| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmen F M van Hooijdonk, Marieke van der Pluijm, Iris Bosch, Therese A M J van Amelsvoort, Jan Booij, Lieuwe de Haan, Jean-Paul Selten, Elsmarieke van de Giesse. The substantia nigra in the pathology of schizophrenia: A review on post-mortem and molecular imaging findings. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 68. 2023-01-14. PMID:36640734. |
despite being one of the main origins of dopaminergic input to the striatum, the (dys)functioning of the substantia nigra (sn) has been relatively understudied in schizophrenia. |
2023-01-14 |
2023-08-14 |
Not clear |
| Shu-Yi Huang, Zong-Ying Su, Yuan-Yuan Han, Li Liu, Ying-Jie Shang, Zi-Fan Mai, Zhi-Wei Zeng, Chu-Hua L. Cordycepin improved the cognitive function through regulating adenosine A Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 110. 2023-01-12. PMID:36634379. |
cordycepin improved the cognitive function through regulating adenosine a parkinson's disease (pd), the most common neurodegenerative disorder, primarily affects dopaminergic neurons in the substantia nigra (sn). |
2023-01-12 |
2023-08-14 |
Not clear |
| Mengjia Li, Zhengbo Wang, Tianqi Zheng, Tianzhuang Huang, Baoguo Liu, Deqiang Han, Sumei Liu, Bochao Liu, Mo Li, Wei Si, Y Alex Zhang, Yuyu Niu, Zhiguo Che. Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats. Stem cells international. vol 2022. 2023-01-09. PMID:36618021. |
inscs were engrafted into the motor cortex and insc-daps into the striatum and substantia nigra (sn) of a nonhuman primate, respectively. |
2023-01-09 |
2023-08-14 |
human |
| Su-Hui Wu, Ya-Jin Shi, Ying-Feng An, Dan-Dan Zhao, Han-Bing Li, Gen-Lin L. [Neuroprotective effect of cinnamaldehyde in MPTP-induced mouse model of subacute Parkinson's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 23. 2023-01-06. PMID:36604895. |
the number of cells in substantia nigra(sn) in the midbrain of mptp-induced pd model mice was detected based on hematoxylin and eosin(he) staining. |
2023-01-06 |
2023-08-14 |
mouse |
| Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumo. Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. Frontiers in molecular neuroscience. vol 15. 2022-12-26. PMID:36568278. |
a stumbling block in the study of dns in the whole substantia nigra (sn) is the lack of tools to analyze the expression of most of the genes involved in neurotransmission, neurodegeneration, and neuroplasticity, since they are also expressed in other cells of the sn. |
2022-12-26 |
2023-08-14 |
mouse |
| Monika Sharma, Nishant Sharma, Amit Khairna. Intranasal Rotenone Induces Alpha-Synuclein Accumulation, Neuroinflammation and Dopaminergic Neurodegeneration in Middle-Aged Mice. Neurochemical research. 2022-12-26. PMID:36571663. |
we found α-syn accumulation in ob, striatum, substantia nigra (sn) and cortex. |
2022-12-26 |
2023-08-14 |
mouse |
| Hong-Yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Еlena Kaznacheyeva, Xiao-Jun Lu, Hai-Gang Ren, Guang-Hui Wan. Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway. Acta pharmacologica Sinica. 2022-12-19. PMID:36536076. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic (da) neurons and the accumulation of lewy bodies (lb) in the substantia nigra (sn). |
2022-12-19 |
2023-08-14 |
mouse |
| Mojtaba Jokar, Zhijia Jin, Pei Huang, Ying Wang, Youmin Zhang, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Jihua Min, Fangtao Liu, Shengdi Chen, Naying He, E Mark Haacke, Fuhua Ya. Diagnosing Parkinson's Disease by Combining Neuromelanin and Iron Imaging Features Using an Automated Midbrain Template Approach. NeuroImage. 2022-12-17. PMID:36528314. |
most previous studies using manual or semi-automated methods for segmenting the substantia nigra (sn) are time-consuming and, despite raters being well-trained, individual variation can be significant. |
2022-12-17 |
2023-08-14 |
Not clear |
| Aliza T Ehrlich, Pierre Couvineau, Selin Schamiloglu, Stefan Wojcik, Dillon Da Fonte, Amina Mezni, Mark von Zastrow, Kevin J Bender, Michel Bouvier, Brigitte L Kieffe. Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice. Frontiers in cellular neuroscience. vol 16. 2022-12-16. PMID:36523815. |
dopamine (da) neurons are primarily concentrated in substantia nigra (sn) and ventral tegmental area (vta). |
2022-12-16 |
2023-08-14 |
mouse |
| Biman Xu, Tingting He, Yuan Lu, Jia Jia, Barbara J Sahakian, Trevor W Robbins, Lirong Jin, Zheng Y. Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic 'hyperdirect' pathway in Parkinson's disease. NeuroImage. Clinical. vol 36. 2022-12-13. PMID:36510410. |
