| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Li Xu, Yu-Feng Wu, Fang Yan, Cui-Cui Li, Zhen Dai, Qi-Dong You, Zheng-Yu Jiang, Bin D. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress. Free radical biology & medicine. vol 134. 2020-04-21. PMID:30615919. |
ddo-7263 improved the behavioral abnormalities induced by mptp in mice, significantly attenuated chemically induced dopaminergic neuron loss of tyrosine hydroxylase (th) in the substantia nigra (sn) and striatum of the mouse brain and inhibited the secretion of inflammatory factors. |
2020-04-21 |
2023-08-13 |
mouse |
| Nafisa M Jadavji, Lauren K Murray, Joshua T Emmerson, Chris A Rudyk, Shawn Hayley, Patrice D Smit. Paraquat Exposure Increases Oxidative Stress Within the Dorsal Striatum of Male Mice With a Genetic Deficiency in One-carbon Metabolism. Toxicological sciences : an official journal of the Society of Toxicology. vol 169. issue 1. 2020-04-20. PMID:30726997. |
there was increased microglial activation within the substantia nigra (sn) of mthfr+/- mice treated with paraquat. |
2020-04-20 |
2023-08-13 |
mouse |
| Bernardo Stutz, Carole Nasrallah, Mariana Nigro, Daniel Curry, Zhong-Wu Liu, Xiao-Bing Gao, John D Elsworth, Liat Mintz, Tamas L Horvat. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular metabolism. vol 24. 2020-04-15. PMID:30833218. |
dopamine neurons in the substantia nigra (sn) play crucial roles in control of voluntary movement. |
2020-04-15 |
2023-08-13 |
mouse |
| Joanna Motyl, Joanna B Strosznajde. Sphingosine kinase 1/sphingosine-1-phosphate receptors dependent signalling in neurodegenerative diseases. The promising target for neuroprotection in Parkinson's disease. Pharmacological reports : PR. vol 70. issue 5. 2020-04-14. PMID:32002951. |
pd is characterized by selective loss of dopaminergic (da) neurons in the substantia nigra (sn), with an enigmatic cause in most individuals. |
2020-04-14 |
2023-08-13 |
Not clear |
| Eunju Lee, Inhwa Hwang, Sangjun Park, Sujeong Hong, Boreum Hwang, Yoeseph Cho, Junghyun Son, Je-Wook Y. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29786072. |
parkinson's disease (pd) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and the reduction of dopamine levels in the striatum. |
2020-04-07 |
2023-08-13 |
mouse |
| Niels Bergsland, Robert Zivadinov, Ferdinand Schweser, Jesper Hagemeier, David Lichter, Thomas Guttus. Ventral posterior substantia nigra iron increases over 3 years in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 34. issue 7. 2020-03-27. PMID:31180615. |
parkinson's disease (pd) is characterized in part by the progressive accumulation of iron within the substantia nigra (sn); however, its spatial and temporal dynamics remain relatively poorly understood. |
2020-03-27 |
2023-08-13 |
Not clear |
| Mi-Yoon Chang, Boram Oh, Jang-Eun Choi, Yanuar Alan Sulistio, Hye-Ji Woo, Ayoung Jo, Jinil Kim, Eun-Hee Kim, Seung Won Kim, Jungwook Hwang, Jungyun Park, Jae-Jin Song, Oh-Chan Kwon, Hyongbum Henry Kim, Young-Hoon Kim, Joo Yeon Ko, Jun Young Heo, Min Joung Lee, Moses Lee, Murim Choi, Sun Ju Chung, Hyun-Seob Lee, Sang-Hun Le. LIN28A loss of function is associated with Parkinson's disease pathogenesis. The EMBO journal. vol 38. issue 24. 2020-03-20. PMID:31750563. |
parkinson's disease (pd) is neurodegenerative movement disorder characterized by degeneration of midbrain-type dopamine (mda) neurons in the substantia nigra (sn). |
2020-03-20 |
2023-08-13 |
mouse |
| Shun Zhang, Rui Wang, Guanghui Wan. Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30592597. |
the characteristic feature of pd is the progressive degeneration of the dopaminergic (daergic) neurons in the substantia nigra (sn). |
2020-02-26 |
2023-08-13 |
mouse |
| Mehmet Bülbül, Osman Sinen, Ayşe Özkan, Mutay Aydın Aslan, Aysel Ağa. Central neuropeptide-S treatment improves neurofunctions of 6-OHDA-induced Parkinsonian rats. Experimental neurology. vol 317. 2020-02-26. PMID:30825442. |
parkinson's disease (pd) is characterized by degeneration of the dopaminergic neurons in substantia nigra (sn). |
2020-02-26 |
2023-08-13 |
rat |
| D J Merlino, J R Barton, B A Charsar, M D Byrne, J A Rappaport, R J Smeyne, A C Lepore, A E Snook, S A Waldma. Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain structure & function. vol 224. issue 8. 2020-02-24. PMID:31485718. |
here, we reveal that hypothalamic gucy2c mrna is confined to the ventral premammillary nucleus (pmv), while in midbrain it is produced by neurons in the ventral tegmental area (vta) and substantia nigra (sn). |
2020-02-24 |
2023-08-13 |
Not clear |
