| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingyu Ren, Xin Jiang, Yam Nath Paudel, Xin Gao, Daili Gao, Pengyu Zhang, Wenlong Sheng, Xueliang Shang, Kechun Liu, Xiujun Zhang, Meng Ji. Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology. 2022-03-31. PMID:35358621. |
parkinson's disease (pd) is the second most devastating age-related neurodegenerative diseases after alzheimer diseases (ad) and is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and aggregation of α-synuclein (α-syn). |
2022-03-31 |
2023-08-13 |
zebrafish |
| Wen Zhang, Jiabing Shen, Yuhui Wang, Kefu Cai, Qi Zhang, Maohong Ca. Blood SSR1: A Possible Biomarker for Early Prediction of Parkinson's Disease. Frontiers in molecular neuroscience. vol 15. 2022-03-21. PMID:35310885. |
three substantia nigra (sn) transcriptome datasets from the gene expression omnibus (geo) database were divided into a training cohort and a test cohort. |
2022-03-21 |
2023-08-13 |
human |
| Zhuo Wang, Yanjun Huang, Zhihua Zhou, Jian Huang, Yitong He, Pingming Qi. Local iron deficiency in the substantia nigra directly contributes to hyperlocomotion phenotypes. Neurobiology of disease. 2022-03-19. PMID:35304229. |
mounting evidence connects the iron status of the substantia nigra (sn) with locomotion-related neural symptomatology. |
2022-03-19 |
2023-08-13 |
mouse |
| Nordeval Cavalcante Araújo, José Hermógenes Rocco Suassuna, Rita de Cássia Leite Fernande. Transcranial sonography depicts a larger substantia nigra echogenic area in renal transplant patients on calcineurin inhibitors than on rapamycin. BMC nephrology. vol 23. issue 1. 2022-03-18. PMID:35300603. |
an enlarged substantia nigra (sn) by transcranial sonography has been recognized as a marker of pd. |
2022-03-18 |
2023-08-13 |
Not clear |
| Colleen S Stein, Jared M McLendon, Nathan H Witmer, Ryan L Boudrea. Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease. Molecular therapy. Nucleic acids. vol 28. 2022-03-14. PMID:35280925. |
parkinson's disease (pd) is caused by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-03-14 |
2023-08-13 |
mouse |
| Maoxin Huang, Liang Xu, Jin Liu, Pei Huang, Yuyan Tan, Shengdi Che. Cell-Cell Communication Alterations Frontiers in aging neuroscience. vol 14. 2022-03-14. PMID:35283752. |
cell-cell communication alterations parkinson's disease (pd) is a neurodegenerative movement disorder characterized with dopaminergic neuron (dan) loss within the substantia nigra (sn). |
2022-03-14 |
2023-08-13 |
human |
| Ian M O'Shea, Haroon S Popal, Ingrid R Olson, Vishnu P Murty, David V Smit. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-03-01. PMID:35228561. |
in parkinson's disease (pd), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (sn), while leaving the ventral tegmental area (vta) relatively spared in early phases of the disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-Hong Chen, Yu-He Yua. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical research. 2022-03-01. PMID:35229270. |
progressive loss of dopaminergic neurons in the substantia nigra (sn) is one of the major pathological changes. |
2022-03-01 |
2023-08-13 |
mouse |
| Abdullah Al Awadhi, Rémi Tyrand, Andreas Horn, Astrid Kibleur, Julia Vincentini, André Zacharia, Pierre R Burkhard, Shahan Momjian, Colette Boë. Electrophysiological confrontation of Lead-DBS-based electrode localizations in patients with Parkinson's disease undergoing deep brain stimulation. NeuroImage. Clinical. vol 34. 2022-03-01. PMID:35231852. |
using the distal atlas implemented in the lead-dbs image reconstruction toolbox, each mer location was determined postoperatively and attributed to specific anatomical structures (sensorimotor, associative or limbic stn; substantia nigra [sn], thalamus, nucleus reticularis polaris, zona incerta [zi]). |
2022-03-01 |
2023-08-13 |
Not clear |
| Weiwei Zhao, Yida Wang, Fangfang Zhou, Gaiying Li, Zhichao Wang, Haodong Zhong, Yang Song, Kelly M Gillen, Yi Wang, Guang Yang, Jianqi L. Automated Segmentation of Midbrain Structures in High-Resolution Susceptibility Maps Based on Convolutional Neural Network and Transfer Learning. Frontiers in neuroscience. vol 16. 2022-02-28. PMID:35221900. |
accurate delineation of the midbrain nuclei, the red nucleus (rn), substantia nigra (sn) and subthalamic nucleus (stn), is important in neuroimaging studies of neurodegenerative and other diseases. |
2022-02-28 |
2023-08-13 |
Not clear |
| Chung-Yin Lin, Ching-Yun Huang, Chiung-Mei Chen, Hao-Li Li. Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhanced α-Synuclein Expression in Mice for Modeling Parkinson's Disease. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35214176. |
