| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Simorgh, Rafieh Alizadeh, Ronk Shabani, Fariba Karimzadeh, Elham Seidkhani, Jamal Majidpoor, Fatemeh Moradi, Hamidreza Kasbiya. Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33433781. |
to do so, we examined the homing variation of oe-mscs in different brain regions such as olfactory bulb (ob), cortex, striatum (str), hippocampus (hpc), and substantia nigra (sn). |
2021-11-29 |
2023-08-13 |
rat |
| Hansol Lee, HyungJoon Cho, Myung Jun Lee, Tae-Hyung Kim, Jieun Roh, Jae-Hyeok Le. Differential Effect of Iron and Myelin on Susceptibility MRI in the Substantia Nigra. Radiology. vol 301. issue 3. 2021-11-29. PMID:34609198. |
background the heterogeneous composition of substantia nigra (sn), including iron, nigrosome-1 substructure, and myelinated white matter, complicates the interpretation of mri signals. |
2021-11-29 |
2023-08-13 |
human |
| Fei Zeng, Yan Fan, Russell W Brown, Wesley Drew Gill, Jennifer B Price, Thomas C Jones, Meng-Yang Zh. Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains. ASN neuro. vol 13. 2021-11-27. PMID:34812056. |
results showed that the administration of l-threo-3,4-dihydroxyphenylserine (l-dops) for 21 days significantly increased the expression of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum and substantia nigra (sn) of 23-month-old rats. |
2021-11-27 |
2023-08-13 |
rat |
| Yang Zhang, Li Zhou, Hui Lian, Yimin Zhang, Shilin Tong, Zhiyong Wan. Dopamine receptor 2 downregulation and brain-derived neurotrophic factor upregulation in the paraventricular nucleus are correlated with brown adipose tissue thermogenesis in rats with bilateral substantia nigra lesions. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34454019. |
our previous studies have found that a large number of dopamine (da) receptors (drs) are expressed on bdnf-positive neurons in the pvn and that the substantia nigra (sn) can directly project to the pvn (forming the sn-pvn pathway). |
2021-11-26 |
2023-08-13 |
rat |
| Bing Cao, Yanqiu Zhang, Jinhu Chen, Pengyue Wu, Yuxuan Dong, Yanqin Wan. Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson's disease. Metabolic brain disease. 2021-11-24. PMID:34817756. |
results showed that liraglutide dose-dependently ameliorated mouse behavior including swimming time and locomotor activity, increased the number of tyrosine hydroxylase (th)-positive neurons and protein level, and reduced iba1 and gfap expression in the substantia nigra (sn). |
2021-11-24 |
2023-08-13 |
mouse |
| Monika Sharma, Jaswinder Kaur, Siddhi Rakshe, Nishant Sharma, Dignesh Khunt, Amit Khairna. Intranasal Exposure to Low-Dose Rotenone Induced Alpha-Synuclein Accumulation and Parkinson's Like Symptoms Without Loss of Dopaminergic Neurons. Neurotoxicity research. 2021-11-24. PMID:34817799. |
pd models targeting olfactory bulb (ob) have demonstrated the dopaminergic (daergic) neurodegeneration in both ob and substantia nigra (sn). |
2021-11-24 |
2023-08-13 |
mouse |
| Ricielle L Augusto, Ingrid P Mendonça, Gabriel N de Albuquerque Rego, Danielle D Pereira, Lílian V da Penha Gonçalves, Maria L Dos Santos, Raphael F de Souza, Giselle M M Moreno, Pablo R G Cardoso, Daniele de Souza Andrade, José C da Silva-Júnior, Michelly C Pereira, Christina A Peixoto, Cybelle F B Medeiros-Linard, Ivone A de Souza, Belmira L da Silveira Andrade-da-Cost. Purified anacardic acids exert multiple neuroprotective effects in pesticide model of Parkinson's disease: in vivo and in silico analysis. IUBMB life. vol 72. issue 8. 2021-11-23. PMID:32449271. |
