| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Kooi Ong, Gabrielle D Briggs, Liying Guan, Peter R Dunkley, Phillip W Dickso. Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra. Neurochemistry international. vol 146. 2021-06-18. PMID:33746005. |
in the substantia nigra (sn), the levels of 8 of the 12 measured cytokines was significantly increased at one day. |
2021-06-18 |
2023-08-13 |
rat |
| Emmi Pakarinen, Tatiana Danilova, Vootele Võikar, Piotr Chmielarz, Petteri Piepponen, Mikko Airavaara, Mart Saarma, Maria Lindah. MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. eNeuro. vol 7. issue 1. 2021-06-18. PMID:32005751. |
in our mouse model, increased upr activation did not lead to neuronal cell loss in the substantia nigra (sn), decrease of striatal dopamine or behavioral changes of manf-deficient mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Ji-Yeong Lee, Hanna Kim, Areum Jo, Rin Khang, Chi-Hu Park, Soo-Jeong Park, Eunsang Kwag, Joo-Ho Shi. α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation. International journal of molecular sciences. vol 22. issue 10. 2021-06-17. PMID:34065515. |
indeed, α-syn a53t significantly reduced the level of histone h3 acetylation in sh-sy5y cells; its reduction was also evident in the striatum (str) and substantia nigra (sn) of mice that were stereotaxically injected with α-syn preformed fibrils (pffs). |
2021-06-17 |
2023-08-13 |
mouse |
| Yanchao Dong, Yi Yuan, Yuan Fang, Tao Zheng, Dan Du, Dawei Gao, Juan Du, Lanxiang Liu, Qingyuan H. Effect of aquaporin 4 protein overexpression in nigrostriatal system on development of Parkinson's disease. The International journal of neuroscience. vol 131. issue 7. 2021-06-16. PMID:32259464. |
in this study, the effect of the aqp4 protein overexpression in nigrostriatal system that include substantia nigra (sn) and striatum (cpu) on the development of pd was investigated. |
2021-06-16 |
2023-08-13 |
Not clear |
| Agnete Prydz, Katja Stahl, Soulmaz Zahl, Nadia Skauli, Øivind Skare, Ole Petter Ottersen, Mahmood Amiry-Moghadda. Pro-Inflammatory Role of AQP4 in Mice Subjected to Intrastriatal Injections of the Parkinsonogenic Toxin MPP. Cells. vol 9. issue 11. 2021-06-15. PMID:33167342. |
neuroinflammation is a hallmark of parkinson's disease (pd), and we have previously shown that astrocytes in substantia nigra (sn) are enriched in aqp4 relative to cortical astrocytes, and that their complement of aqp4 is further increased following treatment with the parkinsonogenic toxin mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). |
2021-06-15 |
2023-08-13 |
mouse |
| J Mašková, D Školoudík, P Štofaniková, V Ibarburu, D Kemlink, D Zogala, J Trnka, R Krupička, K Šonka, E Růžička, P Duše. Comparative study of the substantia nigra echogenicity and Sleep medicine. vol 70. 2021-05-31. PMID:32403038. |
comparative study of the substantia nigra echogenicity and hyperechogenicity of the substantia nigra (sn) and abnormal dopamine transporter-single-photon emission computed tomography (dat-spect) are biomarkers commonly used in the assessment of prodromal synucleinopathy. |
2021-05-31 |
2023-08-13 |
human |
| Hyongjun Jeon, Chang-Hwan Bae, Yukyoung Lee, Hee-Young Kim, Seungtae Ki. Korean red ginseng suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced inflammation in the substantia nigra and colon. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33662500. |
parkinson's disease (pd) is a neurodegenerative disease involving dopaminergic neuronal death in the substantia nigra (sn); recent studies have shown that interactions between gut and brain play a critical role in the pathogenesis of pd. |
2021-05-28 |
2023-08-13 |
mouse |
| Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Pen. Treg Cells Attenuate Neuroinflammation and Protect Neurons in a Mouse Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 2. 2021-05-27. PMID:31802419. |
when blockade the lfa-1 activity in tregs or the icam-1 activity in endothelial cells, the percentage of tregs in substantia nigra (sn) decreased. |
2021-05-27 |
2023-08-13 |
mouse |
| Yan-Liang Mei, Jing Yang, Zheng-Rong Wu, Ying Yang, Yu-Ming X. Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson's Disease and Other Movement Disorders: A Meta-Analysis. Parkinson's disease. vol 2021. 2021-05-20. PMID:34007439. |
this meta-analysis aimed to evaluate the accuracy of hyperechogenicity of the substantia nigra (sn) for the differential diagnosis of parkinson's disease (pd) and other movement disorders. |
2021-05-20 |
2023-08-13 |
human |
