| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A H Rajput, M e Fenton, S Birdi, R Macaula. Is levodopa toxic to human substantia nigra? Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 5. 1997-11-07. PMID:9380042. |
levodopa (ld) is the most effective drug for symptomatic control of parkinson's disease, but has been suspected to be toxic to substantia nigra (sn) dopaminergic neurons. |
1997-11-07 |
2023-08-12 |
human |
| B Lei, N Adachi, T Nagaro, T Ara. The effect of dopamine depletion on the H2O2 production in the rat striatum following transient middle cerebral artery occlusion. Brain research. vol 764. issue 1-2. 1997-10-23. PMID:9295229. |
the changes in the extracellular concentrations of rat striatal h2o2, dopamine (da) and its metabolites during middle cerebral artery (mca) occlusion and reperfusion were simultaneously examined by microdialysis, and the relationship between the ischemia-induced release of da and the generation of h2o2 was estimated by assessing the effect of the lesion of the substantia nigra (sn). |
1997-10-23 |
2023-08-12 |
rat |
| A F Hoffman, C G van Horne, S Eken, B J Hoffer, G A Gerhard. In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF. Experimental neurology. vol 147. issue 1. 1997-10-16. PMID:9294410. |
dopamine (da) release and metabolism within the substantia nigra (sn) were studied in normal rats, rats with unilateral 6-hydroxydopamine (6-ohda) lesions, and 6-ohda-lesioned rats treated with glial cells line-derived neurotrophic factor (gdnf). |
1997-10-16 |
2023-08-12 |
rat |
| E P Wala, J W Sloan, X Jin. Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats. Pharmacology, biochemistry, and behavior. vol 58. issue 1. 1997-09-30. PMID:9264095. |
flumazenil (flu; 25 micrograms) and dmso-vehicle were focally injected (1 microliter) into the substantia nigra (sn) and the dorsal raphe nucleus (dr) in rats chronically implanted with silastic capsules containing diazepam (dz; 540 mg/week). |
1997-09-30 |
2023-08-12 |
rat |
| C Henchcliffe, R E Burk. Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra. Neuroscience letters. vol 230. issue 1. 1997-09-24. PMID:9259459. |
we reported previously that striatal excitotoxic lesion with quinolinic acid of rat pups during the first 2 weeks of postnatal life results in loss of dopaminergic neurons of the substantia nigra (sn) due to induced apoptosis. |
1997-09-24 |
2023-08-12 |
rat |
| S M Johnson, X Luo, P T Bywoo. Neurotoxic effects of kainic acid on substantia nigra neurons in rat brain slices. Experimental neurology. vol 146. issue 2. 1997-09-19. PMID:9270066. |
we have investigated the neurotoxic effects of kainic acid in a rat brain substantia nigra (sn) slice preparation. |
1997-09-19 |
2023-08-12 |
rat |
| D Offen, I Ziv, A Barzilai, S Gorodin, E Glater, A Hochman, E Melame. Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease. Neurochemistry international. vol 31. issue 2. 1997-09-02. PMID:9220453. |
the function of neuromelanin (nm), the oxidized dopamine (da) polymer, within the da-producing cells in the human and primate substantia nigra (sn), is still an enigma. |
1997-09-02 |
2023-08-12 |
human |
| A Capozzo, T Florio, S Di Loreto, D Adorno, E Scarnat. Transplantation of mesencephalic cell suspension in dopamine-denervated striatum of the rat. II. Effects on corticostriatal transmission. Experimental neurology. vol 146. issue 1. 1997-08-07. PMID:9225747. |
the present study has been designed to investigate whether intrastriatal implantation of mesencephalic dopamine (da)-synthetizing neurons into the striatum (st) of rats whose substantia nigra (sn) was previously destroyed by 6-hydroxydopamine (6-ohda) restores the pattern of corticostriatal transmission from the medial prelimbic and sensorimotor cortices. |
1997-08-07 |
2023-08-12 |
rat |
| J Balthazart, P Absi. Identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the Japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry. The Journal of comparative neurology. vol 382. issue 3. 1997-07-30. PMID:9183702. |
in these last two regions, many retrogradely labeled cells were located in dopaminergic areas such as the retroruberal field (rrf), substantia nigra (sn), and area ventralis of tsai (avt) but also in noradrenergic cell groups such as the locus ceruleus and subceruleus. |
1997-07-30 |
2023-08-12 |
Not clear |
| B Hontanilla, A Parent, J M Giménez-Amay. Parvalbumin and calbindin D-28k in the entopeduncular nucleus, subthalamic nucleus, and substantia nigra of the rat as revealed by double-immunohistochemical methods. Synapse (New York, N.Y.). vol 25. issue 4. 1997-07-24. PMID:9097395. |
the cellular localization of calbindin d-28k (cb) and parvalbumin (pv) was analyzed by means of double-immunohistochemical techniques applied to single sections in the entopeduncular nucleus (ep), the subthalamic nucleus (sth), and the substantia nigra (sn) of the rat. |
1997-07-24 |
2023-08-12 |
rat |
