| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengyu Zhao, Toshihiko Kuroiwa, Naoyuki Miyasaka, Tsukasa Nagaoka, Makoto Nakane, Akira Tamura, Hidehiro Mizusaw. Ultrastructural and MRI study of the substantia nigra evolving exofocal post-ischemic neuronal death in the rat. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 22. issue 3. 2002-12-20. PMID:12416550. |
to clarify the morphological characteristics of exofocal post-ischemic neuronal death (epnd) in the substantia nigra (sn), we investigated the course of light- and electron-microscopic changes of the sn of rats subjected to occlusion of the left middle cerebral artery (mca) for 1, 2, 4, 7 and 12 days. |
2002-12-20 |
2023-08-12 |
rat |
| A Nicotra, S Parve. Apoptotic molecules and MPTP-induced cell death. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200191. |
mptp administered in vivo to mice causes selective loss of dopaminergic neurons in the substantia nigra (sn), as in this disease. |
2002-12-19 |
2023-08-12 |
mouse |
| K L Double, D Ben-Shachar, M B H Youdim, L Zecca, P Riederer, M Gerlac. Influence of neuromelanin on oxidative pathways within the human substantia nigra. Neurotoxicology and teratology. vol 24. issue 5. 2002-12-19. PMID:12200193. |
neuromelanin (nm) is a dark-coloured pigment produced in the dopaminergic neurons of the human substantia nigra (sn). |
2002-12-19 |
2023-08-12 |
human |
| S Bharat, B C Cochran, M Hsu, J Liu, B N Ames, J K Anderse. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology. vol 23. issue 4-5. 2002-12-16. PMID:12428720. |
oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (sn) of parkinson's disease (pd) patients. |
2002-12-16 |
2023-08-12 |
Not clear |
| Shur Tzu Chen, Jih Ing Chuang, Mei Huei Hong, Eric I-Chian L. Melatonin attenuates MPP+-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway. Journal of pineal research. vol 32. issue 4. 2002-12-12. PMID:11982797. |
results show that mpp+ caused not only a severe neuronal injury in the striatum and in the ipsilateral substantia nigra (sn), but it also induced a significant decrease in gsh levels and an increase in the gssg/gsh ratio 3 days after intrastriatal mpp+ infusion. |
2002-12-12 |
2023-08-12 |
rat |
| Masaki Sakamoto, Toshiki Uchihara, Masaharu Hayashi, Ayako Nakamura, Etsuko Kikuchi, Toshio Mizutani, Hidehiro Mizusawa, Shunsaku Hira. Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red. Experimental neurology. vol 177. issue 1. 2002-12-09. PMID:12429213. |
on the sections of the substantia nigra (sn) and the cingulate gyrus (cg) obtained from parkinson's disease brains, double amplification by card fluorescent immunohistochemistry with anti-alpha-s monoclonal (lb509) and anti-ub polyclonal antibodies was performed, followed by staining with tr. |
2002-12-09 |
2023-08-12 |
Not clear |
| S Tam, D P Barry, L Beaman, B L Beama. Neuroinvasive Nocardia asteroides GUH-2 induces apoptosis in the substantia nigra in vivo and dopaminergic cells in vitro. Experimental neurology. vol 177. issue 2. 2002-11-26. PMID:12429191. |
n. asteroides strain guh-2 invades the brains of experimentally infected animals and selectively affects dopaminergic neurons of the substantia nigra (sn), causing an l-dopa-responsive movement disorder resembling parkinsonism. |
2002-11-26 |
2023-08-12 |
Not clear |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
the gamma-aminobutyric acid a (gaba(a)) receptor subunit expression of the dopaminergic cells of the substantia nigra (sn) was investigated in the present study. |
2002-11-15 |
2023-08-12 |
human |
| H Jiang, W F Chen, J X Xi. [Relationship between dopamine and iron contents in the brain of parkinsonian rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 53. issue 5. 2002-11-07. PMID:11833414. |
using fast cyclic voltammetry (fcv), atomic absorption/flame emission spectrophotometry and high performance liquid chromatography for electrochemical detection, we studied the change in iron content in the substantia nigra (sn) of 6-hydroxydopamine (6-ohda) lesioned parkinsonian (pd) rats and the toxic effect of intranigral injection of iron on da neurons. |
2002-11-07 |
2023-08-12 |
rat |
| Srinivas Bharath, Michael Hsu, Deepinder Kaur, Subramanian Rajagopalan, Julie K Anderse. Glutathione, iron and Parkinson's disease. Biochemical pharmacology. vol 64. issue 5-6. 2002-10-17. PMID:12213603. |
parkinson's disease (pd) is a progressive neurodegenerative disease involving neurodegeneration of dopaminergic neurons of the substantia nigra (sn), a part of the midbrain. |
