| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haichen Niu, Qian Wang, Weiguang Zhao, Jianxin Liu, Deguang Wang, Bilal Muhammad, Xiaoyu Liu, Ning Quan, Haoyu Zhang, Fang Zhang, Yong Wang, Haiying Li, Rongli Yan. IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-Synuclein pathology in the olfactory bulb, substantia nigra and striatum. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32678959. |
in addition, an aberrant form of α-syn, the phosphorylated serine 129 α-syn (ps129 α-syn), was found in the ob, substantia nigra (sn) and striatum 6 weeks after the lps treatment. |
2021-10-06 |
2023-08-13 |
mouse |
| Min Hyung Seo, Sujung Ye. Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 162. 2021-09-29. PMID:32485229. |
parkinson's disease (pd) is a progressive neurodegenerative disease, which shows distinct manifestations such as significant loss of dopaminergic neurons in the substantia nigra (sn). |
2021-09-29 |
2023-08-13 |
mouse |
| Koki Mimura, Yuji Nagai, Ken-Ichi Inoue, Jumpei Matsumoto, Yukiko Hori, Chika Sato, Kei Kimura, Takashi Okauchi, Toshiyuki Hirabayashi, Hisao Nishijo, Noriaki Yahata, Masahiko Takada, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimot. Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets. iScience. vol 24. issue 9. 2021-09-29. PMID:34568790. |
we injected adeno-associated virus vectors expressing the excitatory dreadd hm3dq into the unilateral substantia nigra (sn) in four marmosets. |
2021-09-29 |
2023-08-13 |
Not clear |
| Nikos Priovoulos, Stan C J van Boxel, Heidi I L Jacobs, Benedikt A Poser, Kamil Uludag, Frans R J Verhey, Dimo Ivano. Unraveling the contributions to the neuromelanin-MRI contrast. Brain structure & function. vol 225. issue 9. 2021-09-28. PMID:33090274. |
the locus coeruleus (lc) and the substantia nigra (sn) are small brainstem nuclei that change with aging and may be involved in the development of various neurodegenerative and psychiatric diseases. |
2021-09-28 |
2023-08-13 |
human |
| Xue Ma, Qiang Wang, Wei Yuan, Yuan Wang, Feng Zhou, Kaiwen Kang, Xiaopeng Tong, Zhibin Li. Electroacupuncture Alleviates Neuroinflammation and Motor Dysfunction by Regulating Intestinal Barrier Function in a Mouse Model of Parkinson Disease. Journal of neuropathology and experimental neurology. vol 80. issue 9. 2021-09-28. PMID:34343334. |
electroacupuncture significantly increased the spontaneous activity of mice with pd and increased the expression of tyrosine hydroxylase, while reducing the expression of iba-1 in substantia nigra (sn), suggesting that motor dysfunction and neurological damage was alleviated. |
2021-09-28 |
2023-08-13 |
mouse |
| Yu Liu, Bin Xiao, Chencheng Zhang, Junchen Li, Yijie Lai, Feng Shi, Dinggang Shen, Linbin Wang, Bomin Sun, Yan Li, Zhijia Jin, Hongjiang Wei, Ewart Mark Haacke, Haiyan Zhou, Qian Wang, Dianyou Li, Naying He, Fuhua Ya. Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study. Frontiers in neuroscience. vol 15. 2021-09-25. PMID:34557069. |
emerging evidence indicates that iron distribution is heterogeneous within the substantia nigra (sn) and it may reflect patient-specific trait of parkinson's disease (pd). |
2021-09-25 |
2023-08-13 |
Not clear |
| Melissa Scholefield, Stephanie J Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M Hooper, Richard D Unwin, Garth J S Coope. Widespread Decreases in Cerebral Copper Are Common to Parkinson's Disease Dementia and Alzheimer's Disease Dementia. Frontiers in aging neuroscience. vol 13. 2021-09-24. PMID:33746735. |
several studies of parkinson's disease (pd) have reported dysregulation of cerebral metals, particularly decreases in copper and increases in iron in substantia nigra (sn). |
2021-09-24 |
2023-08-13 |
Not clear |
| Rui Wang, Hongyang Sun, Haigang Ren, Guanghui Wan. α-Synuclein aggregation and transmission in Parkinson's disease: a link to mitochondria and lysosome. Science China. Life sciences. vol 63. issue 12. 2021-09-23. PMID:32681494. |
the presence of intraneuronal lewy bodies (lbs) and lewy neurites (lns) in the substantia nigra (sn) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in parkinson's disease (pd). |
2021-09-23 |
2023-08-13 |
human |
| Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH. vol 65. issue s1. 2021-09-23. PMID:34468106. |
it is present in various areas of the human brain, most often in the substantia nigra (sn) pars compacta and the locus coeruleus, the main centers of dopaminergic and noradrenergic innervation, respectively. |
2021-09-23 |
2023-08-13 |
human |
| Wakana Oda, Yuki Fujita, Kousuke Baba, Hideki Mochizuki, Hitoshi Niwa, Toshihide Yamashit. Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson's disease. Cell death & disease. vol 12. issue 2. 2021-09-21. PMID:33589594. |
we treated mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and found increased rgma expression in the substantia nigra (sn). |
2021-09-21 |
2023-08-13 |
mouse |
