| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toni S Pearson, Nalin Gupta, Waldy San Sebastian, Jill Imamura-Ching, Amy Viehoever, Ana Grijalvo-Perez, Alex J Fay, Neha Seth, Shannon M Lundy, Youngho Seo, Miguel Pampaloni, Keith Hyland, Erin Smith, Gardenia de Oliveira Barbosa, Jill C Heathcock, Amy Minnema, Russell Lonser, J Bradley Elder, Jeffrey Leonard, Paul Larson, Krystof S Bankiewic. Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons. Nature communications. vol 12. issue 1. 2021-07-21. PMID:34253733. |
seven (7) children, aged 4-9 years underwent convection-enhanced delivery (ced) of aav2-haadc to the bilateral substantia nigra (sn) and ventral tegmental area (vta) (total infusion volume: 80 µl per hemisphere) in 2 dose cohorts: 1.3 × 10 |
2021-07-21 |
2023-08-13 |
Not clear |
| Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Cho. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson's Disease. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-20. PMID:34206041. |
parkinson's disease (pd) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (sn) mediated via oxidative stress. |
2021-07-20 |
2023-08-13 |
Not clear |
| Aysegul O Gezer, Joseph Kochmanski, Sarah E VanOeveren, Allyson Cole-Strauss, Christopher J Kemp, Joseph R Patterson, Kathryn M Miller, Nathan C Kuhn, Danielle E Herman, Alyssa McIntire, Jack W Lipton, Kelvin C Luk, Sheila M Fleming, Caryl E Sortwell, Alison I Bernstei. Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits. Neurobiology of disease. vol 141. 2021-07-14. PMID:32422283. |
however, male offspring showed neither exacerbation of phosphorylated α-syn aggregation (psyn) in the substantia nigra (sn) at 1 or 2 months post-pff injection, nor exacerbation of pff-induced th and neun loss in the sn 6 months post-pff injection. |
2021-07-14 |
2023-08-13 |
mouse |
| Lirong Jin, Jian Wang, Changpeng Wang, Danlan Lian, Ying Zhou, Yong Zhang, Minzhi Lv, Yuanfang Li, Zhen Huang, Xiaoqin Cheng, Guoqiang Fei, Kai Liu, Mengsu Zeng, Chunjiu Zhon. Combined Visualization of Nigrosome-1 and Neuromelanin in the Substantia Nigra Using 3T MRI for the Differential Diagnosis of Essential Tremor and Frontiers in neurology. vol 10. 2021-07-13. PMID:30809189. |
in the current study, we aimed to evaluate whether visual analyses of neuromelanin-sensitive magnetic resonance imaging (nm-mri) combined with nigrosome-1 (n1) imaging using quantitative susceptibility mapping (qsm) in the substantia nigra (sn) are of diagnostic value in the differentiation of |
2021-07-13 |
2023-08-13 |
Not clear |
| Hui Lian, Li Zhou, Yang Zhang, Yan-Hai Song, Yi-Min Zhang, Zheng-Hao Cao, Zhi-Yong Wan. Increased energy expenditure and activated β3-AR-cAMP-PKA signaling pathway in the interscapular brown adipose tissue of 6-OHDA-induced Parkinson's disease model rats. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 4. 2021-07-12. PMID:32865327. |
bilateral injections of 6-hydroxydopamine (6-ohda) into substantia nigra (sn) were performed to induce the pd model rats. |
2021-07-12 |
2023-08-13 |
rat |
| Rayul Wi, Young Cheul Chung, Byung Kwan Ji. Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease. Journal of immunology research. vol 2020. 2021-07-12. PMID:33062722. |
mptp induced a significant loss of nigrostriatal dopamine neurons and glial activation in the substantia nigra (sn) and striatum (str) as visualized by tyrosine hydroxylase (th) or macrophage antigen complex-1 (mac-1) or glial fibrillary acidic protein (gfap) immunocytochemistry, respectively. |
2021-07-12 |
2023-08-13 |
mouse |
| Su Bin Cho, Won Sik Eum, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Duk-Soo Kim, Dae Won Kim, Soo Young Cho. Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416093. |
immunohistochemical analysis revealed that when tat‑ar protein was transduced into the substantia nigra (sn) of mice with pd, it markedly inhibited dopaminergic neuronal cell death. |
2021-07-12 |
2023-08-13 |
mouse |
| Bruk Getachew, Antonei B Csoka, Amna Bhatti, Robert L Copeland, Yousef Tizab. Butyrate Protects Against Salsolinol-Induced Toxicity in SH-SY5Y Cells: Implication for Parkinson's Disease. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32572814. |
parkinson's disease (pd), a progressive neurodegenerative disorder, is associated with the destruction of dopamine neurons in the substantia nigra (sn) and the formation of lewy bodies in basal ganglia. |
2021-07-09 |
2023-08-13 |
human |
| Yasuhiro Nakata, Atsuko Sakamoto, Akihiro Kawat. Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease. Neuroradiology. vol 62. issue 11. 2021-07-07. PMID:32556403. |
pathological studies revealed less melanin-containing dopaminergic neurons in the substantia nigra (sn) pars compacta in mjd/sca3 patients. |
2021-07-07 |
2023-08-13 |
Not clear |
| Elinor Tzvi, Richard Bey, Matthias Nitschke, Norbert Brüggemann, Joseph Classen, Thomas F Münte, Ulrike M Krämer, Jost-Julian Rump. Motor Sequence Learning Deficits in Idiopathic Parkinson's Disease Are Associated With Increased Substantia Nigra Activity. Frontiers in aging neuroscience. vol 13. 2021-07-02. PMID:34194317. |
