| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Araki, M Matsubara, K Fujihara, H Kato, Y Imai, Y Itoyam. Gamma-aminobutyric acidA and benzodiazepine receptor alterations in the rat brain after unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. Neurological research. vol 24. issue 1. 2002-06-21. PMID:11783749. |
degeneration of the nigrostriatal pathway after 6-hydroxydopamine treatment caused a significant loss of dopamine uptake sites in the ipsilateral striatum and substantia nigra (sn) in the lesioned animals. |
2002-06-21 |
2023-08-12 |
rat |
| A H Rajpu. Levodopa prolongs life expectancy and is non-toxic to substantia nigra. Parkinsonism & related disorders. vol 8. issue 2. 2002-06-20. PMID:11489674. |
one parkinsonian patient with substantia nigra (sn) pathology who was extensively studied for 30 years, revealed significant slowing of the disease progression while on ld. |
2002-06-20 |
2023-08-12 |
human |
| J Zhang, T J Montine, M A Smith, S L Siedlak, G Gu, D Robertson, G Perr. The mitochondrial common deletion in Parkinson's disease and related movement disorders. Parkinsonism & related disorders. vol 8. issue 3. 2002-06-19. PMID:12039426. |
one possible explanation for these conflicting results is the difficulty in quantifying mitochondrial dna deletions or mutations in the whole midbrain or substantia nigra (sn) while only a subset of midbrain neurons degenerate in pd. |
2002-06-19 |
2023-08-12 |
Not clear |
| Jorge M Campusano, Jorge Abarca, María Inés Forray, Katia Gysling, Gonzalo Busto. Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra. Biochemical pharmacology. vol 63. issue 7. 2002-06-14. PMID:11960611. |
a superfusion system was used to study the effects of metabotropic glutamate receptor (mglur) ligands upon the release of [(3)h]dopamine ([(3)h]da) previously taken up by rat substantia nigra (sn) slices. |
2002-06-14 |
2023-08-12 |
rat |
| B-Y Zeng, B Dass, A Owen, S Rose, C Cannizzaro, B C Tel, P Jenne. 6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats. Neuroscience letters. vol 322. issue 1. 2002-05-30. PMID:11958837. |
a 6-ohda lesion of the nigro-striatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mrna expression, markedly decreased alpha-synuclein mrna in the lesioned substantia nigra (sn). |
2002-05-30 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Krister S Eriksson, Helmut L Haas, Ritchie E Brow. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regulatory peptides. vol 104. issue 1-3. 2002-05-21. PMID:11830281. |
here we have investigated the effect of orexins on the firing of dopaminergic and gabaergic neurons of the substantia nigra (sn) in brain slices. |
2002-05-21 |
2023-08-12 |
rat |
| José L Venero, El-Hadi Absi, Josefina Cano, Alberto Machad. Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus. Journal of pineal research. vol 32. issue 1. 2002-05-20. PMID:11841594. |
experimental rats received daily late afternoon injections of 1.5 mg/kg melatonin for 30 days and analysis were performed in the ventral mesencephalon including the substantia nigra (sn) and ventral tegmental area (vta), and hypothalamus. |
2002-05-20 |
2023-08-12 |
rat |
| Jakob Wolfart, Jochen Roepe. Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 9. 2002-05-20. PMID:11978817. |
we have shown recently that the small-conductance calcium-activated potassium channel sk3 controls pacemaker frequency and precision in da neurons of the substantia nigra (sn), and previous studies have implicated sk channels in the transition to burst firing. |
2002-05-20 |
2023-08-12 |
Not clear |
| Davide Viggiano, Gerasimos Grammatikopoulos, Adolfo G Sadil. A morphometric evidence for a hyperfunctioning mesolimbic system in an animal model of ADHD. Behavioural brain research. vol 130. issue 1-2. 2002-05-16. PMID:11864733. |
thus, a morphometric analysis was carried out on neurons of origin of substantia nigra (sn) and ventral tegmental area (vta) dopamine systems of the naples high-excitability (nhe), low-excitability (nle) and control lines. |
2002-05-16 |
2023-08-12 |
rat |
| L Wang, S Muramatsu, Y Lu, K Ikeguchi, K Fujimoto, T Okada, H Mizukami, Y Hanazono, A Kume, F Urano, H Ichinose, T Nagatsu, I Nakano, K Ozaw. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease. Gene therapy. vol 9. issue 6. 2002-05-14. PMID:11960314. |
immunostaining for flag demonstrated retrograde transport of gdnfflag to the substantia nigra (sn). |
2002-05-14 |
2023-08-12 |
rat |
| Karen J Maloney, Lynda Mainville, Barbara E Jone. c-Fos expression in dopaminergic and GABAergic neurons of the ventral mesencephalic tegmentum after paradoxical sleep deprivation and recovery. The European journal of neuroscience. vol 15. issue 4. 2002-05-10. PMID:11886456. |
