| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Erhardt, B Andersson, H Nissbrandt, G Engber. Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by gamma-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA(B) receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 6. 1998-10-16. PMID:9686936. |
previous studies have shown that administration of gamma-hydroxybutyric acid (ghba) or the gaba(b) receptor agonist baclofen are associated with a decrease in firing rate, a regularisation of firing pattern and a decrease in burst activity of midbrain dopamine (da) neurons in the substantia nigra (sn). |
1998-10-16 |
2023-08-12 |
rat |
| T Nakagomi, H Kanemitsu, K Narita, H Nakayama, T Ishii, A Tamur. Enhanced protein synthesis in the ipsilateral substantia nigra following middle cerebral artery occlusion in the rat. Acta neuropathologica. vol 95. issue 6. 1998-10-15. PMID:9650747. |
following focal cerebral ischemia, neuronal cell death is detected in remote areas of the brain, including the ipsilateral thalamus and substantia nigra (sn), as well as in the ischemic core. |
1998-10-15 |
2023-08-12 |
rat |
| Y S Kim, W S Joo, B K Jin, Y H Cho, H H Baik, C W Par. Melatonin protects 6-OHDA-induced neuronal death of nigrostriatal dopaminergic system. Neuroreport. vol 9. issue 10. 1998-10-14. PMID:9694233. |
analysis by tyrosine hydroxylase (th) immunocytochemistry revealed the loss of cell bodies in the substantia nigra (sn) and absence of terminals in the dorsolateral striatum ipsilaterally. |
1998-10-14 |
2023-08-12 |
rat |
| D Kirik, C Rosenblad, A Björklun. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Experimental neurology. vol 152. issue 2. 1998-09-24. PMID:9710526. |
the results show that a 60-70% reduction in tyrosine hydroxylase (th)-positive fiber density in the lateral striatum, accompanied by a 50-60% reduction in th-positive cells in substantia nigra (sn), is sufficient for the induction of significant impairment in initiation of stepping. |
1998-09-24 |
2023-08-12 |
rat |
| S M Williams, P S Goldman-Raki. Widespread origin of the primate mesofrontal dopamine system. Cerebral cortex (New York, N.Y. : 1991). vol 8. issue 4. 1998-09-11. PMID:9651129. |
da afferents innervating the macaque frontal cortex as a whole originate from an unexpectedly widespread continuum of neurons distributed in the dorsal aspects of all three of the mesencephalic da cell groups [a9, a10 and a8; generally corresponding to the da cells of the substantia nigra (sn), vta, and the retrorubral area (rra) respectively]. |
1998-09-11 |
2023-08-12 |
monkey |
| D G Walker, K Terai, A Matsuo, T G Beach, E G McGeer, P L McGee. Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases. Brain research. vol 794. issue 2. 1998-08-27. PMID:9622624. |
the use of neurotrophic growth factors as a means of preventing loss of the dopaminergic (da) neurons in the substantia nigra (sn) is becoming an accepted treatment strategy for parkinson's disease (pd). |
1998-08-27 |
2023-08-12 |
human |
| S Chen, W D Le, W J Xie, M E Alexianu, J I Engelhardt, L Siklós, S H Appe. Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins. Archives of neurology. vol 55. issue 8. 1998-08-26. PMID:9708957. |
increased levels of free radicals and oxidative stress may contribute to the pathogenesis of substantia nigra (sn) injury in parkinson disease (pd), but the initiating etiologic factors remain undefined in most cases. |
1998-08-26 |
2023-08-12 |
Not clear |
| S O Castillo, J S Baffi, M Palkovits, D S Goldstein, I J Kopin, J Witta, M A Magnuson, V M Nikode. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Molecular and cellular neurosciences. vol 11. issue 1-2. 1998-08-07. PMID:9608532. |
dopamine (da) was absent in the substantia nigra (sn) and ventral tegmental area (vta) of nurr1-null mice, consistent with absent tyrosine hydroxylase (th), l-aromatic amino acid decarboxylase, and other da neuron markers. |
1998-08-07 |
2023-08-12 |
mouse |
| Y Ishida, H Hashiguchi, K Todaka, I Kuwahara, Y Ishizuka, H Nakane, D Uchimura, T Nishimori, Y Mitsuyam. Serotonergic activity in the rat striatum after intrastriatal transplantation of fetal nigra as measured by microdialysis. Brain research. vol 788. issue 1-2. 1998-07-23. PMID:9555017. |
dialysis perfusates were collected from intact 6-hydroxydopamine (6-ohda) lesion plus sham grafted, and lesion plus fetal substantia nigra (sn) grafted striata. |
1998-07-23 |
2023-08-12 |
rat |
| D G Walker, T G Beach, R Xu, J Lile, K D Beck, E G McGeer, P L McGee. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593897. |
in this study, tissue sections of human substantia nigra (sn) from normal and pd cases were examined to determine the pattern of ret expression in this region, and whether there was continued ret expression in surviving dopaminergic neurons in pd cases. |
1998-07-20 |
2023-08-12 |
human |
| A Fisher, C S Biggs, M S Star. Differential effects of NMDA and non-NMDA antagonists on the activity of aromatic L-amino acid decarboxylase activity in the nigrostriatal dopamine pathway of the rat. Brain research. vol 792. issue 1. 1998-07-13. PMID:9593857. |
this study examined the acute effects of a variety of nmda and non-nmda antagonists on the activity of aromatic l-amino acid decarboxylase (aadc) in the corpus striatum (cs) and substantia nigra (sn) of the rat. |
