| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Elgueta, Ornella Chovar, Valentina Ugalde, Vanesa Sánchez-Guajardo, Alejandra Catenaccio, Felipe Court, Rodrigo Pachec. Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein. Journal of visualized experiments : JoVE. issue 185. 2022-08-15. PMID:35969046. |
notably, the neuroinflammatory process involves microglial activation as well as the infiltration of peripheral t cells into the substantia nigra (sn). |
2022-08-15 |
2023-08-14 |
mouse |
| Jorge E Quintero, John T Slevin, Julie A Gurwell, Christopher J McLouth, Riham El Khouli, Monica J Chau, Zain Guduru, Greg A Gerhardt, Craig G van Horn. Direct delivery of an investigational cell therapy in patients with Parkinson's disease: an interim analysis of feasibility and safety of an open-label study using DBS-Plus clinical trial design. BMJ neurology open. vol 4. issue 2. 2022-08-11. PMID:35949912. |
to evaluate the interim feasibility, safety and clinical measures data of direct delivery of regenerating peripheral nerve tissue (pnt) to the substantia nigra (sn) in participants with parkinson's disease (pd). |
2022-08-11 |
2023-08-14 |
human |
| Sha Zhu, Yaxi Wang, Yinyin Jiang, Ruxin Gu, Min Zhong, Xu Jiang, Bo Shen, Jun Zhu, Jun Yan, Yang Pan, Li Zhan. Clinical Features in Parkinson's Disease Patients with Hyperechogenicity in Substantia Nigra: A Cross-Sectional Study. Neuropsychiatric disease and treatment. vol 18. 2022-08-09. PMID:35942277. |
transcranial ultrasound (tcs) can be used to reveal structural changes in the substantia nigra (sn) and is a potential tool for the early diagnosis of parkinson's disease (pd). |
2022-08-09 |
2023-08-14 |
Not clear |
| Xiaoguang Liu, Kaluvu Balaraman, Ciarán C Lynch, Michaeline Hebron, Priya Ketankumar Shah, Shicheng Hu, Max Stevenson, Christian Wolf, Charbel Mouss. Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897705. |
alpha-synuclein was expressed unilaterally in substantia nigra (sn) of usp13 deficient mice that were treated with a daily intraperitoneal injection of 100 mg/kg bk50118-c or dmso for four consecutive weeks, and behavioral and functional assays were performed. |
2022-07-28 |
2023-08-14 |
mouse |
| Min Kyung Song, Levi Adams, Joo Hee Lee, Yoon-Seong Ki. NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease. PloS one. vol 17. issue 7. 2022-07-28. PMID:35901090. |
to model α-syn induced pd, we stereotactically injected aav particles overexpressing human α-syn into the substantia nigra (sn) of mice. |
2022-07-28 |
2023-08-14 |
mouse |
| Sage S Frehner, Kip T Dooley, Michelle C Palumbo, Aaron L Smith, Mark M Goodman, Karen L Bales, Sara M Freema. Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 377. issue 1858. 2022-07-20. PMID:35858098. |
previous studies from our laboratory found a dense population of oxtr in the human substantia nigra (sn), a basal ganglia structure in the midbrain that is important in both movement and reward pathways. |
2022-07-20 |
2023-08-14 |
human |
| Maximilian Wulf, Katalin Barkovits, Karin Schork, Martin Eisenacher, Peter Riederer, Manfred Gerlach, Britta Eggers, Katrin Marcu. Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes. Journal of neural transmission (Vienna, Austria : 1996). 2022-07-19. PMID:35852604. |
neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (nmgs) in the cell bodies of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-07-19 |
2023-08-14 |
Not clear |
| Jackson Tyler Boonstra, Hugo McGurran, Yasin Temel, Ali Jahanshah. Nigral neuropathology of Parkinson's motor subtypes coincide with circuitopathies: a scoping review. Brain structure & function. 2022-07-19. PMID:35854141. |
ntd pd patients show higher neuronal loss, gliosis, extraneuronal melanin deposits, and neuroaxonal dystrophy in multiple subregions of the substantia nigra (sn) related to the overactivity of the indirect motor loop. |
2022-07-19 |
2023-08-14 |
Not clear |
| Anita Siller, Nadja T Hofer, Giulia Tomagra, Nicole Wiederspohn, Simon Hess, Julia Benkert, Aisylu Gaifullina, Desiree Spaich, Johanna Duda, Christina Poetschke, Kristina Vilusic, Eva Maria Fritz, Toni Schneider, Peter Kloppenburg, Birgit Liss, Valentina Carabelli, Emilio Carbone, Nadine Jasmin Ortner, Jörg Striessni. rβ2-subunit alternative splicing stabilizes Cav2.3 Ca eLife. vol 11. 2022-07-06. PMID:35792082. |
rβ2-subunit alternative splicing stabilizes cav2.3 ca in dopaminergic (da) substantia nigra (sn) neurons cav2.3 r-type ca |
2022-07-06 |
2023-08-14 |
Not clear |
