| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rasem Mustafa, Chahinaz Rawas, Nadja Mannal, Grzegorz Kreiner, Björn Spittau, Katarzyna Kamińska, Rüstem Yilmaz, Christina Pötschke, Joachim Kirsch, Birgit Liss, Kerry L Tucker, Rosanna Parlat. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants (Basel, Switzerland). vol 10. issue 8. 2021-08-30. PMID:34439532. |
here, we report that pc are required for maintenance of substantia nigra (sn) dopaminergic (da) neurons highly vulnerable in parkinson's disease (pd). |
2021-08-30 |
2023-08-13 |
mouse |
| Guoxue Zhu, Wang Wang, Chang Chen, Lili Tang, Yan Liang, Zhennian Zhang, Yan Lu, Yang Zha. UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson's disease mice after oral administration of Wen-Shen-Yang-Gan decoction. Aging. vol 13. issue 15. 2021-08-28. PMID:34339394. |
parkinson's disease (pd), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn). |
2021-08-28 |
2023-08-13 |
mouse |
| Blake L Elliott, Kimberlee D'Ardenne, Prerona Mukherjee, Julie B Schweitzer, Samuel M McClur. Limbic and Executive Meso- and Nigrostriatal Tracts Predict Impulsivity Differences in Attention-Deficit/Hyperactivity Disorder. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2021-08-26. PMID:34051394. |
we tested whether human midbrain pathways (where dopaminergic cell bodies originate) between the substantia nigra (sn) and ventral tegmental area (vta) and the striatum differed between participants with adhd and typically developing adolescent and young adult participants. |
2021-08-26 |
2023-08-13 |
human |
| Yolanda Gómez-Gálvez, Heidi R Fuller, Silvia Synowsky, Sally L Shirran, Monte A Gate. Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. Journal of neuroscience research. vol 98. issue 7. 2021-08-26. PMID:32270889. |
here, proteomic and bioinformatic analysis was conducted on the substantia nigra (sn) of rats at four stages of life to identify and quantify protein changes throughout aging. |
2021-08-26 |
2023-08-13 |
rat |
| Tz-Yun Jan, Lee-Chin Wong, Ming-Tao Yang, Chien-Feng Judith Huang, Chia-Jui Hsu, Steven Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Le. Correlation of dystonia severity and iron accumulation in Rett syndrome. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33436916. |
we recruited 18 rtt-diagnosed participants with mecp2 mutations, from age 4 to 28, and 28 age-gender matched controls and investigated the iron accumulation by susceptibility weighted image (swi) in substantia nigra (sn), globus pallidus (gp), putamen, caudate nucleus, and thalamus. |
2021-08-25 |
2023-08-13 |
human |
| Xiaodi Fu, Wenbin Deng, Xiangqin Cui, Xiao Zhou, Weizheng Song, Mengqiu Pan, Xiao Chi, Jinghui Xu, Ying Jiang, Qun Wang, Yunqi X. Time-Specific Pattern of Iron Deposition in Different Regions in Parkinson's Disease Measured by Quantitative Susceptibility Mapping. Frontiers in neurology. vol 12. 2021-08-24. PMID:34421781. |
the iron content in the subcortical nuclei covering substantia nigra (sn), red nucleus (rn), head of the caudate nucleus (cn), globus pallidus (gp), and putamen (pt) was measured using qsm, and the clinical symptoms of pd were evaluated by various rating scales. |
2021-08-24 |
2023-08-13 |
Not clear |
| Mor Hanan, Alon Simchovitz, Nadav Yayon, Shani Vaknine, Roni Cohen-Fultheim, Miriam Karmon, Nimrod Madrer, Talia Miriam Rohrlich, Moria Maman, Estelle R Bennett, David S Greenberg, Eran Meshorer, Erez Y Levanon, Hermona Soreq, Sebastian Kadene. A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress. EMBO molecular medicine. vol 12. issue 9. 2021-08-18. PMID:32715657. |
in the healthy substantia nigra (sn), circrnas accumulate in an age-dependent manner, but in the pd sn this correlation is lost and the total number of circrnas reduced. |
2021-08-18 |
2023-08-13 |
Not clear |
| Renfan Xu, Guangzhi Chen, Zhijuan Mao, Hongling Gao, Youbin Deng, Anyu Ta. Diagnostic Performance of Transcranial Sonography for Evaluating Substantia Nigra Hyper-echogenicity in Patients with Parkinson's Disease. Ultrasound in medicine & biology. vol 46. issue 5. 2021-08-12. PMID:32102740. |
to determine the diagnostic performance of transcranial sonography (tcs) in assessing increased echogenic area of the substantia nigra (sn) in patients with parkinson's disease (pd). |
2021-08-12 |
2023-08-13 |
Not clear |
| Xuelian Ma, Hui Zhang, Honglei Yin, Shuang Geng, Yajun Liu, Chen Liu, Jing Zhao, Yanqiu Liu, Xiaoyan Wang, Yunliang Wan. Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1. Brain research bulletin. vol 166. 2021-08-11. PMID:33144090. |
