| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Namjoon Cho, Jaegeon Joo, Sunkyung Choi, Bu-Gyeong Kang, Andrew J Lee, So-Yeon Youn, Su-Hyung Park, Eun-Mi Kim, Eliezer Masliah, Yuji Ko, Sun-Shin Cha, Inkyung Jung, Kee K Ki. A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction. Heliyon. vol 9. issue 3. 2023-03-14. PMID:36915530. |
based on the transcriptome analysis of substantia nigra (sn) tissues obtained from pd cases and age-matched healthy controls, we identified a novel alternative splicing variant of |
2023-03-14 |
2023-08-14 |
Not clear |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909534. |
while gdnf dose and delivery methods may have contributed to diminished efficacy, one crucial aspect of these clinical studies is that gdnf treatment across all studies began ∼8 years after pd diagnosis; a time point representing several years after near 100% depletion of nigrostriatal dopamine markers in striatum and at least 50% in substantia nigra (sn), and is later than the timing of gdnf treatment in preclinical studies. |
2023-03-13 |
2023-08-14 |
rat |
| Irais E Valenzuela-Arzeta, Luis O Soto-Rojas, Yazmin M Flores-Martinez, Karen M Delgado-Minjares, Bismark Gatica-Garcia, Juan U Mascotte-Cruz, Porfirio Nava, Omar Emiliano Aparicio-Trejo, David Reyes-Corona, Irma A Martínez-Dávila, M E Gutierrez-Castillo, Armando J Espadas-Alvarez, Carlos E Orozco-Barrios, Daniel Martinez-Fon. LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902058. |
we addressed this issue by inducing acute neuroinflammation in the substantia nigra (sn) with a single local administration (5 µg/2 µl saline solution) of lipopolysaccharide (lps). |
2023-03-11 |
2023-08-14 |
rat |
| Xiaoyuan Guo, Lukui Chen, Jianxia L. Plantamajoside Alleviates Substantia Nigra Damage in Parkinson's Disease Mice by Inhibiting HDAC2/MAPK Signaling and Reducing Microglia Polarization. ACS chemical neuroscience. 2023-03-02. PMID:36859770. |
in this study, lipopolysaccharide (lps) was first injected into the right midbrain substantia nigra (sn) of male c57bl/6 mice to establish the pd mouse model. |
2023-03-02 |
2023-08-14 |
mouse |
| Daniel Torrente, Enming J Su, Gerald P Schielke, Mark Warnock, Kris Mann, Daniel A Lawrenc. Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity. Journal of neuroinflammation. vol 20. issue 1. 2023-03-02. PMID:36864439. |
noradrenergic neurons in the locus coeruleus (lc) are the primary source of norepinephrine (ne) in the brain and degeneration of these neurons is reported in the early stages of parkinson's disease (pd), even prior to dopaminergic neuron degeneration in the substantia nigra (sn), which is a hallmark of pd pathology. |
2023-03-02 |
2023-08-14 |
human |
| Jingjing Wu, Tao Guo, Cheng Zhou, Xueqin Bai, Xiaocao Liu, Luyan Gu, Min Xuan, Quanquan Gu, Peiyu Huang, Zhe Song, Baorong Zhang, Xiaojun Xu, Minming Zhang, Xiaojun Gua. Genetic impacts on nigral iron deposition in Parkinson's disease: A preliminary quantitative susceptibility mapping study. CNS neuroscience & therapeutics. 2023-02-28. PMID:36852447. |
dysfunction of iron metabolism, especially in substantia nigra (sn), is widely acknowledged in parkinson's disease (pd), but the genetic influence on iron deposition remains largely unknown. |
2023-02-28 |
2023-08-14 |
Not clear |
| Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P Manfredsson, Susan B Powell, Davide Dulci. Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835612. |
