| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edson Bor-Seng-Shu, Fernando M Paschoal, Kelson J Almeida, Marcelo De Lima Oliveira, Ricardo C Nogueira, Manoel J Teixeira, Uwe Walte. Transcranial brain sonography for Parkinsonian syndromes. Journal of neurosurgical sciences. vol 63. issue 4. 2020-01-02. PMID:31210040. |
substantia nigra (sn) hyperechogenicity has been proved to be a characteristic finding for idiopathic parkinson's disease (pd), occurring in more than 90% of the patients. |
2020-01-02 |
2023-08-13 |
human |
| Jun Ma, Yao Wang, Shu-Ju Wang, Li Yuan, Ya-Nan Li, Ben-Lu Y. [Effect of electroacupuncture of "Fengfu" (GV16) and "Taichong" (LR3) on EIF2α-ATF4-GRP78/Bip signaling in substantia nigra of rats with Parkinson's disease]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 12. 2020-01-02. PMID:31867905. |
to observe the effect of electroacupuncture (ea) on expression of eukaryotic initiation factor 2α (eif2α), activating transcription factor 4 (atf4), glucose regulator protein-78 / immunoglobulin heavy-chain-binding protein (grp78/bip) in the substantia nigra (sn) in rats with parkinson's disease (pd), so as to explore its mechanism underlying improvement of pd. |
2020-01-02 |
2023-08-13 |
rat |
| Sanford Pc Hsu, Dao-Yuan Wang, Ming-Yuan Min, Yu-Show F. Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats. Neurochemistry international. vol 122. 2019-12-26. PMID:30423424. |
the number of dopaminergic neurons in the substantia nigra (sn), the serotonergic neurons in the dorsal raphe nucleus, and the cholinergic neurons in the tegmental nucleus significantly decreased as compared with normal group, whereas the noradrenergic neurons in the locus coeruleus substantially increased. |
2019-12-26 |
2023-08-13 |
rat |
| Ying Chen, Qiu-Shuang Zhang, Qian-Hang Shao, Shuo Wang, Yu-He Yuan, Nai-Hong Chen, Hong-Bo Wan. NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP. Acta pharmacologica Sinica. vol 40. issue 8. 2019-12-23. PMID:30728466. |
recent studies in parkinson's disease (pd) patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated monkeys have shown that abnormal α-synuclein is accumulated in the olfactory glomeruli, suggesting that the lesions of pd are not only confined to the substantia nigra (sn) but also located in the olfactory bulb. |
2019-12-23 |
2023-08-13 |
mouse |
| Zheng Zhong, Douglas Merkitch, M Muge Karaman, Jiaxuan Zhang, Yi Sui, Jennifer G Goldman, Xiaohong Joe Zho. High-Spatial-Resolution Diffusion MRI in Parkinson Disease: Lateral Asymmetry of the Substantia Nigra. Radiology. vol 291. issue 1. 2019-12-23. PMID:30777809. |
background motor symptoms in parkinson disease (pd) have exhibited lateral asymmetry, suggesting asymmetric neuronal loss in the substantia nigra (sn). |
2019-12-23 |
2023-08-13 |
human |
| Yunseon Jang, Hyosun Choo, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Min Jeong Ryu, Eung Seok Oh, Song-Yi Choi, Woosuk Chung, Gi Ryang Kweon, Jun Young He. Auraptene Mitigates Parkinson's Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species. International journal of molecular sciences. vol 20. issue 14. 2019-12-23. PMID:31336718. |
treatment with aur significantly increased the viability of substantia nigra (sn)-derived sn4741 embryonic dopaminergic neuronal cells and reduced rotenone-induced mitochondrial ros production. |
2019-12-23 |
2023-08-13 |
mouse |
| Karim Fifel, Johanna H Meijer, Tom Deboe. Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures. Scientific reports. vol 8. issue 1. 2019-12-20. PMID:29773830. |
here, using wildtype c57bl mice, we investigated the circadian- and sleep-related modulation of electrical neuronal activity in midbrain ventral-tegmental-area (vta) and substantia nigra (sn). |
2019-12-20 |
2023-08-13 |
mouse |
| S Pandya, Y Zeighami, B Freeze, M Dadar, D L Collins, A Dagher, A Ra. Predictive model of spread of Parkinson's pathology using network diffusion. NeuroImage. vol 192. 2019-12-20. PMID:30851444. |
we extend and tailor previously developed quantitative and predictive network diffusion model (ndm) to pd, by specifically modeling the trans-neuronal spread of alpha-synuclein outward from the substantia nigra (sn). |
2019-12-20 |
2023-08-13 |
human |
| Satoshi Okuyama, Tomoko Kanzaki, Yoshimi Kotani, Mako Katoh, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukaw. Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease. Journal of nutritional science and vitaminology. vol 65. issue 2. 2019-12-19. PMID:31061292. |
our previous study showed that the subcutaneous administration of auraptene (aur) suppresses inflammatory responses including the hyperactivation of microglia in the substantia nigra (sn) of the midbrain of lipopolysaccharide-induced parkinson's disease (pd)-like mice, as well as inhibits dopaminergic neuronal cell death in this region. |
2019-12-19 |
2023-08-13 |
mouse |
| Neda Valian, Abolhassan Ahmadiani, Leila Dargah. Increasing methamphetamine doses inhibit glycogen synthase kinase 3β activity by stimulating the insulin signaling pathway in substantia nigra. Journal of cellular biochemistry. vol 119. issue 10. 2019-12-17. PMID:30011098. |