gradual accumulation of αsnca aggregates in substantia nigra (sn) diminishes the normal functioning of soluble αsnca, leading to a loss of dopamine (da) neurons. |
2022-02-26 |
2023-08-13 |
mouse |
| Cheng-Peng Sun, Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang, Christophe Morisseau, Bruce D Hammock, Xiao-Chi M. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 9. 2022-02-26. PMID:35217618. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by loss of dopaminergic neurons in the substantia nigra (sn), causing bradykinesia and rest tremors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Jannik Prasuhn, Robert Strautz, Felicitas Lemmer, Shalida Dreischmeier, Meike Kasten, Henrike Hanssen, Marcus Heldmann, Norbert Brüggeman. Neuroimaging Correlates of Substantia Nigra Hyperechogenicity in Parkinson's Disease. Journal of Parkinson's disease. 2022-02-18. PMID:35180131. |
degeneration of dopaminergic neurons within the brainstem substantia nigra (sn) is both a pathological hallmark of parkinson's disease (pd) and a major contributor to symptom expression. |
2022-02-18 |
2023-08-13 |
Not clear |
| Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. Molecular neurobiology. 2022-02-17. PMID:35175558. |
parkinson's disease (pd) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the substantia nigra (sn), and accumulation and spread of inclusions of aggregated α-synuclein (α-syn). |
2022-02-17 |
2023-08-13 |
human |
| Tzu-Feng Wang, Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yu-Min Ku. Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits. Cells. vol 11. issue 3. 2022-02-15. PMID:35159290. |
parkinson's disease (pd) is an age-related neurodegenerative disease caused by a selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2022-02-15 |
2023-08-13 |
mouse |
| Justyna Barut, Katarzyna Rafa-Zabłocka, Agnieszka M Jurga, Monika Bagińska, Irena Nalepa, Rosanna Parlato, Grzegorz Kreine. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain. Neurochemistry international. 2022-02-12. PMID:35150790. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor deficits caused by the loss of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta). |
2022-02-12 |
2023-08-13 |
mouse |
| Andrew Gao, Hannah M McCoy, Vandana Zaman, Donald C Shields, Naren L Banik, Azizul Haqu. Calpain activation and progression of inflammatory cycles in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 27. issue 1. 2022-01-29. PMID:35090325. |
all three agents work through similar mechanisms and lead to degeneration of dopaminergic neurons in the substantia nigra (sn) and more recently discovered in motor neurons of the spinal cord (sc). |
2022-01-29 |
2023-08-13 |
Not clear |
| Jianjun Ma, Xiaoxue Shi, Mingjian Li, Siyuan Chen, Qi Gu, Jinhua Zheng, Dongsheng Li, Shaopu Wu, Hongqi Yang, Xue L. MicroRNA-181a-2-3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson's disease by inhibiting EGR1 and NOX4. Cell death discovery. vol 8. issue 1. 2022-01-25. PMID:35075150. |
first, 6-hydroxydopamine (6-ohda)-induced pd cell and mouse models were established, after which mir-181a-2-3p, egr1, and nox4 expression patterns were determined in sh-sy5y cells and substantia nigra (sn) of pd mice. |
2022-01-25 |
2023-08-13 |
mouse |
| Zhijia Jin, Ying Wang, Mojtaba Jokar, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Youmin Zhang, Jihua Min, Fangtao Liu, Naying He, Fuhua Yan, Ewart Mark Haack. Automatic detection of neuromelanin and iron in the midbrain nuclei using a magnetic resonance imaging-based brain template. Human brain mapping. 2022-01-24. PMID:35072301. |
parkinson disease (pd) is a chronic progressive neurodegenerative disorder characterized pathologically by early loss of neuromelanin (nm) in the substantia nigra pars compacta (snpc) and increased iron deposition in the substantia nigra (sn). |
2022-01-24 |
2023-08-13 |
human |
| Victor Blokhin, Maria Shupik, Ulyana Gutner, Ekaterina Pavlova, Albert T Lebedev, Olga Maloshitskaya, Vsevolod Bogdanov, Sergey Sokolov, Alice Alessenko, Michael Ugrumo. The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson's Disease. Biomolecules. vol 12. issue 1. 2022-01-21. PMID:35053241. |
it has been shown that in pd models, the expression of five of the nine studied genes (cers1, cers5, asah1, asah2, and gba1) increases but only in the substantia nigra (sn) containing dopaminergic cell bodies. |
2022-01-21 |
2023-08-13 |
mouse |