| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Safa Bouabid, Anass Tinakoua, Nouria Lakhdar-Ghazal, Abdelhamid Benazzou. Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission. Journal of neurochemistry. vol 136. issue 4. 2019-11-20. PMID:26608821. |
the collected data from available studies show that when accumulated in the globus pallidus, mn influences the subthalamic (stn) and substantia nigra (sn) neurons, which are at the origin of changes in the thalamus and the cortex. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zhibin Wang, Xiao-Guang Luo, Chao Ga. Utility of susceptibility-weighted imaging in Parkinson's disease and atypical Parkinsonian disorders. Translational neurodegeneration. vol 5. 2019-11-20. PMID:27761236. |
when the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (sn) have been lost. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ayse Ozkan, Hande Parlak, Gamze Tanriover, Sayra Dilmac, Seher Nasircilar Ulker, Ilknur Birsen, Aysel Aga. The protective mechanism of docosahexaenoic acid in mouse model of Parkinson: The role of hemeoxygenase. Neurochemistry international. 2019-11-20. PMID:27984168. |
parkinson's disease (pd) is characterized by degeneration of the dopaminergic neurons in substantia nigra (sn). |
2019-11-20 |
2023-08-13 |
mouse |
| Cruz Gloria, Sheng Dong Ni. Diffusion kurtosis imaging for diagnosis of Parkinson's disease: A novel software tool proposal. Journal of X-ray science and technology. 2019-11-20. PMID:28339422. |
in order to diagnose parkinson disease (pd) at an early stage, it is important to develop a sensitive method for detecting structural changes in the substantia nigra (sn). |
2019-11-20 |
2023-08-13 |
Not clear |
| Hilary A Marusak, Joshua R B Hatfield, Moriah E Thomason, Christine A Rabina. Reduced Ventral Tegmental Area-Hippocampal Connectivity in Children and Adolescents Exposed to Early Threat. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2019-11-20. PMID:28740870. |
here, we evaluate the impact of early threat exposure (violence, abuse) on functional connectivity of putative dopaminergic midbrain regions, the ventral tegmental area (vta) and substantia nigra (sn), giving rise to mesocorticolimbic and nigrostriatal pathways, respectively. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rowan Gurney, Yvonne S Davidson, Andrew C Robinson, Anna Richardson, Matthew Jones, Julie S Snowden, David M A Man. Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019-11-20. PMID:29748975. |
we investigated histological alterations in lysosomes and autophagosomes in the substantia nigra (sn) and cingulate gyrus (cg) in 34 patients with lbd employing antibodies against phosphorylated α-synuclein and lysosomal (lysosomal associated membrane proteins 1 and 2 (lamp-1 and lamp-2), cathepsin d (ctsd)) and autophagosomal (microtubule-associated protein light chain 3α (lc3a)) proteins. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mario Rango, Nereo Bresoli. Brain Mitochondria, Aging, and Parkinson's Disease. Genes. vol 9. issue 5. 2019-11-20. PMID:29751692. |
many of these mitochondrial alterations are also found in the pd brain specifically in the substantia nigra (sn). |
2019-11-20 |
2023-08-13 |
Not clear |
| Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He, Ping-Yi X. Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo. Translational neurodegeneration. vol 7. 2019-11-20. PMID:30128145. |
abnormal expression of major histocompatibility complex class i (mhc-i) is increased in dopaminergic (da) neurons in the substantia nigra (sn) in parkinson's disease (pd). |
2019-11-20 |
2023-08-13 |
Not clear |
| Kazumasa Wakamatsu, Kenta Nakao, Hitomi Tanaka, Yuki Kitahori, Yui Tanaka, Makoto Ojika, Shosuke It. The Oxidative Pathway to Dopamine-Protein Conjugates and Their Pro-Oxidant Activities: Implications for the Neurodegeneration of Parkinson's Disease. International journal of molecular sciences. vol 20. issue 10. 2019-11-14. PMID:31130632. |
neuromelanin (nm) is a dark brown pigment found in dopaminergic neurons of the substantia nigra (sn) and in norepinephrinergic neurons of the locus coeruleus (lc). |
2019-11-14 |
2023-08-13 |
Not clear |
| Courtney K Walker, Joy K Roche, Vidushi Sinha, Rosalinda C Robert. Substantia nigra ultrastructural pathology in schizophrenia. Schizophrenia research. vol 197. 2019-11-08. PMID:29274737. |
dopamine is thought to play a role in schizophrenia pathology, yet the substantia nigra (sn), the origin of dopaminergic pathways, has not been studied extensively in schizophrenia. |
2019-11-08 |
2023-08-13 |
human |