numbers of th+/c-fos+ neurons in the substantia nigra (sn) were not significantly different across groups, whereas those in the ventral tegmental area (vta) were significantly different and greatest in ps recovery. |
2002-05-10 |
2023-08-12 |
rat |
| Jae K Ryu, Won H Shin, Jean Kim, Eun H Joe, Yong B Lee, Kyung G Cho, Young J Oh, Seung U Kim, Byung K Ji. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia. vol 38. issue 1. 2002-05-10. PMID:11921200. |
the present study examines the in vivo neurotoxic effects of gt1b on dopaminergic neurons in the substantia nigra (sn) of sprague-dawley rats. |
2002-05-10 |
2023-08-12 |
rat |
| Peiyuan F Hsieh, Lie-Gan Chia, Dah-Ren Ni, Lee-Ju Cheng, Yuh-Pin Ho, Shun-Fen Tzeng, Ming-Hong Chang, Jau-Shyong Hon. Behavior, neurochemistry and histology after intranigral lipopolysaccharide injection. Neuroreport. vol 13. issue 3. 2002-05-02. PMID:11930122. |
inflammation and neuronal degeneration of the substantia nigra (sn) occur in parkinson's disease (pd). |
2002-05-02 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Helmut L Haas, Ritchie E Brow. Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro. Neuroscience letters. vol 320. issue 3. 2002-04-25. PMID:11852180. |
we have investigated the effect of histamine (ha) on spontaneous firing of dopaminergic (da) and gabaergic neurons in the substantia nigra (sn) and the ventral tegmental area (vta) of the rat in vitro. |
2002-04-25 |
2023-08-12 |
rat |
| S A S Shehab, T E Julya. Induction of Fos-like immunoreactivity in the basal ganglia by ether anaesthesia: effects of injections of muscimol in rostral versus caudal substantia nigra pars reticulata. Experimental brain research. vol 142. issue 2. 2002-04-18. PMID:11807577. |
this expression of fl immunoreactivity in the basal ganglia was successfully blocked by local injections of muscimol (gaba(a) agonist) in the substantia nigra (sn). |
2002-04-18 |
2023-08-12 |
rat |
| A Lessard, R Coutur. Modulation of cardiac activity by tachykinins in the rat substantia nigra. British journal of pharmacology. vol 134. issue 8. 2002-04-02. PMID:11739252. |
the effects of tachykinin nk(1), nk(2) and nk(3) receptor agonists and antagonists were measured on blood pressure (map) and heart rate (hr) after bilateral microinjection into the substantia nigra (sn) of awake, unrestrained rats. |
2002-04-02 |
2023-08-12 |
rat |
| Ivar Mendez, Alain Dagher, Murray Hong, Paula Gaudet, Swarna Weerasinghe, Vivian McAlister, David King, Jacques Desrosiers, Sultan Darvesh, Tanya Acorn, Harold Robertso. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases. Journal of neurosurgery. vol 96. issue 3. 2002-03-29. PMID:11883846. |
the patients received implants of fetal mesencephalic cell suspensions in the putamen and substantia nigra (sn) bilaterally. |
2002-03-29 |
2023-08-12 |
Not clear |
| E C Wolter. Intrinsic and extrinsic psychosis in Parkinson's disease. Journal of neurology. vol 248 Suppl 3. 2002-03-27. PMID:11697684. |
these symptoms are caused by a progressive abnormal degeneration of the dopamine (da) producing cells in the substantia nigra (sn) and ventral tegmentum area (vta) in combination with an interindividual fluctuating degree of decay in the noradrenergic (locus coeruleus), cholinergic forebrain (nucleus basalis of meynert) and serotoninergic (dorsal raphe nuclei) systems. |
2002-03-27 |
2023-08-12 |
Not clear |
| S Chatelin, R Wehrlé, P Mercier, D Morello, C Sotelo, M J Webe. Neuronal promoter of human aromatic L-amino acid decarboxylase gene directs transgene expression to the adult floor plate and aminergic nuclei induced by the isthmus. Brain research. Molecular brain research. vol 97. issue 2. 2002-03-21. PMID:11750071. |
in the adult brain parenchyma, transgene expression was observed in the substantia nigra (sn), the ventral tegmental area (vta) and the dorsal, medial and pontine raphe nuclei. |
2002-03-21 |
2023-08-12 |
mouse |
| Jih Ing Chuang, Shur Tzu Che. Differential expression of Bcl-2 and APP immunoreactivity after intrastriatal injection of MPP+ in the rat. Neurochemistry international. vol 40. issue 2. 2002-02-26. PMID:11738483. |
one hour to 2 months after mpp(+) injection into rat striatum, a significant increase in bcl-2 expression was observed in distinct populations of neurons, astrocyte-like and ox-42-positive cells not only in traumatic regions but also in remote areas including the ipsilateral cortex and substantia nigra (sn). |
2002-02-26 |
2023-08-12 |
rat |