| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Tavakoli-Nezhad, A J Barron, D K Pitt. Postnatal inorganic lead exposure decreases the number of spontaneously active midbrain dopamine neurons in the rat. Neurotoxicology. vol 22. issue 2. 2001-12-04. PMID:11405257. |
single-cell electrophysiological recordings were made in the substantia nigra (sn) and ventral tegmental area (vta) of chloral hydrate anesthetized rats. |
2001-12-04 |
2023-08-12 |
rat |
| H Li, S H Li, Z X Yu, P Shelbourne, X J L. Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 21. 2001-12-04. PMID:11606636. |
in early stages of hd, neurodegeneration preferentially occurs in the lateral globus pallidus (lgp) and substantia nigra (sn), two regions in which the axons of striatal neurons terminate. |
2001-12-04 |
2023-08-12 |
mouse |
| M J During, M G Kaplitt, M B Stern, D Eidelber. Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Human gene therapy. vol 12. issue 12. 2001-11-01. PMID:11529246. |
pd is an excellent target for gene therapy, because it is a complex acquired disease of unknown etiology (apart from some rare familial cases) yet it is characterized by a specific neuroanatomical pathology, the degeneration of dopamine neurons of the substantia nigra (sn) with loss of dopamine input to the striatum. |
2001-11-01 |
2023-08-12 |
human |
| K M Hemsley, A D Crocke. Changes in muscle tone are regulated by D1 and D2 dopamine receptors in the ventral striatum and D1 receptors in the substantia nigra. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 4. 2001-11-01. PMID:11557165. |
in the current study the regulatory roles of dopamine d1 and d2 receptor subfamilies in the dorsal (dstr) and ventral striatum (vstr) and substantia nigra (sn) were investigated on muscle tone, assessed as increases in tonic electromyographic (emg) activity. |
2001-11-01 |
2023-08-12 |
rat |
| R Bridi, F P Crossetti, V M Steffen, A T Henrique. The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytotherapy research : PTR. vol 15. issue 5. 2001-10-25. PMID:11507743. |
in this study, the lipid peroxidation (lpo) and the activity of the antioxidant enzymes, catalase (cat) and superoxide dismutase (sod) were evaluated in the hippocampus, striatum and substantia nigra (sn) of rats treated with egb 761. |
2001-10-25 |
2023-08-12 |
rat |
| Y He, S Appel, W L. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain research. vol 909. issue 1-2. 2001-10-11. PMID:11478935. |
the relative number of microglial profiles in the substantia nigra (sn) ipsilateral to the injection increased from 31 to 32% 1-3 days after injection, and increased further to 55% by 7 days and 59% by 14 days, compared with the contralateral sn. |
2001-10-11 |
2023-08-12 |
mouse |
| T Y Zhang, J W Jahng, D G Ki. Dextromethorphan increases tyrosine hydroxylase mRNA in the mesencephalon of adolescent rats. Neuroscience letters. vol 309. issue 2. 2001-10-11. PMID:11502351. |
to examine effects of dm on the reward pathway, we injected a high dose of dm (40 mg/kg; intraperitoneally) into the adolescent rat and measured tyrosine hydroxylase (th) mrna by in situ hybridization in the ventral tegmental area (vta) and the substantia nigra (sn). |
2001-10-11 |
2023-08-12 |
rat |
| K M Welch, V Nagesh, S K Aurora, N Gelma. Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache. vol 41. issue 7. 2001-10-04. PMID:11554950. |
high-resolution magnetic resonance techniques were used to map the transverse relaxation rates r2, r2*, and r2' in the pag, red nucleus (rn), and substantia nigra (sn). |
2001-10-04 |
2023-08-12 |
Not clear |
| J Y Wang, J N Wu, T L Cherng, B J Hoffer, H H Chen, C V Borlongan, Y Wan. Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats. Brain research. vol 904. issue 1. 2001-09-27. PMID:11516412. |
we found that 6-ohda administration significantly reduced dopamine (da), 3,4-dihydroxy-phenylacetic acid (dopac) and homovanilic acid (hva) levels in the substantia nigra (sn) on the lesioned side in the saline-treated rats. |
2001-09-27 |
2023-08-12 |
rat |
| L Groc, L Bezin, J A Foster, H Jiang, T S Jackson, D Weissmann, R A Levin. Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia nigra during development. Neurochemistry international. vol 39. issue 2. 2001-09-13. PMID:11408091. |
the cellular pathways underlying naturally occurring neuronal apoptosis in the rat substantia nigra (sn) during the perinatal period remain largely unknown. |
2001-09-13 |
2023-08-12 |
rat |
