| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Vitalis, O Cases, D Engelkamp, C Verney, D J Pric. Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 17. 2000-09-28. PMID:10964956. |
catecholaminergic neurons of the substantia nigra (sn) and the ventral tegmental area (vta) do not express pax6 protein. |
2000-09-28 |
2023-08-12 |
mouse |
| N Jha, O Jurma, G Lalli, Y Liu, E H Pettus, J T Greenamyre, R M Liu, H J Forman, J K Anderse. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10846169. |
oxidative stress appears to play an important role in degeneration of dopaminergic neurons of the substantia nigra (sn) associated with parkinson's disease (pd). |
2000-09-25 |
2023-08-12 |
Not clear |
| A Serino, K Kan, K Graves, C Kule, A Anthon. Age, strain, and semi-chronic hydergine treatment effects on motor activity and neuronal nucleic acid-protein metabolism in male mice. Life sciences. vol 67. issue 12. 2000-09-25. PMID:10983845. |
this study was designed to examine the effects of hydergine (dhet), co-dergocrine mesylate, treatment on motor activity and neuronal nucleoprotein metabolism in several motor areas of the aging rodent brain, specifically the caudate-putamen (cp), the substantia nigra (sn), and the cerebral cortex layer v (cx). |
2000-09-25 |
2023-08-12 |
mouse |
| T A Ala, K H Yang, J H Sung, W H Fre. Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients: a cliniconeuropathological study. Acta neuropathologica. vol 99. issue 5. 2000-07-17. PMID:10805094. |
in a retrospective cliniconeuropathological study, we reviewed all the cases received in our dementia brain bank during a 4-year period to determine if all patients with severe substantia nigra (sn) degeneration and sn lewy bodies (lbs) exhibited prominent signs of parkinsonism and were treated for parkinsonism during the disease course. |
2000-07-17 |
2023-08-12 |
Not clear |
| M F Salvatore, A Garcia-Espana, M Goldstein, A Y Deutch, J W Haycoc. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854265. |
the striatum (str), substantia nigra (sn), nucleus accumbens (nac), and ventral tegmental area (vta) from sprague-dawley rats were harvested 30-40 min after a single injection of either vehicle, haloperidol (2 mg/kg), raclopride (2 mg/kg), clozapine (30 mg/kg), or sch23390 (0.5 mg/kg). |
2000-07-17 |
2023-08-12 |
rat |
| J Chung, S Chang, Y Kim, H Shi. Zinc increases the excitability of dopaminergic neurons in rat substantia nigra. Neuroscience letters. vol 286. issue 3. 2000-07-12. PMID:10832015. |
the effect of zinc ions (zn(2+)) on the neuronal excitability of substantia nigra (sn) where the zinc level is known higher in parkinsonian brains than that in normal brains has not yet been elucidated. |
2000-07-12 |
2023-08-12 |
rat |
| K P Mohanakumar, D Muralikrishnan, B Thoma. Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced neurotoxicity. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802035. |
this also caused significant decrease in glutathione in substantia nigra (sn) and ncp. |
2000-07-03 |
2023-08-12 |
mouse |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
the substantia nigra (sn) is a midbrain center composed of dopaminergic (da-) and gamma aminobutyric acid (gaba)ergic (gaba-) neurons. |
2000-06-23 |
2023-08-12 |
rat |
| K Ikemoto, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagats. Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640637. |
the substantia nigra (sn) neurons also showed 5-ht2a receptor immunoreactivity. |
2000-06-21 |
2023-08-12 |
human |
| H Kim, W Jhoo, E Shin, G Bin. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain research. vol 862. issue 1-2. 2000-06-21. PMID:10799693. |
the present study was designed to understand the role of an antioxidant, selenium (se) on methamphetamine (ma)-induced dopaminergic cell damage in the substantia nigra (sn). |
2000-06-21 |
2023-08-12 |
mouse |
| O V Anichtchik, J O Rinne, H Kalimo, P Panul. An altered histaminergic innervation of the substantia nigra in Parkinson's disease. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785440. |
the distribution of histaminergic fibers in the substantia nigra (sn) in postmortem brain samples from patients suffering from parkinson's disease (pd) and normal controls was examined with a specific immunohistochemical method. |
2000-06-13 |
