| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siwei Zhou, Xiaofang Zhou, Zewen Jiang, Jinrong Ma, Yuanmei Li, Zhiyong Qian, Hua L. The Mechanism of SNHG8/Microrna-421-3p/Sorting Nexin 8 Axis on Dopaminergic Neurons in Substantia Nigra in a Mouse Model of Parkinson's Disease. Neurochemical research. 2022-11-18. PMID:36401052. |
expression levels of snhg8, microrna-421-3p (mir-421-3p), and sorting nexin 8 (snx8) in the substantia nigra (sn) of pd mice and rotenone-treated mn9d cells were detected. |
2022-11-18 |
2023-08-14 |
mouse |
| Juan Wan, Yijiang Gao, Jian Tan, Shanqing Yi, Kailiang Huang, Yao Liu, Dong Chang, Jiali Xie, Shuangxi Chen, Heng W. Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson's disease model by AMPK-mediated autophagy. Folia neuropathologica. vol 60. issue 3. 2022-11-16. PMID:36382486. |
we revealed that ma-5 obviously up-regulated the phosphorylation of ampk and promoted the autophagy (indicated by the increased lc3ii/lc3i, parkin, pink and decreased p62) in substantia nigra (sn), ameliorated the motor deficits, up-regulated the expression of th, suppressed the inflammation (indicated by the decreased protein levels of interleukin (il)-1b, il-6, tumour necrosis factor a) in sn in mptp-induced mice. |
2022-11-16 |
2023-08-14 |
mouse |
| Simon Chang, Federica Fermani, Chu-Lan Lao, Lianyun Huang, Mira Jakovcevski, Rossella Di Giaimo, Miriam Gagliardi, Danusa Menegaz, Alexandru Adrian Hennrich, Michael Ziller, Matthias Eder, Rüdiger Klein, Na Cai, Jan M Deussin. Tripartite extended amygdala-basal ganglia CRH circuit drives locomotor activation and avoidance behavior. Science advances. vol 8. issue 46. 2022-11-16. PMID:36383658. |
we identified a population of corticotropin-releasing hormone (crh) neurons in the lateral part of the interstitial nucleus of the anterior commissure (ipacl), a subdivision of the extended amygdala, which exclusively innervate the substantia nigra (sn). |
2022-11-16 |
2023-08-14 |
Not clear |
| Min Hyung Seo, Sujung Ye. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Molecular neurobiology. 2022-11-12. PMID:36369636. |
parkinson's disease (pd) is the second most common neurodegenerative disorder and is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2022-11-12 |
2023-08-14 |
mouse |
| Gabrielle Todd, Caroline D Rae, Janet L Taylor, Nigel C Rogasch, Jane E Butler, Michael Hayes, Robert A Wilcox, Simon C Gandevia, Karl Aoun, Adrian Esterman, Simon J G Lewis, Julie M Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina von Thaler, Clarence Chiang, Kay L Doubl. Motor cortical excitability and pre-supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity. Journal of neuroscience research. 2022-11-10. PMID:36353842. |
substantia nigra (sn) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for parkinson's disease. |
2022-11-10 |
2023-08-14 |
human |
| Sara Ponticorvo, Renzo Manara, Maria Claudia Russillo, Valentina Andreozzi, Lorenzo Forino, Roberto Erro, Marina Picillo, Marianna Amboni, Sofia Cuoco, Gianfranco Di Salle, Francesco Di Salle, Paolo Barone, Fabrizio Esposito, Maria Teresa Pellecchi. Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study. Frontiers in neurology. vol 13. 2022-11-07. PMID:36341112. |
we aimed to characterize longitudinal brain changes in 26 patients with msa (14 msa-p and 12 msa-c) over a 1-year follow-up period in terms of local tissue density and t1w/t2w ratio in a-priori regions, namely, bilateral putamen, cerebellar gray matter (gm), white matter (wm), and substantia nigra (sn). |
2022-11-07 |
2023-08-14 |
Not clear |
| Seojin Lee, Ivan Martinez-Valbuena, Carlos E de Andrea, Maria Villalba-Esparza, Suganthini Ilaalagan, Blas Couto, Naomi P Visanji, Anthony E Lang, Gabor G Kovac. Cell-specific dysregulation of iron and oxygen homeostasis as a novel pathophysiology in PSP. Annals of neurology. 2022-10-30. PMID:36309960. |
progressive supranuclear palsy (psp) is a 4r-tauopathy showing heterogeneous tau cytopathology commencing in the globus pallidus (gp) and the substantia nigra (sn), regions also associated with age-related iron accumulation. |
2022-10-30 |
2023-08-14 |
human |
| Yaohua Chen, Yuping Li, Chunxiang Li, Dan Zhu, Oumei Cheng, Jian Cu. Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes. Neuroscience letters. 2022-10-25. PMID:36283628. |
immunofluorescence and western blotting were used to analyze the level of tyrosine hydroxylase (th) in the substantia nigra (sn) and the expression of c-fos, gfap, p-ampk, mtor, nf-κb, tnfα, and il-6 in the dorsal horn of the spinal cord (dhsc). |
2022-10-25 |
2023-08-14 |
mouse |
| Seunghwan Shim, Da Un Jeong, Hyemi Kim, Chae Yun Kim, Hyejun Park, Yinglan Jin, Kyung Min Kim, Hwa Jeong Lee, Dong Hwan Kim, Yun Soo Bae, Yongseok Cho. Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease. European journal of medicinal chemistry. vol 244. 2022-10-24. PMID:36274279. |
oral administration of compound 11 (30 mg/kg/daily, 4 weeks) into the mice resulted in suppression of dopaminergic neuronal death in substantia nigra (sn) and in striatum as well as inhibition of microglial migration into sn. |