| Jannik Prasuhn, Michelle Prasuhn, Anja Fellbrich, Robert Strautz, Felicitas Lemmer, Shalida Dreischmeier, Meike Kasten, Thomas F Münte, Henrike Hanssen, Marcus Heldmann, Norbert Brüggeman. Association of Locus Coeruleus and Substantia Nigra Pathology With Cognitive and Motor Functions in Patients With Parkinson Disease. Neurology. vol 97. issue 10. 2021-09-20. PMID:34187859. |
to investigate the contribution of substantia nigra (sn) and locus coeruleus (lc) pathology to clinical signs and symptoms in parkinson disease (pd) by applying neuromelanin-weighted imaging. |
2021-09-20 |
2023-08-13 |
Not clear |
| Saptarsi Mitra, Sumela Basu, Omprakash Singh, Ronald M Lechan, Praful S Singr. Cocaine- and amphetamine-regulated transcript peptide- and dopamine-containing systems interact in the ventral tegmental area of the zebra finch, Taeniopygia guttata, during dynamic changes in energy status. Brain structure & function. vol 226. issue 8. 2021-09-20. PMID:34392422. |
in the midbrain, tyrosine hydroxylase-immunoreactive (th-i) neurons were seen in the substantia nigra (sn) and vta [anterior (vtaa), mid (vtam) and caudal (vtac)]; those in vta were smaller. |
2021-09-20 |
2023-08-13 |
Not clear |
| Daiane Cattani, Nona Struyf, Vivien Steffensen, Jonas Bergquist, Ariane Zamoner, Eva Brittebo, Malin Andersso. Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology. vol 461. 2021-09-20. PMID:34474092. |
studies of human glyphosate intoxication have reported adverse effects on the nervous system, particularly in substantia nigra (sn). |
2021-09-20 |
2023-08-13 |
human |
| Anna M Lavezzi, Riffat Mehboob, Graziella Alfonsi, Stefano Ferrer. Substantia Nigra Abnormalities Provide New Insight on the Neural Mechanisms Underlying the Sleep-Arousal Phase Dysfunctions in Sudden Infant Death Syndrome. ASN neuro. vol 12. 2021-09-15. PMID:32993318. |
the purpose of this study was to research possible developmental alterations of the substantia nigra (sn) in sudden infant death syndrome (sids), a syndrome frequently attributed to arousal failure from sleep. |
2021-09-15 |
2023-08-13 |
Not clear |
| Taewoo Kim, Jeha Jeon, Jin-Sun Park, Yeongwon Park, Jooeui Kim, Haneul Noh, Hee-Sun Kim, Hyemyung Se. Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice. Biomolecules & therapeutics. vol 29. issue 5. 2021-09-14. PMID:34045367. |
parkinson's disease (pd) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-09-14 |
2023-08-13 |
mouse |
| Maike Hartlage-Rübsamen, Alexandra Bluhm, Sandra Moceri, Lisa Machner, Janett Köppen, Mathias Schenk, Isabel Hilbrich, Max Holzer, Martin Weidenfeller, Franziska Richter, Roland Coras, Geidy E Serrano, Thomas G Beach, Stephan Schilling, Stephan von Hörsten, Wei Xiang, Anja Schulze, Steffen Roßne. A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies. Acta neuropathologica. vol 142. issue 3. 2021-09-09. PMID:34309760. |
parkinson's disease (pd) is a progressive neurodegenerative disorder that is neuropathologically characterized by degeneration of dopaminergic neurons of the substantia nigra (sn) and formation of lewy bodies and lewy neurites composed of aggregated α-synuclein. |
2021-09-09 |
2023-08-13 |
mouse |
| Yilin Huang, Huisheng Liu, Jiaqi Hu, Chongyin Han, Zhenggang Zhong, Wei Luo, Yuhu Zhang, Fei Lin. Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-09-07. PMID:34483877. |
in this study, we analyzed incorporative substantia nigra (sn) expression data and blood expression data using the cibersort to obtain the 22 immune cell fractions and then explored the molecular function to identify the potential key immune cell types and genes of pd. |
2021-09-07 |
2023-08-13 |
Not clear |
| Xinwen Wen, Yawen Sun, Yuzheng Hu, Dahua Yu, Yan Zhou, Kai Yua. Identification of internet gaming disorder individuals based on ventral tegmental area resting-state functional connectivity. Brain imaging and behavior. vol 15. issue 4. 2021-09-06. PMID:33037577. |
as the key nodes of the da pathways, ventral tegmental area (vta) and substantia nigra (sn) and their connected brain regions may serve as potential markers to identify igd. |
2021-09-06 |
2023-08-13 |
human |
| Vaibhavi Peshattiwar, Suraj Muke, Aakruti Kaikini, Sneha Bagle, Vikas Dighe, Sadhana Sathay. Mechanistic evaluation of Ursolic acid against rotenone induced Parkinson's disease- emphasizing the role of mitochondrial biogenesis. Brain research bulletin. vol 160. 2021-08-31. PMID:32147532. |
it is caused due to degeneration of dopaminergic neurons in substantia nigra (sn). |
2021-08-31 |
2023-08-13 |
rat |
| Linlin Zhang, Yanan Zheng, Junxia Xie, Limin Sh. Potassium channels and their emerging role in parkinson's disease. Brain research bulletin. vol 160. 2021-08-31. PMID:32305406. |
parkinson's disease (pd) is the second most common neurodegenerative disorder, which is associated with a selective loss of dopaminergic neurons in the substantia nigra (sn) and a reduction of dopamine in the striatum. |
2021-08-31 |
2023-08-13 |
Not clear |