| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nidhi Sachan, Neha Tiwari, Devendra Kumar Patel, Diksha Katiyar, Saripella Srikrishna, Mahendra Pratap Sing. Dyshomeostasis of Iron and Its Transporter Proteins in Cypermethrin-Induced Parkinson's Disease. Molecular neurobiology. 2023-06-23. PMID:37351784. |
exposure to pesticides causes an accumulation of transition metals in the substantia nigra (sn) region of the brain. |
2023-06-23 |
2023-08-14 |
human |
| Diego Iacono, Hui Peng, Marcie L Rabin, Roger Kurla. Neuropathology and morphometry of dentate nucleus neurons in DYT1 brains: Cerebellar abnormalities in isolated dystonia. Journal of neuropathology and experimental neurology. 2023-06-23. PMID:37352388. |
while the identification of distinctive intra- or extraneuronal abnormalities in childhood-onset generalized dystonia (dyt1) brains remains lacking, recent stereology-based findings demonstrated hypertrophy of neurons in the substantia nigra (sn) of dyt1-carriers manifesting dystonia (dyt1-manif) versus dyt1-carriers nonmanifesting dystonia (dyt1-nonmanif), and age-matched control subjects (c). |
2023-06-23 |
2023-08-14 |
human |
| Chen-Pei Lin, Lydian E J Knoop, Irene Frigerio, John G J M Bol, Annemieke J M Rozemuller, Henk W Berendse, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Nigral Pathology Contributes to Microstructural Integrity of Striatal and Frontal Tracts in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-06-22. PMID:37347552. |
motor and cognitive impairment in parkinson's disease (pd) is associated with dopaminergic dysfunction that stems from substantia nigra (sn) degeneration and concomitant α-synuclein accumulation. |
2023-06-22 |
2023-08-14 |
Not clear |
| Xiaoluan Xia, Xinglin Zeng, Fei Gao, Lin Hua, Shaohui Huang, Zhen Yua. Striatonigrostriatal connectivity-based cross-species parcellation of human and macaque substantia nigra. Human brain mapping. 2023-06-22. PMID:37347619. |
anatomical and functional heterogeneous substantia nigra (sn) has been extensively studied in humans and animals like rhesus monkeys given its crucial role in modulating a broad range of behaviors. |
2023-06-22 |
2023-08-14 |
human |
| Dongling Zhang, Liche Zhou, Junye Yao, Yuting Shi, Hongjian He, Hongjiang Wei, Qiqi Tong, Jun Liu, Tao W. Increased Free Water in the Putamen in Idiopathic REM Sleep Behavior Disorder. Movement disorders : official journal of the Movement Disorder Society. 2023-06-21. PMID:37342973. |
it has been suggested that the loss of nigrostriatal dopaminergic axon terminals occurs before the loss of dopaminergic neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2023-06-21 |
2023-08-14 |
Not clear |
| Rurui Wei, Yan Zhang, Peishan Li, Zeheng Xu, La Zhang, Yan He, Qinfen Wu, Youcai Shi, Yang Yuan, Abudula Aish. Substantia Nigra Echogenicity Signal Correlated with Clinical Features in Patients with Parkinson's Disease in Xinjiang. Parkinson's disease. vol 2023. 2023-06-12. PMID:37304832. |
transcranial sonography (tcs) is a noninvasive test that can reveal structural changes in the substantia nigra (sn) in parkinson's disease (pd). |
2023-06-12 |
2023-08-14 |
Not clear |
| Z K Chatila, A Yadav, J Mares, X Flowers, T D Yun, M Rashid, R Talcoff, Z Pelly, Ya Zhang, P L De Jager, A Teich, R Costa, E Area Gomez, G Martins, R Alcalay, J P Vonsattel, V Menon, E M Bradshaw, S Przedborsk. RNA- and ATAC-sequencing Reveals a Unique bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292857. |
we created a multiomic dataset using substantia nigra (sn) tissues from 19 pd donors and 14 non-pd controls (npcs), as well as three other brain regions from the pd donors which are differentially affected in this disease: the ventral tegmental area (vta), substantia inominata (si), and hypothalamus (hypots). |
2023-06-09 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali K Al-Buhadily, Ali I Al-Gareeb, Engy Elekhnawy, Gaber El-Saber Batih. DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson's disease: a mutual relationship. Pharmacological reports : PR. 2023-06-03. PMID:37269487. |
parkinson's disease (pd) usually occurs due to the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2023-06-03 |
2023-08-14 |
Not clear |
| Sonoko Oshima, Yasutaka Fushimi, Kanae Kawai Miyake, Satoshi Nakajima, Akihiko Sakata, Sachi Okuchi, Takuya Hinoda, Sayo Otani, Hitomi Numamoto, Koji Fujimoto, Atsushi Shima, Masahito Nambu, Nobukatsu Sawamoto, Ryosuke Takahashi, Kentaro Ueno, Tsuneo Saga, Yuji Nakamot. Denoising approach with deep learning-based reconstruction for neuromelanin-sensitive MRI: image quality and diagnostic performance. Japanese journal of radiology. 2023-05-31. PMID:37256470. |
neuromelanin-sensitive mri (nm-mri) has proven useful for diagnosing parkinson's disease (pd) by showing reduced signals in the substantia nigra (sn) and locus coeruleus (lc), but requires a long scan time. |
2023-05-31 |
2023-08-14 |
Not clear |
| Sabina Luchetti, Philippe Liere, Antoine Pianos, Ronald W H Verwer, Arja Sluiter, Inge Huitinga, Michael Schumacher, Dick F Swaab, Matthew R J Maso. Disease stage-dependent changes in brain levels and neuroprotective effects of neuroactive steroids in Parkinson's disease. Neurobiology of disease. 2023-05-31. PMID:37257664. |