2022-10-24 |
2023-08-14 |
mouse |
| Qing-Yuan Liu, Min Yang, Yu-Jing Sheng, Xiao-Fang Chen, Cai-Shan Wang, Ying Zhang, Pan Mao, Chang-Wei Ding, Rui Chen, Ying-Chun Zhang, Chun-Feng Li. Clinical study of transcranial sonography image characteristics in patients with obstructive sleep apnea. Sleep & breathing = Schlaf & Atmung. 2022-10-22. PMID:36272057. |
this study aimed to explore the relationship between patients with obstructive sleep apnea (osa) from subgroups of varying severity and substantia nigra (sn) hyperechogenicity as well as cerebral blood flow detected by transcranial sonography (tcs). |
2022-10-22 |
2023-08-14 |
Not clear |
| Dongling Zhang, Liche Zhou, Yuting Shi, Jun Liu, Hongjiang Wei, Qiqi Tong, Hongjian He, Tao W. Increased Free Water in the Substantia Nigra in Asymptomatic LRRK2 G2019S Mutation Carriers. Movement disorders : official journal of the Movement Disorder Society. 2022-10-17. PMID:36253640. |
the alteration of substantia nigra (sn) degeneration in populations at risk of parkinson's disease (pd) is unclear. |
2022-10-17 |
2023-08-14 |
Not clear |
| Xiaojun Guan, Tao Guo, Cheng Zhou, Jingjing Wu, Qingze Zeng, Kaicheng Li, Xiao Luo, Xueqin Bai, Haoting Wu, Ting Gao, Luyan Gu, Xiaocao Liu, Zhengye Cao, Jiaqi Wen, Jingwen Chen, Hongjiang Wei, Yuyao Zhang, Chunlei Liu, Zhe Song, Yaping Yan, Jiali Pu, Baorong Zhang, Xiaojun Xu, Minming Zhan. Altered brain iron depositions from aging to Parkinson's disease and Alzheimer's disease: a quantitative susceptibility mapping study. NeuroImage. 2022-10-15. PMID:36243270. |
ppd showed a high spatial variation of iron distribution in the subcortical nuclei except for substantia nigra (sn); and iron deposition in sn and red nucleus (rn) were progressively increased from ppd to cpd (p < 0.01). |
2022-10-15 |
2023-08-14 |
human |
| Rui-Chen Xu, Wen-Teng Miao, Jing-Yi Xu, Wen-Xin Xu, Ming-Ran Liu, Song-Tao Ding, Yu-Xin Jian, Yi-Han Lei, Ning Yan, Han-Deng Li. Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice. Nutrients. vol 14. issue 19. 2022-10-14. PMID:36235813. |
we assessed the expression of tight junction (tj) proteins (occludin and claudin-1), gpr109a, and p65 in the colon, performed microscopic examination via he staining, quantified markers of intestinal permeability and proinflammatory cytokines in serum, and evaluated motor symptoms and pathological changes in the substantia nigra (sn) or striatum. |
2022-10-14 |
2023-08-14 |
mouse |
| Nils Schröter, Michel Rijntjes, Horst Urbach, Cornelius Weiller, Martin Treppner, Elias Kellner, Wolfgang H Jost, Bastian E A Sajonz, Marco Reisert, Jonas A Hosp, Alexander Ra. Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-10-14. PMID:36241644. |
the extent to which the degeneration of the substantia nigra (sn) and putamen each contribute to motor impairment in parkinson's disease (pd) is unclear, as they are usually investigated using different imaging modalities. |
2022-10-14 |
2023-08-14 |
Not clear |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Qing Guan, Wei Liu, Ketao Mu, Qi Hu, Jiazhao Xie, Liming Cheng, Xiong Wan. Single-cell RNA sequencing of CSF reveals neuroprotective RAC1 Frontiers in immunology. vol 13. 2022-10-10. PMID:36211372. |
results showed that nk cells infiltrate the substantia nigra (sn) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd model mice and colocalize with dopaminergic neurons and α-syn. |
2022-10-10 |
2023-08-14 |
mouse |
| Sushmaa Chandralekha Selvakumar, K Auxzilia Preethi, Deusdedit Tusubira, Durairaj Seka. MicroRNAs in the epigenetic regulation of disease progression in Parkinson's disease. Frontiers in cellular neuroscience. vol 16. 2022-10-03. PMID:36187290. |
the loss of dopaminergic neurons in the substantia nigra (sn) is thought to be the primary cause of pd disease progression. |
2022-10-03 |
2023-08-14 |
Not clear |
| Srestha Mazumder, Anita Y Bahar, Claire E Shepherd, Asheeta A Prasa. Post-mortem brain histological examination in the substantia nigra and subthalamic nucleus in Parkinson's disease following deep brain stimulation. Frontiers in neuroscience. vol 16. 2022-10-03. PMID:36188463. |
parkinson's disease (pd) is a progressive neurodegenerative disorder, pathologically hallmarked by the loss of dopamine neurons in the substantia nigra (sn) and alpha-synuclein aggregation. |
2022-10-03 |
2023-08-14 |
Not clear |
| Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Le. Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142491. |
we found that dietary morin prevented mptp-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (str) and substantia nigra (sn) in our mouse model. |
2022-09-23 |
2023-08-14 |
mouse |
| Xin Li, Xiao-Wen Jiang, Hai-Xiao Chu, Qing-Chun Zhao, Huai-Wei Ding, Chao-Hong Ca. Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition. Chinese herbal medicines. vol 13. issue 1. 2022-09-19. PMID:36117765. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in substantia nigra (sn). |
2022-09-19 |
2023-08-14 |
Not clear |