since the effect of ma on the signaling insulin pathway is less studied, the current study was designed to evaluate the effect of escalating an ma regimen on different insulin signaling elements in substantia nigra (sn) and striatum of a rat. increasing ma doses (1-14 mg/kg) were administrated intraperitoneally twice a day for 14 days in rats. |
2019-12-17 |
2023-08-13 |
rat |
| Sandra Franco-Iborra, Thais Cuadros, Annabelle Parent, Jordi Romero-Gimenez, Miquel Vila, Celine Perie. Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30405116. |
however, in vivo, while tom20 overexpression exacerbated neurodegeneration in both substantia nigra (sn) pars compacta (pc) and striatum, overexpression of tim23 partially protected dopaminergic neurons in the snpc. |
2019-12-10 |
2023-08-13 |
Not clear |
| Bo Pan, Chao Den. Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain. Psychopharmacology. vol 236. issue 9. 2019-12-02. PMID:31053935. |
the ventral midbrain, mainly containing the ventral tegmental area (vta) and substantia nigra (sn), are the nuclei with dopamine origins in the brain, which are also involved in the actions of antipsychotics. |
2019-12-02 |
2023-08-13 |
rat |
| Wenxin Zhuang, Chao Chen, Yiwen Ma, Lele Song, E Lyu, Wenyu F. [Polyphenols from Toona sinensis seeds alleviate neuroinflammation in rats with Parkinson's disease via inhibiting p38MAPK signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 9. 2019-11-27. PMID:31750820. |
the morphological and quantity changes of da neurons (tyrosine hydroxylase positive, th-positive), microglia cells (ionized calcium binding adaptor molecule-1, iba1-positive) and astrocytes (glial fibrillary acidic protein, gfap-positive) in substantia nigra (sn) of rats from each group were examined by immunohistochemistry. |
2019-11-27 |
2023-08-13 |
rat |
| Aya Zakaria, Mona Rady, Laila Mahran, Khaled Abou-Aish. Pioglitazone Attenuates Lipopolysaccharide-Induced Oxidative Stress, Dopaminergic Neuronal Loss and Neurobehavioral Impairment by Activating Nrf2/ARE/HO-1. Neurochemical research. 2019-11-26. PMID:31713708. |
after assessing spatial memory, anxiety and motor-coordination, th+ neurons in substantia nigra (sn) were counted. |
2019-11-26 |
2023-08-13 |
mouse |
| Jan Kamiński, Adam N Mamelak, Kurtis Birch, Clayton P Mosher, Michele Tagliati, Ueli Rutishause. Novelty-Sensitive Dopaminergic Neurons in the Human Substantia Nigra Predict Success of Declarative Memory Formation. Current biology : CB. vol 28. issue 9. 2019-11-25. PMID:29657115. |
we recorded individual substantia nigra (sn) neurons and cortical field potentials in human patients performing a recognition memory task. |
2019-11-25 |
2023-08-13 |
human |
| Xiao-Yan Feng, Jingting Yang, Xiaoli Zhang, Jinxia Zh. Gastrointestinal non-motor dysfunction in Parkinson's disease model rats with 6-hydroxydopamine. Physiological research. vol 68. issue 2. 2019-11-25. PMID:30628835. |
parkinson's disease (pd) is a neurodegenerative disease with a progressive loss of mesencephalic dopaminergic neurons of the substantia nigra (sn). |
2019-11-25 |
2023-08-13 |
rat |
| M Takanashi, H Mochizuki, K Yokomizo, N Hattori, H Mori, Y Yamamura, Y Mizun. Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP). Parkinsonism & related disorders. vol 7. issue 4. 2019-11-20. PMID:11344015. |
autosomal recessive juvenile parkinsonism (arjp) is a distinct clinical and genetic entity characterized by highly selective neuronal death in the substantia nigra (sn) and locus coeruleus neurons without lewy body formation. |
2019-11-20 |
2023-08-12 |
Not clear |
| M. Angela Cenci, Kenneth Campbell, Klas Wictorin, Anders Björklun. Striatal c-fos Induction by Cocaine or Apomorphine Occurs Preferentially in Output Neurons Projecting to the Substantia Nigra in the Rat. The European journal of neuroscience. vol 4. issue 4. 2019-11-20. PMID:12106364. |
fluorogold or rhodamine-labelled latex beads were injected in the substantia nigra (sn) or the globus pallidus (gp) in order retrogradely to label striatal output neurons that project to the two target structures. |
2019-11-20 |
2023-08-12 |
rat |
| S. Morgan, D. Baker, J.P. Husto. Relationship between Behavioral Recovery from Unilateral 6-OHDA Lesion of the Substania Nigra and Changes in the Tuberomammillary-Striatal Projection as Measured by HRP-Labelling. Restorative neurology and neuroscience. vol 12. issue 4. 2019-11-20. PMID:12671291. |
a unilateral lesion of dopamine cells in the substantia nigra (sn) results in asymmetrical behavior, and recovery from this asymmetry was previously found to be associated with asymmetrical changes in the nigro-striatal projection as determined by anatomical tracing technique. |
2019-11-20 |
2023-08-12 |
rat |
| W Ambrosius, S Michalak, M Owecki, M Łukasik, J Florczak-Wyspiańska, W Kozubsk. Substantia nigra hyperechogenicity in Polish patients with Parkinson's disease. Folia morphologica. vol 73. issue 3. 2019-11-20. PMID:25706660. |
hyperechogenicity of the substantia nigra (sn) measured by transcranial sonography (tcs) is a characteristic feature observed in patients with parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |