| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Thomas G Hedberg, Jana Vel\\xc3\\xadskov\\xc3\\xa1, Ellen F Sperber, Magda L Nunes, Solomon L Mosh\\xc3\\xa. Age-related differences in NMDA/metabotropic glutamate receptor binding in rat substantia nigra. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 2. 2003-04-29. PMID:12615085.' |
both n-methyl-d-aspartate (nmda) and quisqualate/ampa-insensitive metabotropic glutamate (mglu) receptors mediate glutamate neurotransmission in substantia nigra (sn). |
2003-04-29 |
2023-08-12 |
rat |
| Hi-Joon Park, Sabina Lim, Wan-Seok Joo, Chang-Shik Yin, Hyang-Sook Lee, Hye-Jung Lee, Jung Chul Seo, Kanghyun Leem, Yang-Sun Son, Youn-Jung Kim, Chang-Ju Kim, Yong-Sik Kim, Joo-Ho Chun. Acupuncture prevents 6-hydroxydopamine-induced neuronal death in the nigrostriatal dopaminergic system in the rat Parkinson's disease model. Experimental neurology. vol 180. issue 1. 2003-04-17. PMID:12668152. |
analysis via th immunohistochemistry revealed a substantial loss of cell bodies in the substantia nigra (sn) (45.7% loss) and their terminals in the dorsolateral striatum ipsilateral to the 6-ohda-induced lesion. |
2003-04-17 |
2023-08-12 |
rat |
| Petra Ruprecht-Dörfler, Daniela Berg, Oliver Tucha, Peter Benz, Michael Meier-Meitinger, Gesine L Alders, Klaus W Lange, Georg Becke. Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease. NeuroImage. vol 18. issue 2. 2003-04-11. PMID:12595195. |
increased echogenicity of the substantia nigra (sn) on ultrasound is a typical sonographic finding in parkinson's disease (pd). |
2003-04-11 |
2023-08-12 |
human |
| b' T Ravizza, A S Galanopoulou, J Vel\\xc3\\xadskov\\xc3\\xa1, S L Mosh\\xc3\\xa. Sex differences in androgen and estrogen receptor expression in rat substantia nigra during development: an immunohistochemical study. Neuroscience. vol 115. issue 3. 2003-04-07. PMID:12435407.' |
in both substantia nigra (sn) regions, there were developmentally regulated sex differences in ar, eralpha and erbeta immunoreactivity. |
2003-04-07 |
2023-08-12 |
rat |
| Scott A Lyness, Chris Zarow, Helena C Chu. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493547. |
cell counts in the cholinergic nucleus basalis (nb), noradrenergic locus coeruleus (lc), dopaminergic substantia nigra (sn), and the serotonergic dorsal raphe nucleus (drn) were assessed from primary-level reports in patients with alzheimer disease (ad) and in controls. |
2003-03-26 |
2023-08-12 |
Not clear |
| Analía Bortolozzi, Ricardo Duffard, Ana María Evangelista de Duffar. Asymmetrical development of the monoamine systems in 2,4-dichlorophenoxyacetic acid treated rats. Neurotoxicology. vol 24. issue 1. 2003-03-21. PMID:12564390. |
in this study the content of noradrenaline (na) was significantly increased in substantia nigra (sn) while it decreased in cerebellum in male and female rats of t2 group. |
2003-03-21 |
2023-08-12 |
rat |
| Eloisa Carreño-Müller, Antonio J Herrera, Rocio M de Pablos, Mayka Tomás-Camardiel, José L Venero, Josefina Cano, Alberto Machad. Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia. Journal of neurochemistry. vol 84. issue 5. 2003-03-19. PMID:12603843. |
seven days after the injection of different concentrations of thrombin into the nigrostriatal pathway, a strong macrophage/microglial reaction was observed in the substantia nigra (sn), indicated by immunostaining, using ox-42 and ox-6 antibodies, and by the induction of inos, il-1alpha, il-1beta and tnf-alpha. |
2003-03-19 |
2023-08-12 |
Not clear |
| Georg Becker, Antje Müller, Stefan Braune, Thomas Büttner, Reiner Benecke, Wolfgang Greulich, Wolfgang Klein, Günter Mark, Jürgen Rieke, Reiner Thümle. Early diagnosis of Parkinson's disease. Journal of neurology. vol 249 Suppl 3. 2003-03-17. PMID:12522572. |
in idiopathic parkinson's disease (ipd) approximately 60 % of the nigrostriatal neurons of the substantia nigra (sn) are degenerated before neurologists can establish the diagnosis according to the widely accepted clinical diagnostic criteria. |
2003-03-17 |
2023-08-12 |
human |
| Hirobumi Oikawa, Makoto Sasaki, Yoshiharu Tamakawa, Shigeru Ehara, Koujiro Tohyam. The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings. AJNR. American journal of neuroradiology. vol 23. issue 10. 2003-03-12. PMID:12427635. |
a reduction in the area of the substantia nigra (sn) has been shown in patients with parkinson disease. |
2003-03-12 |
2023-08-12 |
human |
| Hirobumi Oikawa, Makoto Sasaki, Yoshiharu Tamakawa, Shigeru Ehara, Koujiro Tohyam. The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings. AJNR. American journal of neuroradiology. vol 23. issue 10. 2003-03-12. PMID:12427635. |
