| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Shahidul Islam, Fazli Azim, Hedaeytullah Saju, Arman Zargaran, Meysam Shirzad, Mostofa Kamal, Kaniz Fatema, Sumbul Rehman, M A Momith Azad, Somayeh Ebrahimi-Baroug. Pesticides and Parkinson's disease: Current and future perspective. Journal of chemical neuroanatomy. vol 115. 2021-11-04. PMID:33991619. |
pesticides strongly inhibit mitochondrial complex-i, causing mitochondrial dysfunction and death of dopaminergic neurons in the substantia nigra (sn), thus leading to pathophysiologic implications of pd. |
2021-11-04 |
2023-08-13 |
Not clear |
| Yan Teng, Zhihao Liu, Xingmin Chen, Yanzhuo Liu, Fan Geng, Weidong Le, Haisong Jiang, Lu Yan. Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34288397. |
to evaluate the necessity of m6a in dopaminergic neuron functions, we conditionally deleted mettl14, one of the most important part of m6a methyltransferase complexes, in the substantia nigra (sn) region enriched with dopaminergic neurons. |
2021-11-04 |
2023-08-13 |
mouse |
| Omid Tavassoly, Esther Del Cid Pellitero, Frederique Larroquette, Eddie Cai, Rhalena A Thomas, Vincent Soubannier, Wen Luo, Thomas M Durcan, Edward A Fo. Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 2. 2021-11-02. PMID:33713002. |
aggregation and deposition of α-synuclein (α-syn) in lewy bodies within dopamine neurons of substantia nigra (sn) is the pathological hallmark of parkinson's disease (pd). |
2021-11-02 |
2023-08-13 |
mouse |
| Mei-Rong Gao, Min Wang, Yan-Yan Jia, Dan-Dan Tian, An Liu, Wen-Ju Wang, Le Yang, Jun-Yu Chen, Qi Yang, Rui Liu, Yu-Mei W. Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model. Brain research bulletin. vol 164. 2021-10-29. PMID:32846198. |
ech administration promoted the reduction of tyrosine hydroxylase (th) expression and the number of th-positive neurons in the substantia nigra (sn) under mptp injury as the molecular docking simulation predicted that ech would interact with th. |
2021-10-29 |
2023-08-13 |
mouse |
| Jui-Chih Chang, Yi-Chun Chao, Huei-Shin Chang, Yu-Ling Wu, Hui-Ju Chang, Yong-Shiou Lin, Wen-Ling Cheng, Ta-Tsung Lin, Chin-San Li. Intranasal delivery of mitochondria for treatment of Parkinson's Disease model rats lesioned with 6-hydroxydopamine. Scientific reports. vol 11. issue 1. 2021-10-28. PMID:34011937. |
dopaminergic (da) neuron survival and recovery > 60% occurred in lesions of the substantia nigra (sn) and striatum in mito and p-mito rats. |
2021-10-28 |
2023-08-13 |
rat |
| Celia Garcia-Malo, Sabela Novo-Ponte, Andrea Castro-Villacañas Farzamnia, Sara Boi, Carolina Miranda Castillo, Sofia Romero Peralta, Verónica Martínez Vidal, Laura Botta, Samantha Anguizola, Irene Cano-Pumarega, Diego Garcia-Borreguer. Correlation between systemic iron parameters and substantia nigra iron stores in restless legs syndrome. Sleep medicine. vol 85. 2021-10-28. PMID:34343769. |
to evaluate the relation between systemic iron parameters (sip) and substantia nigra (sn) iron deposits, as assessed by transcranial sonography (tcs) in restless legs syndrome (rls). |
2021-10-28 |
2023-08-13 |
Not clear |
| Fatema Currim, Jyoti Singh, Anjali Shinde, Dhruv Gohel, Milton Roy, Kritarth Singh, Shatakshi Shukla, Minal Mane, Hitesh Vasiyani, Rajesh Sing. Exosome Release Is Modulated by the Mitochondrial-Lysosomal Crosstalk in Parkinson's Disease Stress Conditions. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33404982. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta region of the brain. |
2021-10-27 |
2023-08-13 |
Not clear |
| Subhrangshu Guhathakurta, Jinil Kim, Levi Adams, Sambuddha Basu, Min Kyung Song, Evan Adler, Goun Je, Mariana Bernardo Fiadeiro, Yoon-Seong Ki. Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson's disease. EMBO molecular medicine. vol 13. issue 2. 2021-10-22. PMID:33428332. |
we investigated these histone marks in post-mortem brains of controls and pd patients and observed that only h3k4me3 was significantly elevated at the snca promoter of the substantia nigra (sn) of pd patients both in punch biopsy and in neun-positive neuronal nuclei samples. |
2021-10-22 |
2023-08-13 |
Not clear |
| Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qi. Transcriptome profiling of five brain regions in a 6-hydroxydopamine rat model of Parkinson's disease. CNS neuroscience & therapeutics. vol 27. issue 11. 2021-10-22. PMID:34347369. |
previous studies mainly focus on the lesions of substantia nigra (sn) and striatum (str) in pd. |
2021-10-22 |
2023-08-13 |
rat |
| Rodrigo D Perea, Rebecca C Rada, Jessica Wilson, Eric D Vidoni1, Jill K Morris, Kelly E Lyons, Rajesh Pahwa, Jeffrey M Burns, Robyn A Hone. A Comparative White Matter Study with Parkinson's disease, Parkinson's Disease with Dementia and Alzheimer's Disease. Journal of Alzheimer's disease & Parkinsonism. vol 3. 2021-10-21. PMID:24724042. |
we used whole brain tract based spatial statistics (tbss) and a region of interest (roi) analysis focused on the substantia nigra (sn). |
2021-10-21 |
2023-08-13 |
Not clear |
