| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E M Nikulina, R P Hammer, K A Miczek, R M Krea. Social defeat stress increases expression of mu-opioid receptor mRNA in rat ventral tegmental area. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549815. |
because opioids mediate significant regulatory activities of brain dopamine neurons, dopaminergic loci in the ventral tegmental area (vta) and substantia nigra (sn) were selected for analysis. |
2000-01-04 |
2023-08-12 |
rat |
| K Honda, J Riehl, E Mignot, S Nishin. Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep [corrected]. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549832. |
we further assessed the roles of the mesostriatal dopaminergic system and found that local perfusion of quinpirole and 7-oh-dpat into the substantia nigra (sn) significantly aggravated cataplexy, while perfusion of a d2/d3 antagonist significantly reduced cataplexy. |
2000-01-04 |
2023-08-12 |
Not clear |
| Y Q Wang, X D Cao, G C W. Role of dopamine receptors and the changes of the tyrosine hydroxylase mRNA in acupuncture analgesia in rats. Acupuncture & electro-therapeutics research. vol 24. issue 2. 1999-12-13. PMID:10579240. |
noxious electric stimulation was found to elevate the th mrna level in substantia nigra (sn) and hypothalamus, while electro-acupuncture attenuated the effect of noxious stimulation on th mrna. |
1999-12-13 |
2023-08-12 |
rat |
| D Berg, G Becker, B Zeiler, O Tucha, E Hofmann, M Preier, P Benz, W Jost, K Reiners, K W Lang. Vulnerability of the nigrostriatal system as detected by transcranial ultrasound. Neurology. vol 53. issue 5. 1999-11-15. PMID:10496262. |
to assess the incidence of a hyperechogenic substantia nigra (sn) by transcranial sonography (tcs) in healthy people and to evaluate whether an enlarged hyperechogenic sn area is associated with functional impairment of the nigrostriatal system. |
1999-11-15 |
2023-08-12 |
Not clear |
| W Le, O M Conneely, Y He, J Jankovic, S H Appe. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537083. |
although adult nurr1 +/- mice show significantly reduced nurr1 protein levels in the substantia nigra (sn), they display a normal range of tyrosine hydroxylase-positive neuron numbers in the sn and normal levels of dopamine in the striatum. |
1999-11-05 |
2023-08-12 |
mouse |
| B Liss, A Neu, J Roepe. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516303. |
the phenotype of substantia nigra (sn) neurons in homozygous weaver (wv/wv) mice was studied by combining patch-clamp and single-cell rt-multiplex pcr techniques in midbrain slices of 14-d-old mice. |
1999-10-28 |
2023-08-12 |
mouse |
| J Han, F C Cheng, Z Yang, G Dryhurs. Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501216. |
in this investigation, microdialysis has been used to study the effects of 1-methyl-4-phenylpyridinium (mpp+), an inhibitor of mitochondrial complex i and alpha-ketoglutarate dehydrogenase and the active metabolite of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), on extracellular concentrations of glutathione (gsh) and cysteine (cysh) in the rat striatum and substantia nigra (sn). |
1999-10-14 |
2023-08-12 |
human |
| D Berg, C Grote, W D Rausch, M Mäurer, W Wesemann, P Riederer, G Becke. Iron accumulation in the substantia nigra in rats visualized by ultrasound. Ultrasound in medicine & biology. vol 25. issue 6. 1999-10-07. PMID:10461717. |
in recent studies, we have found a marked increase in substantia nigra (sn) echogenicity in patients with parkinson's disease (pd) using transcranial ultrasound. |
1999-10-07 |
2023-08-12 |
rat |
| D Wirtshafter, K E Asi. Haloperidol induces Fos expression in the globus pallidus and substantia nigra of cynomolgus monkeys. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415370. |
systemic injections of the dopamine antagonist haloperidol (0.1-2.5 mg/kg) induced a dose dependent increase in fos-like immunoreactivity (fli) in the internal segment of the globus pallidus (gpi) and in the substantia nigra (sn) of cynomolgus monkeys. |
1999-09-28 |
2023-08-12 |
monkey |
| H Théoret, D Boire, M Herbin, M Ptit. Stereological evaluation of substantia nigra cell number in normal and hemispherectomized monkeys. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415395. |
unbiased stereological techniques were used to evaluate cell numbers in the substantia nigra (sn), a structure involved in the control of saccadic eye movements. |
1999-09-28 |
2023-08-12 |
monkey |
| T Araki, H Tanji, H Kato, M Mizugaki, Y Itoyam. Alterations of second messenger systems in the rat brain after 6-hydroxydopamine lesions of the medial forebrain bundle. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 8. issue 4. 1999-09-28. PMID:10425376. |