this study explored the protective effect of microrna (mir)-218-5p on dopaminergic neuron injury in substantia nigra (sn) of rats with pd through the regulation of lim and sh3 domain protein 1 (lasp1). |
2021-08-11 |
2023-08-13 |
rat |
| Osman Sinen, Ayşe Özkan, Aysel Ağar, Mehmet Bülbü. Neuropeptide-S prevents 6-OHDA-induced gastric dysmotility in rats. Brain research. vol 1762. 2021-08-11. PMID:33753063. |
in substantia nigra (sn), dorsal motor nucleus of the vagus (dmv), and gastric whole-mount samples, changes in tyrosine hydroxylase (th), choline acetyltransferase (chat), neuronal nitric oxide synthase (nnos), glial fibrillary acidic protein (gfap), nps receptor (npsr), and alpha-synuclein (ser129) were examined by immunohistochemistry. |
2021-08-11 |
2023-08-13 |
rat |
| Xiaoyi Xu, Xin He, Shanshan Ma, Mingtao Li, Qiaoying Huan. Nurr1 downregulation is caused by CREB inactivation in a Parkinson's disease mouse model. Neuroscience letters. vol 759. 2021-08-06. PMID:34119603. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-08-06 |
2023-08-13 |
mouse |
| Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zen. Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33261640. |
subsequently, dab staining analysis of substantia nigra (sn) dopaminergic neurons with the marker for tyrosine hydroxylase (th) was performed. |
2021-08-05 |
2023-08-13 |
mouse |
| Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang, Degui Wan. Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33230666. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-07-28 |
2023-08-13 |
mouse |
| Hexin Yan, Hui Zhao, Yunxiao Kang, Xiaoming Ji, Tianyun Zhang, Yu Wang, Rui Cui, Guoliang Zhang, Geming Sh. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Neuropharmacology. vol 194. 2021-07-28. PMID:34089729. |
mitochondrial dysfunction manifests as an early event in the substantia nigra (sn) in aging and parkinson disease. |
2021-07-28 |
2023-08-13 |
rat |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (sn) in the midbrain due to loss of dopaminergic neurons. |
2021-07-26 |
2023-08-13 |
rat |
| Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garrau. Parkinson's disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI. NPJ Parkinson's disease. vol 7. issue 1. 2021-07-24. PMID:34238927. |
parkinson's disease (pd) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (nm)-containing dopaminergic neurons and deposition of iron in the substantia nigra (sn). |
2021-07-24 |
2023-08-13 |
Not clear |
| Eun-Young Lee, Michael R Flynn, Guangwei Du, Mechelle M Lewis, Michael Goldenberg, Lan Kong, Richard B Mailman, Young-Seoub Hong, Xuemei Huan. Nigral MRI features of asymptomatic welders. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33691274. |
this study investigated whether asymptomatic welders display differences in the substantia nigra (sn), the key pathological locus of pd. |
2021-07-22 |
2023-08-13 |
Not clear |
| Mahsa Dadar, Janis Miyasaki, Simon Duchesne, Richard Camiciol. White matter hyperintensities mediate the impact of amyloid ß on future freezing of gait in Parkinson's disease. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33770671. |
previous studies have reported relationships between fog, substantia nigra (sn) degeneration, dopamine transporter (dat) concentration, as well as amyloid β deposition. |
2021-07-22 |
2023-08-13 |
Not clear |
| Wenyue Liu, Changpeng Wang, Tingting He, Minghong Su, Yuan Lu, Guanyu Zhang, Thomas F Münte, Lirong Jin, Zheng Y. Substantia nigra integrity correlates with sequential working memory in Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021-07-22. PMID:34099507. |
this study demonstrates that the substantia nigra (sn) integrity correlated with basal ganglia function and sequencing performance in 29 patients with pd (17 women) and 29 healthy controls (hc, 18 women). |
2021-07-22 |
2023-08-13 |
human |
| Raghunandan Kumar Yadav, Birendra Nath Mallic. Dopaminergic- and cholinergic-inputs from substantia nigra and pedunculo-pontine tegmentum, respectively, converge in amygdala to modulate rapid eye movement sleep in rats. Neuropharmacology. vol 193. 2021-07-21. PMID:34023337. |
isolated studies have reported that substantia nigra (sn) withdraws inhibition from pedunculo-pontine tegmentum (ppt) acetylcholine (ach)-ergic rem-on neurons to trigger rems; some rem-on neurons become phasically active during rems; amygdala (amyg), a limbic structure associated with emotions, may be related with dreaming like state; amyg receives projections from both sn-dopamine (da)-ergic and ppt-ach-ergic neurons. |
2021-07-21 |
2023-08-13 |
human |