| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinhui Wang, Pei Huang, Ewart Mark Haacke, Yu Liu, Youmin Zhang, Zhijia Jin, Yan Li, Qiuyun Xu, Peng Liu, Shengdi Chen, Naying He, Fuhua Ya. Locus coeruleus and substantia nigra neuromelanin magnetic resonance imaging differentiates Parkinson's disease and essential tremor. NeuroImage. Clinical. vol 38. 2023-05-04. PMID:37141646. |
these two tremor disorders may have different pathogenesis related to the substantia nigra (sn) and locus coeruleus (lc). |
2023-05-04 |
2023-08-14 |
Not clear |
| Fei Tang, Liu-Yao Zhou, Ping Li, Ling-Ling Jiao, Kang Chen, Yu-Jie Guo, Xu-Long Ding, Si-Yu He, Biao Dong, Ru-Xiang Xu, Huan Xiong, Peng Le. Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-05-03. PMID:37133631. |
here, we report that acsl4 expression in the substantia nigra (sn) was increased in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated model of pd and in dopaminergic neurons in pd patients. |
2023-05-03 |
2023-08-14 |
mouse |
| Yunan Zhou, Zhihui Li, Chunling Chi, Chunmei Li, Meimei Yang, Bin Li. Identification of Hub Genes and Potential Molecular Pathogenesis in Substantia Nigra in Parkinson's Disease via Bioinformatics Analysis. Parkinson's disease. vol 2023. 2023-04-24. PMID:37089789. |
one of the crucial pathological features of pd is the loss of dopaminergic neurons in the substantia nigra (sn). |
2023-04-24 |
2023-08-14 |
Not clear |
| Alexandra Sobczak, Mushfa Yousuf, Nico Bunzec. Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity. NeuroImage. 2023-04-24. PMID:37094625. |
therefore, this study investigated regional responses and interregional functional connectivity of the lateral (l), medial (m), and ventral (v) substantia nigra (sn), nucleus accumbens (nacc), nucleus basalis of meynert (nbm), and medial septum/diagonal band (ms/db) during reward and punishment anticipation in a social incentive delay task with neutral, positive, and negative feedback using high-resolution fmri (1.5mm |
2023-04-24 |
2023-08-14 |
Not clear |
| Hui Wang, Yiran Men. Application value of peripheral blood IgG and IgM combined with ultrasonic echo parameters of substantia nigra in the diagnosis of Parkinson's disease. Biotechnology & genetic engineering reviews. 2023-04-21. PMID:37083103. |
we study the clinical value of peripheral blood immunoglobulin g (igg) and immunoglobulin m (igm) combined with ultrasonic echo parameters of substantia nigra (sn) in the diagnosis of parkinson's disease (pd). |
2023-04-21 |
2023-08-14 |
Not clear |
| Kazutaka Maeda, Ken-Ichi Inoue, Masahiko Takada, Okihide Hikosak. Environmental context-dependent activation of dopamine neurons via putative amygdala-nigra pathway in macaques. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085491. |
here we show that amygdala neurons are sensitive to environments and may regulate putative dopamine (da) neurons via an inhibitory projection to the substantia nigra (sn). |
2023-04-21 |
2023-08-14 |
Not clear |
| Hayder M Al-Kuraishy, Ali I Al-Gareeb, Yaser Hosny Ali Elewa, Mahmoud Hosny Zahran, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Parkinson's Disease Risk and Hyperhomocysteinemia: The Possible Link. Cellular and molecular neurobiology. 2023-04-19. PMID:37074484. |
parkinson's disease (pd) is one of the most common degenerative brain disorders caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2023-04-19 |
2023-08-14 |
Not clear |
| Peter Riederer, Toshiharu Nagatsu, Moussa B H Youdim, Max Wulf, Johannes M Dijkstra, Jeswinder Sian-Huelsman. Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-04-16. PMID:37062012. |
iron, as well as neuromelanin (nm), show age-dependent increases, and iron is significantly increased in the parkinsonian substantia nigra (sn). |
2023-04-16 |
2023-08-14 |
Not clear |
| Cláudia Saraiva, Jéssica Lopes-Nunes, Marta Esteves, Tiago Santos, Ana Vale, Ana Clara Cristóvão, Raquel Ferreira, Liliana Bernardin. CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival. Molecular neurobiology. 2023-04-15. PMID:37060501. |
herein, we showed that ctbp1 and ctbp2 are expressed in neurons, dopaminergic neurons, astrocytes, and microglia in the substantia nigra (sn) and striatum of adult mice. |
2023-04-15 |
2023-08-14 |
mouse |
| Luigi Fiondella, Priya Gami-Patel, Christian A Blok, Annemieke J M Rozemuller, Jeroen J M Hoozemans, Yolande A L Pijnenburg, Marta Scarioni, Anke A Dijkstr. Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors. Acta neuropathologica communications. vol 11. issue 1. 2023-04-12. PMID:37046309. |