importantly, activity in the substantia nigra (sn) and adjacent bilateral midbrain was specifically increased during sequence learning in pwpd compared to healthy controls, and significantly correlated with sequence-specific learning deficits. |
2021-07-02 |
2023-08-13 |
human |
| Cynthia Moore, Mo Xu, Jerry K Bohlen, Charles K Meshu. Differential ultrastructural alterations in the Vglut2 glutamatergic input to the substantia nigra pars compacta/pars reticulata following nigrostriatal dopamine loss in a progressive mouse model of Parkinson's disease. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32619030. |
the stn projects to the substantia nigra (sn) pars compacta (snpc) and pars reticulata (snpr). |
2021-06-29 |
2023-08-13 |
mouse |
| Chao Gu, Fen Wang, Yu-Ting Zhang, Shi-Zhuang Wei, Jun-Yi Liu, Hong-Yang Sun, Guang-Hui Wang, Chun-Feng Li. Microglial MT1 activation inhibits LPS-induced neuroinflammation via regulation of metabolic reprogramming. Aging cell. vol 20. issue 6. 2021-06-26. PMID:33964119. |
melatonin receptor 1 (mt1) is widely expressed in glia cells and neurons in substantia nigra (sn). |
2021-06-26 |
2023-08-13 |
mouse |
| Vandana Zaman, Donald C Shields, Ramsha Shams, Kelsey P Drasites, Denise Matzelle, Azizul Haque, Narendra L Bani. Cellular and molecular pathophysiology in the progression of Parkinson's disease. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33599945. |
parkinson's disease (pd) is a neurodegenerative disorder etiologically linked to the loss of substantia nigra (sn) dopaminergic neurons in the mid-brain. |
2021-06-22 |
2023-08-13 |
human |
| Özge Güzelad, Ayşe Özkan, Hande Parlak, Osman Sinen, Ebru Afşar, Eren Öğüt, Fatoş Belgin Yıldırım, Mehmet Bülbül, Aysel Ağar, Mutay Asla. Protective mechanism of Syringic acid in an experimental model of Parkinson's disease. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33666819. |
the immunoreactivities for tyrosine hydroxylase (th) and inducible nitric oxide synthase (inos) were detected by immunohistochemistry in frozen substantia nigra (sn) sections. |
2021-06-22 |
2023-08-13 |
rat |
| Geon-Ho Bahn, Sang-Min Lee, Minha Hong, Seung-Yup Le. Preliminary Study of ADHD Biomarkers in Adults with Focus on Serum Iron and Transcranial Sonography of the Substantia Nigra. International journal of environmental research and public health. vol 18. issue 9. 2021-06-21. PMID:34063655. |
as previous studies have reported abnormalities in the iron indices of peripheral blood and hyperechogenicity of the substantia nigra (sn) in children and adolescents with attention-deficit/hyperactivity disorder (adhd), we aimed to examine the same in adults with adhd using transcranial doppler sonography (tcs). |
2021-06-21 |
2023-08-13 |
human |
| Masayuki Miyamoto, Tomoyuki Miyamot. Relationship of substantia nigra hyperechogenicity to risk of Lewy body disease in idiopathic REM sleep behavior disorder patients: a longitudinal study. Sleep medicine. vol 68. 2021-06-21. PMID:32018190. |
we examined the relationship between baseline substantia nigra (sn) echogenicity on transcranial sonography (tcs) images and medium-to long-term developments of parkinson's disease (pd) and dementia with lewy bodies (dlb) in idiopathic rbd (irbd) patients. |
2021-06-21 |
2023-08-13 |
Not clear |
| Richard P Allen, Christopher J Earley, Byron C Jones, Erica L Unge. Iron-deficiency and dopaminergic treatment effects on RLS-Like behaviors of an animal model with the brain iron deficiency pattern of the restless legs syndrome. Sleep medicine. vol 71. 2021-06-21. PMID:32094092. |
brain iron deficiency (bid), especially for the substantia nigra (sn), without peripheral iron deficiency (id) has been well documented as a ubiquitous finding for restless legs syndrome (rls) patients. |
2021-06-21 |
2023-08-13 |
Not clear |
| Elena Ferrari, Antonella Cardinale, Barbara Picconi, Fabrizio Gardon. From cell lines to pluripotent stem cells for modelling Parkinson's Disease. Journal of neuroscience methods. vol 340. 2021-06-21. PMID:32311374. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by loss of dopaminergic (daergic) neurons in the substantia nigra (sn) that contributes to the main motor symptoms of the disease. |
2021-06-21 |
2023-08-13 |
mouse |
| Danielle Walu Kasongo, Gioacchino de Leo, Nunzio Vicario, Giampiero Leanza, Giuseppe Legnam. Chronic α-Synuclein Accumulation in Rat Hippocampus Induces Lewy Bodies Formation and Specific Cognitive Impairments. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393581. |
no pathologic α-syn deposits were found within the substantia nigra (sn), the ventral tegmental area (vta), or the striatum, nor was any loss of dopaminergic, noradrenergic, or cholinergic neurons detected in α-syn-injected animals, compared with controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao, Yan-Zhong Chan. Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free radical biology & medicine. vol 162. 2021-06-18. PMID:33248265. |
in contrast to the predicted neuroprotective role of nrf2 in oxidative stress-related diseases, we found that nrf2 ko remarkably improved the motor coordination of aged mice, which was associated with the reduced ros level and decreased apoptosis of dopaminergic neurons in substantia nigra (sn) of 18-month-old nrf2 ko mice. |
2021-06-18 |
2023-08-13 |
mouse |