| Navid Farassat, Kauê Machado Costa, Strahinja Stojanovic, Stefan Albert, Lora Kovacheva, Josef Shin, Richard Egger, Mahalakshmi Somayaji, Sevil Duvarci, Gaby Schneider, Jochen Roepe. In vivo functional diversity of midbrain dopamine neurons within identified axonal projections. eLife. vol 8. 2020-02-19. PMID:31580257. |
bursting also differentiated da neurons in the medial substantia nigra (sn) projecting either to dorsal or ventral striatum. |
2020-02-19 |
2023-08-13 |
mouse |
| Xiaobin Huang, Di Zhang, Yuchen Chen, Peng Wang, Cunnan Mao, Zhengfei Miao, Chunmei Liu, Chenjie Xu, Xinying Wu, Xindao Yi. Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura. The journal of headache and pain. vol 20. issue 1. 2020-02-10. PMID:31711434. |
accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (rn) and substantia nigra (sn), as an important factor in migraine without aura (mwoa). |
2020-02-10 |
2023-08-13 |
Not clear |
| Pierre Antoine Linck, Gregory Kuchcinski, Fanny Munsch, Romain Griffier, Renaud Lopes, Gosuke Okubo, Sharmila Sagnier, Pauline Renou, Julien Asselineau, Paul Perez, Vincent Dousset, Igor Sibon, Thomas Tourdia. Neurodegeneration of the Substantia Nigra after Ipsilateral Infarct: MRI R2* Mapping and Relationship to Clinical Outcome. Radiology. vol 291. issue 2. 2020-01-30. PMID:30860451. |
background the substantia nigra (sn) is suspected to be affected after remote infarction, in view of its large array of connections with the supratentorial brain. |
2020-01-30 |
2023-08-13 |
human |
| Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang, Weifeng Lu. Iron deposition in Parkinson's disease by quantitative susceptibility mapping. BMC neuroscience. vol 20. issue 1. 2020-01-28. PMID:31117957. |
the purpose of this study was to evaluate the iron deposition in the substantia nigra (sn) and other deep gray matter nuclei of pd patients using quantitative susceptibility mapping (qsm) and its clinical relationship, and to explore whether there is a gradient of iron deposition pattern in globus pallidus (gp)-fascicula nigrale (fn)-sn pathway. |
2020-01-28 |
2023-08-13 |
Not clear |
| Gaiying Li, Guoqiang Zhai, Xinxin Zhao, Hedi An, Pascal Spincemaille, Kelly M Gillen, Yixuan Ku, Yi Wang, Dongya Huang, Jianqi L. 3D texture analyses within the substantia nigra of Parkinson's disease patients on quantitative susceptibility maps and R2 NeuroImage. vol 188. 2020-01-22. PMID:30578927. |
3d texture analyses within the substantia nigra of parkinson's disease patients on quantitative susceptibility maps and r2 iron accumulation in the substantia nigra (sn) is spatially heterogeneous, yet no study has quantitatively evaluated how the texture of quantitative susceptibility maps (qsm) and r2 |
2020-01-22 |
2023-08-13 |
Not clear |
| Shao-Jun Li, Yan-De Ren, Jin Li, Bin Cao, Chi Ma, Shan-Shan Qin, Xiang-Rong L. The role of iron in Parkinson's disease monkeys assessed by susceptibility weighted imaging and inductively coupled plasma mass spectrometry. Life sciences. vol 240. 2020-01-13. PMID:31760102. |
mounting evidences indicated that elevated iron levels in the substantia nigra (sn) have been concerned as the underlying mechanisms of neurodegenerative diseases, including parkinson's disease (pd). |
2020-01-13 |
2023-08-13 |
monkey |
| Dulce María Arzate, Magdalena Guerra-Crespo, Luis Covarrubia. Induction of typical and atypical neurogenesis in the adult substantia nigra after mouse embryonic stem cells transplantation. Neuroscience. vol 408. 2020-01-09. PMID:31034794. |
neurogenesis in the substantia nigra (sn) has been a controversial issue. |
2020-01-09 |
2023-08-13 |
mouse |
| Sujung Yeo, Jongbeom Song, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein in Substantia Nigra in an MPTP- Induced Parkinsonism Mouse Model. Advances in experimental medicine and biology. vol 1232. 2020-01-08. PMID:31893437. |
parkinson's disease, a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2020-01-08 |
2023-08-13 |
mouse |
| Ruonan Wang, Min Li, Meng Zhao, Dahua Yu, Yu Hu, Corinde E Wiers, Gene-Jack Wang, Nora D Volkow, Kai Yua. Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway. Brain imaging and behavior. vol 13. issue 4. 2020-01-07. PMID:30054871. |
dopamine projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) and from the substantia nigra (sn) to the dorsal striatum are involved in addiction. |
2020-01-07 |
2023-08-13 |
human |
| Danielle E Mor, Malcolm J Daniels, Harry Ischiropoulo. The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration. Movement disorders : official journal of the Movement Disorder Society. vol 34. issue 2. 2020-01-02. PMID:30633814. |
parkinson's disease (pd) is primarily a movement disorder driven by the loss of dopamine-producing neurons in the substantia nigra (sn). |
2020-01-02 |
2023-08-13 |
mouse |