| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hexin Yan, Hui Zhao, Yunxiao Kang, Xiaoming Ji, Tianyun Zhang, Yu Wang, Rui Cui, Guoliang Zhang, Geming Sh. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Neuropharmacology. vol 194. 2021-07-28. PMID:34089729. |
mitochondrial dysfunction manifests as an early event in the substantia nigra (sn) in aging and parkinson disease. |
2021-07-28 |
2023-08-13 |
rat |
| Mangala Kumari, Premdass Ramdas, Ammu Kutty Radhakrishnan, Methil Kannan Kutty, Nagaraja Haleagrahar. Tocotrienols Ameliorate Neurodegeneration and Motor Deficits in the 6-OHDA-Induced Rat Model of Parkinsonism: Behavioural and Immunohistochemistry Analysis. Nutrients. vol 13. issue 5. 2021-07-26. PMID:34068460. |
parkinson's disease (pd) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (sn) in the midbrain due to loss of dopaminergic neurons. |
2021-07-26 |
2023-08-13 |
rat |
| Frédérique Depierreux, Eric Parmentier, Laurane Mackels, Katherine Baquero, Christian Degueldre, Evelyne Balteau, Eric Salmon, Christophe Phillips, Mohamed Ali Bahri, Pierre Maquet, Gaëtan Garrau. Parkinson's disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI. NPJ Parkinson's disease. vol 7. issue 1. 2021-07-24. PMID:34238927. |
parkinson's disease (pd) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (nm)-containing dopaminergic neurons and deposition of iron in the substantia nigra (sn). |
2021-07-24 |
2023-08-13 |
Not clear |
| Eun-Young Lee, Michael R Flynn, Guangwei Du, Mechelle M Lewis, Michael Goldenberg, Lan Kong, Richard B Mailman, Young-Seoub Hong, Xuemei Huan. Nigral MRI features of asymptomatic welders. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33691274. |
this study investigated whether asymptomatic welders display differences in the substantia nigra (sn), the key pathological locus of pd. |
2021-07-22 |
2023-08-13 |
Not clear |
| Mahsa Dadar, Janis Miyasaki, Simon Duchesne, Richard Camiciol. White matter hyperintensities mediate the impact of amyloid ß on future freezing of gait in Parkinson's disease. Parkinsonism & related disorders. vol 85. 2021-07-22. PMID:33770671. |
previous studies have reported relationships between fog, substantia nigra (sn) degeneration, dopamine transporter (dat) concentration, as well as amyloid β deposition. |
2021-07-22 |
2023-08-13 |
Not clear |
| Wenyue Liu, Changpeng Wang, Tingting He, Minghong Su, Yuan Lu, Guanyu Zhang, Thomas F Münte, Lirong Jin, Zheng Y. Substantia nigra integrity correlates with sequential working memory in Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021-07-22. PMID:34099507. |
this study demonstrates that the substantia nigra (sn) integrity correlated with basal ganglia function and sequencing performance in 29 patients with pd (17 women) and 29 healthy controls (hc, 18 women). |
2021-07-22 |
2023-08-13 |
human |
| Raghunandan Kumar Yadav, Birendra Nath Mallic. Dopaminergic- and cholinergic-inputs from substantia nigra and pedunculo-pontine tegmentum, respectively, converge in amygdala to modulate rapid eye movement sleep in rats. Neuropharmacology. vol 193. 2021-07-21. PMID:34023337. |
isolated studies have reported that substantia nigra (sn) withdraws inhibition from pedunculo-pontine tegmentum (ppt) acetylcholine (ach)-ergic rem-on neurons to trigger rems; some rem-on neurons become phasically active during rems; amygdala (amyg), a limbic structure associated with emotions, may be related with dreaming like state; amyg receives projections from both sn-dopamine (da)-ergic and ppt-ach-ergic neurons. |
2021-07-21 |
2023-08-13 |
human |
| Toni S Pearson, Nalin Gupta, Waldy San Sebastian, Jill Imamura-Ching, Amy Viehoever, Ana Grijalvo-Perez, Alex J Fay, Neha Seth, Shannon M Lundy, Youngho Seo, Miguel Pampaloni, Keith Hyland, Erin Smith, Gardenia de Oliveira Barbosa, Jill C Heathcock, Amy Minnema, Russell Lonser, J Bradley Elder, Jeffrey Leonard, Paul Larson, Krystof S Bankiewic. Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons. Nature communications. vol 12. issue 1. 2021-07-21. PMID:34253733. |
seven (7) children, aged 4-9 years underwent convection-enhanced delivery (ced) of aav2-haadc to the bilateral substantia nigra (sn) and ventral tegmental area (vta) (total infusion volume: 80 µl per hemisphere) in 2 dose cohorts: 1.3 × 10 |
2021-07-21 |
2023-08-13 |
Not clear |
| Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Cho. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson's Disease. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-20. PMID:34206041. |
parkinson's disease (pd) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (sn) mediated via oxidative stress. |
2021-07-20 |
2023-08-13 |
Not clear |
| Aysegul O Gezer, Joseph Kochmanski, Sarah E VanOeveren, Allyson Cole-Strauss, Christopher J Kemp, Joseph R Patterson, Kathryn M Miller, Nathan C Kuhn, Danielle E Herman, Alyssa McIntire, Jack W Lipton, Kelvin C Luk, Sheila M Fleming, Caryl E Sortwell, Alison I Bernstei. Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits. Neurobiology of disease. vol 141. 2021-07-14. PMID:32422283. |
