| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R E Johnston, J B Becke. Behavioral changes associated with grafts of embryonic ventral mesencephalon tissue into the striatum and/or substantia nigra in a rat model of Parkinson's Disease. Behavioural brain research. vol 104. issue 1-2. 2001-01-11. PMID:11125737. |
while considerably less research has been conducted on the topic, vm grafts into the lesioned substantia nigra (sn) may induce recovery on more complex and/or spontaneous tasks. |
2001-01-11 |
2023-08-12 |
human |
| K Bogus-Nowakowska, S Szteyn, A Roba. The neuronal structure of the substantia nigra in the guinea pig: Nissl and Golgi study. Folia morphologica. vol 59. issue 4. 2001-01-05. PMID:11107698. |
four types of neurons were distinguished in the substantia nigra (sn) of the guinea pig: 1. |
2001-01-05 |
2023-08-12 |
Not clear |
| R Usha, D Muralikrishnan, B Thomas, S Ghosh, C Mandal, K P Mohanakuma. Region-specific attenuation of a trypsin-like protease in substantia nigra following dopaminergic neurotoxicity by 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056198. |
dna extracted from nucleus caudatus putamen (ncp) and substantia nigra (sn) was subjected to agarose gel electrophoresis. |
2000-12-28 |
2023-08-12 |
mouse |
| D A Kozlowski, B Connor, J L Tillerson, T Schallert, M C Boh. Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031079. |
the effects of delivering gdnf via an adenoviral vector (adgdnf) 1 week after lesioning dopaminergic neurons in the rat substantia nigra (sn) with 6-hydroxydopamine (6-ohda) were examined. |
2000-12-07 |
2023-08-12 |
rat |
| B E Levi. Glucose-regulated dopamine release from substantia nigra neurons. Brain research. vol 874. issue 2. 2000-11-06. PMID:10960600. |
glucose modulates substantia nigra (sn) dopamine (da) neuronal activity and gaba axon terminal transmitter release by actions on an atp-sensitive potassium channel (k(atp)). |
2000-11-06 |
2023-08-12 |
rat |
| B E Levi. Glucose-regulated dopamine release from substantia nigra neurons. Brain research. vol 874. issue 2. 2000-11-06. PMID:10960600. |
this response may well reflect the known effect of glucose on k(atp) channel activity on both sn da neurons and gaba axon terminals in the substantia nigra. |
2000-11-06 |
2023-08-12 |
rat |
| B Liu, J W Jiang, B C Wilson, L Du, S N Yang, J Y Wang, G C Wu, X D Cao, J S Hon. Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991969. |
a massive degeneration of dopamine-containing neurons in the substantia nigra (sn) in the midbrain is characteristic of parkinson's disease. |
2000-11-03 |
2023-08-12 |
rat |
| T Araki, H Tanji, H Kato, Y Imai, M Mizugaki, Y Itoyam. Temporal changes of dopaminergic and glutamatergic receptors in 6-hydroxydopamine-treated rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 5. 2000-10-30. PMID:10974608. |
in the ipsilateral substantia nigra (sn), a significant decrease in dopamine d(2) receptors was also observed from 1 to 8 weeks of postlesion. |
2000-10-30 |
2023-08-12 |
rat |
| P A Starr, T Subramanian, R A Bakay, T Wichman. Electrophysiological localization of the substantia nigra in the parkinsonian nonhuman primate. Journal of neurosurgery. vol 93. issue 4. 2000-10-16. PMID:11014554. |
new restorative therapies for parkinson disease, aimed at delivering drugs or cells to the substantia nigra (sn), are becoming available. |
2000-10-16 |
2023-08-12 |
monkey |
| A J Herrera, A Castaño, J L Venero, J Cano, A Machad. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964613. |
lps induced a strong macrophage/microglial reaction in substantia nigra (sn), with a characteristic clustering of macrophage cells around blood-vessels. |
2000-10-11 |
2023-08-12 |
rat |
| I Suárez, G Bodega, J A Ramos, J J Fernández-Ruiz, B Fernánde. Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra. Developmental neuroscience. vol 22. issue 4. 2000-10-11. PMID:10965147. |
the responses of neurons and astroglial cells to pre- and perinatal exposure to delta(9)-tetrahydrocannabinol (delta(9)-thc) were evaluated in the substantia nigra (sn) of male and female rats, at three postnatal ages (pd21, pd30 and pd70), by immunohistochemical detection of tyrosine hydroxylase (th) in dopaminergic neurons and of glial fibrillary acidic protein (gfap) in astrocytes. |
