| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pengyue Wu, Yuxuan Dong, Jinhu Chen, Tianyuan Guan, Bing Cao, Yanqiu Zhang, Yueyan Qi, Zhenlong Guan, Yanqin Wan. Liraglutide Regulates Mitochondrial Quality Control System Through PGC-1α in a Mouse Model of Parkinson's Disease. Neurotoxicity research. 2022-01-19. PMID:35043376. |
while liraglutide effectively attenuated the neurotoxicity of mptp, including reversing the dyskinesia caused by mptp and preserving the expression of glp-1r, th, and pgc-1α in the substantia nigra (sn), further experiments showed that downregulation of pgc-1α expression via stereotactic injection pgc-1α lentivirus into the sn reversed the liraglutide protective effects. |
2022-01-19 |
2023-08-13 |
mouse |
| Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi She. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. Molecular medicine reports. vol 25. issue 3. 2022-01-18. PMID:35039876. |
in the mptp group, the loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta, the reduction of the tyrosine hydroxylase content in the sn and striatum and the astrocyte proliferation and microglial activation in the sn were more significant compared with the rotenone group. |
2022-01-18 |
2023-08-13 |
mouse |
| Hanjiang Luo, Caixia Peng, Xiaofeng Xu, Yuntao Peng, Fang Shi, Qinghua Li, Jianghui Dong, Min Che. The Protective Effects of Mogroside V Against Neuronal Damages by Attenuating Mitochondrial Dysfunction via Upregulating Sirtuin3. Molecular neurobiology. 2022-01-18. PMID:35040040. |
in addition, the sirtuin3 (sirt3) protein level and activity were decreased upon exposure to rot both in substantia nigra (sn) of mice and sh-sy5y cells. |
2022-01-18 |
2023-08-13 |
mouse |
| Jelena Radulovic, Sanja Ivkovic, Miroslav Adzi. From chronic stress and anxiety to neurodegeneration: Focus on neuromodulation of the axon initial segment. Handbook of clinical neurology. vol 184. 2022-01-17. PMID:35034756. |
in some individuals, anxiety disorders precede the development of motor symptoms of parkinson's disease (pd) caused by degeneration of neurons in the substantia nigra (sn). |
2022-01-17 |
2023-08-13 |
Not clear |
| Qingyu Ren, Xin Jiang, Shanshan Zhang, Xin Gao, Yam Nath Paudel, Pengyu Zhang, Rongchun Wang, Kechun Liu, Meng Ji. Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 147. 2022-01-14. PMID:35030435. |
parkinson's disease (pd) is characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and aggregation of α-synuclein (α-syn). |
2022-01-14 |
2023-08-13 |
cat |
| Maximilian Wulf, Katalin Barkovits-Boeddinghaus, Paula Sommer, Karin Schork, Martin Eisenacher, Peter Riederer, Manfred Gerlach, Steffen Kösters, Britta Eggers, Katrin Marcu. Laser Microdissection-Based Protocol for the LC-MS/MS Analysis of the Proteomic Profile of Neuromelanin Granules. Journal of visualized experiments : JoVE. issue 178. 2022-01-03. PMID:34978295. |
thus, an automated laser microdissection (lmd)-based protocol is established here which allows the collection of nmgs and surrounding substantia nigra (sn) tissue using minimal amounts of tissue in an unbiased, automatized way. |
2022-01-03 |
2023-08-13 |
human |
| Emmanuel Vazquez-Mayorga, Mariana Grigoruta, Raul Dagda, Bridget Martinez, Ruben K Dagd. Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats. Journal of Parkinson's disease. 2021-12-27. PMID:34957950. |
sparkinson's disease (pd) is a relentless, chronic neurodegenerative disease characterized by the progressive loss of substantia nigra (sn) neurons that leads to the onset of motor and non-motor symptoms. |
2021-12-27 |
2023-08-13 |
rat |
| Tian Zhang, Tan Wang, Xinxu Chen, Zhenqiang Zhao, Zhibin Che. Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and therapeutic medicine. vol 23. issue 1. 2021-12-22. PMID:34934429. |
chronic, low-dose, mptp-treated mice exhibited upregulated gene expression levels of tnf-α and il-1β in the substantia nigra (sn) of the mice, and induced intestinal microbial disorders. |
2021-12-22 |
2023-08-13 |
mouse |
| Alexandra Sobczak, Stefan Repplinger, Eva M Bauch, Norbert Brueggemann, Christina Lohse, Hermann Hinrichs, Lars Buentjen, Juergen Voges, Tino Zaehle, Nico Bunzec. Anticipating social incentives recruits alpha-beta oscillations in the human substantia nigra and invigorates behavior across the life span. NeuroImage. vol 245. 2021-12-11. PMID:34732325. |
however, little is known about possible age-related behavioral changes, and how the human substantia nigra (sn) signals positive and negative social information. |
2021-12-11 |
2023-08-13 |
human |
| Min Hyung Seo, Sabina Lim, Sujung Ye. Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model. BMC neuroscience. vol 22. issue 1. 2021-12-11. PMID:34736417. |
parkinson's disease (pd) represent a loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain. |
2021-12-11 |
2023-08-13 |
mouse |
| Meiqiu Liu, Qian Jiao, Xixun Du, Mingxia Bi, Xi Chen, Hong Jian. Potential Crosstalk Between Parkinson's Disease and Energy Metabolism. Aging and disease. vol 12. issue 8. 2021-12-11. PMID:34881082. |
