| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y He, T Lee, S K Leon. Effect of 6-OHDA injection on the AMPA glutamate receptor subunits in the substantia nigra of Sprague-Dawley rats. Neuroscience letters. vol 241. issue 1. 1998-04-28. PMID:9502201. |
parkinson's disease (pd) is characterized by the destruction of dopaminergic cells in the substantia nigra (sn). |
1998-04-28 |
2023-08-12 |
rat |
| T González-Hernández, P Abdala, M Rodrígue. NOS expression in nigral cells after excitotoxic and non-excitotoxic lesion of the pedunculopontine tegmental nucleus. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517471. |
the substantia nigra (sn) receives afferents from cholinergic neurons of the pedunculopontine tegmental nucleus (pptg), a neuronal population that shows high levels of nitric oxide synthase (nos), the enzyme responsible for the synthesis of nitric oxide. |
1998-04-24 |
2023-08-12 |
rat |
| W Löscher, U Ebert, H Lehmann, C Rosenthal, G Nikkha. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. Journal of neuroscience research. vol 51. issue 2. 1998-03-30. PMID:9469573. |
we previously showed that amygdala kindling results in a significant decrease of gaba and its synthesizing enzyme glutamate decarboxylase in substantia nigra (sn), i.e., a region thought to be critically involved in seizure propagation in various models of epilepsy. |
1998-03-30 |
2023-08-12 |
rat |
| Y Chen, E Engidawork, F Loidl, E Dell'Anna, M Goiny, G Lubec, K Andersson, M Herrera-Marschit. Short- and long-term effects of perinatal asphyxia on monoamine, amino acid and glycolysis product levels measured in the basal ganglia of the rat. Brain research. Developmental brain research. vol 104. issue 1-2. 1998-03-20. PMID:9466704. |
the effects of perinatal asphyxia on levels of dopamine (da) and its metabolites, amino acids and glycolysis products, measured in tissue samples from substantia nigra (sn), striatum, ventral tegmental area (vta), and nucleus accumbens (acb), were studied 80 min to 8 days after birth with high performance liquid chromatography (hplc). |
1998-03-20 |
2023-08-12 |
rat |
| Y Fang, A Janowsky, O K Rønneklei. Cocaine exposure in fetal rhesus monkey: consequences for dopamine D1- and D2-like receptor binding densities. Brain research. Developmental brain research. vol 104. issue 1-2. 1998-03-20. PMID:9466719. |
image analysis of receptor autoradiograms revealed a high-density dopamine d1-like receptor binding in the striatum, nucleus accumbens (acb) and the substantia nigra (sn), whereas lower binding densities were observed in the frontal cortex and the habenula (hb). |
1998-03-20 |
2023-08-12 |
monkey |
| T Shishido, Y Watanabe, I Matsuoka, H Nakanishi, S Niw. Acute methamphetamine administration increases tyrosine hydroxylase mRNA levels in the rat locus coeruleus. Brain research. Molecular brain research. vol 52. issue 1. 1998-03-10. PMID:9450687. |
tyrosine hydroxylase (th) mrna levels in the rat substantia nigra (sn), ventral tegmental area (vta) and locus coeruleus (lc) were measured by in situ hybridization histochemistry 1, 4, 6 and 24 h after a single injection of methamphetamine (map, 4 mg/kg, i.p.) |
1998-03-10 |
2023-08-12 |
rat |
| P E Schauwecker, J P Cogen, T Jiang, H W Cheng, T J Collier, T H McNeil. Differential regulation of astrocytic mRNAs in the rat striatum after lesions of the cortex or substantia nigra. Experimental neurology. vol 149. issue 1. 1998-03-06. PMID:9454618. |
this study evaluates the time course of expression of three astrocytic mrnas, glial fibrillary acidic protein (gfap), apolipoprotein e (apoe), and clusterin, in the rat striatum (st) following a unilateral lesion of either the cortex (cx) or the substantia nigra (sn), using northern blot and in situ hybridization analyses. |
1998-03-06 |
2023-08-12 |
rat |
| T J Counihan, G B Landwehrmeyer, D G Standaert, C M Kosinski, C R Scherzer, L P Daggett, G Veliçelebi, A B Young, J B Penne. Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: mesencephalic dopaminergic neurons. The Journal of comparative neurology. vol 390. issue 1. 1998-03-03. PMID:9456178. |
however, detailed knowledge of the anatomical distribution and subtype specificity of glutamate receptors in the dopamine neurons of human substantia nigra (sn) has been lacking. |
1998-03-03 |
2023-08-12 |
human |
| H C Hung, E H Le. MPTP produces differential oxidative stress and antioxidative responses in the nigrostriatal and mesolimbic dopaminergic pathways. Free radical biology & medicine. vol 24. issue 1. 1998-03-02. PMID:9436616. |
results revealed that mptp increased lipid peroxidation in the striatum (st) and decreased glutathione concentration in the substantia nigra (sn) without markedly affecting these measures in the nucleus accumbens (nac) and ventral tegmental area (vta). |
1998-03-02 |
2023-08-12 |
mouse |
| P A Lapchak, D M Araujo, D C Hilt, J Sheng, S Jia. Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease. Brain research. vol 777. issue 1-2. 1998-02-24. PMID:9449424. |