nicotine, a neuroactive component of tobacco, can directly alter the activity of midbrain da neurons and induce non-da neurons in the substantia nigra (sn) to acquire a da phenotype. |
2023-02-25 |
2023-08-14 |
mouse |
| Yu-Hsuan Chen, Yi-Ying Kuo, Yi-Qian You, Ya-Tin Lin, Pei-Chun Che. Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease. Journal of neurochemistry. 2023-02-25. PMID:36840377. |
parkinson's disease (pd) is a common movement disorder caused by a characteristic loss of dopaminergic neurons in the substantia nigra (sn) and degeneration of dopamine terminals in the dorsal striatum. |
2023-02-25 |
2023-08-14 |
mouse |
| Shangpei Wang, Tong Wu, Yajie Cai, Yongqiang Yu, Xianwen Chen, Longsheng Wan. Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson's disease with freezing of gait. Frontiers in aging neuroscience. vol 15. 2023-02-23. PMID:36819729. |
the downregulation of monoamines, especially dopamine in substantia nigra (sn) and norepinephrine in locus coeruleus (lc), may be responsible for freezing of gait (fog) pathological basis in parkinson's disease (pd). |
2023-02-23 |
2023-08-14 |
Not clear |
| Dongning Su, Yawen Gan, Zhe Zhang, Yusha Cui, Zhijin Zhang, Zhu Liu, Zhan Wang, Junhong Zhou, Vesna Sossi, A Jon Stoessl, Tao Wu, Jing Jing, Tao Fen. Multimodal Imaging of Substantia Nigra in Parkinson's Disease with Levodopa-Induced Dyskinesia. Movement disorders : official journal of the Movement Disorder Society. 2023-02-17. PMID:36799459. |
degeneration of the substantia nigra (sn) may contribute to levodopa-induced dyskinesia (lid) in parkinson's disease (pd), but the exact characteristics of sn in lid remain unclear. |
2023-02-17 |
2023-08-14 |
Not clear |
| Anna Kolacheva, Ekaterina Pavlova, Alyona Bannikova, Vsevolod Bogdanov, Dmitry Troshev, Michael Ugrumo. The Gene Expression of Proteins Involved in Intercellular Signaling and Neurodegeneration in the Substantia Nigra in a Mouse Subchronic Model of Parkinson's Disease. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769355. |
the aim of this study was to evaluate changes in the expression of a wide range of genes in the substantia nigra (sn), the central link in the regulation of motor function, in mice in our subchronic model of pd. |
2023-02-11 |
2023-08-14 |
mouse |
| Waijiao Cai, Kazumasa Wakamatsu, Fabio A Zucca, Qing Wang, Kai Yang, Niyaz Mohamadzadehonarvar, Pranay Srivastava, Hitomi Tanaka, Gabriel Holly, Luigi Casella, Shosuke Ito, Luigi Zecca, Xiqun Che. DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease. Progress in neurobiology. 2023-02-06. PMID:36746222. |
neuromelanin (nm) in dopaminergic neurons of human substantia nigra (sn) has a melanic component that consists of pheomelanin and eumelanin moieties and has been proposed as a key factor contributing to dopaminergic neuron vulnerability in parkinson's disease (pd). |
2023-02-06 |
2023-08-14 |
human |
| Nicole K Brown, Joy K Roche, Charlene B Farmer, Rosalinda C Robert. Evidence for upregulation of excitatory synaptic transmission in the substantia nigra in Schizophrenia: a postmortem ultrastructural study. Journal of neural transmission (Vienna, Austria : 1996). 2023-02-03. PMID:36735096. |
we examined and quantified synaptic morphology, which correlates with function, in the postmortem substantia nigra (sn) from 15 schizophrenia and 12 normal subjects. |
2023-02-03 |
2023-08-14 |
human |
| Andrea McKavanagh, Adam Ridzuan-Allen, Barbara A K Kreilkamp, Yachin Chen, José V Manjón, Pierrick Coupé, Martyn Bracewell, Kumar Das, Peter N Taylor, Anthony G Marson, Simon S Kelle. Midbrain structure volume, estimated myelin and functional connectivity in idiopathic generalised epilepsy. Epilepsy & behavior : E&B. vol 140. 2023-01-26. PMID:36702054. |
