| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Martín-Ruiz, L Ugedo, M A Honrubia, G Mengod, F Artiga. Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus. Journal of neurochemistry. vol 77. issue 3. 2001-06-28. PMID:11331405. |
in situ hybridization showed that the dopamine (da) d(2) receptor transcript was almost absent in the dr and abundant in the substantia nigra (sn) and the periaqueductal grey matter (pag). |
2001-06-28 |
2023-08-12 |
rat |
| J Wolfart, H Neuhoff, O Franz, J Roepe. Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331374. |
perforated patch recordings of da neurons in the substantia nigra (sn) demonstrated that sk3 channels dynamically control the frequency of spontaneous firing. |
2001-06-21 |
2023-08-12 |
mouse |
| K Mukhida, K A Baker, D Sadi, I Mende. Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 10. 2001-06-21. PMID:11331381. |
the current transplantation paradigm that focuses on ectopic placement of fetal grafts in the striatum (st) fails to reconstruct the basal ganglia circuitry or normalize neuronal activity in important basal ganglia structures, such as the substantia nigra (sn) and the subthalamic nucleus (stn). |
2001-06-21 |
2023-08-12 |
rat |
| A J Grau, V Willig, W Fogel, E Werl. Assessment of plasma lactoferrin in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 1. 2001-06-14. PMID:11215573. |
recent studies have shown that the iron-transporting glycoprotein lactoferrin (lf) and its receptor are increased in the substantia nigra (sn) in pd. |
2001-06-14 |
2023-08-12 |
human |
| G W Hubert, M Paquet, Y Smit. Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey Substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245668. |
neurons in the rat substantia nigra (sn) are enriched in group i metabotropic glutamate receptor (mglur) subtypes and respond to group i mglur activation. |
2001-06-07 |
2023-08-12 |
rat |
| B Connor, D A Kozlowski, J R Unnerstall, J D Elsworth, J L Tillerson, T Schallert, M C Boh. Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration. Experimental neurology. vol 169. issue 1. 2001-06-07. PMID:11312561. |
previously, we observed that injection of an adenoviral (ad) vector expressing glial cell line-derived neurotrophic factor (gdnf) into the striatum, but not the substantia nigra (sn), prior to a partial 6-ohda lesion protects dopaminergic (da) neuronal function and prevents the development of behavioral impairment in the aged rat. |
2001-06-07 |
2023-08-12 |
rat |
| H Panet, A Barzilai, D Daily, E Melamed, D Offe. Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299301. |
the etiology of parkinson's disease is still unknown, though current investigations support the notion of the pivotal involvement of oxidative stress in the process of neurodegeneration in the substantia nigra (sn). |
2001-05-17 |
2023-08-12 |
Not clear |
| J E Galvin, T M Schuck, V M Lee, J Q Trojanowsk. Differential expression and distribution of alpha-, beta-, and gamma-synuclein in the developing human substantia nigra. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259122. |
for example, alphas forms lewy bodies (lbs) in substantia nigra (sn) neurons of pd. |
2001-05-10 |
2023-08-12 |
human |
| M R Palmer, A C Granholm, C G van Horne, K E Giardina, R K Freund, J W Moorhead, G A Gerhard. Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats. Brain research. vol 890. issue 1. 2001-04-26. PMID:11164771. |
parkinson's disease (pd) is characterized by a degeneration of the dopamine (da) pathway from the substantia nigra (sn) to the basal forebrain. |
2001-04-26 |
2023-08-12 |
rat |
| A M Li. Coexistence of zinc and iron augmented oxidative injuries in the nigrostriatal dopaminergic system of SD rats. Free radical biology & medicine. vol 30. issue 3. 2001-04-26. PMID:11165868. |
clinical studies have demonstrated an excess of transition metals, including zinc and iron, in the substantia nigra (sn) of parkinson's patients. |
2001-04-26 |
2023-08-12 |
rat |
| E C Wolter. Psychiatric complications in Parkinson's disease. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205148. |
parkinson's disease (pd) is caused by an abnormal degeneration of the dopamine (da) producing cells in the substantia nigra (sn) and ventral tegmentum area (vta) in combination with a varying decay of the noradrenergic (locus coeruleus), cholinergic forebrain (nucleus basalis of meynert) and serotoninergic (dorsal raphe nuclei) systems, leading to a multitude of motor and non-motor behavioral disturbances, known as parkinsonism. |