2000-10-11 |
2023-08-12 |
rat |
| T Nomura, T Yabe, E S Rosenthal, M Krzan, J P Schwart. PSA-NCAM distinguishes reactive astrocytes in 6-OHDA-lesioned substantia nigra from those in the striatal terminal fields. Journal of neuroscience research. vol 61. issue 6. 2000-10-10. PMID:10972955. |
6-hydroxydopamine (6-ohda) lesion of the substantia nigra (sn) causes the appearance of reactive astrocytes not only in the sn but also in the striatal terminal fields, as measured by increased size of the cells and their processes, as well as enhanced expression of glial fibrillary acidic protein (gfap) and an epitope recognized by monoclonal antibody 19d1. |
2000-10-10 |
2023-08-12 |
Not clear |
| G Mateu, A Privat, J Thibault, J Vigno. Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 6. 2000-09-28. PMID:10884605. |
glutamate toxicity was compared in substantia nigra (sn)/striatum (str) and sn/cerebellum (crb) co-cultures on both the entire neuronal population (neuron specific enolase (nse) immunopositive cells) and dopaminergic neurons (tyrosine hydroxylase (th) immunopositive cells). |
2000-09-28 |
2023-08-12 |
Not clear |
| T Vitalis, O Cases, D Engelkamp, C Verney, D J Pric. Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 17. 2000-09-28. PMID:10964956. |
catecholaminergic neurons of the substantia nigra (sn) and the ventral tegmental area (vta) do not express pax6 protein. |
2000-09-28 |
2023-08-12 |
mouse |
| N Jha, O Jurma, G Lalli, Y Liu, E H Pettus, J T Greenamyre, R M Liu, H J Forman, J K Anderse. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10846169. |
oxidative stress appears to play an important role in degeneration of dopaminergic neurons of the substantia nigra (sn) associated with parkinson's disease (pd). |
2000-09-25 |
2023-08-12 |
Not clear |
| A Serino, K Kan, K Graves, C Kule, A Anthon. Age, strain, and semi-chronic hydergine treatment effects on motor activity and neuronal nucleic acid-protein metabolism in male mice. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983845. |
this study was designed to examine the effects of hydergine (dhet), co-dergocrine mesylate, treatment on motor activity and neuronal nucleoprotein metabolism in several motor areas of the aging rodent brain, specifically the caudate-putamen (cp), the substantia nigra (sn), and the cerebral cortex layer v (cx). |
2000-09-25 |
2023-08-12 |
mouse |
| T A Ala, K H Yang, J H Sung, W H Fre. Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients: a cliniconeuropathological study. Acta neuropathologica. vol 99. issue 5. 2000-07-17. PMID:10805094. |
in a retrospective cliniconeuropathological study, we reviewed all the cases received in our dementia brain bank during a 4-year period to determine if all patients with severe substantia nigra (sn) degeneration and sn lewy bodies (lbs) exhibited prominent signs of parkinsonism and were treated for parkinsonism during the disease course. |
2000-07-17 |
2023-08-12 |
Not clear |
| M F Salvatore, A Garcia-Espana, M Goldstein, A Y Deutch, J W Haycoc. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854265. |
the striatum (str), substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) from sprague-dawley rats were harvested 30-40 min after a single injection of either vehicle, haloperidol (2 mg/kg), raclopride (2 mg/kg), clozapine (30 mg/kg), or sch23390 (0.5 mg/kg). |
2000-07-17 |
2023-08-12 |
rat |
| J Chung, S Chang, Y Kim, H Shi. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neuroscience letters. vol 286. issue 3. 2000-07-12. PMID:10832015. |
the effect of zinc ions (zn(2+)) on the neuronal excitability of substantia nigra (sn) where the zinc level is known higher in parkinsonian brains than that in normal brains has not yet been elucidated. |
2000-07-12 |
2023-08-12 |
rat |
| K P Mohanakumar, D Muralikrishnan, B Thoma. Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced neurotoxicity. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802035. |
this also caused significant decrease in glutathione in substantia nigra (sn) and ncp. |
2000-07-03 |
2023-08-12 |
mouse |