| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Zhang, G Perry, M A Smith, D Robertson, S J Olson, D G Graham, T J Montin. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. The American journal of pathology. vol 154. issue 5. 1999-06-03. PMID:10329595. |
oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (sn) of patients with parkinson's disease (pd). |
1999-06-03 |
2023-08-12 |
Not clear |
| T Torii, T Kawarai, S Nakamura, H Kawakam. Organization of the human orphan nuclear receptor Nurr1 gene. Gene. vol 230. issue 2. 1999-06-01. PMID:10216261. |
recent reports have revealed that nurr1 (also known as not/tinur/rnr-1/hzf-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (sn) and ventral tegmental area (vta). |
1999-06-01 |
2023-08-12 |
mouse |
| T A Ala, K H Yang, J H Sung, W H Fre. Clinical parkinsonism in dementia patients with substantia nigra Lewy bodies. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 1. 1999-05-25. PMID:10195334. |
in a retrospective clinicopathological study, we examined the substantia nigra (sn) of 48 dementia patients with sn lewy bodies (lbs) to determine if the severity of degeneration correlated with either the occurrence of signs of parkinsonism at dementia presentation or with the frequency of treatment for parkinsonism during the disease course. |
1999-05-25 |
2023-08-12 |
Not clear |
| M K Lakshmana, B S Rao, N K Dhingra, R Ravikumar, Govindaiah, S Sudha, B L Meti, T R Raj. Role of monoamine oxidase type A and B on the dopamine metabolism in discrete regions of the primate brain. Neurochemical research. vol 23. issue 8. 1999-05-21. PMID:9704592. |
levels of da and its metabolites, dihydroxy phenylacetic acid (dopac) and homovanillic acid (hva) were estimated in frontal cortex (fc), motor cortex (mc), occipital cortex (oc), entorhinal cortex (ec), hippocampus (hi), hypothalamus (hy), caudate nucleus (cn), globus pallidus (gp) and substantia nigra (sn). |
1999-05-21 |
2023-08-12 |
monkey |
| M Yamada, T Oligino, M Mata, J R Goss, J C Glorioso, D J Fin. Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 7. 1999-05-12. PMID:10097166. |
6-hydroxydopamine (6-ohda) is widely used to selectively lesion dopaminergic neurons of the substantia nigra (sn) in the creation of animal models of parkinson's disease. |
1999-05-12 |
2023-08-12 |
rat |
| E M Mills, P G Gunasekar, L Li, J L Borowitz, G E Iso. Differential susceptibility of brain areas to cyanide involves different modes of cell death. Toxicology and applied pharmacology. vol 156. issue 1. 1999-05-07. PMID:10101094. |
on the other hand, in the substantia nigra (sn), kcn produced a progressive, bilateral necrotic lesion that was evident by 3 days of treatment. |
1999-05-07 |
2023-08-12 |
mouse |
| S Hunot, N Dugas, B Faucheux, A Hartmann, M Tardieu, P Debré, Y Agid, B Dugas, E C Hirsc. FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 9. 1999-05-07. PMID:10212304. |
among several toxic oxidative species, nitric oxide (no) has been proposed as a key element on the basis of the increased density of glial cells expressing inducible nitric oxide synthase (inos) in the substantia nigra (sn) of patients with pd. |
1999-05-07 |
2023-08-12 |
human |
| D A McRitchie, H Cartwright, S M Pond, C J van der Schyf, N Castagnoli, D G van der Nest, G M Hallida. The midbrain dopaminergic cell groups in the baboon Papio ursinus. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078618. |
dorsal and ventral tiers of the a9 substantia nigra (sn) pars compacta and all divisions of the a8 and a10 cell groups were identified revealing a high degree of homology in the arrangement of chemically distinct midbrain neurons between primates. |
1999-05-06 |
2023-08-12 |
human |
| I Lamensdorf, N Meiri, J Harvey-White, D M Jacobowitz, I J Kopi. Kir6.2 oligoantisense administered into the globus pallidus reduces apomorphine-induced turning in 6-OHDA hemiparkinsonian rats. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082813. |
basal ganglia (bg), especially in the substantia nigra (sn) reticulata and the globus pallidus (gp), have a high density of katps. |
1999-05-06 |
2023-08-12 |
rat |
| B Liss, R Bruns, J Roepe. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. The EMBO journal. vol 18. issue 4. 1999-04-26. PMID:10022826. |
we combined functional analysis of k-atp channels with expression profiling of k-atp subunits at the level of single substantia nigra (sn) neurons in mouse brain slices using an rt-multiplex pcr protocol. |
