantia nigra (sn). |
2003-07-07 |
2023-08-12 |
human |
| Lisa Giovannelli, Francesca Decorosi, Piero Dolara, Luigi Pulvirent. Vulnerability to DNA damage in the aging rat substantia nigra: a study with the comet assay. Brain research. vol 969. issue 1-2. 2003-07-02. PMID:12676385. |
oxidative dna damage was measured in the substantia nigra (sn), cortex, hippocampus, striatum and hypothalamus of 3- and 24-month-old rats, using single-cell gel electrophoresis (scge, 'comet' assay) which allows the detection of dna breaks and oxidized bases. |
2003-07-02 |
2023-08-12 |
rat |
| Joshua P Fessel, Christine Hulette, Suzanne Powell, L Jackson Roberts, Jing Zhan. Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. Journal of neurochemistry. vol 85. issue 3. 2003-06-17. PMID:12694390. |
in this study, we attempted to compare the levels of f2-isops and isofs esterified in phospholipids in the substantia nigra (sn) from patients with pd to those of age-matched controls as well as patients with other neurodegenerative diseases, including dementia with lewy body disease (dlb), multiple system atrophy (msa), and alzheimer's disease (ad). |
2003-06-17 |
2023-08-12 |
Not clear |
| W J Burk. 3,4-dihydroxyphenylacetaldehyde: a potential target for neuroprotective therapy in Parkinson's disease. Current drug targets. CNS and neurological disorders. vol 2. issue 2. 2003-06-17. PMID:12769806. |
the simplest explanation for the selective loss of substantia nigra (sn) dopamine (da) neurons in parkinson's disease (pd) is that da or a metabolite is neurotoxic. |
2003-06-17 |
2023-08-12 |
rat |
| Xi-Bin Liang, Xian-Yu Liu, Feng-Qiao Li, Yong Luo, Jun Lu, Wang-Ming Zhang, Xiao-Min Wang, Ji-Sheng Ha. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480178. |
the results show a marked decrease of dopaminergic neurons on the lesioned side of the substantia nigra (sn) comparing with the unlesioned side. |
2003-06-16 |
2023-08-12 |
rat |
| S Behnke, D Berg, G Becke. Does ultrasound disclose a vulnerability factor for Parkinson's disease? Journal of neurology. vol 250 Suppl 1. 2003-06-11. PMID:12761631. |
transcranial ultrasound is a new tool allowing the detection of abnormalities in the echomorphology of the substantia nigra (sn) in patients with parkinson's disease (pd). |
2003-06-11 |
2023-08-12 |
Not clear |
| Nirit Lev, Eldad Melamed, Daniel Offe. Apoptosis and Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 2. 2003-05-29. PMID:12657363. |
it is caused by the selective loss of the dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2003-05-29 |
2023-08-12 |
human |
| Laura Parkkinen, Hilkka Soininen, Irina Alafuzof. Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease. Journal of neuropathology and experimental neurology. vol 62. issue 4. 2003-05-21. PMID:12722828. |
this challenges the traditional view that the substantia nigra (sn) is the region that is predominately affected in the spectrum of lb disorders. |
2003-05-21 |
2023-08-12 |
human |
| C J Schindler, R Slamberová, I Vath. Bicuculline seizure susceptibility and nigral GABAA alpha1 receptor mRNA is altered in adult prenatally morphine-exposed females. Psychoneuroendocrinology. vol 28. issue 3. 2003-05-13. PMID:12573301. |
the present study examines the effects of prenatal morphine exposure on seizure susceptibility to the gaba antagonist and convulsant bicuculline and gaba(a) alpha(1) receptor mrna in the substantia nigra (sn) of female rats. |
2003-05-13 |
2023-08-12 |
rat |
| Toyoko Arimoto, Guoying Bin. Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. Neurobiology of disease. vol 12. issue 1. 2003-05-09. PMID:12609487. |
the present study was designed to examine whether expression of inos was involved in lps-induced neurodegeneration in rat substantia nigra (sn) and to study the role of no in the loss of the sn dopaminergic neurons. |
2003-05-09 |
2023-08-12 |
rat |
| J M Henderson, S Watson, G M Halliday, T Heinemann, M Gerlac. Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat. Behavioural brain research. vol 139. issue 1-2. 2003-05-02. PMID:12642181. |
we analysed the relationships between several deficits induced by unilateral 6-ohda lesions and striatal neurochemistry, as well as neuronal loss in the dopaminergic substantia nigra (sn). |
2003-05-02 |
2023-08-12 |
rat |
| Deepinder Kaur, Ferda Yantiri, Subramanian Rajagopalan, Jyothi Kumar, Jun Qin Mo, Rapee Boonplueang, Veena Viswanath, Russell Jacobs, Lichuan Yang, M Flint Beal, Dino DiMonte, Irene Volitaskis, Lisa Ellerby, Robert A Cherny, Ashley I Bush, Julie K Anderse. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron. vol 37. issue 6. 2003-05-01. PMID:12670420. |
studies on postmortem brains from parkinson's patients reveal elevated iron in the substantia nigra (sn). |
2003-05-01 |
2023-08-12 |
Not clear |