| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Zampese, D James Surmeie. Calcium, Bioenergetics, and Parkinson's Disease. Cells. vol 9. issue 9. 2021-04-27. PMID:32911641. |
degeneration of substantia nigra (sn) dopaminergic (daergic) neurons is responsible for the core motor deficits of parkinson's disease (pd). |
2021-04-27 |
2023-08-13 |
Not clear |
| Ricardo Leitão, Carla Guerreiro, Rita G Nunes, Nilza Gonçalves, Giulia Galati, Madalena Rosário, Leonor Correia Guedes, Joaquim J Ferreira, Sofia Reimã. Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in Huntington's Disease. Journal of Huntington's disease. vol 9. issue 2. 2021-04-27. PMID:32065802. |
pathological changes in the extra-striatal structures, such as the substantia nigra (sn), and abnormalities in pre-synaptic striatal dopamine neurotransmission are also known to occur. |
2021-04-27 |
2023-08-13 |
Not clear |
| Timothy M Ellmore, Jessika Suescun, Richard J Castriotta, Mya C Schies. A Study of the Relationship Between Uric Acid and Substantia Nigra Brain Connectivity in Patients With REM Sleep Behavior Disorder and Parkinson's Disease. Frontiers in neurology. vol 11. 2021-04-21. PMID:32849245. |
despite these independent findings, the relationship between ua and substantia nigra (sn) functional connectivity remains unknown. |
2021-04-21 |
2023-08-13 |
Not clear |
| Celia Garcia-Malo, Vivian Wanner, Carolina Miranda, Sofia Romero Peralta, Lina Agudelo, Irene Cano-Pumarega, Juan José Granizo, Diego Garcia-Borreguer. Quantitative transcranial sonography of the substantia nigra as a predictor of therapeutic response to intravenous iron therapy in restless legs syndrome. Sleep medicine. vol 66. 2021-04-19. PMID:31875533. |
to analyze changes in substantia nigra (sn) iron deposits, assessed by quantitative transcranial sonography (tcs), to obtain and compare substantia nigra echogenicity indices (snei) at baseline and after intravenous (iv) iron therapy in patients with restless legs syndrome (rls)/willis-ekbom disease (wed). |
2021-04-19 |
2023-08-13 |
Not clear |
| Helena Xicoy, Jos F Brouwers, Bé Wieringa, Gerard J M Marten. Explorative Combined Lipid and Transcriptomic Profiling of Substantia Nigra and Putamen in Parkinson's Disease. Cells. vol 9. issue 9. 2021-04-12. PMID:32858884. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons from the substantia nigra (sn) that project to the dorsal striatum (caudate-putamen). |
2021-04-12 |
2023-08-13 |
Not clear |
| Tingting Du, Le Wang, Weijin Liu, Guanyu Zhu, Yingchuan Chen, Jianguo Zhan. Biomarkers and the Role of α-Synuclein in Parkinson's Disease. Frontiers in aging neuroscience. vol 13. 2021-04-10. PMID:33833675. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the presence of α-synuclein (α-syn)-rich lewy bodies (lbs) and the preferential loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta (snpc). |
2021-04-10 |
2023-08-13 |
Not clear |
| Wenlong Zhang, Junwei Gong, Liuyan Ding, Zhiling Zhang, Xiaowen Pan, Xiang Chen, Wenyuan Guo, Xiaokang Zhang, Xinling Yang, Guoyou Peng, Yuwan Lin, Feng Gao, Yuanquan Li, Xiaoqin Zhu, Aiguo Xuan, Shu Wang, Xiangdong Sun, Yunlong Zhang, Pingyi X. Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease. Cell death & disease. vol 11. issue 10. 2021-04-09. PMID:33093440. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by lewy body formation and progressive dopaminergic neuron death in the substantia nigra (sn). |
2021-04-09 |
2023-08-13 |
mouse |
| Tianbin Song, Jiping Li, Shanshan Mei, Xiaofei Jia, Hongwei Yang, Yongquan Ye, Jianmin Yuan, Yuqing Zhang, Jie L. Nigral Iron Deposition Is Associated With Levodopa-Induced Dyskinesia in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-04-09. PMID:33828454. |
to investigate iron deposition in the substantia nigra (sn) of parkinson's disease (pd) patients associated with levodopa-induced dyskinesia (lid). |
2021-04-09 |
2023-08-13 |
Not clear |
| Sergio Ortiz-Padilla, Elier Soto-Orduño, Marisa Escobar Barrios, Abril Armenta Manjarrez, Yadira Bastián, J Alfredo Mende. Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra. Neuropharmacology. vol 166. 2021-04-02. PMID:31870855. |
here, our results suggest that the somatodendritic release of dopamine in the substantia nigra (sn) may stimulate gabaergic neurons that project their axons into the hippocampus. |
2021-04-02 |
2023-08-13 |
Not clear |
| Abbas Mohammadipour, Hossein Haghir, Alireza Ebrahimzadeh Bideska. A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful? Reviews on environmental health. vol 35. issue 4. 2021-03-30. PMID:32681785. |