this study evaluated the efficacy of 50 mg/kg purified anacardic acids (aas), isolated from cashew nut shell liquid, on multiple steps of oxidative stress and inflammation induced by rotenone in the substantia nigra (sn) and striatum. |
2021-11-23 |
2023-08-13 |
mouse |
| Hai-Yue Tu, Bao-Shi Yuan, Xiao-Ou Hou, Xiao-Jun Zhang, Chong-Shuang Pei, Ya-Ting Ma, Ya-Ping Yang, Yi Fan, Zheng-Hong Qin, Chun-Feng Liu, Li-Fang H. α-synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson's disease. Aging cell. 2021-11-23. PMID:34811872. |
the in vitro findings were verified in microglia-enriched population isolated from α-syn-overexpressing mice induced by adeno-associated virus (aav2/9)-encoded wildtype human α-syn injection into the substantia nigra (sn). |
2021-11-23 |
2023-08-13 |
mouse |
| Maurice A Curtis, Vinata Vedam-Ma. Advancing Our Understanding of Brain Disorders: Research Using Postmortem Brain Tissue. Methods in molecular biology (Clifton, N.J.). vol 2389. 2021-11-22. PMID:34558012. |
it is thought that proliferative potential of neural progenitor cells, from postmortem tissue obtained from idiopathic pd patients, present in the substantia nigra (sn) as well as other brain regions can be maintained in vitro. |
2021-11-22 |
2023-08-13 |
human |
| Tony Oosterveen, Pedro Garção, Emma Moles-Garcia, Clement Soleilhavoup, Marco Travaglio, Shahida Sheraz, Rosa Peltrini, Kieran Patrick, Valerie Labas, Lucie Combes-Soia, Ulrika Marklund, Peter Hohenstein, Lia Panma. Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem cell reports. vol 16. issue 11. 2021-11-20. PMID:34678205. |
in parkinson's disease (pd), substantia nigra (sn) dopaminergic (da) neurons degenerate, while related ventral tegmental area (vta) da neurons remain relatively unaffected. |
2021-11-20 |
2023-08-13 |
mouse |
| Brent J Ryan, Nora Bengoa-Vergniory, Matthew Williamson, Ecem Kirkiz, Rosalind Roberts, Gabriele Corda, Maximilian Sloan, Saba Saqlain, Marta Cherubini, Josse Poppinga, Helle Bogtofte, Milena Cioroch, Svenja Hester, Richard Wade-Martin. REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 16. 2021-11-19. PMID:33563726. |
alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (sn) of parkinson's patients. |
2021-11-19 |
2023-08-13 |
mouse |
| I Friedrich, K Reimann, S Jankuhn, E Kirilina, J Stieler, M Sonntag, J Meijer, N Weiskopf, T Reinert, T Arendt, M Morawsk. Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33752749. |
particularly in parkinson's disease (pd) changes in iron concentrations in the substantia nigra (sn) was suggested to play a key role in degeneration of dopaminergic neurons in nigrosome 1. |
2021-11-18 |
2023-08-13 |
Not clear |
| Véronne A J de Vrind, Lisanne J van 't Sant, Annemieke Rozeboom, Mieneke C M Luijendijk-Berg, Azar Omrani, Roger A H Ada. Leptin Receptor Expressing Neurons in the Substantia Nigra Regulate Locomotion, and in The Ventral Tegmental Area Motivation and Feeding. Frontiers in endocrinology. vol 12. 2021-11-18. PMID:34276560. |
in most studies that target the midbrain, either all lepr neurons of the midbrain or those of the ventral tegmental area (vta) were targeted, but the role of substantia nigra (sn) lepr neurons has not been investigated. |
2021-11-18 |
2023-08-13 |
mouse |
