| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
the substantia nigra (sn) is a midbrain center composed of dopaminergic (da-) and gamma aminobutyric acid (gaba)ergic (gaba-) neurons. |
2000-06-23 |
2023-08-12 |
rat |
| K Ikemoto, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagats. Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640637. |
the substantia nigra (sn) neurons also showed 5-ht2a receptor immunoreactivity. |
2000-06-21 |
2023-08-12 |
human |
| H Kim, W Jhoo, E Shin, G Bin. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799693. |
the present study was designed to understand the role of an antioxidant, selenium (se) on methamphetamine (ma)-induced dopaminergic cell damage in the substantia nigra (sn). |
2000-06-21 |
2023-08-12 |
mouse |
| O V Anichtchik, J O Rinne, H Kalimo, P Panul. An altered histaminergic innervation of the substantia nigra in Parkinson's disease. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785440. |
the distribution of histaminergic fibers in the substantia nigra (sn) in postmortem brain samples from patients suffering from parkinson's disease (pd) and normal controls was examined with a specific immunohistochemical method. |
2000-06-13 |
2023-08-12 |
human |
| B Kriem, J C Rostain, J H Abrain. Administration of either non-NMDA receptor agonists or NMDA receptor antagonists into the substantia nigra or the globus pallidus reduces the psychostimulant effect of high helium pressure on locomotor activity in rats. Neuroreport. vol 10. issue 18. 2000-05-23. PMID:10716209. |
we investigated the effects of bilateral injection in either the substantia nigra (sn) or the globus pallidus (gp) of the ampa receptor agonist (+/-)ampa, the kainate receptor agonist kainic acid, the nmda receptor agonist (+/-)-cis-piperidine-2,3-dicarboxylic acid (pda), and the nmda receptor antagonist (+/-)-2-amino-7-phosphono-heptanoic acid (ap-7) in the occurrence of helium pressure-induced lma and myoclonia. |
2000-05-23 |
2023-08-12 |
rat |
| K A Baker, M Hong, D Sadi, I Mende. Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739641. |
in this study, we describe the transplantation of hnt neurons in the substantia nigra (sn) and striatum of the rat model for pd. |
2000-05-23 |
2023-08-12 |
human |
| S W Bottjer, J D Brady, B Cribb. Connections of a motor cortical region in zebra finches: relation to pathways for vocal learning. The Journal of comparative neurology. vol 420. issue 2. 2000-05-12. PMID:10753310. |
the major efferent projections of ad are to: (1) the striatum of avian basal ganglia; (2) a dorsal thalamic zone (including the song-control nuclei dorsomedial nucleus of the posterior thalamus [dmp] and dorsolateral nucleus of the medial thalamus [dlm]); (3) restricted regions within the lateral hypothalamus (stratum cellulare externum [sce]), which may also relay information to the same dorsal thalamic zone; (4) a nucleus in the caudal thalamus (medial spiriform nucleus [spm]); (5) deep layers of the tectum, which project to the thalamic song-control nucleus uva; (6) broad regions of pontine and midbrain reticular formation; and (7) areas within the ventral tegmental area and substantia nigra (ventral tegmental area [avt], substantia nigra [sn]), which overlap with regions that project to area x, a song-control nucleus of avian striatum. |
2000-05-12 |
2023-08-12 |
Not clear |
| J Dymecki, E Bertrand, Z Tomankiewicz, H Szuniewic. Hallervorden-Spatz disease in an adult patient. Folia neuropathologica. vol 37. issue 4. 2000-04-27. PMID:10705643. |
in the brain autopsy symmetric hyperpigmentation of globus pallidus (gp) and reticular part of substantia nigra (sn) was found. |
2000-04-27 |
2023-08-12 |
Not clear |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
the pathologic hallmark of parkinson's disease is the dopaminergic cell death in the substantia nigra (sn). |
2000-04-25 |
2023-08-12 |
rat |
| N G Kholodilov, M Neystat, T F Oo, S M Hutson, R E Burk. Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. Brain research. Molecular brain research. vol 75. issue 2. 2000-04-21. PMID:10686349. |
we have previously shown that apoptotic cell death can be induced in substantia nigra (sn) by developmental striatal target lesion. |
2000-04-21 |
2023-08-12 |
Not clear |