this study aimed to investigate whether damage to the locus coeruleus (lc) or substantia nigra (sn) might impact inhibitory functions of the fronto-subthalamic hyperdirect or fronto-striatal indirect pathway. |
2022-12-13 |
2023-08-14 |
Not clear |
| Shuanglong Yi, Linfang Wang, Honglei Wang, Margaret S Ho, Shiping Zhan. Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499080. |
pathologically, the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn) and the accumulation of α-synuclein (α-syn)-composed lewy bodies (lbs) and lewy neurites (lns) are key hallmarks. |
2022-12-11 |
2023-08-14 |
Not clear |
| Xue Gan, Jiahan Ren, Tianzhuang Huang, Kunhua Wu, Shulin Li, Yanchao Duan, Zhengbo Wang, Wei Si, Jingkuan We. Pathological α-Synuclein Accumulation, CSF Metabolites Changes and Brain Microstructures in Cynomolgus Monkeys Treated with 6-hydroxydopamine. Neurotoxicology. 2022-12-08. PMID:36476940. |
we found the dopaminergic neurons were significantly reduced and had fragmented morphology in substantia nigra (sn). |
2022-12-08 |
2023-08-14 |
monkey |
| Qinyu Peng, Guoxin Zhang, Xiaodi Guo, Lijun Dai, Min Xiong, Zhaohui Zhang, Liam Chen, Zhentao Zhan. Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-12-08. PMID:36479526. |
microglial activation and neuroinflammation play a key role in the degeneration of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2022-12-08 |
2023-08-14 |
mouse |
| Ying Duan, Pei-Jung Tsai, Betty Jo Salmeron, Yuzheng Hu, Hong Gu, Hanbing Lu, Jean Lud Cadet, Elliot A Stein, Yihong Yan. Compulsive drug-taking is associated with habenula-frontal cortex connectivity. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 50. 2022-12-05. PMID:36469769. |
functional connectivity of lhb with the frontal cortices and substantia nigra (sn) after the punishment phase was positively correlated with the ci in rats that maintained drug sa despite receiving increasing-intensity footshock. |
2022-12-05 |
2023-08-14 |
rat |
| Wei Liang, Lulu Yao, Jiahao Chen, Zhiying Chen, Xiling Wu, Xiaobo Huan. Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-11-28. PMID:36437828. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-11-28 |
2023-08-14 |
rat |
| Hanna Kim, Ji-Yeong Lee, Soo Jeong Park, Eunsang Kwag, Jihye Kim, Joo-Ho Shi. S-nitrosylated PARIS Leads to the Sequestration of PGC-1α into Insoluble Deposits in Parkinson's Disease Model. Cells. vol 11. issue 22. 2022-11-26. PMID:36429110. |
in the sporadic pd model, α-synuclein preformed fibrils (α-syn pffs)-injected mice, we found an increase in paris, sno-paris, and insoluble sequestration of pgc-1α in substantia nigra (sn), resulting in the reduction of mitochondrial dna copy number and atp concentration that were restored by n(ω)-nitro-l-arginine methyl ester, a nitric oxide synthase (nos) inhibitor. |
2022-11-26 |
2023-08-14 |
mouse |
| Vandana Zaman, Kelsey P Drasites, Ali Myatich, Ramsha Shams, Donald C Shields, Denise Matzelle, Azizul Haque, Narendra L Bani. Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430329. |
calpain, a calcium-dependent neutral protease, is widely expressed in the brain, including substantia nigra (sn) dopaminergic (da) neurons. |
2022-11-26 |
2023-08-14 |
human |
| Yura Jang, Olga Pletnikova, Juan C Troncoso, Alexander Y Pantelyat, Ted M Dawson, Liana S Rosenthal, Chan Hyun N. Mass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease. Molecular & cellular proteomics : MCP. 2022-11-24. PMID:36423813. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) of the brain. |
2022-11-24 |
2023-08-14 |
human |
| I O Ishola, A K Oloyo, T G Olubodun-Obadun, O D Godswill, S A Omilabu, O O Adeyem. Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation. Metabolic brain disease. 2022-11-19. PMID:36401682. |
mptp-induced expression of microglia (iba-1), astrocytes (glia fibrillary acidic protein; gfap) as well as degeneration of dopamine neurons (tyrosine hydroxylase positive neurons) in the substantia nigra (sn) were reversed by dsc. |
2022-11-19 |
2023-08-14 |
mouse |
| Diego Perez-Rodriguez, Maria Kalyva, Catherine Santucci, Christos Proukaki. Somatic CNV Detection by Single-Cell Whole-Genome Sequencing in Postmortem Human Brain. Methods in molecular biology (Clifton, N.J.). vol 2561. 2022-11-18. PMID:36399272. |
we also present an unpublished comparison of scwgs generated from the same control substantia nigra (sn) sample, using the latest versions of popular wga chemistries, mda and picoplex. |
2022-11-18 |
2023-08-14 |
human |