| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Liu, J W Jiang, B C Wilson, L Du, S N Yang, J Y Wang, G C Wu, X D Cao, J S Hon. Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991969. |
a massive degeneration of dopamine-containing neurons in the substantia nigra (sn) in the midbrain is characteristic of parkinson's disease. |
2000-11-03 |
2023-08-12 |
rat |
| T Araki, H Tanji, H Kato, Y Imai, M Mizugaki, Y Itoyam. Temporal changes of dopaminergic and glutamatergic receptors in 6-hydroxydopamine-treated rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 5. 2000-10-30. PMID:10974608. |
in the ipsilateral substantia nigra (sn), a significant decrease in dopamine d(2) receptors was also observed from 1 to 8 weeks of postlesion. |
2000-10-30 |
2023-08-12 |
rat |
| P A Starr, T Subramanian, R A Bakay, T Wichman. Electrophysiological localization of the substantia nigra in the parkinsonian nonhuman primate. Journal of neurosurgery. vol 93. issue 4. 2000-10-16. PMID:11014554. |
new restorative therapies for parkinson disease, aimed at delivering drugs or cells to the substantia nigra (sn), are becoming available. |
2000-10-16 |
2023-08-12 |
monkey |
| A J Herrera, A Castaño, J L Venero, J Cano, A Machad. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiology of disease. vol 7. issue 4. 2000-10-11. PMID:10964613. |
lps induced a strong macrophage/microglial reaction in substantia nigra (sn), with a characteristic clustering of macrophage cells around blood-vessels. |
2000-10-11 |
2023-08-12 |
rat |
| I Suárez, G Bodega, J A Ramos, J J Fernández-Ruiz, B Fernánde. Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra. Developmental neuroscience. vol 22. issue 4. 2000-10-11. PMID:10965147. |
the responses of neurons and astroglial cells to pre- and perinatal exposure to delta(9)-tetrahydrocannabinol (delta(9)-thc) were evaluated in the substantia nigra (sn) of male and female rats, at three postnatal ages (pd21, pd30 and pd70), by immunohistochemical detection of tyrosine hydroxylase (th) in dopaminergic neurons and of glial fibrillary acidic protein (gfap) in astrocytes. |
2000-10-11 |
2023-08-12 |
rat |
| T Nomura, T Yabe, E S Rosenthal, M Krzan, J P Schwart. PSA-NCAM distinguishes reactive astrocytes in 6-OHDA-lesioned substantia nigra from those in the striatal terminal fields. Journal of neuroscience research. vol 61. issue 6. 2000-10-10. PMID:10972955. |
6-hydroxydopamine (6-ohda) lesion of the substantia nigra (sn) causes the appearance of reactive astrocytes not only in the sn but also in the striatal terminal fields, as measured by increased size of the cells and their processes, as well as enhanced expression of glial fibrillary acidic protein (gfap) and an epitope recognized by monoclonal antibody 19d1. |
2000-10-10 |
2023-08-12 |
Not clear |
| G Mateu, A Privat, J Thibault, J Vigno. Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 6. 2000-09-28. PMID:10884605. |
glutamate toxicity was compared in substantia nigra (sn)/striatum (str) and sn/cerebellum (crb) co-cultures on both the entire neuronal population (neuron specific enolase (nse) immunopositive cells) and dopaminergic neurons (tyrosine hydroxylase (th) immunopositive cells). |
2000-09-28 |
2023-08-12 |
Not clear |
| T Vitalis, O Cases, D Engelkamp, C Verney, D J Pric. Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 17. 2000-09-28. PMID:10964956. |
catecholaminergic neurons of the substantia nigra (sn) and the ventral tegmental area (vta) do not express pax6 protein. |
2000-09-28 |
2023-08-12 |
mouse |
| N Jha, O Jurma, G Lalli, Y Liu, E H Pettus, J T Greenamyre, R M Liu, H J Forman, J K Anderse. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10846169. |
oxidative stress appears to play an important role in degeneration of dopaminergic neurons of the substantia nigra (sn) associated with parkinson's disease (pd). |
2000-09-25 |
2023-08-12 |
Not clear |
| A Serino, K Kan, K Graves, C Kule, A Anthon. Age, strain, and semi-chronic hydergine treatment effects on motor activity and neuronal nucleic acid-protein metabolism in male mice. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983845. |