| Lei Wang, Xinghong Wu, Ge Yang, Nan Hu, Zijian Zhao, Lei Zhao, Shengyu L. Cannabidiol alleviates the damage to dopaminergic neurons in MPTP-induced Parkinson's disease mice via regulating neuronal apoptosis and neuroinflammation. Neuroscience. 2022-07-06. PMID:35792194. |
the main pathological feature of pd is the loss or apoptosis of dopaminergic neurons in the substantia nigra (sn). |
2022-07-06 |
2023-08-14 |
mouse |
| Wenbin Gu, Chen He, Juping Chen, Junchen L. Proton Magnetic Resonance Spectroscopy for the Early Diagnosis of Parkinson Disease in the Substantia Nigra and Globus Pallidus: A Meta-Analysis With Trial Sequential Analysis. Frontiers in neurology. vol 13. 2022-07-05. PMID:35785357. |
this study aimed to investigate the metabolic changes in globus pallidus (gp) and substantia nigra (sn) during the early stage of parkinson disease (pd) using magnetic resonance spectroscopy (mrs). |
2022-07-05 |
2023-08-14 |
Not clear |
| Amnon A Berger, Ariel Winnick, Jonathan Izygon, Binil M Jacob, Jessica S Kaye, Rachel J Kaye, Elisa E Neuchat, Adam M Kaye, Edward S Alpaugh, Elyse M Cornett, Andrew H Han, Alan D Kay. Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson's Disease "Off" Episodes. Health psychology research. vol 10. issue 3. 2022-07-01. PMID:35774903. |
the traditional pathogenesis theory of pd involves the loss of dopaminergic neurons in the substantia nigra (sn). |
2022-07-01 |
2023-08-14 |
Not clear |
| Abel Worku Tessema, Hansol Lee, Yelim Gong, Hwapyeong Cho, Hamdia Murad Adem, Ilwoo Lyu, Jae-Hyeok Lee, Hyung Joon Ch. Automated Volumetric Determination of High R NMR in biomedicine. 2022-07-01. PMID:35775868. |
automated volumetric determination of high r the establishment of an unbiased protocol for the automated volumetric measurement of iron-rich regions in the substantia nigra (sn) is clinically important for diagnosing neurodegenerative diseases exhibiting midbrain atrophy, such as progressive supranuclear palsy (psp). |
2022-07-01 |
2023-08-14 |
Not clear |
| Anna C Stoll, Caryl E Sortwel. Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity. Neurobiology of disease. 2022-06-28. PMID:35764290. |
studies consistently demonstrate an association between pathologic α-syn aggregation in the substantia nigra (sn) and activation of the innate immune system. |
2022-06-28 |
2023-08-14 |
Not clear |
| Periyasamy Ravisankar, Panneerselvam Ravishankar, Elumalai Prithviraj, Rajan Ravindra. Evaluation of Antioxidants in Discrete Regions of Brain after the Transplantation of Human Amniotic Epithelial Cells in 2,4,5-Trihydroxyphenylethylamine-lesioned Wistar Albino Rats. International journal of applied & basic medical research. vol 12. issue 2. 2022-06-27. PMID:35754664. |
however oxidative stress in the substantia nigra (sn) and corpus striatum is the most broadly accepted hypothesis for the etiopathology of pd. |
2022-06-27 |
2023-08-14 |
human |
| Consolato M Serg. Epigallocatechin Gallate (EGCG) for Parkinson's Disease. Clinical and experimental pharmacology & physiology. 2022-06-24. PMID:35748799. |
ecgc may be beneficial in delaying the neurodegeneration of the substantia nigra (sn) regardless of the origin of parkinson's disease (pd). |
2022-06-24 |
2023-08-14 |
human |
| Thomas Musacchio, Jing Yin, Fabian Kremer, James B Koprich, Jonathan M Brotchie, Jens Volkmann, Chi Wang I. Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease. Behavioural brain research. 2022-06-23. PMID:35738338. |
a differential intraneuronal vulnerability of dopaminergic neurons within the substantia nigra (sn) has been suggested, starting as an axonopathy followed by neuronal cell loss that is accompanied with motor deficits. |
2022-06-23 |
2023-08-14 |
human |
| Binlin Xu, Xiaoquan Wang, Zhengshuang Xu, Qinkai Li, Junmin Qua. N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson's disease. Neuroscience letters. 2022-06-23. PMID:35738458. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn), which is highly associated with oxidative stress. |
2022-06-23 |
2023-08-14 |
mouse |
| Isaac Deng, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson's Disease. Frontiers in bioscience (Scholar edition). vol 14. issue 2. 2022-06-22. PMID:35730438. |
the major hallmark of parkinson's disease (pd) is the degeneration of dopaminergic neurons in the substantia nigra (sn), which is responsible for the core motor symptoms of pd. |
2022-06-22 |
2023-08-14 |
mouse |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson's disease mice. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732806. |
striatal dopamine depletion caused by substantia nigra (sn) degeneration is a pathological hallmark of pd and is strongly associated with cardinal motor and non-motor symptoms. |
2022-06-22 |
2023-08-14 |
mouse |