| H Ishiguro, K Yamada, H Sawada, K Nishii, N Ichino, M Sawada, Y Kurosawa, N Matsushita, K Kobayashi, J Goto, H Hashida, N Masuda, I Kanazawa, T Nagats. Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene. Journal of neuroscience research. vol 65. issue 4. 2001-09-13. PMID:11494364. |
glial fibrillary acidic protein (gfap)-positive cells have been found to be increased in the substantia nigra (sn), globus pallidus (gp), and striatum (st) in the brains of 40-week-old affected mice, although without neuronal cell death. |
2001-09-13 |
2023-08-12 |
mouse |
| S Yoshida, A Ektessabi, S Fujisaw. XANES spectroscopy of a single neuron from a patient with Parkinson's disease. Journal of synchrotron radiation. vol 8. issue Pt 2. 2001-09-06. PMID:11513007. |
chemical state of transition metals such as iron in a single neuron of the substantia nigra (sn) from a patient with parkinson's disease (pd) was studied in this paper, using autopsy midbrain specimens including sn. |
2001-09-06 |
2023-08-12 |
Not clear |
| T R Werkman, C G Kruse, H Nievelstein, S K Long, W J Wadma. In vitro modulation of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area by antipsychotic drugs. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378163. |
an in vitro experimental midbrain slice preparation is described which allows simultaneous extracellular recordings of the (spontaneous) electrical activity of dopamine neurons in the rat substantia nigra (sn) and the ventral tegmental area (vta). |
2001-08-09 |
2023-08-12 |
rat |
| H Nissbrandt, F Bergquist, J Jonason, G Engber. Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway? Synapse (New York, N.Y.). vol 40. issue 4. 2001-07-26. PMID:11309845. |
we presented data previously on dopamine (da) synthesis and catabolism in the rat substantia nigra (sn) suggesting that a substantial part of the synthesized da in this brain part is metabolized by unknown nonclassical metabolic pathways. |
2001-07-26 |
2023-08-12 |
rat |
| F Zhao, T Kuroiwa, N Miyasaka, T Nagaoka, M Nakane, A Tamura, H Mizusaw. Characteristic changes in T(2)-value, apparent diffusion coefficient, and ultrastructure of substantia nigra evolving exofocal postischemic neuronal death in rats. Brain research. vol 895. issue 1-2. 2001-07-19. PMID:11259783. |
to correlate the magnetic resonance (mr) imaging characteristics of exofocal postischemic neuronal death (epnd) in the substantia nigra (sn) with associated histologic changes, we occluded the left middle cerebral artery of rats for 1, 4, 7, or 12 days. |
2001-07-19 |
2023-08-12 |
rat |
| F Yantiri, A Gasparyan, J K Anderse. Glutamyl cysteine synthetase catalytic and regulatory subunits localize to dopaminergic nigral neurons as well as to astrocytes. Journal of neuroscience research. vol 64. issue 2. 2001-07-12. PMID:11288148. |
gsh levels have been reported to be significantly lower in the substantia nigra (sn) of parkinson patients vs. age-matched controls. |
2001-07-12 |
2023-08-12 |
Not clear |
| P A Johansson, M Andersson, K E Andersson, M A Cenc. Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of l-DOPA-induced dyskinesia. Neurobiology of disease. vol 8. issue 2. 2001-07-12. PMID:11300719. |
autoradiographic analysis of mu-, delta-, and kappa-opioid binding sites was carried out in the caudate-putamen (cpu), the globus pallidus (gp), the substantia nigra (sn), the primary motor area, and the premotor-cingulate cortex. |
2001-07-12 |
2023-08-12 |
rat |
| A Natsume, M Mata, J Goss, S Huang, D Wolfe, T Oligino, J Glorioso, D J Fin. Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration. Experimental neurology. vol 169. issue 2. 2001-07-05. PMID:11358438. |
in this study we used recombinant, replication-incompetent, genomic herpes simplex virus-based vectors to deliver the genes coding for bcl-2 and gdnf into rat substantia nigra (sn) 1 week prior to 6-ohda injection into the striatum. |
2001-07-05 |
2023-08-12 |
rat |
| D Berg, C Siefker, P Ruprecht-Dörfler, G Becke. Relationship of substantia nigra echogenicity and motor function in elderly subjects. Neurology. vol 56. issue 1. 2001-06-28. PMID:11148229. |
patients with parkinson's disease (pd) exhibit an increased echogenicity of the substantia nigra (sn) on transcranial sonography. |
2001-06-28 |
2023-08-12 |
human |
| S Dallvechia-Adams, Y Smith, M J Kuha. CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat. The Journal of comparative neurology. vol 434. issue 1. 2001-06-28. PMID:11329127. |
cartir terminal-like varicosities were located throughout the rostrocaudal extent of the substantia nigra (sn), vta, and retrorubral field (rrf). |
2001-06-28 |
2023-08-12 |
rat |