| Y Kawaguch. Neostriatal cell subtypes and their functional roles. Neuroscience research. vol 27. issue 1. 1997-07-21. PMID:9089693. |
the neostriatum is considered to be involved in the induction of purposeful movements or in the suppression of other movements through the internal segment of the globus pallidus (gp; the entopeduncular nucleus in the rodents) and the substantia nigra (sn) to which the striatal spiny neurons project. |
1997-07-21 |
2023-08-12 |
Not clear |
| P S Mohankumar, S M Mohankumar, S K Quadri, J L Voog. Chronic hyperprolactinemia and changes in dopamine neurons. Brain research bulletin. vol 42. issue 6. 1997-07-18. PMID:9128918. |
there was no change in the levels of da, norepinephrine (ne), serotonin (5-ht), or their metabolites in the arcuate nucleus (an), medial preoptic area (mpa), caudate putamen (cp), substantia nigra (sn), and zona incerta (zi), except for a decrease in 5-hydroxyindoleacetic acid (5-hiaa) in the an after 6-months of hyperprolactinemia and an increase in da concentrations in the an after 9-months of hyperprolactinemia. |
1997-07-18 |
2023-08-12 |
rat |
| C Thiffault, L Lamarre-Théroux, R Quirion, J Poirie. L-Deprenyl and MDL72974 do not improve the recovery of dopaminergic cells following systemic administration of MPTP in mouse. Brain research. Molecular brain research. vol 44. issue 2. 1997-07-08. PMID:9073165. |
in addition, l-deprenyl, administered 72 h following mptp, improves the recovery of tyrosine hydroxylase (th) immunopositive neurons in the substantia nigra (sn) of mice. |
1997-07-08 |
2023-08-12 |
mouse |
| G Engberg, A Elverfors, J Jonason, H Nissbrand. Inhibition of dopamine re-uptake: significance for nigral dopamine neuron activity. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021902. |
in the present study the effect of inhibition of the re-uptake of dopamine (da) was analysed with respect to da release and to the firing pattern of da neurons in the substantia nigra (sn). |
1997-07-07 |
2023-08-12 |
Not clear |
| N E Saadé, S F Atweh, N B Bahuth, S J Jabbu. Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons. Brain research. vol 751. issue 1. 1997-06-09. PMID:9098562. |
using various pain tests for acute (hot plate test, hpt, tail flick, tft, paw pressure test, ppt and paw immersion test, pit) and chronic deafferentation (autotomy, at, following peripheral neurectomy) pains in rats, we have investigated the effects on these tests of selective chemical lesions with 6-hydroxydopamine (6-ohda) or/and kainic acid (ka) either in the striatum or in the substantia nigra (sn) and ventral tegmental area (vta). |
1997-06-09 |
2023-08-12 |
rat |
| T Verina, J A Norton, J J Sorbel, L C Triarhou, D Laferty, J A Richter, J R Simon, B Ghett. Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice. Experimental brain research. vol 113. issue 1. 1997-05-29. PMID:9028770. |
we counted tyrosine hydroxylase (th)-immunopositive cells in the substantia nigra (sn), retrorubral nucleus (rrn), and ventral tegmental area (vta), and measured cross-sectional areas of neuronal somata in the sn of wv/+ and age-matched wild-type controls (+/+). |
1997-05-29 |
2023-08-12 |
mouse |
| T F Oo, R E Burk. The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051260. |
we have previously shown that apoptotic natural cell death occurs within the substantia nigra (sn) pars compacta of the rat postnatally. |
1997-05-27 |
2023-08-12 |
rat |
| F Wat. Nuclear microscope analysis in Alzheimer's and Parkinson's disease: A review. Cellular and molecular biology (Noisy-le-Grand, France). vol 42. issue 1. 1997-05-23. PMID:8833663. |
in parkinson's disease (pd) nuclear microscope studies have concentrated on measurements of iron in the substantia nigra (sn) region of the brain; iron was observed to be elevated by a factor 2 in mptp induced parkinsonism in african green monkeys, and by a factor of 1.25 in 6-ohda induced parkinsonism in sprague dawley rats. |
1997-05-23 |
2023-08-12 |
rat |
| M F Kritze. Selective colocalization of immunoreactivity for intracellular gonadal hormone receptors and tyrosine hydroxylase in the ventral tegmental area, substantia nigra, and retrorubral fields in the rat. The Journal of comparative neurology. vol 379. issue 2. 1997-05-21. PMID:9050788. |
to identify which midbrain cells may be targets of genomic influence, double label immunocytochemistry was used to map intracellular estrogen and androgen receptors and tyrosine hydroxylase (th) in the ventral tegmental area (vta), substantia nigra (sn), and retrorubral fields (rrf) in intact, adult rats. |
1997-05-21 |
2023-08-12 |
rat |
| A A Dunn-Meynell, V H Routh, J J McArdle, B E Levi. Low-affinity sulfonylurea binding sites reside on neuronal cell bodies in the brain. Brain research. vol 745. issue 1-2. 1997-04-29. PMID:9037388. |
high-affinity sulfonylurea binding sites are concentrated in areas such as the substantia nigra (sn) where glucose and sulfonylureas increase transmitter release from gaba neurons. |
1997-04-29 |
2023-08-12 |
Not clear |