| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maximilian Wulf, Katalin Barkovits, Karin Schork, Martin Eisenacher, Peter Riederer, Manfred Gerlach, Britta Eggers, Katrin Marcu. Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes. Journal of neural transmission (Vienna, Austria : 1996). 2022-07-19. PMID:35852604. |
neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (nmgs) in the cell bodies of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-07-19 |
2023-08-14 |
Not clear |
| Jackson Tyler Boonstra, Hugo McGurran, Yasin Temel, Ali Jahanshah. Nigral neuropathology of Parkinson's motor subtypes coincide with circuitopathies: a scoping review. Brain structure & function. 2022-07-19. PMID:35854141. |
ntd pd patients show higher neuronal loss, gliosis, extraneuronal melanin deposits, and neuroaxonal dystrophy in multiple subregions of the substantia nigra (sn) related to the overactivity of the indirect motor loop. |
2022-07-19 |
2023-08-14 |
Not clear |
| Anita Siller, Nadja T Hofer, Giulia Tomagra, Nicole Wiederspohn, Simon Hess, Julia Benkert, Aisylu Gaifullina, Desiree Spaich, Johanna Duda, Christina Poetschke, Kristina Vilusic, Eva Maria Fritz, Toni Schneider, Peter Kloppenburg, Birgit Liss, Valentina Carabelli, Emilio Carbone, Nadine Jasmin Ortner, Jörg Striessni. rβ2-subunit alternative splicing stabilizes Cav2.3 Ca eLife. vol 11. 2022-07-06. PMID:35792082. |
rβ2-subunit alternative splicing stabilizes cav2.3 ca in dopaminergic (da) substantia nigra (sn) neurons cav2.3 r-type ca |
2022-07-06 |
2023-08-14 |
Not clear |
| Lei Wang, Xinghong Wu, Ge Yang, Nan Hu, Zijian Zhao, Lei Zhao, Shengyu L. Cannabidiol alleviates the damage to dopaminergic neurons in MPTP-induced Parkinson's disease mice via regulating neuronal apoptosis and neuroinflammation. Neuroscience. 2022-07-06. PMID:35792194. |
the main pathological feature of pd is the loss or apoptosis of dopaminergic neurons in the substantia nigra (sn). |
2022-07-06 |
2023-08-14 |
mouse |
| Wenbin Gu, Chen He, Juping Chen, Junchen L. Proton Magnetic Resonance Spectroscopy for the Early Diagnosis of Parkinson Disease in the Substantia Nigra and Globus Pallidus: A Meta-Analysis With Trial Sequential Analysis. Frontiers in neurology. vol 13. 2022-07-05. PMID:35785357. |
this study aimed to investigate the metabolic changes in globus pallidus (gp) and substantia nigra (sn) during the early stage of parkinson disease (pd) using magnetic resonance spectroscopy (mrs). |
2022-07-05 |
2023-08-14 |
Not clear |
| Amnon A Berger, Ariel Winnick, Jonathan Izygon, Binil M Jacob, Jessica S Kaye, Rachel J Kaye, Elisa E Neuchat, Adam M Kaye, Edward S Alpaugh, Elyse M Cornett, Andrew H Han, Alan D Kay. Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson's Disease "Off" Episodes. Health psychology research. vol 10. issue 3. 2022-07-01. PMID:35774903. |
the traditional pathogenesis theory of pd involves the loss of dopaminergic neurons in the substantia nigra (sn). |
2022-07-01 |
2023-08-14 |
Not clear |
| Abel Worku Tessema, Hansol Lee, Yelim Gong, Hwapyeong Cho, Hamdia Murad Adem, Ilwoo Lyu, Jae-Hyeok Lee, Hyung Joon Ch. Automated Volumetric Determination of High R NMR in biomedicine. 2022-07-01. PMID:35775868. |
automated volumetric determination of high r the establishment of an unbiased protocol for the automated volumetric measurement of iron-rich regions in the substantia nigra (sn) is clinically important for diagnosing neurodegenerative diseases exhibiting midbrain atrophy, such as progressive supranuclear palsy (psp). |
2022-07-01 |
2023-08-14 |
Not clear |
| Anna C Stoll, Caryl E Sortwel. Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity. Neurobiology of disease. 2022-06-28. PMID:35764290. |
studies consistently demonstrate an association between pathologic α-syn aggregation in the substantia nigra (sn) and activation of the innate immune system. |
2022-06-28 |
2023-08-14 |
Not clear |
| Periyasamy Ravisankar, Panneerselvam Ravishankar, Elumalai Prithviraj, Rajan Ravindra. Evaluation of Antioxidants in Discrete Regions of Brain after the Transplantation of Human Amniotic Epithelial Cells in 2,4,5-Trihydroxyphenylethylamine-lesioned Wistar Albino Rats. International journal of applied & basic medical research. vol 12. issue 2. 2022-06-27. PMID:35754664. |
however oxidative stress in the substantia nigra (sn) and corpus striatum is the most broadly accepted hypothesis for the etiopathology of pd. |
2022-06-27 |
2023-08-14 |
human |
| Consolato M Serg. Epigallocatechin Gallate (EGCG) for Parkinson's Disease. Clinical and experimental pharmacology & physiology. 2022-06-24. PMID:35748799. |
ecgc may be beneficial in delaying the neurodegeneration of the substantia nigra (sn) regardless of the origin of parkinson's disease (pd). |
2022-06-24 |
2023-08-14 |
human |