| Andre Chevrier, Mehereen Bhaijiwala, Jonathan Lipszyc, Douglas Cheyne, Simon Graham, Russell Schacha. Disrupted reinforcement learning during post-error slowing in ADHD. PloS one. vol 14. issue 2. 2019-10-29. PMID:30785885. |
further, although reinforcement leaning critically relies on ventral striatum exerting error magnitude related thresholding influences on substantia nigra (sn) and dorsal striatum, these thresholding influences have never been identified with neuroimaging. |
2019-10-29 |
2023-08-13 |
Not clear |
| Yuichiro Mita, Yuto Kataoka, Yoshiro Saito, Takuma Kashi, Kojiro Hayashi, Asa Iwasaki, Takanori Imanishi, Tomohiro Miyasaka, Noriko Noguch. Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30104666. |
in the brain, oxdj-1 was detected in pd-related brain sites such as the substantia nigra (sn) of the midbrain, olfactory bulb (ob), and striatum. |
2019-10-28 |
2023-08-13 |
mouse |
| Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczn. Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30295916. |
prolonged impairment of astrocytic functions could increase the vulnerability of dopaminergic neurons in the substantia nigra (sn), accelerate their degeneration and affect ability to compensate for partial degeneration at the presymptomatic stages of the disease. |
2019-10-28 |
2023-08-13 |
Not clear |
| Xiang-Xing Zhu, Yi-Zhi Zhong, Yao-Wen Ge, Ke-Huan Lu, Sheng-Sheng L. CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson's Disease. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:30127453. |
parkinson's disease (pd) is a common, progressive neurodegenerative disorder characterized by classical motor dysfunction and is associated with α-synuclein-immunopositive pathology and the loss of dopaminergic neurons in the substantia nigra (sn). |
2019-10-24 |
2023-08-13 |
Not clear |
| James Cunningham, Yi Zheng, Thyagarajan Subramanian, Mohamed Almekkaw. Improved Real-Time Capability for Nonlinear Seperable Harmonic Filtering of Ultrasound Images Using a Damped Regularization Method With In-Vivo Results. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2018. 2019-10-24. PMID:30440534. |
hyperechogenicity in the substantia nigra is one marker that has been shown to help make this differential diagnosis, and transcranial ultrasound imaging is the preferred method for detecting sn hyperechogenicity. |
2019-10-24 |
2023-08-13 |
Not clear |
| Oleg Solopchuk, Moustapha Sebti, Céline Bouvy, Charles-Etienne Benoit, Thibault Warlop, Anne Jeanjean, Alexandre Zéno. Locus Coeruleus atrophy doesn't relate to fatigue in Parkinson's disease. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30120287. |
we quantified lc and substantia nigra (sn) atrophy using neuromelanin-sensitive imaging, analyzed with a novel, fully automated algorithm. |
2019-10-18 |
2023-08-13 |
Not clear |
| Sujung Yeo, Sabina Li. Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model. The American journal of Chinese medicine. vol 47. issue 3. 2019-10-17. PMID:30966771. |
parkinson's disease (pd), a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra (sn). |
2019-10-17 |
2023-08-13 |
mouse |
| Tian Guo, Yang Song, Jianqi Li, Mingxia Fan, Xu Yan, Andi He, Dongya Huang, Chaomin Shen, Guixu Zhang, Guang Yan. Seed point discontinuity-based segmentation method for the substantia nigra and the red nucleus in quantitative susceptibility maps. Journal of magnetic resonance imaging : JMRI. vol 48. issue 4. 2019-09-30. PMID:29603826. |
however, as the most frequently used segmentation method, the atlas method provides unsatisfactory results when segmenting the substantia nigra (sn) and the red nucleus (rn). |
2019-09-30 |
2023-08-13 |
Not clear |
| Lei Du, Zifang Zhao, Ailing Cui, Yijiang Zhu, Lu Zhang, Jing Liu, Sumin Shi, Chao Fu, Xiaowei Han, Wenwen Gao, Tianbin Song, Lizhi Xie, Lei Wang, Shilong Sun, Runcai Guo, Guolin M. Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer's Disease. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29722955. |
the magnetic susceptibilities of the regions of interest (rois), including caudate nucleus (cd), putamen (pt), globus pallidus (gp), thalamus (th), red nucleus (rn), substantia nigra (sn), and dentate nucleus (dn), were quantified by qsm. |
2019-09-30 |
2023-08-13 |
human |
| Bingxu Huang, Juxiong Liu, Tianyu Meng, Yuhang Li, Dewei He, Xin Ran, Guangxin Chen, Wenjin Guo, Xingchi Kan, Shoupeng Fu, Wei Wang, Dianfeng Li. Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis. Frontiers in immunology. vol 9. 2019-09-26. PMID:30455692. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by selective loss of dopaminergic neurons in the substantia nigra (sn). |
2019-09-26 |
2023-08-13 |
rat |