they can damage neurons, in particular dopaminergic neurons in the substantia nigra (sn) and striatal neurons which their lesion is associated with parkinson's disease (pd). |
2021-03-30 |
2023-08-13 |
Not clear |
| Melanie M Pina, Dipanwita Pati, Lara S Hwa, Sarah Y Wu, Alexandra A Mahoney, Chiazam G Omenyi, Montserrat Navarro, Thomas L Kas. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrainprojections from the insular cortex. Neuropharmacology. vol 165. 2021-03-30. PMID:31870854. |
within this microcircuit, dyn is robustly expressed in layer 2/3, while kor is localized to deep layer 5, which sends a long-range projection to the substantia nigra (sn). |
2021-03-30 |
2023-08-13 |
Not clear |
| Lu-Lu Bu, Ying-Yu Xie, Dan-Yu Lin, Ying Chen, Xiu-Na Jing, Yan-Ran Liang, Su-Dan Peng, Kai-Xun Huang, En-Xiang Ta. LncRNA-T199678 Mitigates α-Synuclein-Induced Dopaminergic Neuron Injury via miR-101-3p. Frontiers in aging neuroscience. vol 12. 2021-03-29. PMID:33328976. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by dopaminergic neuron death and the abnormal accumulation and aggregation of α-synuclein (α-syn) in the substantia nigra (sn). |
2021-03-29 |
2023-08-13 |
Not clear |
| Ekaterina Lazdon, Nofar Stolero, Dan Frenke. Microglia and Parkinson's disease: footprints to pathology. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 2. 2021-03-26. PMID:32016606. |
markers of inflammation can be found around the regions of risk and adjacent to the appearance of lewy bodies within the basal ganglia and the substantia nigra (sn) that are associated with pd pathology. |
2021-03-26 |
2023-08-13 |
Not clear |
| Seyed-Ahmad Ahmadi, Kai Bötzel, Johannes Levin, Juliana Maiostre, Tassilo Klein, Wolfgang Wein, Verena Rozanski, Olaf Dietrich, Birgit Ertl-Wagner, Nassir Navab, Annika Plat. Analyzing the co-localization of substantia nigra hyper-echogenicities and iron accumulation in Parkinson's disease: A multi-modal atlas study with transcranial ultrasound and MRI. NeuroImage. Clinical. vol 26. 2021-03-26. PMID:32050136. |
transcranial b-mode sonography (tcs) can detect hyperechogenic speckles in the area of the substantia nigra (sn) in parkinson's disease (pd). |
2021-03-26 |
2023-08-13 |
Not clear |
| Yong Wang, Qian Wang, Ruobing Yu, Qi Zhang, Zhonghai Zhang, Haiying Li, Chao Ren, Rongli Yang, Haichen Ni. Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression. Aging. vol 12. issue 14. 2021-03-24. PMID:32706757. |
the mαsyn expression leads to the loss of dopaminergic neurons in the substantia nigra (sn) and consequent motor dysfunctions. |
2021-03-24 |
2023-08-13 |
human |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Clara Domínguez Vivero, Yago Leira, Marta Saavedra Piñeiro, Xiana Rodríguez-Osorio, Pedro Ramos-Cabrer, Carmen Villalba Martín, Tomás Sobrino, Francisco Campos, José Castillo, Rogelio Leir. Iron Deposits in Periaqueductal Gray Matter Are Associated with Poor Response to OnabotulinumtoxinA in Chronic Migraine. Toxins. vol 12. issue 8. 2021-03-12. PMID:32731573. |
selected biomarkers in plasma during interictal periods (calcitonin gene-related peptide (cgrp) and pentraxin-3 (ptx3)) and neuroimaging changes (iron deposits in the red nucleus (rn), substantia nigra (sn), globus pallidus (gp), and periaqueductal gray matter (pag), and white matter lesions (wml)) were determined. |
2021-03-12 |
2023-08-13 |
human |
| Dong-Xin Wang, An-Di Chen, Qing-Jun Wang, Yue-Yang Xin, Jie Yin, Yu-Hong Jin. Protective effect of metformin against rotenone-induced parkinsonism in mice. Toxicology mechanisms and methods. vol 30. issue 5. 2021-03-12. PMID:32189544. |
pd animal model was established by unilateral rotenone injection into the right substantia nigra (sn) of c57bl/6 mice. |
2021-03-12 |
2023-08-13 |
mouse |
| Violina Kakoty, Sarathlal K C, Ruei-Dun Tang, Chih Hao Yang, Sunil Kumar Dubey, Rajeev Taliya. Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-03-11. PMID:32361164. |
the predominant pathological hallmark is progressive loss of dopaminergic (da) neurones in the substantia nigra (sn) complicated by aggregation of misfolded forms of alpha-synuclein (α-syn). |
2021-03-11 |
2023-08-13 |
Not clear |
| Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zh. miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in International journal of molecular medicine. vol 47. issue 4. 2021-03-10. PMID:33649797. |
mir‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-10 |
2023-08-13 |
Not clear |