Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
S A S Shehab, T E Julya. Induction of Fos-like immunoreactivity in the basal ganglia by ether anaesthesia: effects of injections of muscimol in rostral versus caudal substantia nigra pars reticulata. Experimental brain research. vol 142. issue 2. 2002-04-18. PMID:11807577. |
this expression of fl immunoreactivity in the basal ganglia was successfully blocked by local injections of muscimol (gaba(a) agonist) in the substantia nigra (sn). |
2002-04-18 |
2023-08-12 |
rat |
A Lessard, R Coutur. Modulation of cardiac activity by tachykinins in the rat substantia nigra. British journal of pharmacology. vol 134. issue 8. 2002-04-02. PMID:11739252. |
the effects of tachykinin nk(1), nk(2) and nk(3) receptor agonists and antagonists were measured on blood pressure (map) and heart rate (hr) after bilateral microinjection into the substantia nigra (sn) of awake, unrestrained rats. |
2002-04-02 |
2023-08-12 |
rat |
Ivar Mendez, Alain Dagher, Murray Hong, Paula Gaudet, Swarna Weerasinghe, Vivian McAlister, David King, Jacques Desrosiers, Sultan Darvesh, Tanya Acorn, Harold Robertso. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases. Journal of neurosurgery. vol 96. issue 3. 2002-03-29. PMID:11883846. |
the patients received implants of fetal mesencephalic cell suspensions in the putamen and substantia nigra (sn) bilaterally. |
2002-03-29 |
2023-08-12 |
Not clear |
E C Wolter. Intrinsic and extrinsic psychosis in Parkinson's disease. Journal of neurology. vol 248 Suppl 3. 2002-03-27. PMID:11697684. |
these symptoms are caused by a progressive abnormal degeneration of the dopamine (da) producing cells in the substantia nigra (sn) and ventral tegmentum area (vta) in combination with an interindividual fluctuating degree of decay in the noradrenergic (locus coeruleus), cholinergic forebrain (nucleus basalis of meynert) and serotoninergic (dorsal raphe nuclei) systems. |
2002-03-27 |
2023-08-12 |
Not clear |
S Chatelin, R Wehrlé, P Mercier, D Morello, C Sotelo, M J Webe. Neuronal promoter of human aromatic L-amino acid decarboxylase gene directs transgene expression to the adult floor plate and aminergic nuclei induced by the isthmus. Brain research. Molecular brain research. vol 97. issue 2. 2002-03-21. PMID:11750071. |
in the adult brain parenchyma, transgene expression was observed in the substantia nigra (sn), the ventral tegmental area (vta) and the dorsal, medial and pontine raphe nuclei. |
2002-03-21 |
2023-08-12 |
mouse |
Jih Ing Chuang, Shur Tzu Che. Differential expression of Bcl-2 and APP immunoreactivity after intrastriatal injection of MPP+ in the rat. Neurochemistry international. vol 40. issue 2. 2002-02-26. PMID:11738483. |
one hour to 2 months after mpp(+) injection into rat striatum, a significant increase in bcl-2 expression was observed in distinct populations of neurons, astrocyte-like and ox-42-positive cells not only in traumatic regions but also in remote areas including the ipsilateral cortex and substantia nigra (sn). |
2002-02-26 |
2023-08-12 |
rat |
Henrike Neuhoff, Axel Neu, Birgit Liss, Jochen Roepe. I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11850457. |
dopaminergic (da) midbrain neurons in the substantia nigra (sn) and ventral tegmental area (vta) are involved in various brain functions such as voluntary movement and reward and are targets in disorders such as parkinson's disease and schizophrenia. |
2002-02-26 |
2023-08-12 |
mouse |
William S Cobb, Elizabeth D Abercrombi. Distinct roles for nigral GABA and glutamate receptors in the regulation of dendritic dopamine release under normal conditions and in response to systemic haloperidol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11850467. |
the regulation of dendritic dopamine release in the substantia nigra (sn) likely involves multiple mechanisms. |
2002-02-26 |
2023-08-12 |
Not clear |
Timothy J Collier, Caryl E Sortwell, John D Elsworth, Jane R Taylor, Robert H Roth, John R Sladek, D Eugene Redmon. Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease. The Journal of comparative neurology. vol 442. issue 4. 2002-02-21. PMID:11793337. |
in the present study, we assessed the feasibility of grafting embryonic da neurons into the substantia nigra (sn) of adult parkinsonian monkeys as an approach to restoration of the da modulation of striatal-nigral afferents that is lost after degeneration of sn neurons. |
2002-02-21 |
2023-08-12 |
monkey |