here, we acquired t1-weighted, t2-weighted, and resting-state fmri scans to investigate differences in volume, estimated myelin content and functional connectivity of the substantia nigra (sn), subthalamic nuclei (subtn) and red nuclei (rn) of the midbrain in ige. |
2023-01-26 |
2023-08-14 |
Not clear |
| Marco Travaglio, Filippos Michopoulos, Yizhou Yu, Rebeka Popovic, Edmund Foster, Muireann Coen, L Miguel Martin. Increased cysteine metabolism in PINK1 models of Parkinson's disease. Disease models & mechanisms. vol 16. issue 1. 2023-01-25. PMID:36695500. |
parkinson's disease (pd), an age-dependent neurodegenerative disease, is characterised by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2023-01-25 |
2023-08-14 |
human |
| Mangui Lin, Guoen Cai, YongJie Li, Yifang Sun, Yang Song, Guofa Cai, Rifeng Jian. Association between Beta Oscillations from Subthalamic Nucleus and Quantitative Susceptibility Mapping in Deep Gray Matter Structures in Parkinson's Disease. Brain sciences. vol 13. issue 1. 2023-01-21. PMID:36672062. |
psdxb showed a significant positive correlation with the average qsm values in dgm structures, including caudate and substantia nigra (sn) ( |
2023-01-21 |
2023-08-14 |
Not clear |
| Qionghui Cai, Na Xu, Yan He, Jiamin Zhu, Fenfen Ye, Zhi Luo, Ruojun Lu, Linshan Huang, Feiyang Zhang, Jiang-Fan Chen, Yan L. α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine A International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36674880. |
here, we coupled two unique behavioral paradigms with two pd models to reveal the following: (i) focally injecting α-syn fibrils into the dorsolateral striatum (dls) and the transgenic expression of a53t-α-syn in the dopaminergic neurons in the substantia nigra (sn, pitx3-ires2-tta/teto-a53t mice) selectively impaired forelimb fine movements induced by the single-pellet reaching task. |
2023-01-21 |
2023-08-14 |
mouse |
| Yufan Chen, Tao Gong, Cong Sun, Aocai Yang, Fei Gao, Tong Chen, Weibo Chen, Guangbin Wan. Regional age-related changes of neuromelanin and iron in the substantia nigra based on neuromelanin accumulation and iron deposition. European radiology. 2023-01-21. PMID:36680605. |
to investigate age-related neuromelanin signal variation and iron content changes in the subregions of substantia nigra (sn) using magnetization transfer contrast neuromelanin-sensitive multi-echo fast field echo sequence in a normal population. |
2023-01-21 |
2023-08-14 |
Not clear |
| Yu Guo, Huan Zhu, Yuanyuan Wang, Tingting Sun, Jiajia Xu, Tie Wang, Weijun Guan, Chunjing Wang, Changqing Liu, Caiyun M. Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model. Cell and tissue research. 2023-01-16. PMID:36645476. |
furthermore, the grafted mipsc-igabaps could survive and migrate from the graft site into the surrounding brain tissue including striatum (st) and substantia nigra (sn) for at least 32 weeks, and significantly improved functional recovery of pd rats from their parkinsonian behavioral defects. |
2023-01-16 |
2023-08-14 |
rat |
| Jin Yi Han, Eun-Hye Lee, Sang-Mi Kim, Chang-Hwan Par. Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes. Biomolecules & therapeutics. 2023-01-15. PMID:36642416. |
pd is caused by loss of dopaminergic (da) neurons in the midbrain substantia nigra (sn) and therefore, replenishment of da neurons via stem cell-based therapy is a potential treatment option. |
2023-01-15 |
2023-08-14 |
mouse |