2002-10-17 |
2023-08-12 |
Not clear |
| Yi He, Wei-Dong Le, Stanley H Appe. Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra. Experimental neurology. vol 176. issue 2. 2002-10-17. PMID:12359173. |
immunoglobulin g (igg) from patients with pd can induce injury of dopaminergic neurons following stereotaxic injection into rat substantia nigra (sn). |
2002-10-17 |
2023-08-12 |
human |
| U Walter, M Wittstock, R Benecke, D Dressle. Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 2. 2002-10-16. PMID:12075859. |
transcranial sonography (tcs) revealed substantia nigra (sn) hyperechogenicity in idiopathic parkinson's disease (ipd). |
2002-10-16 |
2023-08-12 |
human |
| C R Cabello, J J Thune, H Pakkenberg, B Pakkenber. Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy. Neuropathology and applied neurobiology. vol 28. issue 4. 2002-09-26. PMID:12175340. |
in a stereological study of the human substantia nigra (sn), the total number of melanin-positive and melanin-negative neurones from 28 male subjects aged 19-92 years was estimated using a uniform sampling design and optical disectors. |
2002-09-26 |
2023-08-12 |
human |
| Michelle Smeyne, Richard J Smeyn. Method for culturing postnatal substantia nigra as an in vitro model of experimental Parkinson's disease. Brain research. Brain research protocols. vol 9. issue 2. 2002-09-10. PMID:12034329. |
here, we describe a method for generating mixed and chimeric neuron/glial cultures of postnatal substantia nigra (sn), independent of other monoaminergic nuclei in the ventral midbrain. |
2002-09-10 |
2023-08-12 |
Not clear |
| S Al-Sarraj, S Maekawa, M Kibble, I Everall, N Leig. Ubiquitin-only intraneuronal inclusion in the substantia nigra is a characteristic feature of motor neurone disease with dementia. Neuropathology and applied neurobiology. vol 28. issue 2. 2002-09-06. PMID:11972798. |
we investigated the substantia nigra (sn) in mnd cases; two cases of motor neurone disease inclusion body (mnd-ib) dementia, six cases of dmnd, 14 cases of mnd (including one case from guam and two cases of familial sod1 mutation), four cases of parkinson's disease (pd), and 10 cases of age-matched normal controls. |
2002-09-06 |
2023-08-12 |
Not clear |
| Szilvia Mezey, András Csilla. Selective striatal connections of midbrain dopaminergic nuclei in the chick (Gallus domesticus). Cell and tissue research. vol 308. issue 1. 2002-09-06. PMID:12012204. |
the tracer fast blue was injected into the ventral tegmental area (avt) or substantia nigra (sn) of 1-week-old domestic chicks, and the position of retrogradely labelled neurons was mapped in striatal subregions. |
2002-09-06 |
2023-08-12 |
chicken |
| Alison L McCormack, Mona Thiruchelvam, Amy B Manning-Bog, Christine Thiffault, J William Langston, Deborah A Cory-Slechta, Donato A Di Mont. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiology of disease. vol 10. issue 2. 2002-09-06. PMID:12127150. |
repeated intraperitoneal paraquat injections killed dopaminergic neurons in the substantia nigra (sn) pars compacta, as assessed by stereological counting of tyrosine hydroxylase (th)-immunoreactive and nissl-stained neurons. |
2002-09-06 |
2023-08-12 |
mouse |
| Fumino Fujiyama, F Anne Stephenson, J Paul Bola. Synaptic localization of GABA(A) receptor subunits in the substantia nigra of the rat: effects of quinolinic acid lesions of the striatum. The European journal of neuroscience. vol 15. issue 12. 2002-09-04. PMID:12099902. |
the inhibitory amino acid, gamma-aminobutyric acid (gaba), plays a critical role in the substantia nigra (sn) in health and disease. |
2002-09-04 |
2023-08-12 |
rat |
| Rosario Barroso-Moguel, Marisela Mendez-Armenta, Juana Villeda-Hernandez, Concepcion Nava-Ruiz, Abel Santamari. Brain lesions induced by chronic cocaine administration to rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 1. 2002-08-20. PMID:11853120. |
the parietal cortex (cx), hippocampus (hp), substantia nigra (sn), and cerebellum (ce) were morphologically analyzed. |
2002-08-20 |
2023-08-12 |
rat |
| Guangyu Gu, Patricio E Reyes, Gregory T Golden, Randall L Woltjer, Christine Hulette, Thomas J Montine, Jing Zhan. Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders. Journal of neuropathology and experimental neurology. vol 61. issue 7. 2002-08-07. PMID:12125742. |
inhibition of mitochondrial respiratory chain function may contribute to dopaminergic neurodegeneration in the substantia nigra (sn) of patients with parkinson disease (pd). |
2002-08-07 |
2023-08-12 |
Not clear |