D Berg, C Siefker, G Becke. Echogenicity of the substantia nigra in Parkinson's disease and its relation to clinical findings. Journal of neurology. vol 248. issue 8. 2002-02-20. PMID:11569897. |
recently an increased echogenicity of the substantia nigra (sn) in patients with parkinson's disease (pd) was demonstrated by transcranial ultrasound (tcs). |
2002-02-20 |
2023-08-12 |
Not clear |
L Mao, Y S Lau, E Petroske, J Q Wan. Profound astrogenesis in the striatum of adult mice following nigrostriatal dopaminergic lesion by repeated MPTP administration. Brain research. Developmental brain research. vol 131. issue 1-2. 2002-02-04. PMID:11718836. |
a 5-fold increase was also seen in the substantia nigra (sn). |
2002-02-04 |
2023-08-12 |
mouse |
Greg A Gerhardt, Wayne A Cass, Ai Yi, Zhiming Zhang, Don M Gas. Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys. Journal of neurochemistry. vol 80. issue 1. 2002-01-29. PMID:11796755. |
in vivo microdialysis studies showed that basal levels of the da metabolites, homovanillic acid (hva) and 3,4-dihydroxyphenylacetic acid (dopac) were diminished by 44% and 79%, respectively, in the substantia nigra (sn) of aged monkeys. |
2002-01-29 |
2023-08-12 |
monkey |
V Viswanath, Y Wu, R Boonplueang, S Chen, F F Stevenson, F Yantiri, L Yang, M F Beal, J K Anderse. Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 24. 2002-01-23. PMID:11739563. |
parkinson's disease (pd) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) toxicity are both associated with dopaminergic neuron death in the substantia nigra (sn). |
2002-01-23 |
2023-08-12 |
mouse |
Z Zhang, A Andersen, R Grondin, T Barber, R Avison, G Gerhardt, D Gas. Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. NeuroImage. vol 14. issue 5. 2002-01-02. PMID:11697947. |
apomorphine, a mixed d(1)/d(2) dopamine receptor agonist, evoked little change in the substantia nigra (sn) of aged animals while significantly reducing activation in young adult monkeys. |
2002-01-02 |
2023-08-12 |
monkey |
B E Jabs, D Berg, U Merschdorf, A J Bartsch, B Pfuhlman. Differences in substantia nigra echogenicity of nosological subtypes within the schizophrenic spectrum. A preliminary transcranial ultrasound study. Neuropsychobiology. vol 44. issue 4. 2002-01-02. PMID:11702018. |
here, transcranial sonography (tcs) was used to test for differences in the susceptibility to nip related to the echogenicity of the substantia nigra (sn) in different schizophrenic subforms. |
2002-01-02 |
2023-08-12 |
Not clear |
S Erhardt, H Oberg, J M Mathé, G Engber. Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons. Amino acids. vol 20. issue 4. 2001-12-17. PMID:11452979. |
in the present electrophysiological study pnu 156561a was utilized to elevate endogenous concentrations of kynurenic acid and subsequent effects on the firing pattern of dopamine (da) neurons of rat substantia nigra (sn) were analyzed. |
2001-12-17 |
2023-08-12 |
rat |
D Berg, B Jabs, U Merschdorf, H Beckmann, G Becke. Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy. Biological psychiatry. vol 50. issue 6. 2001-12-07. PMID:11566164. |
increased echogenicity of the substantia nigra (sn) detected by transcranial sonography is a characteristic ultrasound feature of parkinson's disease. |
2001-12-07 |
2023-08-12 |
human |
B Liss, O Franz, S Sewing, R Bruns, H Neuhoff, J Roepe. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. The EMBO journal. vol 20. issue 20. 2001-12-05. PMID:11598014. |
the activity of dopaminergic (da) substantia nigra (sn) neurons is essential for voluntary movement control. |
2001-12-05 |
2023-08-12 |
Not clear |
B Conno. Adenoviral vector-mediated delivery of glial cell line-derived neurotrophic factor provides neuroprotection in the aged parkinsonian rat. Clinical and experimental pharmacology & physiology. vol 28. issue 11. 2001-12-05. PMID:11703392. |
in the aged (20 month) fischer 344 rat, ad gdnf was injected either near da cell bodies in the substantia nigra (sn) or at the da terminals in the striatum. |
2001-12-05 |
2023-08-12 |
human |
A Bortolozzi, A M Evangelista de Duffard, F Dajas, R Duffard, R Silveir. Intracerebral administration of 2,4-diclorophenoxyacetic acid induces behavioral and neurochemical alterations in the rat brain. Neurotoxicology. vol 22. issue 2. 2001-12-04. PMID:11405254. |
these last rats also exhibited diminished levels of striatal 5-ht, dopamine (da) and their metabolites without changes in the substantia nigra (sn). |
2001-12-04 |
2023-08-12 |
rat |