| Amit Khairnar, Jana Ruda-Kucerova, Anas Arab, Constantinos Hadjistyllis, Alzbeta Sejnoha Minsterova, Qi Shang, Alexandra Chovsepian, Eva Drazanova, Nikoletta Szabó, Zenon Starcuk, Irena Rektorova, Francisco Pan-Montoj. Diffusion kurtosis imaging detects the time-dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease. Journal of neurochemistry. vol 158. issue 3. 2021-11-16. PMID:34107061. |
clinical diagnosis of parkinson's disease (pd) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (sn) already died, and the first motor symptoms appear. |
2021-11-16 |
2023-08-13 |
mouse |
| Rachel Underwood, Mary Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A Yacoubia. 14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model. Acta neuropathologica communications. vol 9. issue 1. 2021-11-15. PMID:33413679. |
14-3-3θ overexpression by aav in the substantia nigra (sn) also delayed αsyn aggregation in the sn and partially rescued pff-induced reduction in tyrosine hydroxylase (th)-positive dopaminergic cells in the sn. |
2021-11-15 |
2023-08-13 |
Not clear |
| Aqilah M McCane, Meredyth A Wegener, Mojdeh Faraji, Maria T Rivera-Garcia, Kathryn G Wallin-Miller, Vincent D Costa, Bita Moghadda. Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-14. PMID:34611024. |
both forms of learning, when associated with a rewarding outcome, rely on midbrain dopamine neurons in the ventral tegmental area (vta) and substantia nigra (sn). |
2021-11-14 |
2023-08-13 |
rat |
| Hansol Lee, Myung Jun Lee, Eun-Joo Kim, Gi Yeong Huh, Jae-Hyeok Lee, HyungJoon Ch. Iron accumulation in the oculomotor nerve of the progressive supranuclear palsy brain. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33536537. |
abnormal iron accumulation around the substantia nigra (sn) is a diagnostic indicator of parkinsonism. |
2021-11-12 |
2023-08-13 |
Not clear |
| Fumihiko Ueno, Yusuke Iwata, Shinichiro Nakajima, Fernando Caravaggio, Jose M Rubio, Guillermo Horga, Clifford M Cassidy, Edgardo Torres-Carmona, Vincenzo de Luca, Sakiko Tsugawa, Shiori Honda, Sho Moriguchi, Yoshihiro Noda, Philip Gerretsen, Ariel Graff-Guerrer. Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. 2021-11-12. PMID:34718049. |
the patient group (n = 163) showed higher nm levels in the substantia nigra (sn) than hcs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 nm-mri studies. |
2021-11-12 |
2023-08-13 |
Not clear |
| Melissa Scholefield, Stephanie J Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M Hooper, Richard D Unwin, Garth J S Coope. Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson's Disease Dementia. Frontiers in molecular neuroscience. vol 14. 2021-11-10. PMID:34751215. |
here we report measurements of tissue urea from nine neuropathologically confirmed regions of the brain in pdd and post-mortem delay (pmd)-matched controls, in regions including the cerebellum, motor cortex (mcx), sensory cortex, hippocampus (hp), substantia nigra (sn), middle temporal gyrus (mtg), medulla oblongata (med), cingulate gyrus, and pons, by applying ultra-high-performance liquid chromatography-tandem mass spectrometry (uhplc-ms/ms). |
2021-11-10 |
2023-08-13 |
human |
| Amandine Isenbrandt, Marc Morissette, Mélanie Bourque, Jérôme Lamontagne-Proulx, Katherine Coulombe, Denis Soulet, Thérèse Di Paol. Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice. Neuropharmacology. vol 201. 2021-11-09. PMID:34555366. |
the main neuropathological feature of parkinson's disease (pd) is degeneration of dopamine (da) neurons in the substantia nigra (sn); pd prevalence is higher in men, suggesting a role of sex hormones in neuroprotection. |
2021-11-09 |
2023-08-13 |
mouse |