this study was designed to examine the effects of hydergine (dhet), co-dergocrine mesylate, treatment on motor activity and neuronal nucleoprotein metabolism in several motor areas of the aging rodent brain, specifically the caudate-putamen (cp), the substantia nigra (sn), and the cerebral cortex layer v (cx). |
2000-09-25 |
2023-08-12 |
mouse |
| T A Ala, K H Yang, J H Sung, W H Fre. Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients: a cliniconeuropathological study. Acta neuropathologica. vol 99. issue 5. 2000-07-17. PMID:10805094. |
in a retrospective cliniconeuropathological study, we reviewed all the cases received in our dementia brain bank during a 4-year period to determine if all patients with severe substantia nigra (sn) degeneration and sn lewy bodies (lbs) exhibited prominent signs of parkinsonism and were treated for parkinsonism during the disease course. |
2000-07-17 |
2023-08-12 |
Not clear |
| M F Salvatore, A Garcia-Espana, M Goldstein, A Y Deutch, J W Haycoc. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854265. |
the striatum (str), substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) from sprague-dawley rats were harvested 30-40 min after a single injection of either vehicle, haloperidol (2 mg/kg), raclopride (2 mg/kg), clozapine (30 mg/kg), or sch23390 (0.5 mg/kg). |
2000-07-17 |
2023-08-12 |
rat |
| J Chung, S Chang, Y Kim, H Shi. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neuroscience letters. vol 286. issue 3. 2000-07-12. PMID:10832015. |
the effect of zinc ions (zn(2+)) on the neuronal excitability of substantia nigra (sn) where the zinc level is known higher in parkinsonian brains than that in normal brains has not yet been elucidated. |
2000-07-12 |
2023-08-12 |
rat |
| K P Mohanakumar, D Muralikrishnan, B Thoma. Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced neurotoxicity. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802035. |
this also caused significant decrease in glutathione in substantia nigra (sn) and ncp. |
2000-07-03 |
2023-08-12 |
mouse |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
the substantia nigra (sn) is a midbrain center composed of dopaminergic (da-) and gamma aminobutyric acid (gaba)ergic (gaba-) neurons. |
2000-06-23 |
2023-08-12 |
rat |
| K Ikemoto, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagats. Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640637. |
the substantia nigra (sn) neurons also showed 5-ht2a receptor immunoreactivity. |
2000-06-21 |
2023-08-12 |
human |
| H Kim, W Jhoo, E Shin, G Bin. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799693. |
the present study was designed to understand the role of an antioxidant, selenium (se) on methamphetamine (ma)-induced dopaminergic cell damage in the substantia nigra (sn). |
2000-06-21 |
2023-08-12 |
mouse |
| O V Anichtchik, J O Rinne, H Kalimo, P Panul. An altered histaminergic innervation of the substantia nigra in Parkinson's disease. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785440. |
the distribution of histaminergic fibers in the substantia nigra (sn) in postmortem brain samples from patients suffering from parkinson's disease (pd) and normal controls was examined with a specific immunohistochemical method. |
2000-06-13 |
2023-08-12 |
human |
| B Kriem, J C Rostain, J H Abrain. Administration of either non-NMDA receptor agonists or NMDA receptor antagonists into the substantia nigra or the globus pallidus reduces the psychostimulant effect of high helium pressure on locomotor activity in rats. Neuroreport. vol 10. issue 18. 2000-05-23. PMID:10716209. |
we investigated the effects of bilateral injection in either the substantia nigra (sn) or the globus pallidus (gp) of the ampa receptor agonist (+/-)ampa, the kainate receptor agonist kainic acid, the nmda receptor agonist (+/-)-cis-piperidine-2,3-dicarboxylic acid (pda), and the nmda receptor antagonist (+/-)-2-amino-7-phosphono-heptanoic acid (ap-7) in the occurrence of helium pressure-induced lma and myoclonia. |
2000-05-23 |
2023-08-12 |
rat |
| K A Baker, M Hong, D Sadi, I Mende. Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739641. |
in this study, we describe the transplantation of hnt neurons in the substantia nigra (sn) and striatum of the rat model for pd. |
2000-05-23 |
2023-08-12 |
human |