| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rania M Salama, Mariane G Tadros, Mona F Schaalan, Nevine Bahaa, Ahmed M Abdel-Tawab, Amani E Khalif. Potential neuroprotective effect of androst-5-ene-3β, 17β-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model. Journal of cellular physiology. vol 233. issue 8. 2019-09-23. PMID:29266208. |
amelioration in striatal dopamine (da), nuclear factor-kappa b (nf-κb), and the expression of down-stream inflammatory mediators, as well as apoptotic markers were observed in the striatum and substantia nigra (sn) upon pre-treatment with the three doses of adiol. |
2019-09-23 |
2023-08-13 |
rat |
| Marcus Heldmann, Janna Heeren, Christine Klein, Linus Rauch, Johann Hagenah, Thomas F Münte, Meike Kasten, Norbert Brüggeman. Neuroimaging abnormalities in individuals exhibiting Parkinson's disease risk markers. Movement disorders : official journal of the Movement Disorder Society. vol 33. issue 9. 2019-09-12. PMID:29756356. |
the concept of prodromal parkinson's disease (pd) involves variable combinations of nonmotor features and subtle motor abnormalities as a result of ongoing neurodegeneration in the brain stem including substantia nigra (sn) and abnormal findings upon transcranial sonography and nuclear imaging. |
2019-09-12 |
2023-08-13 |
Not clear |
| Thea Pinholt Lillethorup, Andreas Nørgaard Glud, Natalie Landeck, Aage Kristian Olsen Alstrup, Steen Jakobsen, Kim Vang, Doris J Doudet, David J Brooks, Deniz Kirik, Rainer Hinz, Jens Christian Sørensen, Anne M Landa. In vivo quantification of glial activation in minipigs overexpressing human α-synuclein. Synapse (New York, N.Y.). vol 72. issue 12. 2019-09-10. PMID:30009467. |
parkinson's disease is characterized by a progressive loss of substantia nigra (sn) dopaminergic neurons and the formation of lewy bodies containing accumulated alpha-synuclein (α-syn). |
2019-09-10 |
2023-08-13 |
human |
| Estefania Rojo-Bustamante, Miguel Angel Abellanas, Pedro Clavero, Marie-Laure Thiolat, Qin Li, Maria Rosario Luquin, Erwan Bezard, Maria S Aymeric. The expression of cannabinoid type 1 receptor and 2-arachidonoyl glycerol synthesizing/degrading enzymes is altered in basal ganglia during the active phase of levodopa-induced dyskinesia. Neurobiology of disease. vol 118. 2019-09-09. PMID:29936234. |
the basal ganglia nuclei, putamen, external segment of the globus pallidus (gpe), internal segment of the globus pallidus (gpi), subthalamic nucleus (stn) and substantia nigra (sn) were dissected out from cryostat sections obtained from two groups of parkinsonian monkeys treated with levodopa to induce dyskinesias. |
2019-09-09 |
2023-08-13 |
monkey |
| Elizabeth B Moloney, Alyssa Moskites, Eliza J Ferrari, Ole Isacson, Penelope J Hallet. The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Neurobiology of disease. vol 120. 2019-09-06. PMID:30149180. |
in the current study, gpnmb increases were seen in the substantia nigra (sn) of pd patients compared to age-matched controls. |
2019-09-06 |
2023-08-13 |
mouse |
| Juciano Gasparotto, Camila Tiefensee Ribeiro, Helen Tais da Rosa-Silva, Rafael Calixto Bortolin, Thallita Kelly Rabelo, Daniel Oppermann Peixoto, José Claudio Fonseca Moreira, Daniel Pens Gelai. Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30094805. |
fifteen days after lps administration, the content of rage was analyzed in the prefrontal cortex (pfc), hippocampus (hipp), cerebellum (cb), and substantia nigra (sn) were investigated. |
2019-08-20 |
2023-08-13 |
rat |
| Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research. vol 83. issue 6. 2019-08-12. PMID:29741516. |
the effect of propofol and isoflurane on the dopaminergic neurotransmitter phenotype in the substantia nigra (sn) was studied using tyrosine hydroxylase immunohistochemistry. |
2019-08-12 |
2023-08-13 |
Not clear |
| Michael F Salvatore, Tamara R McInnis, Mark A Cantu, Deana M Apple, Brandon S Pruet. Tyrosine Hydroxylase Inhibition in Substantia Nigra Decreases Movement Frequency. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30056575. |
in contrast, moderate da or th loss in the substantia nigra (sn), as occurs in aging, is of similar magnitude (~ 40%) to nigral th loss at bradykinesia onset in parkinson's disease. |
2019-08-06 |
2023-08-13 |
human |
| Yunhu Bai, Yayun Wang, Yanling Yan. Hepatic encephalopathy changes mitochondrial dynamics and autophagy in the substantia nigra. Metabolic brain disease. vol 33. issue 5. 2019-07-26. PMID:29998403. |
we used molecular biology and morphology methods to evaluate changes in mitochondrial dynamics and autophagy of the substantia nigra (sn) and prefrontal cortex (pfc) in he. |
2019-07-26 |
2023-08-13 |
mouse |
| Congcong Sun, Yun Wang, Mingshu Mo, Chengyuan Song, Xingbang Wang, Si Chen, Yiming Li. Minocycline Protects against Rotenone-Induced Neurotoxicity Correlating with Upregulation of Nurr1 in a Parkinson's Disease Rat Model. BioMed research international. vol 2019. 2019-07-22. PMID:30949504. |