1999-04-26 |
2023-08-12 |
mouse |
| A F Hoffman, G A Gerhard. Differences in pharmacological properties of dopamine release between the substantia nigra and striatum: an in vivo electrochemical study. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10087038. |
the properties of dopamine (da) release in the rat substantia nigra (sn) and striatum were investigated using high-speed chronoamperometric recordings in brain slices. |
1999-04-21 |
2023-08-12 |
rat |
| C Winkler, C Bentlage, G Nikkhah, M Samii, A Björklun. Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072293. |
in line with the current model of basal ganglia function, this suggests that the lesion-induced overactivity of the basal ganglia output structures, i.e., the substantia nigra (sn) and the entopeduncular nucleus, may not be completely reversed by intrastriatal vm grafts. |
1999-04-07 |
2023-08-12 |
rat |
| A Bortolozzi, R O Duffard, M Rubio, N Sturtz, A M Evangelista de Duffar. Regionally specific changes in central brain monoamine levels by 2,4-dichlorophenoxyacetic acid in acute treated rats. Neurotoxicology. vol 19. issue 6. 1999-03-16. PMID:9863773. |
the prefrontal cortex (pfc), striatum, nucleus accumbens (na), midbrain, ventral tegmental area (vta), substantia nigra (sn) and cerebellum were assayed. |
1999-03-16 |
2023-08-12 |
rat |
| T Araki, H Tanji, H Kato, Y Itoyam. Sequential changes of dopaminergic receptors in the rat brain after 6-hydroxydopamine lesions of the medial forebrain bundle. Journal of the neurological sciences. vol 160. issue 2. 1999-03-03. PMID:9849794. |
degeneration of the nigrostriatal pathway caused a significant loss of dopamine uptake sites in the ipsilateral striatum, substantia nigra (sn) and ventral tegmental area (vta) in the lesioned animals. |
1999-03-03 |
2023-08-12 |
rat |
| A Inanobe, Y Yoshimoto, Y Horio, K I Morishige, H Hibino, S Matsumoto, Y Tokunaga, T Maeda, Y Hata, Y Takai, Y Kurach. Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 3. 1999-02-25. PMID:9920664. |
in substantia nigra (sn), however, mrna of kir3.1 does not express, whereas that of kir3.2 clearly does. |
1999-02-25 |
2023-08-12 |
Not clear |
| T F Oo, C Henchcliffe, D James, R E Burk. Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra. Journal of neurochemistry. vol 72. issue 2. 1999-02-11. PMID:9930727. |
we have shown that programmed cell death, with the morphology of apoptosis, occurs in dopamine neurons of the substantia nigra (sn) during normal postnatal development and that this death event can be induced by early striatal target injury. |
1999-02-11 |
2023-08-12 |
Not clear |
| M E Olds, D B Jacques, O Kopyo. Globus pallidus lesions depress the excitatory responses to apomorphine but not amphetamine in the subthalamic nucleus of the behaving rat with a 6-OHDA nigra lesion. Brain research. vol 812. issue 1-2. 1999-02-10. PMID:9813239. |
bilateral electrolytic lesions of the globus pallidus (gp), superimposed on the earlier unilateral lesion in substantia nigra (sn) with 6-hydroxydopamine (6-ohda) affected differently the excitatory responses in the stn evoked by amphetamine and apomorphine and the motor responses to the drugs recorded concurrently. |
1999-02-10 |
2023-08-12 |
rat |
| S H Tseng, S M Li. Substantia nigra lesion suppresses the antagonistic effects of N-methyl-D-aspartate receptor antagonist (MK-801) on the autotomy in the rat. Neuroscience letters. vol 255. issue 3. 1999-02-10. PMID:9832199. |
rats received right dorsal root ganglionectomy (drgn) to induce autotomy, and were treated with mk-801 and/or left substantia nigra (sn) lesion after drgn. |
1999-02-10 |
2023-08-12 |
rat |
| J H Son, H S Chun, T H Joh, S Cho, B Conti, J W Le. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 1. 1999-02-05. PMID:9870933. |
the major pathological lesion of parkinson's disease (pd) is the selective cell death of dopaminergic (da) neurons in substantia nigra (sn). |
1999-02-05 |
2023-08-12 |
mouse |
| D L Choi-Lundberg, Q Lin, T Schallert, D Crippens, B L Davidson, Y N Chang, Y L Chiang, J Qian, L Bardwaj, M C Boh. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878166. |
previously, we observed that an adenoviral (ad) vector encoding human glial cell line-derived neurotrophic factor (gdnf), injected near the rat substantia nigra (sn), protects sn dopaminergic (da) neuronal soma from 6-hydroxydopamine (6-ohda)-induced degeneration. |
1999-02-04 |
2023-08-12 |
human |