however, male offspring showed neither exacerbation of phosphorylated α-syn aggregation (psyn) in the substantia nigra (sn) at 1 or 2 months post-pff injection, nor exacerbation of pff-induced th and neun loss in the sn 6 months post-pff injection. |
2021-07-14 |
2023-08-13 |
mouse |
| Lirong Jin, Jian Wang, Changpeng Wang, Danlan Lian, Ying Zhou, Yong Zhang, Minzhi Lv, Yuanfang Li, Zhen Huang, Xiaoqin Cheng, Guoqiang Fei, Kai Liu, Mengsu Zeng, Chunjiu Zhon. Combined Visualization of Nigrosome-1 and Neuromelanin in the Substantia Nigra Using 3T MRI for the Differential Diagnosis of Essential Tremor and Frontiers in neurology. vol 10. 2021-07-13. PMID:30809189. |
in the current study, we aimed to evaluate whether visual analyses of neuromelanin-sensitive magnetic resonance imaging (nm-mri) combined with nigrosome-1 (n1) imaging using quantitative susceptibility mapping (qsm) in the substantia nigra (sn) are of diagnostic value in the differentiation of |
2021-07-13 |
2023-08-13 |
Not clear |
| Hui Lian, Li Zhou, Yang Zhang, Yan-Hai Song, Yi-Min Zhang, Zheng-Hao Cao, Zhi-Yong Wan. Increased energy expenditure and activated β3-AR-cAMP-PKA signaling pathway in the interscapular brown adipose tissue of 6-OHDA-induced Parkinson's disease model rats. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 4. 2021-07-12. PMID:32865327. |
bilateral injections of 6-hydroxydopamine (6-ohda) into substantia nigra (sn) were performed to induce the pd model rats. |
2021-07-12 |
2023-08-13 |
rat |
| Rayul Wi, Young Cheul Chung, Byung Kwan Ji. Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease. Journal of immunology research. vol 2020. 2021-07-12. PMID:33062722. |
mptp induced a significant loss of nigrostriatal dopamine neurons and glial activation in the substantia nigra (sn) and striatum (str) as visualized by tyrosine hydroxylase (th) or macrophage antigen complex-1 (mac-1) or glial fibrillary acidic protein (gfap) immunocytochemistry, respectively. |
2021-07-12 |
2023-08-13 |
mouse |
| Su Bin Cho, Won Sik Eum, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Hyun Jung Kwon, Sung-Woo Cho, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Duk-Soo Kim, Dae Won Kim, Soo Young Cho. Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416093. |
immunohistochemical analysis revealed that when tat‑ar protein was transduced into the substantia nigra (sn) of mice with pd, it markedly inhibited dopaminergic neuronal cell death. |
2021-07-12 |
2023-08-13 |
mouse |
| Bruk Getachew, Antonei B Csoka, Amna Bhatti, Robert L Copeland, Yousef Tizab. Butyrate Protects Against Salsolinol-Induced Toxicity in SH-SY5Y Cells: Implication for Parkinson's Disease. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32572814. |
parkinson's disease (pd), a progressive neurodegenerative disorder, is associated with the destruction of dopamine neurons in the substantia nigra (sn) and the formation of lewy bodies in basal ganglia. |
2021-07-09 |
2023-08-13 |
human |
| Yasuhiro Nakata, Atsuko Sakamoto, Akihiro Kawat. Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease. Neuroradiology. vol 62. issue 11. 2021-07-07. PMID:32556403. |
pathological studies revealed less melanin-containing dopaminergic neurons in the substantia nigra (sn) pars compacta in mjd/sca3 patients. |
2021-07-07 |
2023-08-13 |
Not clear |
| Elinor Tzvi, Richard Bey, Matthias Nitschke, Norbert Brüggemann, Joseph Classen, Thomas F Münte, Ulrike M Krämer, Jost-Julian Rump. Motor Sequence Learning Deficits in Idiopathic Parkinson's Disease Are Associated With Increased Substantia Nigra Activity. Frontiers in aging neuroscience. vol 13. 2021-07-02. PMID:34194317. |
importantly, activity in the substantia nigra (sn) and adjacent bilateral midbrain was specifically increased during sequence learning in pwpd compared to healthy controls, and significantly correlated with sequence-specific learning deficits. |
2021-07-02 |
2023-08-13 |
human |
| Cynthia Moore, Mo Xu, Jerry K Bohlen, Charles K Meshu. Differential ultrastructural alterations in the Vglut2 glutamatergic input to the substantia nigra pars compacta/pars reticulata following nigrostriatal dopamine loss in a progressive mouse model of Parkinson's disease. The European journal of neuroscience. vol 53. issue 7. 2021-06-29. PMID:32619030. |
the stn projects to the substantia nigra (sn) pars compacta (snpc) and pars reticulata (snpr). |
2021-06-29 |
2023-08-13 |
mouse |
| Chao Gu, Fen Wang, Yu-Ting Zhang, Shi-Zhuang Wei, Jun-Yi Liu, Hong-Yang Sun, Guang-Hui Wang, Chun-Feng Li. Microglial MT1 activation inhibits LPS-induced neuroinflammation via regulation of metabolic reprogramming. Aging cell. vol 20. issue 6. 2021-06-26. PMID:33964119. |
melatonin receptor 1 (mt1) is widely expressed in glia cells and neurons in substantia nigra (sn). |
2021-06-26 |
2023-08-13 |
mouse |
| Vandana Zaman, Donald C Shields, Ramsha Shams, Kelsey P Drasites, Denise Matzelle, Azizul Haque, Narendra L Bani. Cellular and molecular pathophysiology in the progression of Parkinson's disease. Metabolic brain disease. vol 36. issue 5. 2021-06-22. PMID:33599945. |
parkinson's disease (pd) is a neurodegenerative disorder etiologically linked to the loss of substantia nigra (sn) dopaminergic neurons in the mid-brain. |
2021-06-22 |
2023-08-13 |
human |