2023-08-12 |
human |
| B Kriem, J C Rostain, J H Abrain. Administration of either non-NMDA receptor agonists or NMDA receptor antagonists into the substantia nigra or the globus pallidus reduces the psychostimulant effect of high helium pressure on locomotor activity in rats. Neuroreport. vol 10. issue 18. 2000-05-23. PMID:10716209. |
we investigated the effects of bilateral injection in either the substantia nigra (sn) or the globus pallidus (gp) of the ampa receptor agonist (+/-)ampa, the kainate receptor agonist kainic acid, the nmda receptor agonist (+/-)-cis-piperidine-2,3-dicarboxylic acid (pda), and the nmda receptor antagonist (+/-)-2-amino-7-phosphono-heptanoic acid (ap-7) in the occurrence of helium pressure-induced lma and myoclonia. |
2000-05-23 |
2023-08-12 |
rat |
| K A Baker, M Hong, D Sadi, I Mende. Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease. Experimental neurology. vol 162. issue 2. 2000-05-23. PMID:10739641. |
in this study, we describe the transplantation of hnt neurons in the substantia nigra (sn) and striatum of the rat model for pd. |
2000-05-23 |
2023-08-12 |
human |
| S W Bottjer, J D Brady, B Cribb. Connections of a motor cortical region in zebra finches: relation to pathways for vocal learning. The Journal of comparative neurology. vol 420. issue 2. 2000-05-12. PMID:10753310. |
the major efferent projections of ad are to: (1) the striatum of avian basal ganglia; (2) a dorsal thalamic zone (including the song-control nuclei dorsomedial nucleus of the posterior thalamus [dmp] and dorsolateral nucleus of the medial thalamus [dlm]); (3) restricted regions within the lateral hypothalamus (stratum cellulare externum [sce]), which may also relay information to the same dorsal thalamic zone; (4) a nucleus in the caudal thalamus (medial spiriform nucleus [spm]); (5) deep layers of the tectum, which project to the thalamic song-control nucleus uva; (6) broad regions of pontine and midbrain reticular formation; and (7) areas within the ventral tegmental area and substantia nigra (ventral tegmental area [avt], substantia nigra [sn]), which overlap with regions that project to area x, a song-control nucleus of avian striatum. |
2000-05-12 |
2023-08-12 |
Not clear |
| J Dymecki, E Bertrand, Z Tomankiewicz, H Szuniewic. Hallervorden-Spatz disease in an adult patient. Folia neuropathologica. vol 37. issue 4. 2000-04-27. PMID:10705643. |
in the brain autopsy symmetric hyperpigmentation of globus pallidus (gp) and reticular part of substantia nigra (sn) was found. |
2000-04-27 |
2023-08-12 |
Not clear |
| Y He, T Lee, S K Leon. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700609. |
the pathologic hallmark of parkinson's disease is the dopaminergic cell death in the substantia nigra (sn). |
2000-04-25 |
2023-08-12 |
rat |
| N G Kholodilov, M Neystat, T F Oo, S M Hutson, R E Burk. Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury. Brain research. Molecular brain research. vol 75. issue 2. 2000-04-21. PMID:10686349. |
we have previously shown that apoptotic cell death can be induced in substantia nigra (sn) by developmental striatal target lesion. |
2000-04-21 |
2023-08-12 |
Not clear |
| P T Bywood, S M Johnso. Differential vulnerabilities of substantia nigra catecholamine neurons to excitatory amino acid-induced degeneration in rat midbrain slices. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716898. |
in the present study we investigated whether catecholamine neurons in different regions of the substantia nigra (sn) are differentially vulnerable to excitatory amino acid-induced damage in a midbrain slice preparation. |
2000-04-18 |
2023-08-12 |
rat |
| J N Kay, M Blu. Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. Developmental neuroscience. vol 22. issue 1-2. 2000-04-11. PMID:10657698. |
a robust proliferative response was seen specifically in the substantia nigra (sn) and the dorsal striatum 3 days postlesion; the response persisted 10-14 days. |
2000-04-11 |
2023-08-12 |
mouse |
| S N Haber, J L Fudge, N R McFarlan. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 6. 2000-04-03. PMID:10704511. |
in contrast, the dorsolateral striatum (dls) receives input from a broad expanse of dopamine cells and has a confined input to the substantia nigra (sn). |
2000-04-03 |
2023-08-12 |
Not clear |