| Congcong Sun, Guoyong Jia, Xingbang Wang, Yun Wang, Yiming Li. Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model. Neuroscience letters. vol 738. 2021-05-17. PMID:32905834. |
two major catalytic subunits of i-proteasome (psmb9 and psmb8) were seldom expressed in rat substantia nigra (sn) under normal condition, but they were significantly up-regulated with the release of tnf-α and ifn-γ after exposure to rotenone. |
2021-05-17 |
2023-08-13 |
rat |
| Li Liu, Mingchao Li, Mingze Xu, Zhen Wang, Zhi Zeng, Yunqing Li, Yi Zhang, Rong You, Chu-Hua Li, Yan-Qing Gua. Actively targeted gold nanoparticle composites improve behavior and cognitive impairment in Parkinson's disease mice. Materials science & engineering. C, Materials for biological applications. vol 114. 2021-05-14. PMID:32994016. |
parkinson's disease (pd) is characterized by motor and non-motor symptoms, primarily affecting dopaminergic neurons (daergic neurons) in substantia nigra (sn). |
2021-05-14 |
2023-08-13 |
mouse |
| Michelle S Massaquoi, William A Liguore, Madeline J Churchill, Cindy Moore, Heather L Melrose, Charles K Meshu. Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson's Disease. Neuroscience. vol 433. 2021-05-14. PMID:32142862. |
in both the dl striatum and substantia nigra (sn)/midbrain, phosphorylated trkb and secondary messengers were significantly increased following dhf compared to the mptp only group. |
2021-05-14 |
2023-08-13 |
mouse |
| Mustafa Makav, Hüseyin Avni Eroğl. Recuperative effect of estrogen on rotenone-induced experimental model of Parkinson's disease in rats. Environmental science and pollution research international. vol 28. issue 17. 2021-05-12. PMID:33410082. |
parkinson's disease (pd) is described as the loss of dopaminergic neurons located in the substantia nigra (sn) region of the brain and a progressive motor failure. |
2021-05-12 |
2023-08-13 |
rat |
| Min Kyung Song, Joo Hee Lee, Jinil Kim, Ji Hyun Kim, Soonhye Hwang, Yoon-Seong Kim, Youn-Jung Ki. Neuroprotective effect of NXP031 in the MPTP-induced Parkinson's disease model. Neuroscience letters. vol 740. 2021-05-07. PMID:33075422. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2021-05-07 |
2023-08-13 |
mouse |
| Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Do-Yeon Kim, Hee-Sun Ki. Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS. Biomolecules & therapeutics. vol 29. issue 3. 2021-05-07. PMID:33911050. |
these pathological and inflammatory changes, including microglial activation and dopaminergic cell loss in the substantia nigra (sn) area were reversed by papaverine (pap) administration. |
2021-05-07 |
2023-08-13 |
mouse |
| Thomas M Berry, Ahmed A Moustaf. A novel treatment strategy to prevent Parkinson's disease: focus on iron regulatory protein 1 (IRP1). The International journal of neuroscience. 2021-05-05. PMID:33535005. |
iron deposits are associated with neuronal cell death in substantia nigra (sn) resulting in pd where high levels of iron in sns are due to dysregulation of iron utilization. |
2021-05-05 |
2023-08-13 |
rat |
| Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang, Degui Wan. Protective effect of thioredoxin reductase 1 in Parkinson's disease. Neuroscience letters. vol 741. 2021-05-04. PMID:33171211. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2021-05-04 |
2023-08-13 |
mouse |
| Mark F McCarty, Aaron Lerne. Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin. Advances in nutrition (Bethesda, Md.). vol 12. issue 2. 2021-05-03. PMID:32945884. |
mitochondrial dysfunction in dopaminergic neurons of the substantia nigra (sn) appears to be a key mediating feature of parkinson's disease (pd), a complex neurodegenerative disorder of still unknown etiology. |
2021-05-03 |
2023-08-13 |
Not clear |
| Caleb Vegh, Darcy Wear, Iva Okaj, Rachel Huggard, Lauren Culmone, Sezen Eren, Jerome Cohen, Arun K Rishi, Siyaram Pande. Combined Ubisol-Q Antioxidants (Basel, Switzerland). vol 10. issue 4. 2021-05-02. PMID:33917328. |
combined ubisol-q parkinson's disease (pd) is characterized by progressive neurodegeneration in the substantia nigra (sn) region resulting in loss of movement coordination. |
2021-05-02 |
2023-08-13 |
Not clear |
| Yingchuan Chen, Guanyu Zhu, Defeng Liu, Xin Zhang, Yuye Liu, Tianshuo Yuan, Tingting Du, Jianguo Zhan. Subthalamic nucleus deep brain stimulation suppresses neuroinflammation by Fractalkine pathway in Parkinson's disease rat model. Brain, behavior, and immunity. vol 90. 2021-04-27. PMID:32726685. |
we found that motor deficits were alleviated by stn-dbs, with increased survival of dopaminergic neurons in the substantia nigra (sn). |
2021-04-27 |
2023-08-13 |
rat |