parkinson's disease (pd) is characterized by the accumulation of alpha-synuclein (α-syn) in the substantia nigra (sn) and the degeneration of nigrostriatal dopaminergic (daergic) neurons. |
2021-12-11 |
2023-08-13 |
Not clear |
| Ling Qi, Yao Wang, Ya-Nan Li, Lei Guo, Jun M. [Electroacupuncture improves behavioral activities by suppressing neuroinflammation and TLR4/NF-κB signaling in substantia nigra of midbrain in Parkinson's disease rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 11. 2021-12-08. PMID:34865329. |
to observe the effect of electroacupuncture(ea) at "fengfu" (gv16) and "taichong"(lr3) on the expression of tyrosine hydroxylase (th), α-synuclein (α-syn) and microglial-related microglial (mg), toll-like receptor 4（tlr4）/nuclear factor kappa b （nf-κb） signaling pathway in the substantia nigra (sn) of midbrain in rotenone-induced parkinson's disease (pd) rats, so as to explore its mechanisms underlying improvement of pd. |
2021-12-08 |
2023-08-13 |
rat |
| Yan Xu, Shicong Wang, Longmao Chen, Ziqiang Shao, Min Zhang, Shuang Liu, Xinwen Wen, Yangding Li, Wenhan Yang, Fei Tang, Jing Luo, Li Fan, Cui Yan, Jun Liu, Kai Yua. Reduced midbrain functional connectivity and recovery in abstinent heroin users. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34662755. |
the resting-state functional connectivity (rsfc) patterns of midbrain (i.e., the ventral tegmental area (vta) and substantia nigra (sn)) were compared between 40 abstinent heroin users with opioid use disorder (hus) and 35 healthy controls (hcs). |
2021-12-07 |
2023-08-13 |
human |
| Min Hyung Seo, Bo-Ram Jin, Hyo-Jung Kim, Hyo-Jin An, Sujung Ye. Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. Neuroscience letters. 2021-12-07. PMID:34875351. |
parkinson's disease (pd) occurs when dopaminergic cells in the substantia nigra (sn) region are destroyed; however, the cause of the destruction of dopamine cells has not yet been determined. |
2021-12-07 |
2023-08-13 |
rat |
| Altair B Dos Santos, Line K Skaanning, Eyd Mikkelsen, Cesar R Romero-Leguizamón, Morten P Kristensen, Anders B Klein, Siganya Thaneshwaran, Annette E Langkilde, Kristi A Kohlmeie. α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum, and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson's Disease. Journal of Parkinson's disease. vol 11. issue 4. 2021-12-04. PMID:34151857. |
while pd is diagnosed by motor symptoms putatively due to aggregated α-synuclein-mediated damage to substantia nigra (sn) neurons, up to a decade before motor symptom appearance, patients exhibit sleep disorders (sds). |
2021-12-04 |
2023-08-13 |
Not clear |
| Jingjing Xu, Xiaojun Guan, Jiaqi Wen, Tao Wang, Minming Zhang, Xiaojun X. Substantia nigra iron affects functional connectivity networks modifying working memory performance in younger adults. The European journal of neuroscience. 2021-12-03. PMID:34779047. |
higher substantia nigra (sn) iron concentration was associated with lower rsfc between sn and brain regions of the temporal/frontal lobe but with better wm performance after controlling for age, gender and education. |
2021-12-03 |
2023-08-13 |
human |
| Amanda L Sharpe, Marta Trzeciak, Nicole L Eliason, Harris E Blankenship, Bre' Ana M Byrd, Phillip D Douglas, Willard M Freeman, Michael J Beckstea. Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addiction biology. 2021-12-03. PMID:34825430. |
dopamine neurons in the substantia nigra (sn) and ventral tegmental area (vta) play a central role in the reinforcing properties of abused drugs including methamphetamine and cocaine. |
2021-12-03 |
2023-08-13 |
mouse |
| Zhong-Rui Du, Yu Gu, Xiao-Man Xie, Mei Zhang, Guo-Yi Jiang, Wen-Fang Che. GPER and IGF-1R mediate the anti-inflammatory effect of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in rats. The Journal of steroid biochemistry and molecular biology. vol 214. 2021-12-01. PMID:34478828. |
genistein attenuated lps-induced decrease of the contents of dopamine (da) and its metabolites in striatum as well as the loss of tyrosine hydroxylase-immunoreactive (th-ir) neurons in the substantia nigra (sn) of the lesioned side, which could be blocked by gper antagonist g15 or igf-1r antagonist jb1. |
2021-12-01 |
2023-08-13 |
rat |
| Sheelu Monga, Nunzio Denora, Valentino Laquintana, Rami Yashaev, Abraham Weizman, Moshe Gavis. The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson's Disease. Biology. vol 10. issue 11. 2021-11-30. PMID:34827176. |
parkinson's disease (pd) is a progressive neurodegenerative disorder which is characterized by the degeneration of dopaminergic neurons in substantia nigra (sn). |
2021-11-30 |
2023-08-13 |
Not clear |
| Niels Bergsland, Laura Pelizzari, Maria Marcella Laganá, Sonia Di Tella, Federica Rossetto, Raffaello Nemni, Mario Clerici, Francesca Bagli. Automated Assessment of the Substantia Nigra Pars Compacta in Parkinson's Disease: A Diffusion Tensor Imaging Study. Journal of personalized medicine. vol 11. issue 11. 2021-11-30. PMID:34834587. |
the substantia nigra (sn) pars compacta (snpc) and pars reticulata (snpr) are differentially affected in parkinson's disease (pd). |
2021-11-30 |
2023-08-13 |
Not clear |