we previously found that expression of the enzymes synthesizing 5α-dihydroprogesterone (5α-dhp), allopregnanolone (allo), and dehydroepiandrosterone sulfate (dheas) were reduced in the substantia nigra (sn) of parkinson's disease (pd) brain. |
2023-05-31 |
2023-08-14 |
human |
| Yea-Hyun Leem, Do-Yeon Kim, Jung-Eun Park, Hee-Sun Ki. Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-05-31. PMID:37258791. |
furthermore, nsa inhibited the phosphorylation, ubiquitylation, and oligomerization of mlkl, all of which are associated with mlkl cell death-inducing activity in dopaminergic cells in the substantia nigra (sn). |
2023-05-31 |
2023-08-14 |
mouse |
| Yiyuan Xu, Xinyu Huang, Xin Geng, Fei Wan. Meta-analysis of iron metabolism markers levels of Parkinson's disease patients determined by fluid and MRI measurements. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 78. 2023-05-24. PMID:37224790. |
parkinson' s disease (pd) is a progressive neurodegenerative disease featured neuropathologically by the loss of dopaminergic neurons of the substantia nigra (sn). |
2023-05-24 |
2023-08-14 |
Not clear |
| Le-le Liu, Yu Han, Zi-Jia Zhang, Yi-Qi Wang, Yu-Wei Hu, Elena Kaznacheyeva, Jian-Qing Ding, Dong-Kai Guo, Guang-Hui Wang, Bin Li, Hai-Gang Re. Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation. Acta pharmacologica Sinica. 2023-05-24. PMID:37225849. |
in dj-1-knockout (ko) mice, mao-b protein levels in the substantia nigra (sn) and striatal regions were significantly increased. |
2023-05-24 |
2023-08-14 |
mouse |
| Victoria Madge, Vladimir S Fonov, Yiming Xiao, Lucy Zou, Courtney Jackson, Ronald B Postuma, Alain Dagher, Edward A Fon, D Louis Collin. A dataset of multi-contrast unbiased average MRI templates of a Parkinson's disease population. Data in brief. vol 48. 2023-05-22. PMID:37213552. |
parkinson's disease (pd) is a complex neurodegenerative disorder affecting regions such as the substantia nigra (sn), red nucleus (rn) and locus coeruleus (lc). |
2023-05-22 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Majid S Jabir, Hebatallah M Saad, Gaber El-Saber Batih. NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective. Journal of cellular and molecular medicine. 2023-05-21. PMID:37210624. |
particularly, insulin resistance (ir) in t2dm promotes the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2023-05-21 |
2023-08-14 |
Not clear |
| Juan García-Revilla, Antonio Boza-Serrano, Yiyun Jin, Devkee M Vadukul, Jesús Soldán-Hidalgo, Lluís Camprubí-Ferrer, Marta García-Cruzado, Isak Martinsson, Oxana Klementieva, Rocío Ruiz, Francesco A Aprile, Tomas Deierborg, José Luis Vener. Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease. Acta neuropathologica. 2023-05-18. PMID:37202527. |
parkinson's disease (pd) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called lewy bodies (lb) and degeneration of dopaminergic neurons in the substantia nigra (sn). |
2023-05-18 |
2023-08-14 |
mouse |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. Experimental neurology. 2023-05-13. PMID:37178997. |
while gdnf dose and delivery methods may have contributed to diminished efficacy, one crucial aspect of these clinical studies is that gdnf treatment began ~8 years after pd diagnosis; a time point representing several years after near 100% depletion of nigrostriatal dopamine markers in striatum and at least 50% in substantia nigra (sn), which represents a time point of initiating gdnf treatment later than reported in some preclinical studies. |
2023-05-13 |
2023-08-14 |
rat |
| Haorei Yarreiphang, D J Vidyadhara, Anand Krishnan Nambisan, Trichur R Raju, B K Chandrashekar Sagar, Phalguni Anand Allad. Apoptotic Factors and Mitochondrial Complexes Assist Determination of Strain-Specific Susceptibility of Mice to Parkinsonian Neurotoxin MPTP. Molecular neurobiology. 2023-05-10. PMID:37162724. |
our earlier studies comparing the substantia nigra (sn) and striatum of c57bl/6j, cd-1 mice, and their f1-crossbreds demonstrated the neuroprotective role of admixing against the neurotoxin mptp. |
2023-05-10 |
2023-08-14 |
mouse |
| Ramu Elango, Babajan Banaganapalli, Abdulrahman Mujalli, Nuha AlRayes, Sarah Almaghrabi, Majid Almansouri, Ahmed Sahly, Gada Ali Jadkarim, Md Zubbair Malik, Hussam Ibrahim Kutbi, Noor Ahmad Shaik, Eman Alefisha. Potential Biomarkers for Parkinson Disease from Functional Enrichment and Bioinformatic Analysis of Global Gene Expression Patterns of Blood and Substantia Nigra Tissues. Bioinformatics and biology insights. vol 17. 2023-05-09. PMID:37153842. |
therefore, this study aimed to compare the fidelity of blood to substantia nigra (sn) tissue gene expression from pd patients to provide a systematic approach to predict role of the key genes of pd pathobiology. |
2023-05-09 |
2023-08-14 |
Not clear |
| Mohammed Alrouji, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Dalia Zaafar, Gaber El-Saber Batih. Orexin pathway in Parkinson's disease: a review. Molecular biology reports. 2023-05-08. PMID:37155018. |
parkinson's disease (pd) is a progressive neurodegenerative disease (ndd) caused by dopaminergic neuron degeneration in the substantia nigra (sn). |
2023-05-08 |
2023-08-14 |
Not clear |