movement disorders (md) have been linked to degeneration of the substantia nigra (sn) in parkinson's disease and include bradykinesia, rigidity, and tremor. |
2023-04-12 |
2023-08-14 |
Not clear |
| Yi Zhuo, Xuan Li, Zhengwen He, Ming L. Pathological mechanisms of neuroimmune response and multitarget disease-modifying therapies of mesenchymal stem cells in Parkinson's disease. Stem cell research & therapy. vol 14. issue 1. 2023-04-11. PMID:37041580. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn); the etiology and pathological mechanism of the disease are still unclear. |
2023-04-11 |
2023-08-14 |
Not clear |
| Zihua Liu, Qiang Ye, Ying Jian. Transcriptomic analysis: the protection of over-expression thioredoxin reductase 1 in Parkinson's disease. Chinese neurosurgical journal. vol 9. issue 1. 2023-04-04. PMID:37013627. |
the pathologic characteristic feature is the loss of dopaminergic neurons in the substantia nigra (sn). |
2023-04-04 |
2023-08-14 |
Not clear |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Leila Asad Samani, Kamran Ghaedi, Ahmad Majd, Maryam Peymani, Masoud Etemadifa. Coordinated modification in expression levels of HSPA1A/B, DGKH, and NOTCH2 in Parkinson's patients' blood and substantia nigra as a diagnostic sign: the transcriptomes' relationship. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-27. PMID:36973590. |
this study aimed to assess the overlap of pd patients' transcriptomes in the substantia nigra (sn) with peripheral blood mononuclear cells (pbmcs) to discover potential biomarkers for diagnosis. |
2023-03-27 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Hebatallah M Saad, Gaber El-Saber Batih. A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects. Inflammopharmacology. 2023-03-24. PMID:36961665. |
parkinson's disease (pd) is an advanced neurodegenerative disease (ndd) caused by the degeneration of dopaminergic neurons (dns) in the substantia nigra (sn). |
2023-03-24 |
2023-08-14 |
Not clear |
| Alexander Grotemeyer, Judith F Fischer, James B Koprich, Jonathan M Brotchie, Robert Blum, Jens Volkmann, Chi Wang I. Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-03-22. PMID:36945016. |
we have used a human α-synuclein mouse model of progressive pd to examine the anti-inflammatory and neuroprotective effects of inflammasome inhibition on dopaminergic (da) neurons in the substantia nigra (sn). |
2023-03-22 |
2023-08-14 |
mouse |
| Alexa F Iannitelli, Arielle Segal, Jean-Francoise Pare, Bernard Mulvey, L Cameron Liles, Steven A Sloan, Katharine E McCann, Joseph D Dougherty, Yoland Smith, David Weinshenke. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945637. |
motor symptoms in parkinson's disease (pd) are caused by degeneration of dopamine (da) neurons of the substantia nigra (sn), while early non-motor symptoms such as anxiety and sleep disturbances are likely mediated by dysfunction of locus coeruleus (lc) norepinephrine (ne) neurons. |
2023-03-22 |
2023-08-14 |
mouse |
| Gaiyan Zhou, Jingru Ren, Danyan Rong, Hao Zhou, Houxu Ning, Hui Wang, Chenxi Pan, Yajie Wang, Ronggui Zhang, Zhiying Guo, Peiyu Huang, Weiguo Li. Monitoring Substantia Nigra Degeneration Using Free Water Imaging across Prodromal and Clinical Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-03-22. PMID:36947674. |
substantia nigra (sn) free water has been suggested as a good surrogate marker in parkinson's disease (pd). |
2023-03-22 |
2023-08-14 |
Not clear |
| Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu, Fabio A Zucca, Luigi Zecca, Moussa Youdim, Maximilian Wulf, Peter Riederer, Johannes M Dijkstr. The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-03-20. PMID:36939908. |
the dark pigment neuromelanin (nm) is abundant in cell bodies of dopamine (da) neurons in the substantia nigra (sn) and norepinephrine (ne) neurons in the locus coeruleus (lc) in the human brain. |
2023-03-20 |
2023-08-14 |
human |
| Regan Odongo, Orhan Bellur, Ecehan Abdik, Tunahan Çakı. Brain-wide transcriptome-based metabolic alterations in Parkinson's disease: human inter-region and human-experimental model correlations. Molecular omics. 2023-03-17. PMID:36928892. |
we found high metabolic correlations between the substantia nigra (sn)- and cerebral cortex-derived tissues. |
2023-03-17 |
2023-08-14 |
human |