| Thomas Musacchio, Jing Yin, Fabian Kremer, James B Koprich, Jonathan M Brotchie, Jens Volkmann, Chi Wang I. Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson's disease. Behavioural brain research. 2022-06-23. PMID:35738338. |
a differential intraneuronal vulnerability of dopaminergic neurons within the substantia nigra (sn) has been suggested, starting as an axonopathy followed by neuronal cell loss that is accompanied with motor deficits. |
2022-06-23 |
2023-08-14 |
human |
| Binlin Xu, Xiaoquan Wang, Zhengshuang Xu, Qinkai Li, Junmin Qua. N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson's disease. Neuroscience letters. 2022-06-23. PMID:35738458. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra (sn), which is highly associated with oxidative stress. |
2022-06-23 |
2023-08-14 |
mouse |
| Isaac Deng, Sanjay Garg, Xin-Fu Zhou, Larisa Bobrovskay. The Effects of Novel Formulations of Edaravone and Curcumin in the Mouse Intrastriatal Lipopolysaccharide Model of Parkinson's Disease. Frontiers in bioscience (Scholar edition). vol 14. issue 2. 2022-06-22. PMID:35730438. |
the major hallmark of parkinson's disease (pd) is the degeneration of dopaminergic neurons in the substantia nigra (sn), which is responsible for the core motor symptoms of pd. |
2022-06-22 |
2023-08-14 |
mouse |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson's disease mice. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732806. |
striatal dopamine depletion caused by substantia nigra (sn) degeneration is a pathological hallmark of pd and is strongly associated with cardinal motor and non-motor symptoms. |
2022-06-22 |
2023-08-14 |
mouse |
| Minghao Yan, Haibo Jin, Chun Pan, Hexing Hang, Dongmei Li, Xiaodong Ha. Movement Disorder and Neurotoxicity Induced by Chronic Exposure to Microcystin-LR in Mice. Molecular neurobiology. 2022-06-22. PMID:35732866. |
we observed that 15 μg/l mc-lr could enter mouse brain tissues such as the cortex, hippocampus, and substantia nigra (sn). |
2022-06-22 |
2023-08-14 |
mouse |
| Zhenhua Liu, Nannan Yang, Jie Dong, Wotu Tian, Lisa Chang, Jinghong Ma, Jifeng Guo, Jieqiong Tan, Ao Dong, Kaikai He, Jingheng Zhou, Resat Cinar, Junbing Wu, Armando G Salinas, Lixin Sun, Mantosh Kumar, Breanna T Sullivan, Braden B Oldham, Vanessa Pitz, Mary B Makarious, Jinhui Ding, Justin Kung, Chengsong Xie, Sarah L Hawes, Lupeng Wang, Tao Wang, Piu Chan, Zhuohua Zhang, Weidong Le, Shengdi Chen, David M Lovinger, Cornelis Blauwendraat, Andrew B Singleton, Guohong Cui, Yulong Li, Huaibin Cai, Beisha Tan. Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction. Nature communications. vol 13. issue 1. 2022-06-17. PMID:35715418. |
daglb is the main 2-ag synthase in human and mouse substantia nigra (sn) dopaminergic neurons (dans). |
2022-06-17 |
2023-08-14 |
mouse |
| Philippe De Deurwaerdère, Maurizio Casarrubea, Daniel Cassar, Manuela Radic, Emilie Puginier, Abdeslam Chagraoui, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovann. Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats. Frontiers in cellular neuroscience. vol 16. 2022-06-09. PMID:35677756. |
these behavioral changes correlate with the reduction of 5-ht in the hippocampus and substantia nigra (sn) and noradrenaline (na) in the entopeduncular nucleus (epn) in vehicle-treated gaers compared to nec rats, which could contribute to their low anxiety status and hypermotility, respectively. |
2022-06-09 |
2023-08-14 |
rat |
| M Abrishamdar, M S Jalali, M Rashn. MALAT1 lncRNA and Parkinson's Disease: The role in the Pathophysiology and Significance for Diagnostic and Therapeutic Approaches. Molecular neurobiology. 2022-06-06. PMID:35665903. |
pd is characterized by progressive loss of dopamine-producing neurons in the substantia nigra (sn) region of brain tissue followed by the α-synuclein-based lewy bodies' formation. |
2022-06-06 |
2023-08-14 |
Not clear |
| Guoen Cai, Fabin Lin, Dihang Wu, Chenxin Lin, Huiyun Chen, Yicong Wei, Huidan Weng, Zhiting Chen, Minxia Wu, En Huang, Zucheng Ye, Qinyong Y. Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response. Frontiers in pharmacology. vol 13. 2022-06-02. PMID:35652041. |
this study looked into ra's protective effect against mitochondrial loss in the substantia nigra (sn) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), the underlying mechanism associated with the mtupr. |
2022-06-02 |
2023-08-13 |
mouse |
| Michael F Salvatore, Ella A Kasanga, D Parker Kelley, Katy E Venable, Tamara R McInnis, Mark A Cantu, Jennifer Terrebonne, Kathryn Lanza, Samantha M Meadows, Ashley Centner, Christopher Bishop, Donald K Ingra. Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake. GeroScience. 2022-05-31. PMID:35635679. |
however, in substantia nigra (sn), similar loss of da signaling markers in pd or aging coincide with parkinsonian signs. |
2022-05-31 |
2023-08-13 |
human |