| Atsushi Yoshida, Frank Q Ye, David K Yu, David A Leopold, Okihide Hikosak. Visualization of iron-rich subcortical structures in non-human primates in vivo by quantitative susceptibility mapping at 3T MRI. NeuroImage. vol 241. 2021-10-20. PMID:34311068. |
the qsm significantly improved the visualization of important structures, including the ventral pallidum (vp), globus pallidus external and internal segments (gpe and gpi), substantia nigra (sn), subthalamic nucleus (stn) in the basal ganglia and the dentate nucleus (dn) in the cerebellum. |
2021-10-20 |
2023-08-13 |
human |
| Masaaki Hirayama, Kinji Ohn. Parkinson's Disease and Gut Microbiota. Annals of nutrition & metabolism. vol 77 Suppl 2. 2021-10-20. PMID:34500451. |
accumulating knowledge points to the notion that α-synuclein fibrils start from the dorsal vagal nucleus and ascend to the locus ceruleus and the substantia nigra (sn). |
2021-10-20 |
2023-08-13 |
human |
| Lu Wang, Yayun Yan, Liyao Zhang, Yan Liu, Ruirui Luo, Ying Chan. Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 2. 2021-10-15. PMID:33559725. |
diagnostic accuracy of using lateral substantia nigra (sn) in td and pigd groups was 79% (sensitivity 76.5%, specificity 78.6%). |
2021-10-15 |
2023-08-13 |
human |
| Jianjun Ma, Zhidong Wang, Siyuan Chen, Wenhua Sun, Qi Gu, Dongsheng Li, Jinhua Zheng, Hongqi Yang, Xue L. EphA1 Activation Induces Neuropathological Changes in a Mouse Model of Parkinson's Disease Through the CXCL12/CXCR4 Signaling Pathway. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33057926. |
the purpose of this study is to investigate the effect of epha1 in mice and pd cell models and its mechanism.in this study, we verified the difference in expression of epha1 and the effect and mechanism of epha1 on neuropathological changes through parkinson's patient samples, parkinson's mice model, and parkinson's model prepared from sh-sy5y cells in vitro.epha1 was highly expressed in the substantia nigra (sn) region of parkinson mice and the parkinson cell model, while the expression of tyrosine hydroxylase (th) in the sn region of parkinson mice was significantly reduced. |
2021-10-13 |
2023-08-13 |
mouse |
| Ito Kawakami, Atsuko Motoda, Masashi Hashimoto, Aki Shimozawa, Masami Masuda-Suzukake, Reiko Ohtani, Mina Takase, Mari Kumashiro, Kazuyuki Samejima, Masato Hasegaw. Progression of phosphorylated α-synuclein in Macaca fuscata. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-10-13. PMID:33754430. |
the left substantia nigra (sn) and the bilateral frontal cortex also contained some ncis and neurites. |
2021-10-13 |
2023-08-13 |
human |
| Naying He, Kiarash Ghassaban, Pei Huang, Mojtaba Jokar, Ying Wang, Zenghui Cheng, Zhijia Jin, Yan Li, Sean K Sethi, Yixi He, Yongsheng Chen, Sara Gharabaghi, Shengdi Chen, Fuhua Yan, E Mark Haack. Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson's disease. NeuroImage. vol 230. 2021-10-12. PMID:33524572. |
previous studies using iron, neuromelanin (nm) or the nigrosome-1 (n1) sign in the substantia nigra (sn) by themselves have been unable to provide sufficiently high diagnostic performance for these methods to be adopted clinically. |
2021-10-12 |
2023-08-13 |
human |
| Abhishek Kumar Mishra, Anubhuti Dixi. Dopaminergic Axons: Key Recitalists in Parkinson's Disease. Neurochemical research. 2021-10-12. PMID:34637100. |
the dopamine level in the striatum is preserved because of the innervation of the substantia nigra (sn) dopaminergic neurons into it. |
2021-10-12 |
2023-08-13 |
Not clear |
| Alexandra Lang, Eva Dassler, Ivan Milenkovic, Mirjam I Lutz, Gabor G Kovac. Variable expression of mitochondrial complex IV in the course of nigral intracellular accumulation of α-synuclein. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34385008. |
accordingly, α-synuclein pathology affects the substantia nigra (sn) only in braak stage 3 out of 6. |
2021-10-11 |
2023-08-13 |
human |
| Weitang Liu, Wenwen Lao, Renxing Zhang, Hongyan Zh. Altered expression of voltage gated sodium channel Nav1.1 is involved in motor ability in MPTP-treated mice. Brain research bulletin. vol 170. 2021-10-07. PMID:33610724. |
parkinson's disease (pd) is a motor disabling disorder owing to the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2021-10-07 |
2023-08-13 |
mouse |
| Zhaoqiang Zhang, Xiao Sun, Kun Wang, Yang Yu, Li Zhang, Keping Zhang, Jinglongfei Gu, Xiaofan Yuan, Guohua Son. Hydrogen-saturated saline mediated neuroprotection through autophagy via PI3K/AKT/mTOR pathway in early and medium stages of rotenone-induced Parkinson's disease rats. Brain research bulletin. vol 172. 2021-10-07. PMID:33838212. |
decreased levels of reactive oxygen species (ros) and alpha-synuclein (α-syn), transformation of microtubule associated protein 1 light chain 3 (lc3)-i/ii and degradation of sequestosome 1 (p62) were detected, as well as increased expression level of autophagy related protein 5 (atg5) and b-cell lymphoma-2 interacting protein 1 (beclin-1) in the rvlm and substantia nigra (sn) after hs treatment in early and medium stages of pd rats. |
2021-10-07 |
2023-08-13 |
rat |