2001-04-12 |
2023-08-12 |
Not clear |
| K L Double, M Gerlach, M B Youdim, P Riedere. Impaired iron homeostasis in Parkinson's disease. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205155. |
pd is associated with a significant increase in iron in the degenerating substantia nigra (sn) and is measureable in living pd patients and in post-mortem brain. |
2001-04-12 |
2023-08-12 |
human |
| R Klink, A de Kerchove d'Exaerde, M Zoli, J P Changeu. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 5. 2001-04-05. PMID:11222635. |
nicotinic acetylcholine receptors (nachrs) on dopaminergic (da) and gabaergic (gaba) projection neurons of the substantia nigra (sn) and ventral tegmental area (vta) are characterized by single-cell rt-pcr and patch-clamp recordings in slices of rat and wild-type, beta2-/-, alpha4-/-, and alpha7-/- mice. |
2001-04-05 |
2023-08-12 |
mouse |
| P M Kid. Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Alternative medicine review : a journal of clinical therapeutic. vol 5. issue 6. 2001-03-01. PMID:11134975. |
parkinson's disease (pd) is the most common movement pathology, severely afflicting dopaminergic neurons within the substantia nigra (sn) along with non-dopaminergic, extra-nigral projection bundles that control circuits for sensory, associative, premotor, and motor pathways. |
2001-03-01 |
2023-08-12 |
Not clear |
| T Araki, H Tanji, K Fujihara, H Kato, Y Imai, M Mizugaki, Y Itoyam. Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041269. |
no significant change was observed in the substantia nigra (sn) of both ipsilateral and contralateral sides throughout the postlesion periods. |
2001-02-15 |
2023-08-12 |
rat |
| J Witta, J S Baffi, M Palkovits, E Mezey, S O Castillo, V M Nikode. Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation. Brain research. Molecular brain research. vol 84. issue 1-2. 2001-02-15. PMID:11113533. |
da biosynthetic enzymes, transporters and receptors are absent in the substantia nigra (sn) and the ventral tegmental area (vta) of nurr1-null neonates. |
2001-02-15 |
2023-08-12 |
mouse |
| G Costa, J A Abin-Carriquiry, F Daja. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain research. vol 888. issue 2. 2001-02-15. PMID:11150495. |
in this context, we investigated the capability of various systemic administration schedules of nicotine to prevent the loss of striatal dopamine levels produced by partial or extensive 6-hydroxydopamine (6-ohda) lesion of rat substantia nigra (sn). |
2001-02-15 |
2023-08-12 |
rat |
| J Strelau, A Sullivan, M Böttner, P Lingor, E Falkenstein, C Suter-Crazzolara, D Galter, J Jaszai, K Krieglstein, K Unsicke. Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102463. |
unilateral injections of gdf-15/mic-1 into the medial forebrain bundle just above the substantia nigra (sn) and into the left ventricle (20 microgram each) immediately before a 6-ohda injection (8 microgram) prevented 6-ohda-induced rotational behavior and significantly reduced losses of daergic neurons in the sn. |
2001-02-08 |
2023-08-12 |
rat |
| J Diaz, C Pilon, B Le Foll, C Gros, A Triller, J C Schwartz, P Sokolof. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102473. |
in rat brain, the distribution of immunoreactivity matched that of d(3)r binding, revealed using [(125)i]r(+)trans-7-hydroxy-2-[n-propyl-n-(3'-iodo-2'-propenyl)amino] tetralin ([(125)i]7-trans-oh-pipat), with dense signals in the islands of calleja and mammillary bodies, and moderate to low signals in the shell of nucleus accumbens (accsh), frontoparietal cortex, substantia nigra (sn), ventral tegmental area (vta) and lobules 9 and 10 of the cerebellum. |
2001-02-08 |
2023-08-12 |
mouse |
| C Verney, N Zecevic, L Puelle. Structure of longitudinal brain zones that provide the origin for the substantia nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions. The Journal of comparative neurology. vol 429. issue 1. 2001-01-18. PMID:11086287. |
in a previous work, mapping early tyrosine hydroxylase (th) expressing primordia in human embryos, the tegmental origin of the substantia nigra (sn) and ventral tegmental area (vta) was located across several neuromeric domains: prosomeres 1-3, midbrain, and isthmus (puelles and verney, [1998] j. comp. |
2001-01-18 |
2023-08-12 |
human |