double immunofluorescence staining was used to detect the expression of tyrosine hydroxylase (th) and nurr1 in the substantia nigra (sn) of rats. |
2019-07-22 |
2023-08-13 |
rat |
| Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook O. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice. Journal of the neurological sciences. vol 392. 2019-07-18. PMID:30031172. |
parkinson's disease (pd) is a progressive neurodegenerative disorder accompanied by movement deficits with selective degeneration of dopaminergic neurons in the substantia nigra (sn). |
2019-07-18 |
2023-08-13 |
mouse |
| Nathalie Arnal, Gustavo Morel, Carlos A Marra, Mariana Asti. Pro-apoptotic effects of low doses of dimethoate in rat brain. Toxicology and applied pharmacology. vol 363. 2019-07-18. PMID:30502393. |
the induction of cell death programs was investigated in two brain regions, cortex (cx) and substantia nigra (sn), after the exposure period. |
2019-07-18 |
2023-08-13 |
rat |
| Liyan Lu, Fengfang Li, Yuehu Ma, Huiyou Chen, Peng Wang, Mingyang Peng, Yu-Chen Chen, Xindao Yi. Functional connectivity disruption of the substantia nigra associated with cognitive impairment in acute mild traumatic brain injury. European journal of radiology. vol 114. 2019-07-18. PMID:31005180. |
accumulating evidence is pointing to the malfunctioning of the substantia nigra (sn) as an important factor for head trauma. |
2019-07-18 |
2023-08-13 |
Not clear |
| Zhuo Liu, Hui-Cong Shen, Teng-Hong Lian, Lei Mao, Shou-Xian Tang, Li Sun, Xi-Yan Huang, Peng Guo, Chen-Jie Cao, Shu-Yang Yu, Li-Jun Zuo, Xiao-Min Wang, Sheng-Di Chen, Piu Chan, Wei Zhan. Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance. Scientific reports. vol 7. issue 1. 2019-07-15. PMID:29097764. |
results showed that corrected phase (cp) value of substantia nigra (sn) was significantly decreased in pd group compared to control group, hence, sn was the main region with excessive iron deposition. |
2019-07-15 |
2023-08-13 |
human |
| T N Seyfried, H Choi, A Chevalier, D Hogan, Z Akgoc, J S Schneide. Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson's Disease. ASN neuro. vol 10. 2019-07-11. PMID:29932343. |
parkinson's disease (pd) is a neurodegenerative movement disorder involving the selective loss of dopamine-producing neurons in the substantia nigra (sn). |
2019-07-11 |
2023-08-13 |
human |
| Tim E Moors, Silvia Paciotti, Angela Ingrassia, Marialuisa Quadri, Guido Breedveld, Anna Tasegian, Davide Chiasserini, Paolo Eusebi, Gonzalo Duran-Pacheco, Thomas Kremer, Paolo Calabresi, Vincenzo Bonifati, Lucilla Parnetti, Tommaso Beccari, Wilma D J van de Ber. Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies. Molecular neurobiology. vol 56. issue 2. 2019-07-11. PMID:29948939. |
enzymatic activities of gcase, β-hexosaminidase, and cathepsin d were measured in the frontal cortex, putamen, and substantia nigra (sn) of a cohort of patients with advanced pd and dlb as well as age-matched non-demented controls (n = 15/group) using fluorometric assays. |
2019-07-11 |
2023-08-13 |
Not clear |
| Xiaojun Guan, Yuyao Zhang, Hongjiang Wei, Tao Guo, Qiaoling Zeng, Cheng Zhou, Jiaqiu Wang, Ting Gao, Min Xuan, Quanquan Gu, Xiaojun Xu, Peiyu Huang, Jiali Pu, Baorong Zhang, Chunlei Liu, Minming Zhan. Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease. Neurobiology of aging. vol 75. 2019-07-11. PMID:30554085. |
in parkinson's disease (pd), iron accumulation in the substantia nigra (sn) exacerbates oxidative stress and α-synuclein aggregation, leading to neuronal death. |
2019-07-11 |
2023-08-13 |
Not clear |
| Stephanie C Gantz, Christopher P Ford, Hitoshi Morikawa, John T William. The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area. Annual review of physiology. vol 80. 2019-07-04. PMID:28938084. |
in recent years, the population of neurons in the ventral tegmental area (vta) and substantia nigra (sn) has been examined at multiple levels. |
2019-07-04 |
2023-08-13 |
Not clear |
| Katherine W Turk, Margaret E Flanagan, Samuel Josephson, C Dirk Keene, Suman Jayadev, Thomas D Bir. Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra. Cerebellum (London, England). vol 17. issue 2. 2019-06-26. PMID:28887803. |
we studied a retrospective clinical case series of eight subjects with spinocerebellar ataxias (scas) 2, 3, 7, and 17, all displaying features of psychosis, and also measured tyrosine hydroxylase (th) staining of the substantia nigra (sn) at autopsy, among four of the subjects. |
2019-06-26 |
2023-08-13 |
human |
| Antje Haehner, Veronika Schöpf, Ana Loureiro, Jennifer Linn, Heinz Reichmann, Thomas Hummel, Hagen H Kitzle. Substantia nigra fractional anisotropy changes confirm the PD at-risk status of patients with idiopathic smell loss. Parkinsonism & related disorders. vol 50. 2019-06-21. PMID:29477459. |
in this study, we measured the fractional anisotropy (fa) in the substantia nigra (sn) in pd patients, in patients with idiopathic smell loss, and in healthy controls. |
2019-06-21 |
2023-08-13 |
Not clear |