a recombinant adenoviral vector encoding the human glial cell line-derived neurotrophic factor (gdnf) gene (ad-gdnf) was used to express the neurotrophic factor gdnf in the unilaterally 6-hydroxydopamine (6-ohda) denervated substantia nigra (sn) of adult rats ten weeks following the 6-ohda injection. |
1998-02-24 |
2023-08-12 |
human |
| K Thorré, S Sarre, G Ebinger, Y Michott. Characterization of the extracellular serotonin release in the substantia nigra of the freely moving rat using microdialysis. Brain research. vol 772. issue 1-2. 1998-02-19. PMID:9406952. |
the characteristics of the serotonin release were investigated in the substantia nigra (sn) of the freely moving rat using microdialysis. |
1998-02-19 |
2023-08-12 |
rat |
| W Lu, M E Wol. Expression of dopamine transporter and vesicular monoamine transporter 2 mRNAs in rat midbrain after repeated amphetamine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387873. |
we examined ventral tegmental area (vta), substantia nigra (sn) and the transitional zone between vta and sn. |
1998-02-11 |
2023-08-12 |
rat |
| G J Kirouac, J Ciriell. Cardiovascular depressor responses to stimulation of substantia nigra and ventral tegmental area. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435586. |
experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of l-glutamate (glu) stimulation of the substantia nigra (sn) and ventral tegmental area (vta) on arterial pressure (ap) and heart rate (hr). |
1998-02-09 |
2023-08-12 |
rat |
| A F Hoffman, G A Gerhard. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422361. |
high-speed chronoamperometric recordings were used to measure the uptake and clearance of locally applied dopamine (da) within the substantia nigra (sn) of anesthetized rats. |
1998-02-02 |
2023-08-12 |
rat |
| L F Jarskog, H Xiao, M B Wilkie, J M Lauder, J H Gilmor. Cytokine regulation of embryonic rat dopamine and serotonin neuronal survival in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 15. issue 6. 1998-01-29. PMID:9402221. |
this study measured the effects of cytokines on the survival of tyrosine hydroxylase (th) immunoreactive dopamine neurons from the substantia nigra (sn), and 5-hydroxytryptamine (5-ht) immunoreactive serotonin neurons from the rostral raphe (rr), using cultures from embryonic day 14 (e14) rat brain. |
1998-01-29 |
2023-08-12 |
rat |
| P D Shilling, J R Kelsoe, D S Sega. Dopamine transporter mRNA is up-regulated in the substantia nigra and the ventral tegmental area of amphetamine-sensitized rats. Neuroscience letters. vol 236. issue 3. 1998-01-12. PMID:9406754. |
pretreatment with amph which resulted in a sensitization response profile after amph challenge also produced a significant up-regulation of dat mrna in both the ventral tegmental area (vta) (p = 0.01) and substantia nigra (sn) (p < 0.05) compared to the saline controls, whereas there were no significant group differences in d2 mrna in either the sn or the vta. |
1998-01-12 |
2023-08-12 |
rat |
| J Gałazka-Friedman, A Friedma. Controversies about iron in parkinsonian and control substantia nigra. Acta neurobiologiae experimentalis. vol 57. issue 3. 1998-01-12. PMID:9407708. |
this review presents the results of studies, obtained by various methods, of iron in substantia nigra (sn)--a cerebral structure which degenerates in pd--and shows controversies concerning the amount of iron, its redox state, and the iron binding compounds. |
1998-01-12 |
2023-08-12 |
Not clear |
| S J Cragg, C R Hawkey, S A Greenfiel. Comparison of serotonin and dopamine release in substantia nigra and ventral tegmental area: region and species differences. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375669. |
in this study, we compare the electrically evoked, somatodendritic release of dopamine (da) with axonal release of serotonin (5-ht) in the substantia nigra (sn) and ventral tegmental area (vta) in vitro by using fast-scan cyclic voltammetry with carbon-fibre microelectrodes. |
1997-12-12 |
2023-08-12 |
rat |
| B Bontempi, F R Shar. Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 21. 1997-11-20. PMID:9334431. |
to characterize how systemic morphine induces fos protein in dorsomedial striatum and nucleus accumbens (nac), we examined the role of receptors in striatum, substantia nigra (sn), and ventral tegmental area (vta). |
1997-11-20 |
2023-08-12 |
rat |
| S Y Ma, M Röyttä, J O Rinne, Y Collan, U K Rinn. Correlation between neuromorphometry in the substantia nigra and clinical features in Parkinson's disease using disector counts. Journal of the neurological sciences. vol 151. issue 1. 1997-11-20. PMID:9335015. |
previous studies based on single sections have suggested a significant correlation between pigmented neuronal loss in the substantia nigra (sn) and clinical features in parkinson's disease (pd). |
1997-11-20 |
2023-08-12 |
Not clear |