1998-07-13 |
2023-08-12 |
rat |
| S H Lin, S Miyata, W Matsunaga, T Kawarabayashi, T Nakashima, T Kiyohar. Metabolic mapping of the brain in pregnant, parturient and lactating rats using fos immunohistochemistry. Brain research. vol 787. issue 2. 1998-07-10. PMID:9518626. |
in parturient rats, a significant number of fos-positive neurons was observed as compared to virgin or pregnant females in the following brain regions; the bed nucleus of the stria terminalis (bst), lateral septal nucleus (ls), medial preoptic area (mpa), periventricular hypothalamic nucleus (pe), parvocellular paraventricular hypothalamic nucleus (papvn), magnocellular paraventricular hypothalamic nucleus (mapvn), supraoptic nucleus (son), paraventricular thalamic nucleus (pv), anterior hypothalamic area (aha), lateral hypothalamic area (lh), amygdaloid nucleus (am), supramammillary nucleus (sum), substantia nigra (sn), central grey (cg), microcellular tegmental nucleus (mitg), subparafascicular thalamic nucleus (spf), posterior hypothalamic area (ph), dorsal raphe nucleus (dr), locus coeruleus (lc), dorsal parabrachial nucleus (dpb), nucleus of solitary tract (sol), and ventrolateral medulla (vlm). |
1998-07-10 |
2023-08-12 |
rat |
| S M Johnson, P T Bywoo. Degeneration of the dendritic arbor as an index of neurotoxicity in identified catecholamine neurons in rat brain slices. Experimental neurology. vol 151. issue 2. 1998-07-09. PMID:9628757. |
in this study we examined neurons in the substantia nigra (sn). |
1998-07-09 |
2023-08-12 |
rat |
| S M Johnson, P T Bywoo. Excitatory amino acid-induced degeneration of dendrites of catecholamine neurons in rat substantia nigra. Experimental neurology. vol 151. issue 2. 1998-07-09. PMID:9628758. |
we have recently established a rat substantia nigra (sn) slice preparation in which a sensitive index of excitatory amino acid (eaa) toxicity was degeneration of the dendritic arbor of catecholamine neurons labelled by immunostaining for tyrosine hydroxylase (th). |
1998-07-09 |
2023-08-12 |
rat |
| I Grofova, M Zho. Nigral innervation of cholinergic and glutamatergic cells in the rat mesopontine tegmentum: light and electron microscopic anterograde tracing and immunohistochemical studies. The Journal of comparative neurology. vol 395. issue 3. 1998-07-08. PMID:9596529. |
the substantia nigra (sn) has long been known as an important source of afferents to the pedunculopontine tegmental nucleus (ppn). |
1998-07-08 |
2023-08-12 |
rat |
| H Moore, C L Todd, A A Grac. Striatal extracellular dopamine levels in rats with haloperidol-induced depolarization block of substantia nigra dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634572. |
correlations between substantia nigra (sn) dopamine (da) cell activity and striatal extracellular da were examined using simultaneous extracellular single-unit recordings and in vivo microdialysis performed in drug-naive rats and in rats treated repeatedly with haloperidol (hal). |
1998-07-02 |
2023-08-12 |
rat |
| R F Seegal, B A Pappas, G A Par. Neurochemical effects of consumption of Great Lakes salmon by rats. Regulatory toxicology and pharmacology : RTP. vol 27. issue 1 Pt 2. 1998-06-23. PMID:9618335. |
concentrations of biogenic amines, their metabolites, and choline acetyltransferase (chat) were determined in the frontal cortex (fc), nucleus accumbens, caudate nucleus (cn), hippocampus (hc), and substantia nigra (sn) of adult rats who had been exposed, both perinatally and as adults, to standard rat chow adulterated with either 5 or 20% (w/w) lyophilized fillets from either lake huron (lh) or lake ontario (lo) salmon. |
1998-06-23 |
2023-08-12 |
human |
| N S Kolomeets, N A Uranov. [Synaptic contacts in schizophrenia: study with immunocytochemical identification of dopaminergic neurons]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 97. issue 12. 1998-06-09. PMID:9591064. |
the ultrastructure of synaptic contacts located on dopaminergic (tyrosine hydroxylase immunopositive--tp) neurons was investigated in substantia nigra (sn) of postmortem brains in 4 schizophrenic patients compared to 3 mentally healthy control cases. |
1998-06-09 |
2023-08-12 |
Not clear |
| D F Brown, M A Dababo, E H Bigio, R C Risser, K P Eagan, C L Hladik, C L Whit. Neuropathologic evidence that the Lewy body variant of Alzheimer disease represents coexistence of Alzheimer disease and idiopathic Parkinson disease. Journal of neuropathology and experimental neurology. vol 57. issue 1. 1998-06-08. PMID:9600196. |
we retrieved 30 autopsy cases in which lewy bodies (lb) had been identified in the substantia nigra (sn) in routine hematoxylin-eosin-stained sections. |
1998-06-08 |
2023-08-12 |
rabbit |
| M Turgu. Asymmetry of sympathetic activity in a rat model of Parkinson's disease induced by 6-hydroxydopamine: haemodynamic, electrocardiographic and biochemical changes. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 197. issue 5. 1998-05-27. PMID:9561558. |
one day after apomorphine testing following lesioning of the substantia nigra (sn) with 6-ohda, heart rate (hr), mean arterial blood pressure (map), and electrocardiogram (ecg) were monitored. |
1998-05-27 |
2023-08-12 |
rat |