we studied the sequential changes in second messenger systems in the striatum and substantia nigra (sn) after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. |
1999-09-28 |
2023-08-12 |
rat |
| F Lévy, M Meurisse, G Ferreira, J Thibault, Y Tille. Afferents to the rostral olfactory bulb in sheep with special emphasis on the cholinergic, noradrenergic and serotonergic connections. Journal of chemical neuroanatomy. vol 16. issue 4. 1999-09-28. PMID:10450873. |
other retrogradely labeled neurons were observed in the taenia tecta, the septum, the nucleus of the lateral olfactory tract, the preoptic area, the lateral hypothalamic area, the mediobasal hypothalamus, the lateral part of the premammillary nucleus, the paraventricular nucleus of the hypothalamus, the paraventricular thalamic nucleus, the central grey, the substantia nigra (sn), the ventral tegmental area (vta), the lateral nucleus to the interpeduncular nucleus (iip), the raphe and the locus coeruleus (lc). |
1999-09-28 |
2023-08-12 |
Not clear |
| Z C Xu, W Chwang, X Li, X Chen, P H. Gender difference in dopamine concentration and postischemic neuronal damage in neostriatum after unilateral dopamine depletion. Experimental neurology. vol 158. issue 1. 1999-09-09. PMID:10448430. |
it has been shown that the number of surviving neurons in the right neostriatum dramatically increased following ischemia after lesions were made in the right substantia nigra (sn), whereas no such protective effect was observed in the left neostriatum after left sn lesion. |
1999-09-09 |
2023-08-12 |
rat |
| S ThyagaRajan, S Y Stevens, D L Felte. Region-specific alterations in the concentrations of catecholamines and indoleamines in the brains of young and old F344 rats after L-deprenyl treatment. Brain research bulletin. vol 48. issue 5. 1999-07-28. PMID:10372512. |
the effects of l-deprenyl, a monoamine oxidase-b (mao-b) inhibitor, on the concentrations of norepinephrine (ne), dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), serotonin (5-hydroxytryptamine), and 5-hydroxyindoleacetic acid (5-hiaa) in medial basal hypothalamus (mbh), substantia nigra (sn), striatum (str), and nucleus accumbens (nac) of young (3 month) and old (21 month) male f344 rats were examined after a 7-day wash-out period following 1, 15, or 30 days of deprenyl treatment in young rats and a 9-day wash-out period after a 10-week deprenyl treatment in old rats. |
1999-07-28 |
2023-08-12 |
rat |
| W Duan, M P Mattso. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398297. |
parkinson's disease (pd) is an age-related disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and corresponding motor deficits. |
1999-07-28 |
2023-08-12 |
mouse |
| A F Hoffman, N R Zahniser, C R Lupica, G A Gerhard. Voltage-dependency of the dopamine transporter in the rat substantia nigra. Neuroscience letters. vol 260. issue 2. 1999-06-18. PMID:10025710. |
the possible voltage-dependence of the dopamine transporter (dat) was investigated using electrophysiological and electrochemical recordings in rat brain slices containing the substantia nigra (sn). |
1999-06-18 |
2023-08-12 |
rat |
| K A Jellinge. The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease. Drugs & aging. vol 14. issue 2. 1999-06-09. PMID:10084365. |
a review of the available data in pd provides the following evidence in support of this hypothesis: (i) an increase of iron in the brain, which in pd selectively involves neuromelanin in substantia nigra (sn) neurons; (ii) decreased availability of glutathione (gsh) and other antioxidant substances; (iii) increase of lipid peroxidation products and reactive oxygen (o2)species (ros); and (iv) impaired mitochondrial electron transport mechanisms. |
1999-06-09 |
2023-08-12 |
human |
| M Mikkelsen, A Møller, L H Jensen, A Pedersen, J B Harajehi, H Pakkenber. MPTP-induced Parkinsonism in minipigs: A behavioral, biochemical, and histological study. Neurotoxicology and teratology. vol 21. issue 2. 1999-06-09. PMID:10192277. |
the number of cells in substantia nigra (sn) showed a decline only 3 months after mptp treatment. |
1999-06-09 |
2023-08-12 |
Not clear |
| E Charpantier, P Barnéoud, P Moser, F Besnard, F Sgar. Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804323. |
using the reverse transcriptase-polymerase chain reaction we have analyzed the mrna for nachr subunits expressed in the substantia nigra (sn) and ventral tegmental area (vta) following unilateral 6-hydroxydopamine lesion of the dopaminergic system. |
1999-06-07 |
2023-08-12 |
rat |
| I Kurkowska-Jastrzebska, A Wrońska, M Kohutnicka, A Członkowski, A Członkowsk. MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson's disease. Acta neurobiologiae experimentalis. vol 59. issue 1. 1999-06-03. PMID:10230070. |
microglial activation was observed in the striatum and in the substantia nigra (sn) in this model. |
1999-06-03 |
2023-08-12 |
mouse |