the substantia nigra is anteroinferolateral to the red nucleus, and it is important to precisely locate its true anatomic location to accurately measure sn area. |
2003-03-12 |
2023-08-12 |
human |
| L Cathala, A Guyon, D Eugene, D Paupardin-Tritsc. Alpha2-adrenoceptor activation increases a cationic conductance and spontaneous GABAergic synaptic activity in dopaminergic neurones of the rat substantia nigra. Neuroscience. vol 115. issue 4. 2003-03-12. PMID:12453479. |
noradrenaline (na) plays an important role in compensating for the loss in dopaminergic (da) function following lesions of the da neurones of the substantia nigra (sn). |
2003-03-12 |
2023-08-12 |
rat |
| Jon C Horvit. Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum. Behavioural brain research. vol 137. issue 1-2. 2003-03-03. PMID:12445716. |
dopamine (da) neurons of the substantia nigra (sn) and ventral tegmental area (vta) respond to a wide category of salient stimuli. |
2003-03-03 |
2023-08-12 |
Not clear |
| E I Mukhin, Iu K Mukhina, T N Nabiev. [The role of substantia nigra in the cognitive activity in cats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 88. issue 10. 2003-02-26. PMID:12503373. |
the role of substantia nigra (sn) in the cat cognitive activity of different complexity degree, was investigated by original technique. |
2003-02-26 |
2023-08-12 |
cat |
| Ji-Young Choi, Chang-Shin Park, Dae-Joong Kim, Myung-Haeng Cho, Byung-Kwan Jin, Jae-Eun Pie, Woon-Gye Chun. Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicology. vol 23. issue 3. 2003-02-21. PMID:12387363. |
both tea and the oral administration of egcg prevented the loss of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and of th activity in the striatum. |
2003-02-21 |
2023-08-12 |
mouse |
| Tracey K Murray, Marcus J Messenger, Mark A Ward, Sandra Woodhouse, David J Osborne, Susan Duty, Michael J O'Neil. Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 73. issue 2. 2003-02-05. PMID:12117601. |
in contrast, systemic administration of ly379268 (0.1, 1, 10 mg/kg ip) did not reverse reserpine-induced akinesia and failed to effect rotational behaviour 1 month after unilateral lesioning of the nigrostriatal tract by 6-hydroxydopamine (6-ohda; 4 microg infused into the substantia nigra (sn)). |
2003-02-05 |
2023-08-12 |
rat |
| Petra T Bywood, Stephen M Johnso. Mitochondrial complex inhibitors preferentially damage substantia nigra dopamine neurons in rat brain slices. Experimental neurology. vol 179. issue 1. 2003-01-30. PMID:12504867. |
using a rat brain slice preparation, we investigated the role of energy impairment on the selective loss of dopamine neurons in the substantia nigra (sn). |
2003-01-30 |
2023-08-12 |
rat |
| Keiko Ikemoto, Takahiro Suzuki, Hiroshi Ichinose, Tamae Ohye, Akiyoshi Nishimura, Katsuji Nishi, Ikuko Nagatsu, Toshiharu Nagats. Localization of sepiapterin reductase in the human brain. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414107. |
human brain homogenates from the substantia nigra (sn), caudate nucleus (cn), gray and white matters of the cerebral cortex (ctx), and dorsal and ventral parts of the medulla oblongata (mo) were subjected to western blot analysis with anti-hspr antibody or with anti-th antibody. |
2003-01-28 |
2023-08-12 |
human |
| Silvia Mandel, Edna Grünblatt, Gila Maor, Moussa B H Youdi. Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray. Neurochemical research. vol 27. issue 10. 2003-01-27. PMID:12462421. |
in an attempt to elucidate early gene expression profile in the region of the substantia nigra (sn) and the striatum of acute mptp-treated mice (3-24 h), we elected a restricted number of genes affected by the long-term mptp treatment, and their expression was examined. |
2003-01-27 |
2023-08-12 |
mouse |
| Grazyna Kunikowska, Imelda Gallagher, Vivette Glover, Angela Clow, Peter Jenne. Effects of short- and long-term (--)-deprenyl administration on mRNA for copper, zinc- and manganese-superoxide dismutase and glutathione peroxidase in rat brain. Brain research. vol 953. issue 1-2. 2003-01-10. PMID:12384232. |
in rats which received (-)-deprenyl for 12 months, there was a significant increase in mn-sod mrna in the na, cp, gp, and substantia nigra (sn) (all p<0.05); there were no changes in either cu,zn-sod or gpx mrna. |
2003-01-10 |
2023-08-12 |
rat |
| Lidia Serova, Esther L Sabba. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438507. |
the effects of several concentrations of nicotine (0.08, 0.17, or 0.33 mg/kg body weight) and involvement of alpha7 nicotinic acetylcholine receptors (nachrs) in gene expression of key enzymes in dopamine biosynthesis were evaluated in the ventral tegmental area (vta) and substantia nigra (sn), cell bodies of the mesocorticolimbic and nigrostriatal pathways. |
2002-12-24 |
2023-08-12 |
rat |