| P T Bywood, S M Johnso. Differential vulnerabilities of substantia nigra catecholamine neurons to excitatory amino acid-induced degeneration in rat midbrain slices. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716898. |
in the present study we investigated whether catecholamine neurons in different regions of the substantia nigra (sn) are differentially vulnerable to excitatory amino acid-induced damage in a midbrain slice preparation. |
2000-04-18 |
2023-08-12 |
rat |
| J N Kay, M Blu. Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. Developmental neuroscience. vol 22. issue 1-2. 2000-04-11. PMID:10657698. |
a robust proliferative response was seen specifically in the substantia nigra (sn) and the dorsal striatum 3 days postlesion; the response persisted 10-14 days. |
2000-04-11 |
2023-08-12 |
mouse |
| S N Haber, J L Fudge, N R McFarlan. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 6. 2000-04-03. PMID:10704511. |
in contrast, the dorsolateral striatum (dls) receives input from a broad expanse of dopamine cells and has a confined input to the substantia nigra (sn). |
2000-04-03 |
2023-08-12 |
Not clear |
| C Rosenblad, D Kirik, A Björklun. Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Experimental neurology. vol 161. issue 2. 2000-03-29. PMID:10686072. |
we report here the time course of nigrostriatal axon degeneration in the partial lesion model of parkinson's disease and the morphological and functional effects of sequential administration of gdnf in the substantia nigra (sn) and striatum during the first 5 weeks postlesion. |
2000-03-29 |
2023-08-12 |
Not clear |
| F M Corrigan, C L Wienburg, R F Shore, S E Daniel, D Man. Organochlorine insecticides in substantia nigra in Parkinson's disease. Journal of toxicology and environmental health. Part A. vol 59. issue 4. 2000-03-20. PMID:10706031. |
the concentrations of organochlorine (oc) compounds in the substantia nigra (sn) were compared in parkinson's disease (pd) with concentrations in brain from cortical lewy body dementia (clbd), alzheimer's disease (ad), and nondemented nonparkinsonian controls (con). |
2000-03-20 |
2023-08-12 |
Not clear |
| A M Lin, T Y Luh, C K Chou, L T H. The antioxidative effect of carboxyfullerenes (C3/D3) on iron-induced oxidative injury in CNS. Annals of the New York Academy of Sciences. vol 890. 2000-03-15. PMID:10668440. |
in urethane-anesthetized rats, intranigral infusion of iron degenerated the nigrostriatal dopaminergic system, including as elevation in lipid peroxidation in the infused substantia nigra (sn) and reductions in k(+)-evoked dopamine overflow and dopamine content in the ipsilateral striatum 7 days after the infusion. |
2000-03-15 |
2023-08-12 |
rat |
| P T Bywood, S M Johnso. Loss of tyrosine hydroxylase immunoreactivity in dendrites is a sensitive index of kainic acid-induced damage in rat substantia nigra neurons in vivo. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696798. |
), the brain fixed and substantia nigra (sn) dopamine neurons and their dendrites labeled using an antibody to tyrosine hydroxylase (th). |
2000-03-13 |
2023-08-12 |
rat |
| B Connor, D A Kozlowski, T Schallert, J L Tillerson, B L Davidson, M C Boh. Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat. Gene therapy. vol 6. issue 12. 2000-02-24. PMID:10637445. |
injection of an adenoviral (ad) vector encoding human glial cell line-derived neurotrophic factor (gdnf) protects dopaminergic (da) neurons in the substantia nigra (sn) of young rats. |
2000-02-24 |
2023-08-12 |
human |
| H C Kim, W K Jhoo, D Y Choi, D H Im, E J Shin, J H Suh, R A Floyd, G Bin. Protection of methamphetamine nigrostriatal toxicity by dietary selenium. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642830. |
ma treatment decreased the dopamine (da) levels in the striatum and substantia nigra (sn) of both se-replete and se-deficient animals. |
2000-02-24 |
2023-08-12 |
mouse |
| C Bäckman, T Perlmann, A Wallén, B J Hoffer, M Morale. A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642835. |
our results indicate that the majority of th-immunoreactive neurons in the substantia nigra (sn; 96%), ventral tegmental area (vta; 95%), retrorubral field (91%), olfactory bulb (85%), linear nucleus raphe (91%) and central grey (61%) express nurr1. |
2000-02-24 |
2023-08-12 |
mouse |